A. Strauss

发表

Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay.

J. Mestan, D. Fabbro, W. Jahnke, 2010, Journal of the American Chemical Society.

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

John T. Powers, G. Daley, W. Jahnke, 2010, Nature.

Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.

W. Jahnke, M. Geiser, T. Roddy, 2010, Nature chemical biology.

Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs

Wolfgang Jahnke, Jean-Michel Rondeau, W. Jahnke, 2006, ChemMedChem.

Second-Site NMR Screening with a Spin-Labeled First Ligand

Wolfgang Jahnke, C. Gregory Paris, W. Jahnke, 2000 .

Amino–acid-type selective isotope labeling of proteins expressed in Baculovirus-infected insect cells useful for NMR studies

W. Jahnke, G. Fendrich, J. Liebetanz, 2003, Journal of biomolecular NMR.

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.

G. Rummel, M. Geiser, S. Cowan-Jacob, 2009, Journal of medicinal chemistry.

Improved expression of kinases in Baculovirus-infected insect cells upon addition of specific kinase inhibitors to the culture helpful for structural studies.

R. Schmitz, G. Fendrich, J. Liebetanz, 2007, Protein expression and purification.

Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands.

P. Furet, C. García-echeverría, H. Fretz, 1998, Journal of molecular biology.

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.

G. Rummel, S. Cowan-Jacob, E. Vangrevelinghe, 2011, Bioorganic & medicinal chemistry letters.

Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha.

M. Geiser, Alain Schilb, V. Riou, 2004, The Journal of biological chemistry.

Solution Conformations and Dynamics of ABL Kinase-Inhibitor Complexes Determined by NMR Substantiate the Different Binding Modes of Imatinib/Nilotinib and Dasatinib*♦

Wolfgang Jahnke, W. Jahnke, S. Grzesiek, 2008, Journal of Biological Chemistry.

L 3 Differences in the kinase binding modes of imatinib , nilotinib and dasatinib are reflected in Abl transphosphorylation assays

D. Fabbro, S. Grzesiek, S. Cowan-Jacob, 2009 .

Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site.

Wolfgang Jahnke, Doriano Fabbro, Pascal Furet, 2010, Biochimica et biophysica acta.

Structural basis for specificity of GRB2-SH2 revealed by a novel ligand binding mode

D. Erdmann, P. Furet, C. García-echeverría, 1996, Nature Structural Biology.

Recombinant hirustasin: Production in yeast, crystallization, and interaction with serine proteases

M. Grütter, G. Fendrich, J. Priestle, 1997, Protein science : a publication of the Protein Society.

Bcr-Abl Binding Modes of Dasatinib, Imatinib and Nilotinib: An NMR Study.

W. Jahnke, S. Grzesiek, S. Cowan-Jacob, 2006 .

Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis.

J. Mestan, C. Schnell, J. Wood, 2004, Biochimica et biophysica acta.

Crystal Structure of Human Estrogen-related Receptor α in Complex with a Synthetic Inverse Agonist Reveals Its Novel Molecular Mechanism*

M. Geiser, M. Blommers, B. Fournier, 2007, Journal of Biological Chemistry.

Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib

W. Jahnke, S. Grzesiek, S. Cowan-Jacob, 2008, Biomolecular NMR assignments.

Efficient uniform isotope labeling of Abl kinase expressed in Baculovirus-infected insect cells

W. Jahnke, G. Fendrich, A. Strauss, 2005, Journal of biomolecular NMR.

The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold*

N. Schmiedeberg, G. Fendrich, T. Troxler, 2015, The Journal of Biological Chemistry.

Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics.

Stephen Hanessian, Nicolas Moitessier, Gaoqiang Yang, 2005, Journal of medicinal chemistry.

NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.

W. Jahnke, M. Geiser, M. Blommers, 2008, Topics in current chemistry.

Evidence for Ligand-independent Transcriptional Activation of the Human Estrogen-related Receptor α (ERRα)

M. Geiser, Alain Schilb, V. Riou, 2004, Journal of Biological Chemistry.

Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site.

J. Mestan, D. Fabbro, W. Jahnke, 2010, Biochimica et biophysica acta.

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.

G. Rummel, S. Cowan-Jacob, E. Vangrevelinghe, 2011, Bioorganic & medicinal chemistry letters.