F. Giordanetto

发表

Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening.

F. Giordanetto, B. Kull, A. Dellsén, 2011, Bioorganic & medicinal chemistry letters.

Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation.

A. Wallberg, S. Ghosal, F. Giordanetto, 2012, Bioorganic & medicinal chemistry letters.

Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.

U. Zachariae, A. Leach, F. Giordanetto, 2009, Journal of medicinal chemistry.

Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties?

Fabrizio Giordanetto, Jan Kihlberg, J. Kihlberg, 2014, Journal of medicinal chemistry.

Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates.

Fabrizio Giordanetto, Jan Kihlberg, J. Kihlberg, 2014, Chemistry & biology.

Stabilization of protein-protein interactions by small molecules.

Fabrizio Giordanetto, Christian Ottmann, C. Ottmann, 2014, Drug discovery today.

Fragment Hits: What do They Look Like and How do They Bind?

Miklos Feher, Fabrizio Giordanetto, D. Shaw, 2019, Journal of medicinal chemistry.

Assessment of Docking Poses: Interactions-Based Accuracy Classification (IBAC) versus Crystal Structure Deviations.

Anna Vulpetti, Pieter F. W. Stouten, Joseph J. McDonald, 2004 .

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Richard Svensson, Giovanni Muncipinto, Fabrizio Giordanetto, 2014, Journal of medicinal chemistry.

Physical interaction of apoptosis-inducing factor with DNA and RNA

G. Kroemer, E. L. Cam, E. Herker, 2006, Oncogene.

Optimization of 2-piperidin-4-yl-acetamides as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Designing out hERG inhibition.

F. Giordanetto, Bryan J. Egner, Susanne Berglund, 2009, Bioorganic & medicinal chemistry letters.

Optimization of piperidin-4-yl-urea-containing melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Reducing hERG-associated liabilities.

F. Giordanetto, Bryan J. Egner, Susanne Berglund, 2009, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Fsp(3)-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening.

J. Sánchez-Quesada, M. Winkler, F. Giordanetto, 2016, ACS combinatorial science.

Follow-on drugs: how far should chemists look?

Jonas Boström, Christian Tyrchan, Fabrizio Giordanetto, 2011, Drug discovery today.

Stereoselective synthesis of a natural product inspired tetrahydroindolo[2,3-a]-quinolizine compound library.

Herbert Waldmann, Fabrizio Giordanetto, Carsten Strohmann, 2015, Bioorganic & medicinal chemistry.

Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion.

A. Gill, Cl Priest, F. Giordanetto, 2013, ACS medicinal chemistry letters.

Are sigma receptor modulators a weapon against multiple sclerosis disease?

D. Rossi, S. Collina, G. Cavaletti, 2017, Future medicinal chemistry.

Early Drug Development: Progressing a Candidate Compound to the Clinics

F. Giordanetto, 2018, Early Drug Development.

Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent melanin-concentrating hormone receptor 1 (MCH-R1) antagonists.

F. Giordanetto, Bryan J. Egner, Susanne Berglund, 2008, Bioorganic & medicinal chemistry letters.

Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid.

Tomas Åkerud, N. Selmi, E. Hurt-Camejo, 2018, ACS medicinal chemistry letters.

Intramolecular Hydrogen Bond Expectations in Medicinal Chemistry.

J. Ulander, C. Tyrchan, F. Giordanetto, 2017, ACS medicinal chemistry letters.

European Lead Factory

Adam Nelson, Gerhard Müller, Fabrizio Giordanetto, 2017 .

Fragment-Based Discovery of AZD2716: A Novel, Potent Secreted Phospholipase A 2 (sPLA 2 ) Inhibitor for the Treatment of Coronary Artery Disease

F. Giordanetto, D. Pettersen, 2017 .

Competition in the Pharmaceutical Drug Development

C. Tyrchan, F. Giordanetto, 2012 .

Structure‐Based Discovery of Allosteric Modulators of Two Related Class B G‐Protein‐Coupled Receptors

Didier Rognan, Fabrizio Giordanetto, D. Rognan, 2011, ChemMedChem.

A three-dimensional model of Suppressor Of Cytokine Signalling 1 (SOCS-1).

F. Giordanetto, R. Kroemer, 2003, Protein engineering.

A human mitochondriopathy caused by AIF mutation

G. Kroemer, F. Giordanetto, N. Modjtahedi, 2010, Cell Death and Differentiation.

Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.

H. Zachrisson, F. Giordanetto, J. Björkman, 2013, Journal of medicinal chemistry.

Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor.

A. Åstrand, A. Wallberg, N. Selmi, 2013, Bioorganic & medicinal chemistry letters.

On Evaluating Molecular-Docking Methods for Pose Prediction and Enrichment Factors. [J. Chem. Inf. Model. 46, 401-415 (2006)]

Jin Li, Hongming Chen, Fabrizio Giordanetto, 2008, J. Chem. Inf. Model..

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

Simona Collina, Fabrizio Giordanetto, Dimitrios Tzalis, 2018, Molecules.

Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as oral PI3Kβ inhibitors, useful as antiplatelet agents.

B. Barlaam, F. Giordanetto, K. Edman, 2014, Bioorganic & medicinal chemistry letters.

Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours.

S. Green, B. Barlaam, S. Degorce, 2014, Bioorganic & medicinal chemistry letters.

Effects of the Pyridine 3‐Substituent on Regioselectivity in the Nucleophilic Aromatic Substitution Reaction of 3‐Substituted 2,6‐Dichloropyridines with 1‐Methylpiperazine Studied by a Chemical Design Strategy

Michaela Marczynke, F. Giordanetto, P. Bach, 2012 .

Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective.

Adam Nelson, Tuomo Kalliokoski, Gerhard Müller, 2015, Drug discovery today.

Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT.

C. Ehrt, O. Koch, F. Giordanetto, 2017, Journal of medicinal chemistry.

Optimization of ketone-based P2Y(12) receptor antagonists as antithrombotic agents: pharmacodynamics and receptor kinetics considerations.

H. Zachrisson, F. Giordanetto, J. Björkman, 2014, Bioorganic & medicinal chemistry letters.

Overview of Macrocycles in Clinical Development and Clinically Used

F. Giordanetto, Silvia Stotani, 2017 .

DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance.

A. Poso, S. Collina, T. Laitinen, 2019, Journal of medicinal chemistry.

Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists.

A. Linusson, F. Giordanetto, E. Evertsson, 2007, Bioorganic & medicinal chemistry letters.

Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease

N. Selmi, N. Dekker, E. Hurt-Camejo, 2016, ACS medicinal chemistry letters.

Apoptosis-inducing factor: vital and lethal.

G. Kroemer, F. Madeo, F. Giordanetto, 2006, Trends in cell biology.

Small molecule inhibitors of ebola virus infection.

F. Giordanetto, Edwige Picazo, 2015, Drug discovery today.

Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance.

A. Wallberg, S. Ghosal, F. Giordanetto, 2012, Bioorganic & medicinal chemistry letters.

In silico rationalization of the structural and physicochemical requirements for photobiological activity in angelicine derivatives and their heteroanalogues

Fabrizio Giordanetto, Paola Fossa, Giulia Menozzi, 2003, J. Comput. Aided Mol. Des..

T-type calcium channels inhibitors: a patent review

Laurent Knerr, Fabrizio Giordanetto, A. Wallberg, 2011, Expert opinion on therapeutic patents.

Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors.

C. Enroth, F. Giordanetto, W. Knecht, 2012, Bioorganic & medicinal chemistry letters.

Suppressing Kv1.3 Ion Channel Activity with a Novel Small Molecule Inhibitor Ameliorates Inflammation in a Humanised Mouse Model of Ulcerative Colitis

M. Jensen, D. Shaw, A. Aszódi, 2021, Journal of Crohn's & colitis.

Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.

D. Dix, G. Kroemer, J. Penninger, 2003, Cancer research.

Structural basis of AMPK regulation by small molecule activators

David Carling, Fabrizio Giordanetto, Steven J. Gamblin, 2013, Nature Communications.

Structure–function analysis of the interaction between Bax and the cytomegalovirus-encoded protein vMIA

G. Kroemer, N. Larochette, D. Poncet, 2007, Oncogene.

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7.

Fabrizio Giordanetto, F. Giordanetto, R. Kroemer, 2002, Protein engineering.

On Evaluating Molecular-Docking Methods for Pose Prediction and Enrichment Factors

Jin Li, Hongming Chen, Fabrizio Giordanetto, 2006, J. Chem. Inf. Model..

Disruption of the PP1/GADD34 complex induces calreticulin exposure

L. Zitvogel, L. Galluzzi, O. Kepp, 2009, Cell cycle.

2-Sulfonylpyrimidines Target the Kinesin HSET via Cysteine Alkylation

H. Waldmann, T. Förster, H. Osada, 2019, European Journal of Organic Chemistry.

High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.

Anders Tunek, Fabrizio Giordanetto, Fredrik Bergström, 2007, Journal of medicinal chemistry.

Ticagrelor binds to human P2Y12 independently from ADP but antagonizes ADP‐induced receptor signaling and platelet aggregation

F. Giordanetto, P. Greasley, J. V. van Giezen, 2009, Journal of thrombosis and haemostasis : JTH.

AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

G. Kroemer, J. Luban, J. Penninger, 2004, Oncogene.

DYRK1A inhibition as potential treatment for Alzheimer's disease.

Fabrizio Giordanetto, F. Giordanetto, Silvia Stotani, 2016, Future medicinal chemistry.

Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors.

N. Selmi, F. Giordanetto, A. Llinàs, 2011, Bioorganic & medicinal chemistry letters.

Discovery and validation of the binding poses of allosteric fragment hits to PTP1b: From molecular dynamics simulations to X-ray crystallography

Hunter M Nisonoff, Hunter M. Nisonoff, D. Shaw, 2023, bioRxiv.

Potential strategies for increasing drug-discovery productivity.

Fabrizio Giordanetto, John G Cumming, M Raymond V Finlay, 2014, Future medicinal chemistry.

Branching cascades provide access to two amino-oxazoline compound libraries.

Fabrizio Giordanetto, Kamal Kumar, M. Winkler, 2015, Bioorganic & medicinal chemistry.

Direct AMP-activated protein kinase activators: a review of evidence from the patent literature

F. Giordanetto, D. Karis, David Karis, 2012, Expert opinion on therapeutic patents.

Inefficacy of a Highly Selective T‐Type Calcium Channel Blocker in Preventing Atrial Fibrillation Related Remodeling

S. Nattel, Y. Iwasaki, F. Giordanetto, 2014, Journal of cardiovascular electrophysiology.

Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors.

Tomas Åkerud, N. Selmi, K. Hallberg, 2018, ACS Medicinal Chemistry Letters.

Targeting HSP70 for cancer therapy.

Fabrizio Giordanetto, Lorenzo Galluzzi, Guido Kroemer, 2009, Molecular cell.

Assessment of Docking Poses: Interactions-Based Accuracy Classification (IBAC) versus Crystal Structure Deviations

Anna Vulpetti, Pieter F. W. Stouten, Colin McMartin, 2004, J. Chem. Inf. Model..

Collaborative Approaches to Lead Generation

Fabrizio Giordanetto, Anna Karawajczyk, Graham A. Showell, 2016 .

Re-examining the role of cytochrome c in cell death

G. Kroemer, E. Solary, F. Giordanetto, 2008, Nature Genetics.

Molecular Basis of Small-Molecule Binding to α-Synuclein

Albert C. Pan, Paul Robustelli, D. Shaw, 2021, bioRxiv.

Transient expression, purification and characterisation of human full-length PPARγ2 in HEK293 cells.

A. Nyström, M. Ormö, F. Giordanetto, 2013, Protein expression and purification.

Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation.

A. Hogner, F. Giordanetto, K. Bamberg, 2022, ACS medicinal chemistry letters.

Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)

Maria Paola Costi, L. Naesens, E. Cichero, 2018, European Journal of Medicinal Chemistry.

Large scale molecular dynamics simulation of native and mutant dihydropteroate synthase–sulphanilamide complexes suggests the molecular basis for dihydropteroate synthase drug resistance

Peter V Coveney, Philip W Fowler, Mansoor Saqi, 2005, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

Abstract 3327: Discovery and characterization of the potent, allosteric SHP2 inhibitor GDC-1971 for the treatment of RTK/RAS driven tumors

D. Bergstrom, M. Murcko, D. Shaw, 2022, Cancer Research.

The European lead factory—an experiment in collaborative drug discovery

Fabrizio Giordanetto, Dimitrios Tzalis, Hugh Laverty, 2016, Journal of Medicines Development Sciences.

Design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries.

Jorge Sanchez-Quesada, Fabrizio Giordanetto, Anna Karawajczyk, 2015, Bioorganic & medicinal chemistry.

Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography

Hunter M. Nisonoff, D. Shaw, P. Maragakis, 2023, J. Chem. Inf. Model..

Virtual screening to enrich a compound collection with CDK2 inhibitors using docking, scoring, and composite scoring models

Patrizia Crivori, Anna Vulpetti, Fabrizio Giordanetto, 2005, Proteins.

Exploiting Structural Information in Patent Specifications for Key Compound Prediction

Jonas Boström, Jon Winter, Sorel Muresan, 2012, J. Chem. Inf. Model..

Structural basis for selective PDE 3 inhibition: a docking study

P. Fossa, F. Giordanetto, L. Mosti, 2002 .

Small molecule inhibitors of ebola virus infection.

F. Giordanetto, Edwige Picazo, 2015, Drug discovery today.

Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.

Andrew G. Leach, U. Zachariae, F. Giordanetto, 2009, Journal of medicinal chemistry.

Exploring the molecular basis of selectivity in A1 adenosine receptors agonists: a case study

Fabrizio Giordanetto, Paola Fossa, Giulia Menozzi, 2003, J. Comput. Aided Mol. Des..

Design and synthesis of 4,5,6,7-tetrahydro-1H-1,2-diazepin-7-one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors.

P. Fossa, F. Giordanetto, Sara Guariento, 2017, Bioorganic & medicinal chemistry letters.

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

S. Collina, F. Giordanetto, Silvia Stotani, 2018, Molecules.

Transient expression, purification and characterisation of human full-length PPARγ2 in HEK293 cells.

A. Nyström, M. Ormö, F. Giordanetto, 2013, Protein expression and purification.

Novel Scoring Functions Comprising QXP, SASA, and Protein Side-Chain Entropy Terms

Anna Vulpetti, Cornel Catana, Pieter F. W. Stouten, 2004, J. Chem. Inf. Model..