Huchen Zhou

发表

Toward understanding the molecular basis for chemical allosteric modulator design.

Qi Wang, Jian Zhang, Ting Shi, 2012, Journal of Molecular Graphics and Modelling.

In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors

Yaxue Zhao, L. Bai, Huchen Zhou, 2014, International journal of molecular sciences.

Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis.

Weiliang Zhu, Yaxue Zhao, Huaiyu Yang, 2012, Bioorganic & medicinal chemistry.

An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site

Vincent Hernandez, Stephen J Benkovic, Lucy Shapiro, 2007, Science.

The structural and bonding evolution in cysteine-gold cluster complexes.

Yaxue Zhao, H. Su, Feng Zhou, 2013, Physical chemistry chemical physics : PCCP.

Benzothiophene-2-carboxamide derivatives as SENPs inhibitors with selectivity within SENPs family.

Yaxue Zhao, S. Ullah, Huchen Zhou, 2020, European journal of medicinal chemistry.

Progress in the Discovery of Small Molecule Modulators of DeSUMOylation.

Huchen Zhou, Duoling Dong, Shiyao Chen, 2019, Current issues in molecular biology.

Development and evaluation of a highly reliable assay for SUMO-specific protease inhibitors.

Yaxue Zhao, Huchen Zhou, Zhongli Wang, 2016, Bioorganic & medicinal chemistry letters.

Synthesis of biologically active boron-containing compounds.

Huchen Zhou, Fei Yang, Mingyan Zhu, 2018, MedChemComm.

Pattern recognition of proteins based on an array of functionalized porphyrins.

A. Hamilton, Andrew J. Wilson, Huchen Zhou, 2006, Journal of the American Chemical Society.

Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.

K. R. Maples, S. Baker, Huchen Zhou, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of α-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors.

Huchen Zhou, Qing Wang, Mingyan Zhu, 2019, European journal of medicinal chemistry.

Novel pyrrolobenzoxaboroles: design, synthesis, and biological evaluation against Trypanosoma brucei.

B. Nare, Huchen Zhou, Qingqing Meng, 2014, European journal of medicinal chemistry.

Discovery of N-(4-sulfamoylphenyl)thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors.

Yaxue Zhao, Huchen Zhou, Qing Wang, 2013, Organic & biomolecular chemistry.

The synthesis of benzoxaboroles and their applications in medicinal chemistry

Yinan Lin, Huchen Zhou, Mingyan Zhu, 2013, Science China Chemistry.

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.

F. Gamo, Laura M Sanz, Huchen Zhou, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of a novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel–Crafts reaction catalyzed by anhydrous stannic chloride

Huchen Zhou, Qingqing Meng, Puhua Wu, 2011 .

Discovery of novel benzoxaborole-based potent antitrypanosomal agents.

Yaxue Zhao, B. Nare, J. McKerrow, 2010, ACS medicinal chemistry letters.

Convenient and versatile synthesis of formyl-substituted benzoxaboroles

Hui Guo, Huchen Zhou, Qingqing Meng, 2009 .

Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis.

S. Baker, Huchen Zhou, J. Plattner, 2006, Journal of medicinal chemistry.

Induces Autophagy of Female Germline Stem Cells via Inhibition of the PI 3 K-Akt Pathway In Vitro

Ji Wu, Geng G. Tian, Huchen Zhou, 2019 .

C89 Induces Autophagy of Female Germline Stem Cells via Inhibition of the PI3K-Akt Pathway In Vitro

Ji Wu, Geng G. Tian, Huchen Zhou, 2019, Cells.

C28-induced autophagy of female germline stem cells in vitro and its potential mechanisms

Ji Wu, Geng G. Tian, Xinyang Zhao, 2019 .

Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation.

S. Sebti, A. Hamilton, Huchen Zhou, 2006, Organic & biomolecular chemistry.

Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors.

Huchen Zhou, Mingyan Zhu, Zhongli Wang, 2017, Bioorganic & medicinal chemistry letters.

Selective Removal of Aberrant Extender Units by a Type II Thioesterase for Efficient FR-008/Candicidin Biosynthesis in Streptomyces sp. Strain FR-008

Z. Deng, L. Bai, Delin You, 2008, Applied and Environmental Microbiology.

2,3,6-Trideoxy sugar nucleotides: synthesis and stability

L. Bai, Huchen Zhou, Qingqing Meng, 2011 .

Recent developments in the synthesis of bioactive boron-containing compounds

Huchen Zhou, Liyang Ji, 2021, Tetrahedron Letters.

Characterization of the Polyoxin Biosynthetic Gene Cluster from Streptomyces cacaoi and Engineered Production of Polyoxin H*

Z. Deng, L. Bai, Delin You, 2009, Journal of Biological Chemistry.

Chalcone-benzoxaborole hybrid molecules as potent antitrypanosomal agents.

B. Nare, Huchen Zhou, Dazhong Ding, 2012, Journal of medicinal chemistry.

Host-guest interactions of cyclodextrins and metalloporphyrins: supramolecular building blocks toward artificial heme proteins

J. Groves, Huchen Zhou, 2004 .

Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors

Huchen Zhou, Yunqi Liu, Shiyao Chen, 2021, International journal of molecular sciences.

Signaling through Rho GTPase pathway as viable drug target.

Qun Lu, Q. Lu, Huchen Zhou, 2009, Current medicinal chemistry.

Azobenzene-based small molecular photoswitches for protein modulation.

Huchen Zhou, Mingyan Zhu, 2018, Organic & biomolecular chemistry.

GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In Vitro

Ji Wu, Huchen Zhou, Xiaopeng Hu, 2019, Molecular therapy. Nucleic acids.

ZCL-082, a boron-containing compound, induces apoptosis of non-Hodgkin's lymphoma via targeting p90 ribosomal S6 kinase 1/NF-κB signaling pathway.

Hanzhang Xu, Ligen Liu, Huchen Zhou, 2021, Chemico-biological interactions.

Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents.

Yaxue Zhao, B. Nare, Dawei Li, 2011, Journal of medicinal chemistry.

Discovery of benzhydrol-oxaborole derivatives as Streptococcus pneumoniae leucyl-tRNA synthetase inhibitors.

Hao Li, Yingying Ding, Huchen Zhou, 2020, Bioorganic & medicinal chemistry.

Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents.

Huchen Zhou, Fei Yang, Mingyan Zhu, 2019, Journal of medicinal chemistry.

Inhibition of Cdc42–intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth

Yaxue Zhao, Q. Lu, Huchen Zhou, 2019, Cancer biology & therapy.

Small molecule targeting Cdc42–intersectin interaction disrupts Golgi organization and suppresses cell motility

Yaxue Zhao, Q. Lu, Huchen Zhou, 2013, Proceedings of the National Academy of Sciences.

Hemodextrin: a self-assembled cyclodextrin-porphyrin construct that binds dioxygen.

J. Groves, Huchen Zhou, 2003, Biophysical chemistry.

Cdc42 Signaling Pathway Inhibition as a Therapeutic Target in Ras- Related Cancers.

Q. Lu, Huchen Zhou, Byron J. Aguilar, 2017, Current medicinal chemistry.

Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors.

Qingqing Meng, Qing Wang, Yaxue Zhao, 2011, Bioorganic & medicinal chemistry letters.

A human leucyl-tRNA synthetase as an anticancer target

Huchen Zhou, Guangwei Gao, Dawei Li, 2015, OncoTargets and therapy.

C28 induced autophagy of female germline stem cells in vitro with changes of H3K27 acetylation and transcriptomics.

Ji Wu, Xinyang Zhao, Huchen Zhou, 2020, Gene.

Chalcone-benzoxaborole hybrids as novel anticancer agents.

Huchen Zhou, Fei Yang, Mingyan Zhu, 2016, Bioorganic & medicinal chemistry letters.

Design and synthesis of N-(3-sulfamoylphenyl)amides as Trypanosoma brucei leucyl-tRNA synthetase inhibitors.

Huchen Zhou, Qing Wang, Mingyan Zhu, 2021, European journal of medicinal chemistry.

Identification of SENP1 inhibitors through in silico screening and rational drug design.

Yaxue Zhao, Huchen Zhou, Zhongli Wang, 2016, European journal of medicinal chemistry.

Design, Synthesis, and Structure−Activity Relationship of Trypanosoma brucei Leucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents

Yaxue Zhao, B. Nare, Dawei Li, 2011 .