C. Grütter

发表

Strategies for the selective regulation of kinases with allosteric modulators: exploiting exclusive structural features.

Zhizhou Fang, C. Grütter, D. Rauh, 2013, ACS chemical biology.

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

K. Cibulskis, J. Shendure, G. Getz, 2012, Nature Genetics.

Natural-product-derived fragments for fragment-based ligand discovery

Stefan Wetzel, Herbert Waldmann, Daniel Rauh, 2012, Nature Chemistry.

Structural characterization of the RLCK family member BSK8: a pseudokinase with an unprecedented architecture.

G. Sessa, C. Grütter, D. Rauh, 2013, Journal of molecular biology.

Displacement assay for the detection of stabilizers of inactive kinase conformations.

C. Grütter, D. Rauh, M. Rabiller, 2010, Journal of medicinal chemistry.

Electronic structure of a-Ga

S. Hoffmann, P. Hofmann, Zheshen Li, 2003 .

High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha.

Daniel Rauh, Christian Ottmann, C. Ottmann, 2009, Journal of the American Chemical Society.

ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors

William Pao, Michael Hölzel, Martin Peifer, 2011, Clinical Cancer Research.

Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.

C. Grütter, D. Rauh, M. Rabiller, 2009, Journal of medicinal chemistry.

A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions

M. Grütter, L. Jermutus, M. Mccourt, 2008, Proceedings of the National Academy of Sciences.

Identification of type II and III DDR2 inhibitors.

H. Nguyen, T. Phan, C. Grütter, 2014, Journal of medicinal chemistry.

Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.

M. Sos, C. Grütter, D. Rauh, 2011, Bioorganic & medicinal chemistry.

Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance

C. Grütter, M. Rabiller, H. Raaijmakers, 2010, Chembiochem : a European journal of chemical biology.

Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.

Daniel Rauh, Jeffrey R. Simard, C. Grütter, 2009, Journal of the American Chemical Society.

A Biomimetic Chromanol Cyclization Leading to α-Tocopherol†

C. Grütter, W. Woggon, A. Chougnet, 2006 .

Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.

H. Nguyen, W. V. van Otterlo, C. Grütter, 2012, European journal of medicinal chemistry.

Bulk and surface premelting phenomena in α-gallium

W. Donner, H. Dosch, H. Reichert, 2003 .

ELECTRON-LATTICE INTERACTION ON ALPHA -GA(010)

P. Hofmann, Y. Cai, C. Grütter, 1998 .

Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components.

Jeremy Luban, Caterina Strambio-De-Castillia, L. Mazzucchelli, 2009, The Journal of clinical investigation.

Selective detection of allosteric phosphatase inhibitors.

C. Grütter, D. Rauh, J. Simard, 2013, Journal of the American Chemical Society.

Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.

C. Grütter, D. Rauh, Matthäus Getlik, 2010, Journal of the American Chemical Society.

A new screening assay for allosteric inhibitors of cSrc.

Daniel Rauh, C. Grütter, D. Rauh, 2009, Nature chemical biology.

The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1β processing

F. Martinon, J. Tschopp, M. Grütter, 2007, Cell Death and Differentiation.

Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.

Roman K. Thomas, M. Sos, Anu Gupta, 2013, Journal of medicinal chemistry.

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.

Jochen Heil, Franziska Hoffgaard, Julian Engel, 2015, Journal of medicinal chemistry.

Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR.

C. Grütter, D. Rauh, A. Michalczyk, 2008, Bioorganic & medicinal chemistry.

Structure of the PRYSPRY‐domain: Implications for autoinflammatory diseases

J. Tschopp, C. Briand, M. Grütter, 2006, FEBS letters.

Identification of Ustilago maydis Aurora kinase as a novel antifungal target.

M. E. Beck, K. Tietjen, P. Schreier, 2011, ACS chemical biology.

Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase.

D. Schollmeyer, Stefan A. Laufer, S. Fischer, 2012, Journal of medicinal chemistry.

The crystal structure of human pyrin b30.2 domain: implications for mutations associated with familial Mediterranean fever.

M. Grütter, P. Mittl, H. Roschitzki-Voser, 2009, Journal of molecular biology.

An Invariant Surface Patch on the TRIM5α PRYSPRY Domain Is Required for Retroviral Restriction but Dispensable for Capsid Binding

Jeremy Luban, J. Luban, M. Grütter, 2009, Journal of Virology.

Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase

W. V. van Otterlo, C. Grütter, D. Rauh, 2012, PloS one.

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.

Wolfgang Albrecht, Daniel Rauh, Oliver Werz, 2012, Nature chemical biology.

The surface phase transition and low-temperature phase of α-Ga(0 1 0) studied by SPA-LEED

P. Hofmann, S. Lizzit, A. Baraldi, 2009 .

Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.

Daniel Rauh, Kirsten Storch, Frank M Boeckler, 2013, Journal of medicinal chemistry.

Targeting GSK3 from Ustilago maydis: type-II kinase inhibitors as potential antifungals.

M. E. Beck, P. Schreier, J. Pérez-Martín, 2012, ACS chemical biology.

Alpha-Gallium (010) surface reconstruction: a LEED structural analysis of the (1x1) room temperature and (2rt2xrt2)R45 degrees low temperature structures

M. Hove, S. Lizzit, A. Baraldi, 2003 .

Interplay between electronic structure and surface phase transition on α-Ga(010)

S. Hoffmann, P. Hofmann, Zheshen Li, 2003 .

SURFACE STRUCTURE OF ALPHA -GA(010)

I. Robinson, C. Grütter, D. Walko, 1998 .

Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance

C. Grütter, M. Rabiller, H. Raaijmakers, 2010, Chembiochem : a European journal of chemical biology.

A new screening assay for allosteric inhibitors of cSrc.

C. Grütter, D. Rauh, M. Rabiller, 2009, Nature chemical biology.