Abdelouahid Samadi

发表

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.

Oscar M. Bautista-Aguilera, K. Nikolić, D. Agbaba, 2014, European journal of medicinal chemistry.

Some biochemical properties of guaiacol peroxidases as modified by salt stress in leaves of salt-tolerant and salt-sensitive safflower ( Carthamus tinctorius L.cv. ) cultivars

Abdelouahid Samadi, G. Dehghan, H. Tayefi-Nasrabadi, 2011 .

Identification of a Tool Compound to Study the Mechanisms of Functional Selectivity between D2 and D3 Dopamine Receptors

J. Mestres, R. Franco, Gemma Navarro, 2018, ACS Omega.

The Reaction of Thiyl Radical with Methyl Linoleate: Completing the Picture.

C. Chatgilialoglu, C. Ferreri, Abdelouahid Samadi, 2017, Journal of the American Chemical Society.

Drugs for stroke: action of nitrone (Z)-N-(2-bromo-5-hydroxy-4-methoxybenzylidene)-2-methylpropan-2-amine oxide on rat cortical neurons in culture subjected to oxygen-glucose-deprivation.

Abdelouahid Samadi, J. Marco-Contelles, M. P. González, 2012, European journal of medicinal chemistry.

Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.

D. Hadjipavlou-Litina, A. Alcázar, Abdelouahid Samadi, 2012, Journal of medicinal chemistry.

Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia.

B. Bartolomé, Abdelouahid Samadi, E. Soriano, 2011, Bioorganic & medicinal chemistry.

Silver‐Catalyzed Cyclization of N‐(Prop‐2‐yn‐1‐yl)pyridin‐2‐amines

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2013 .

Synthesis and Biological Applications of Some Novel 8-Hydroxyquinoline Urea and Thiourea Derivatives

Abdelouahid Samadi, M. Khasawneh, Haythem A. Saadeh, 2022, Arabian Journal of Chemistry.

Design, Synthesis and Biological Evaluation of Potent Antioxidant 1-(2,5-Dimethoxybenzyl)-4-arylpiperazines and N-Azolyl Substituted 2-(4-Arylpiperazin-1-yl)

Oscar M. Bautista-Aguilera, J. Mestres, A. Bojarski, 2017 .

Synthesis, analytical features, and biological relevance of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, a microbial metabolite derived from the catabolism of dietary flavan-3-ols.

B. Bartolomé, M. Moreno-Arribas, M. Monagas, 2011, Journal of agricultural and food chemistry.

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer’s Disease Therapy

M. Bartolini, Ignacio Moraleda, I. Iriepa, 2019, Molecules.

The reaction of 2-amino-4$$H$$H-pyrans with $$N$$N-bromosuccinimide

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2015, Molecular Diversity.

Affinity purification and characterization of recombinant Bacillus sphaericus phenylalanine dehydrogenase produced by pET expression vector system

D. Lelie, Y. Asano, H. Taherkhani, 2002 .

Nontoxic and neuroprotective β-naphthotacrines for Alzheimer's disease.

Abdelouahid Samadi, J. Marco-Contelles, M. Oset-Gasque, 2013, Chemical research in toxicology.

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.

A. Mattevi, R. Ramsay, G. Esteban, 2014, Biochimica et biophysica acta.

Synthesis of all-trans arachidonic acid and its effect on rabbit platelet aggregation.

C. Chatgilialoglu, C. Ferreri, Abdelouahid Samadi, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.

Manuela G. López, Abdelouahid Samadi, J. Marco-Contelles, 2011, European journal of medicinal chemistry.

Cloning and expression of Bacillus sphaericus phenylalanine dehydrogenase gene in Bacillus subtilis cells: purification and enzyme properties

Y. Asano, H. Taherkhani, Abdelouahid Samadi, 2002 .

Molecularly Imprinted Fibers with Recognition Capability

R. K. Marcus, Bogdan Zdyrko, Xiaoling Wei, 2007 .

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease

Hunter S. Futch, H. Futch, Abdelouahid Samadi, 2017, Journal of psychiatry & neuroscience : JPN.

Probing lipid peroxidation by using linoleic acid and benzophenone.

D. Neshchadin, G. Gescheidt, Abdelouahid Samadi, 2011, Chemistry.

Mechanism of Lipid Peroxidation Photosensitized by Tiaprofenic Acid: Product Studies Using Linoleic Acid and 1,4‐Cyclohexadienes as Model Substrates ¶

Abdelouahid Samadi, M. Miranda, Luis A. Martínez, 2001 .

Mechanism of Lipid Peroxidation Photosensitized by Tiaprofenic Acid: Product Studies Using Linoleic Acid and 1,4-Cyclohexadienes as Model Substrates¶

Abdelouahid Samadi, M. Miranda, L. A. Martínez, 2001, Photochemistry and photobiology.

The reaction of 2-amino-4$$H$$H-pyrans with $$N$$N-bromosuccinimide

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2015, Molecular Diversity.

Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2010, Bioorganic & medicinal chemistry letters.

Silver Triflate-Catalyzed Cyclization of 2-Amino-6-propargyl- amineazines Leading to Iminoimidazoazines

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2014 .

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

V. Andrisano, M. Bartolini, Irene Bolea, 2012, European journal of medicinal chemistry.

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.

Manuela G. López, Abdelouahid Samadi, J. Marco-Contelles, 2011, Bioorganic & medicinal chemistry.

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.

Manuela G. López, J. Roda, Abdelouahid Samadi, 2010, Bioorganic & medicinal chemistry.

Recent advances in the Friedländer reaction.

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2009, Chemical reviews.

Convenient Synthesis of 11-Aryl-1,12-dihydro-11H-naphthopyrano[2,3-d]pyrimidin-12-ones

Abdelouahid Samadi, J. M. Contelles, F. Chabchoub, 2010 .

Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.

A. Morreale, A. Perona, Abdelouahid Samadi, 2011, Bioorganic & medicinal chemistry letters.

Analysis of the antioxidant properties of differently substituted 2- and 3-indolyl carbohydrazides and related derivatives.

D. Hadjipavlou-Litina, Abdelouahid Samadi, M. Unzeta, 2013, European journal of medicinal chemistry.

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors.

L. Meijer, O. Lozach, Abdelouahid Samadi, 2009, Bioorganic & medicinal chemistry letters.

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

C. Pérez, Ignacio Moraleda, I. Iriepa, 2012, European journal of medicinal chemistry.

A practical two-step synthesis of imidazo[1,2-a]pyridines from N-(prop-2-yn-1-yl)pyridin-2-amines.

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2011, Chemical communications.

Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer's disease.

D. Hadjipavlou-Litina, Abdelouahid Samadi, E. Soriano, 2014, European journal of medicinal chemistry.

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.

Li Wang, Alejandro Romero, Isabel Iriepa, 2014, European journal of medicinal chemistry.

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.

Xavier Barril, F. J. Luque, F Javier Luque, 2009, Journal of medicinal chemistry.

Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2011, European journal of medicinal chemistry.

N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.

Stefano Alcaro, Katarina Nikolic, Francesco Ortuso, 2014, Journal of medicinal chemistry.

Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease.

R. Cacabelos, Abdelouahid Samadi, J. Marco-Contelles, 2013, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.

Irene Bolea, F. J. Luque, Jordi Juárez-Jiménez, 2011, Journal of medicinal chemistry.

Chemical and Pharmacological Studies on Enantiomerically Pure p‐Methoxytacripyrines, Promising Multi‐Target‐Directed Ligands for the Treatment of Alzheimer’s Disease

V. Andrisano, M. Bartolini, Manuela G. López, 2011, ChemMedChem.

Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.

R. León, Manuela G. López, Ignacio Moraleda, 2010, Journal of medicinal chemistry.

Convenient Synthesis of 11-Aryl-1,12-dihydro-11H-naphthopyrano[2,3-d]pyrimidin-12-ones.

Abdelouahid Samadi, J. M. Contelles, F. Chabchoub, 2011 .

Synthesis of (E)-diethyl 6,6'-(diazene-1,2-diyl)bis(5-cyano-2-methyl-4-phenylnicotinates), a new type of 2,2'-azopyridine dyes

Abdelouahid Samadi, J. Marco-Contelles, M. Carreiras, 2010 .

Microwave Irradiation–Assisted Amination of 2-Chloropyridine Derivatives with Amide Solvents

Abdelouahid Samadi, J. Marco-Contelles, M. Chioua, 2011 .

Novel 5‐Nitroimidazole and 5‐Nitrothiazole Piperazine Derivatives and Their Antiparasitic Activity

Abdelouahid Samadi, J. Marco-Contelles, K. Goyal, 2017 .

Chiral discrimination in the intramolecular abstraction of allylic hydrogens by benzophenone triplets

Abdelouahid Samadi, M. Miranda, I. Andreu, 2003 .

Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity.

S. Smaili, R. León, A. Caricati‐Neto, 2011, European journal of pharmacology.

Use of Phosphorus Adsorption Isotherms for Determining Fertilizer Requirement of Wheat

A. Samadi, E. Sepehr, Abdelouahid Samadi, 2013 .

Synthesis of 5-Amino-3,3-dimethyl-7-phenyl-3H-[1,2]oxathiolo [4,3-b]pyridine-6-carbonitrile 1,1-Dioxides.

J. Balzarini, Abdelouahid Samadi, J. Marco-Contelles, 2014 .

Thiyl radical-catalyzed isomerization of oils: An entry to the trans lipid library

C. Chatgilialoglu, C. Ferreri, Abdelouahid Samadi, 2004 .

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro.

C. Pérez, Irene Bolea, Abdelouahid Samadi, 2013, Current Alzheimer research.

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

P. Agostinho, C. Pérez, Ignacio Moraleda, 2013, ACS chemical neuroscience.

A reinvestigation of the acid-promoted heterocyclization of 2-(2-oxo-2-arylethyl)malononitriles in the presence of amines

R. León, Abdelouahid Samadi, E. Soriano, 2009, Molecular Diversity.

Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia.

Abdelouahid Samadi, M. Unzeta, J. Marco-Contelles, 2014, Current pharmaceutical design.

The kinetics of Z/E isomerization of methyl oleate catalyzed by photogenerated thiyl radicals.

C. Chatgilialoglu, Abdelouahid Samadi, H. Fischer, 2005, Chemphyschem : a European journal of chemical physics and physical chemistry.

Regioselective cis-trans isomerization of arachidonic double bonds by thiyl radicals: the influence of phospholipid supramolecular organization.

L. Landi, C. Chatgilialoglu, C. Ferreri, 2004, Journal of the American Chemical Society.

SOME BIOCHEMICAL PROPERTIES OF CATALASE FROM SAFFLOWER (CARTHAMUS TINCTORIUS L.CV. IL-111)

Abdelouahid Samadi, A. Movafegi, D. Gh.R., 2010 .

D‐ and L‐Mannose‐Containing glyco‐Oligoamides Show Distinct Recognition Properties When Interacting with DNA

C. Vicent, F. Cañada, Abdelouahid Samadi, 2015 .

Synthesis of novel thiourea-/urea-benzimidazole derivatives as anticancer agents

Abdelouahid Samadi, M. Khasawneh, Haythem A. Saadeh, 2021, Open Chemistry.

Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease.

Irene Bolea, G. Esteban, Ignacio Moraleda, 2011, European journal of medicinal chemistry.

PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.

Manuela G. López, Abdelouahid Samadi, J. Marco-Contelles, 2013, ACS chemical neuroscience.

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids

Katarina Nikolic, Isabel Iriepa, Elena Soriano, 2014, Drug design, development and therapy.

N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists.

F. Sala, S. Sala, M. Criado, 2016, ACS chemical neuroscience.

Stereoselective intramolecular hydrogen abstraction by a chiral benzophenone derivative.

Abdelouahid Samadi, M. Miranda, Luis A. Martínez, 2002, Chemical communications.

Involvement of type I and type II mechanisms in the linoleic acid peroxidation photosensitized by tiaprofenic acid.

Abdelouahid Samadi, M. Miranda, I. Morera, 2000, Journal of photochemistry and photobiology. B, Biology.

Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.

C. Pérez, M. de la Fuente Revenga, Ignacio Moraleda, 2013, European journal of medicinal chemistry.

Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.

C. Pérez, Ignacio Moraleda, I. Iriepa, 2012, European journal of medicinal chemistry.

Studies on the acetylation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile derivatives

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2010 .

Using optogenetics to assess neuroendocrine modulation of heart rate in Drosophila melanogaster larvae

R. Cooper, Abdelouahid Samadi, A. Omar, 2017, Journal of Comparative Physiology A.

Monitoring of Newcastle Disease Virus Vaccine Strain Replication in Embryonated Chicken Eggs by Reverse Transcription-Polymerase Chain Reaction.

Abdelouahid Samadi, M. Taghizadeh, M. Bashashati, 2023, Archives of Razi Institute.

D. Hadjipavlou-Litina, A. Alcázar, Abdelouahid Samadi, 2012, Journal of medicinal chemistry.

PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.

Manuela G. López, Abdelouahid Samadi, J. Marco-Contelles, 2013, ACS chemical neuroscience.

K. Nikolić, D. Agbaba, Irene Bolea, 2014, European journal of medicinal chemistry.

A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE

Irene Bolea, P. Sun, G. Esteban, 2013, Journal of Neural Transmission.