J. Marco-Contelles

发表

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.

Oscar M. Bautista-Aguilera, K. Nikolić, D. Agbaba, 2014, European journal of medicinal chemistry.

Synthesis and Pharmacology of Galantamine

J. Marco-Contelles, M. Carreiras, C. Rodríguez, 2006 .

Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease

José Marco-Contelles, R. León, J. Marco-Contelles, 2013, Medicinal research reviews.

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

Keith F. Tipton, Irene Bolea, Rona R. Ramsay, 2016, Front. Neurosci..

Mechanistic insights on the cycloisomerization of polyunsaturated precursors catalyzed by platinum and gold complexes.

E. Soriano, J. Marco-Contelles, 2009, Accounts of chemical research.

5‐Amino‐6,7,8,9‐Tetrahydrobenzo[b][1,8]Naphthyridin‐2(1H)‐One: The first Example of a new Family of HuperTacrines for Alzheimer's Disease Therapy

J. Borrell, J. Marco-Contelles, R. Estrada-Tejedor, 2017 .

Erratum to: Computational analysis of the binding ability of heterocyclic and conformationally constrained epibatidine analogs in the neuronal nicotinic acetylcholine receptor

E. Soriano, J. Marco-Contelles, L. Gandía, 2009, Molecular Diversity.

One or More CH, CC, and/or C C Bond(s) Formed by Rearrangement

M. Molina, J. Marco-Contelles, M. Molina, 2005 .

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.

Ondřej Soukup, Ewgenij Proschak, Lena Kalinowsky, 2017, Angewandte Chemie.

Chemical synthesis of galantamine, an acetylcholinesterase inhibitor for treatment of Alzheimer’s disease

J. Marco-Contelles, C. Rodríguez, Antonio G. García, 2005 .

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.

Oscar M. Bautista-Aguilera, D. Jun, R. León, 2016, Journal of medicinal chemistry.

Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease.

Manuela G. López, F. Allouche, R. Cacabelos, 2014, Future medicinal chemistry.

Controlled heterocyclization/cross-coupling domino reaction of β,γ-allendiols and α-allenic esters: method and mechanistic insight for the preparation of functionalized buta-1,3-dienyl dihydropyrans.

E. Soriano, J. Marco-Contelles, B. Alcaide, 2013, Chemistry.

Synthesis of Eight- to Ten-Membered Ring Ethers

E. Soriano, J. Marco-Contelles, 2014 .

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

K. Musílek, Ignacio Moraleda, I. Iriepa, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological assessment of new pyrimidopyrimidines as inhibitors of breast cancer resistance protein (ABCG2).

J. Marco-Contelles, M. Wiese, L. Ismaili, 2021, Bioorganic chemistry.

Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer’s Disease. Review of Reviews

J. Marco-Contelles, M. Torrecilla, C. Bruzos-Cidón, 2021, Biomedicines.

The multifactorial nature of Alzheimer's disease for developing potential therapeutics.

J. Marco-Contelles, A. Francisco, M. J. Perry, 2013, Current topics in medicinal chemistry.

Corrigendum: Melatonin and Nitrones As Potential Therapeutic Agents for Stroke

F. López-Muñoz, M. I. Ayuso, A. Alcázar, 2017, Front. Aging Neurosci..

Melatonin and Nitrones As Potential Therapeutic Agents for Stroke

F. López-Muñoz, M. I. Ayuso, A. Alcázar, 2016, Front. Aging Neurosci..

Drugs for stroke: action of nitrone (Z)-N-(2-bromo-5-hydroxy-4-methoxybenzylidene)-2-methylpropan-2-amine oxide on rat cortical neurons in culture subjected to oxygen-glucose-deprivation.

Abdelouahid Samadi, J. Marco-Contelles, M. P. González, 2012, European journal of medicinal chemistry.

Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.

D. Hadjipavlou-Litina, A. Alcázar, Abdelouahid Samadi, 2012, Journal of medicinal chemistry.

Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia.

B. Bartolomé, Abdelouahid Samadi, E. Soriano, 2011, Bioorganic & medicinal chemistry.

Recent Advances on Nitrones Design for Stroke Treatment.

J. Marco-Contelles, 2020, Journal of medicinal chemistry.

Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.

J. Marco-Contelles, L. Ismaili, Maria do Carmo Carreiras, 2019, Bioorganic & medicinal chemistry letters.

The Synthesis of Ipsenol and Ipsdienol: A Review (1968–2020)

J. Marco-Contelles, 2021, Chemical record.

Silver‐Catalyzed Cyclization of N‐(Prop‐2‐yn‐1‐yl)pyridin‐2‐amines

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2013 .

A DFT-based analysis of the gold-catalyzed cycloisomerization of 1-siloxy 1,5-enynes to cyclohexadienes.

E. Soriano, J. Marco-Contelles, 2012, The Journal of organic chemistry.

Design, Synthesis and Biological Evaluation of Potent Antioxidant 1-(2,5-Dimethoxybenzyl)-4-arylpiperazines and N-Azolyl Substituted 2-(4-Arylpiperazin-1-yl)

Oscar M. Bautista-Aguilera, J. Mestres, A. Bojarski, 2017 .

Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.

J. Marco-Contelles, C. de los Ríos, 1969, European journal of medicinal chemistry.

Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease.

R. Vitale, J. Marco-Contelles, B. Pejin, 2016, European journal of medicinal chemistry.

Highly functionalized, enantiomerically pure furo(x,y-c)pyrans via alkylidenecarbenes derived from sugar templates: synthesis and mechanism study via computational chemistry

E. Soriano, J. Marco-Contelles, Sébastien Delacroix, 2009 .

The synthesis of polyoxygenated, enantiomerically pure cyclopentane derivatives on route to neplanocin A stereoisomers via alkylidenecarbene species prepared from sugar templates.

E. Soriano, J. Marco-Contelles, A. Nguyen Van Nhien, 2009, Carbohydrate research.

Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy

Oscar M. Bautista-Aguilera, I. Iriepa, J. Marco-Contelles, 2020, Molecules.

Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.

B. Malawska, O. Soukup, Ignacio Moraleda, 2017, European journal of medicinal chemistry.

Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices.

Manuela G. López, R. Cacabelos, J. Marco-Contelles, 2016, Neurotoxicology.

Synthesis, analytical features, and biological relevance of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, a microbial metabolite derived from the catabolism of dietary flavan-3-ols.

B. Bartolomé, M. Moreno-Arribas, M. Monagas, 2011, Journal of agricultural and food chemistry.

Synthesis, Neuroprotection, and Antioxidant Activity of 1,1′-Biphenylnitrones as α-Phenyl-N-tert-butylnitrone Analogues in In Vitro Ischemia Models

F. López-Muñoz, D. Hadjipavlou-Litina, J. Marco-Contelles, 2021, Molecules.

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

Oscar M. Bautista-Aguilera, F. López-Muñoz, K. Kieć‐Kononowicz, 2020, ACS chemical neuroscience.

ASS 234 , As a New Multi-Target Directed Propargylamine for Alzheimer ’ s Disease Therapy

Irene Bolea, R. Ramsay, G. Esteban, 2016 .

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy

Irene Bolea, R. Ramsay, G. Esteban, 2016, Front. Neurosci..

Synthesis of Bioactive Natural Products by Propargylic Carboxylic Ester Rearrangements

E. Soriano, J. Marco-Contelles, S. Anjum, 2013 .

Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations

G. Guinea, E. Martínez-Alonso, A. Alcázar, 2022, International journal of molecular sciences.

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer’s Disease Therapy

M. Bartolini, Ignacio Moraleda, I. Iriepa, 2019, Molecules.

CholesteroNitrones for Stroke.

J. Montaner, D. Hadjipavlou-Litina, M. I. Ayuso, 2015, Journal of medicinal chemistry.

Rearrangements in Natural Product Synthesis

E. Soriano, J. Marco-Contelles, 2012 .

Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine.

J. Marco-Contelles, J. del Pino, J. Egea, 2018, Future medicinal chemistry.

Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout.

J. Marco-Contelles, M. Chioua, A. Lopez-Rodriguez, 2022, Journal of medicinal chemistry.

Mechanisms of the transition metal-mediated hydroarylation of alkynes and allenes

E. Soriano, J. Marco-Contelles, 2006 .

Donepezil-ferulic acid hybrids as anti-Alzheimer drugs.

T. Gharbi, J. Marco-Contelles, M. Pudlo, 2015, Future medicinal chemistry.

The reaction of 2-amino-4$$H$$H-pyrans with $$N$$N-bromosuccinimide

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2015, Molecular Diversity.

Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment

F. López-Muñoz, D. Hadjipavlou-Litina, I. Iriepa, 2022, Antioxidants.

Synthesis and Antioxidant Properties of HeteroBisNitrones Derived from Benzene Dicarbaldehydes

F. López-Muñoz, D. Hadjipavlou-Litina, I. Iriepa, 2022, Antioxidants.

Homo-Tris-Nitrones Derived from α-Phenyl-N-tert-butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties

F. López-Muñoz, D. Hadjipavlou-Litina, I. Iriepa, 2020, International journal of molecular sciences.

Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities

M. Valis, K. Kuča, O. Soukup, 2022, Journal of enzyme inhibition and medicinal chemistry.

Nontoxic and neuroprotective β-naphthotacrines for Alzheimer's disease.

Abdelouahid Samadi, J. Marco-Contelles, M. Oset-Gasque, 2013, Chemical research in toxicology.

Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1−42 Aggregation Inhibitors for Alzheimer's Disease Therapy

Oscar M. Bautista-Aguilera, M. Decker, B. Malawska, 2016, ChemMedChem.

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.

A. Mattevi, R. Ramsay, G. Esteban, 2014, Biochimica et biophysica acta.

The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents.

F. López-Muñoz, M. Gütschow, C. D. Beadle, 2022, ACS pharmacology & translational science.

Tacrines as Therapeutic Agents for Alzheimer's Disease. IV. The Tacripyrines and Related Annulated Tacrines.

M. Bartolini, J. Marco-Contelles, 2018, Chemical record.

Synthesis of New Statin Derivatives

J. Marco-Contelles, M. Chioua, 2021, ChemistrySelect.

Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke

E. Martínez-Alonso, Alejandro Escobar-Peso, J. Masjuán, 2022, Antioxidants.

Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.

Manuela G. López, Abdelouahid Samadi, J. Marco-Contelles, 2011, European journal of medicinal chemistry.

Issue Information

A. Galanopoulou, Jun Chen, C. Borlongan, 2022 .

Melatonin as potential candidate to prevent the toxicity induced by chemical warfare agents

J. Marco-Contelles, R. Pita, A. Romero, 2013, Archives of Toxicology.

Synthesis of new ferulic/lipoic/comenic acid-melatonin hybrids as antioxidants and Nrf2 activators via Ugi reaction.

J. Marco-Contelles, H. Martin, B. Refouvelet, 2019, Future medicinal chemistry.

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease

Hunter S. Futch, H. Futch, Abdelouahid Samadi, 2017, Journal of psychiatry & neuroscience : JPN.

Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives

Ignacio Moraleda, I. Iriepa, J. Marco-Contelles, 2020, International journal of molecular sciences.

Free-radical cyclizations onto differently substituted 1,2,3-triazoles installed in sugar templates.

J. Marco-Contelles, M. Rodríguez-Fernández, 2001, The Journal of organic chemistry.

Synthesis of fused triazole-piperidinoses: a free radical cyclization approach

J. Marco-Contelles, M. Rodríguez-Fernández, 2000 .

New glycosyl-α-aminotetrazole-based catalysts for highly enantioselective aldol reactions

E. Soriano, J. Marco-Contelles, Sébastien Delacroix, 2013 .

Facile one-pot synthesis of new [1,2,4]triazolo[1,5-a]pyridine derivatives by ultrasonic irradiation

J. Marco-Contelles, L. Ismaili, F. Chabchoub, 2017 .

N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases

I. Iriepa, J. Marco-Contelles, S. Gobec, 2022, Molecules.

Structure, bonding, and reactivity of reactant complexes and key intermediates.

E. Soriano, J. Marco-Contelles, 2011, Topics in current chemistry.

Regioselectivity control in the metal-catalyzed O-C functionalization of gamma-allenols, part 1: Experimental study.

E. Soriano, J. Marco-Contelles, B. Alcaide, 2009, Chemistry.

Theoretical analysis of the high versatility in PtCl2-mediated cycloisomerization of enynes on a common mechanistic basis.

E. Soriano, J. Marco-Contelles, 2005, The Journal of organic chemistry.

Theoretical Investigation on the Mechanisms of the PtCl2-Mediated Cycloisomerization of Polyfunctionalized 1,6-Enynes. 2. Propargylic Carboxylates

E. Soriano, J. Marco-Contelles, and Paloma Ballesteros, 2005 .

Theoretical Investigation on the Mechanisms of the PtCl2-Mediated Cycloisomerization of Polyfunctionalized 1,6-Enynes. 1. Role of the Propargylic Substituents

E. Soriano, J. Marco-Contelles, and Paloma Ballesteros, 2005 .

A theoretical investigation on the mechanism of the PtCl2-mediated cycloisomerization of heteroatom-tethered 1,6-enynes.

P. Ballesteros, E. Soriano, J. Marco-Contelles, 2004, The Journal of organic chemistry.

PtCl 2-catalyzed cycloisomerizations of allenynes.

J. Marco-Contelles, N. Cadran, L. Fensterbank, 2004, Journal of the American Chemical Society.

The effect of a hydroxy protecting group on the PtCl2-catalyzed cyclization of dienynes--a novel, efficient, and selective synthesis of carbocycles.

J. Marco-Contelles, L. Fensterbank, M. Malacria, 2002, Angewandte Chemie.

Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile.

Oscar M. Bautista-Aguilera, F. López-Muñoz, Ignacio Moraleda, 2018, Journal of medicinal chemistry.

Upregulation of Antioxidant Enzymes by ASS234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy

J. Marco-Contelles, A. Romero, E. Ramos, 2016, CNS neuroscience & therapeutics.

Updating the CSIC Reaction (2003–2020)

J. Marco-Contelles, Alexey V. Dobrydnev, A. Dobrydnev, 2021 .

Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: role of Asn181 and Ile335 validated by spectroscopic and computational studies.

F. J. Luque, J. Juárez-Jiménez, R. Ramsay, 2014, Biochimica et biophysica acta.

Improving the Efficacy of Quinolylnitrones for Ischemic Stroke Therapy, QN4 and QN15 as New Neuroprotective Agents after Oxygen–Glucose Deprivation/Reoxygenation-Induced Neuronal Injury

Alejandro Escobar-Peso, A. Alcázar, J. Marco-Contelles, 2022, Pharmaceuticals.

The reaction of 2-amino-4$$H$$H-pyrans with $$N$$N-bromosuccinimide

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2015, Molecular Diversity.

Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism

R. Ramsay, J. Marco-Contelles, J. Mavri, 2018, Front. Chem..

Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2010, Bioorganic & medicinal chemistry letters.

DIBALH mediated reduction of the acetal moiety on perhydrofuro[2,3-b]pyran derivatives.

J. Marco-Contelles, J. Ruiz-Caro, 2001, Carbohydrate research.

Silver Triflate-Catalyzed Cyclization of 2-Amino-6-propargyl- amineazines Leading to Iminoimidazoazines

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2014 .

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

V. Andrisano, M. Bartolini, Irene Bolea, 2012, European journal of medicinal chemistry.

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.

Manuela G. López, Abdelouahid Samadi, J. Marco-Contelles, 2011, Bioorganic & medicinal chemistry.

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.

Manuela G. López, J. Roda, Abdelouahid Samadi, 2010, Bioorganic & medicinal chemistry.

Recent advances in the Friedländer reaction.

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2009, Chemical reviews.

Heterocyclization of allenes catalyzed by late transition metals: mechanisms and regioselectivity.

E. Soriano, J. Marco-Contelles, B. Alcaide, 2011, Topics in current chemistry.

Bicyclic 5-5 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Three Extra Heteroatoms 2:1

P. Ballesteros, J. Marco-Contelles, E. Pérez-Mayoral, 2020, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.

Synthesis and biological evaluation of heterocyclic privileged medicinal structures containing (benz)imidazole unit

J. Marco-Contelles, A. Bouraiou, S. Bouacida, 2016, Monatshefte für Chemie - Chemical Monthly.

Synthesis of 6‐Amino‐1,4‐dihydropyridines that Prevent Calcium Overload and Neuronal Death.

R. León, Manuela G. López, J. Marco-Contelles, 2008 .

Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death.

R. León, Manuela G. López, J. Marco-Contelles, 2008, European journal of medicinal chemistry.

Pyranopyrazolotacrines as nonneurotoxic, Aβ-anti-aggregating and neuroprotective agents for Alzheimer's disease.

Ignacio Moraleda, I. Iriepa, E. Soriano, 2015, Future medicinal chemistry.

Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.

A. Morreale, A. Perona, Abdelouahid Samadi, 2011, Bioorganic & medicinal chemistry letters.

Benzochromenopyrimidines: Synthesis, Antiproliferative Activity against Colorectal Cancer and Physicochemical Properties

S. Aifa, J. Marco-Contelles, L. Ismaili, 2022, Molecules.

Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy.

Ignacio Moraleda, I. Iriepa, J. Marco-Contelles, 2017, Future medicinal chemistry.

Synthesis, Biological Assessment and Molecular Modeling of Racemic QuinoPyranoTacrines for Alzheimer's Disease Therapy

D. Jun, O. Soukup, Ignacio Moraleda, 2018 .

Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.

José Marco-Contelles, Antonio Guglietta, R. León, 2006, Journal of medicinal chemistry.

β-Lactam Synthesis by the Kinugasa Reaction

J. Marco-Contelles, 2004 .

Synthesis and transformations of alkyl N-(1-cyclohex-3-enyl)carbamates prepared from cyclohex-3-ene carboxylic acid via Curtius rearrangement

J. Marco-Contelles, E. Gómez-Sánchez, 2005 .

Cleavage of N−O Bonds Promoted by Samarium Diiodide: Reduction of Free or N-Acylated O-Alkylhydroxylamines

J. Marco-Contelles, J. L. Chiara, C. Destabel, 1996 .

Synthesis of higher-carbon sugars by addition of organometallic reagents to aldehydes or lactols derived from carbohydrates

J. Marco-Contelles, E. Opazo, Nieves Arroyo, 2001 .

Strategies and tactics for free radical carbocyclization: synthesis of polyfunctionalized cyclopentanoid molecules from carbohydrates

J. Marco-Contelles, Angeles Martínez-Grau, Luis A. Martínez, 1993 .

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.

Simone Brogi, G. Campiani, S. Butini, 2016, European journal of medicinal chemistry.

Purine homo-N-nucleoside+coumarin hybrids as pleiotropic agents for the potential treatment of Alzheimer's disease.

D. Hadjipavlou-Litina, E. Soriano, J. Marco-Contelles, 2015, Future medicinal chemistry.

Analysis of the antioxidant properties of differently substituted 2- and 3-indolyl carbohydrazides and related derivatives.

D. Hadjipavlou-Litina, Abdelouahid Samadi, M. Unzeta, 2013, European journal of medicinal chemistry.

Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy

D. Jun, O. Soukup, Ignacio Moraleda, 2018, Journal of enzyme inhibition and medicinal chemistry.

Recent developments in the metal-catalyzed reactions of metallocarbenoids from propargylic esters.

E. Soriano, J. Marco-Contelles, 2007, Chemistry.

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors.

L. Meijer, O. Lozach, Abdelouahid Samadi, 2009, Bioorganic & medicinal chemistry letters.

New Tacrines as Anti-Alzheimer's Disease Agents. The (Benzo)Chromeno- PyranoTacrines.

J. Marco-Contelles, M. Oset-Gasque, 2018, Current topics in medicinal chemistry.

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

C. Pérez, Ignacio Moraleda, I. Iriepa, 2012, European journal of medicinal chemistry.

Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapy

J. Marco-Contelles, A. Romero, E. Ramos, 2019, Neural regeneration research.

From Seeds of Apium graveolens Linn. to a Cerebral Ischemia Medicine: The Long Journey of 3-n-Butylphthalide.

Yihua Zhang, J. Marco-Contelles, 2020, Journal of medicinal chemistry.

A practical two-step synthesis of imidazo[1,2-a]pyridines from N-(prop-2-yn-1-yl)pyridin-2-amines.

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2011, Chemical communications.

Synthesis and biological evaluation of new 4H-pyrano[2,3-b]quinoline derivatives that block acetylcholinesterase and cell calcium signals, and cause neuroprotection against calcium overload and free radicals.

R. León, Manuela G. López, J. Marco-Contelles, 2006, European journal of medicinal chemistry.

Synthesis of Enantiomerically Pure, Highly Functionalized, Medium-Sized Carbocycles from Carbohydrates: Formal Total Synthesis of (+)-Calystegine B2

J. Marco-Contelles, E. Opazo, 2002 .

STRATEGIES FOR THE SYNTHESIS OF ENANTIOMERICALLY PURE MEDIUM-SIZED CARBOCYCLES FROM CARBOHYDRATES

J. Marco-Contelles, E. de Opazo, 2002 .

Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer's disease.

D. Hadjipavlou-Litina, Abdelouahid Samadi, E. Soriano, 2014, European journal of medicinal chemistry.

Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

Simone Brogi, K. Nikolić, D. Agbaba, 2017, Progress in Neurobiology.

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.

Li Wang, Alejandro Romero, Isabel Iriepa, 2014, European journal of medicinal chemistry.

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.

Xavier Barril, F. J. Luque, F Javier Luque, 2009, Journal of medicinal chemistry.

New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.

F. J. Luque, X. Barril, R. León, 2008, Bioorganic & medicinal chemistry.

Multitarget-Directed Antioxidants as Therapeutic Agents: Putting the Focus on the Oxidative Stress

J. Marco-Contelles, M. Carreiras, L. Ismaili, 2017 .

Synthesis, antioxidant and Aβ anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction.

J. Marco-Contelles, H. Martin, V. Luzet, 2019, Bioorganic chemistry.

Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2011, European journal of medicinal chemistry.

Tacrine-Natural-Product Hybrids for Alzheimer's Disease Therapy.

J. Marco-Contelles, M. Oset-Gasque, 2018, Current medicinal chemistry.

Predicting targets of compounds against neurological diseases using cheminformatic methodology

Lazaros Mavridis, John B. O. Mitchell, Holger Stark, 2015, Journal of Computer-Aided Molecular Design.

N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.

Stefano Alcaro, Katarina Nikolic, Francesco Ortuso, 2014, Journal of medicinal chemistry.

Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease.

R. Cacabelos, Abdelouahid Samadi, J. Marco-Contelles, 2013, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.

Irene Bolea, F. J. Luque, Jordi Juárez-Jiménez, 2011, Journal of medicinal chemistry.

Chemical and Pharmacological Studies on Enantiomerically Pure p‐Methoxytacripyrines, Promising Multi‐Target‐Directed Ligands for the Treatment of Alzheimer’s Disease

V. Andrisano, M. Bartolini, Manuela G. López, 2011, ChemMedChem.

Synthesis, electrochemical and biological studies on polyfunctionalized 4-ferrocenyl-4H-pyran and 4-ferrocenyl-1,4-dihydropyridine derivatives

R. León, E. Morales, J. Marco-Contelles, 2004 .

Synthesis of 4-Amino-5H-2,3-dihydroisothiazole-1,1-dioxide Ring Systems on Sugar Templates via Carbanion-Mediated Sulfonamide Intramolecular Cyclization Reactions (CSIC Protocols) of Glyco-α-sulfonamidonitriles.

C. Len, J. Marco-Contelles, D. Postel, 2004 .

Synthesis, biological evaluation, and molecular modeling of nitrile‐containing compounds: Exploring multiple activities as anti‐Alzheimer agents

P. Agostinho, Irene Bolea, R. Ramsay, 2020, Drug development research.

TRIBUTYLTIN HYDRIDE-MEDIATED FREE-RADICAL CYCLIZATION OF ALLENE-TETHERED OXIME ETHERS AND HYDRAZONES

J. Marco-Contelles, D. Bouyssi, G. Balme, 1997 .

Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues.

R. León, J. Marco-Contelles, M. Villarroya, 2005, Bioorganic & medicinal chemistry.

Free-radical mediated synthesis of enantiomerically pure, highly functionalized inositols from carbohydrates.

J. Marco-Contelles, E. de Opazo, C. Pozuelo, 2001, Carbohydrate research.

CARBOCYCLES FROM CARBOHYDRATES VIA FREE RADICAL CYCLIZATIONS : SYNTHESIS AND MANIPULATION OF ANNULATED FURANOSES

J. Marco-Contelles, Angeles Martínez-Grau, C. Alhambra, 1998 .

Synthesis of Aminocyclitols by Intramolecular Reductive Coupling of Carbohydrate Derived δ- and ε-Functionalized Oxime Ethers Promoted by Tributyltin Hydride or Samarium Diiodide†

J. Marco-Contelles, N. Khiar, J. L. Chiara, 1997 .

Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation

J. Marco-Contelles, H. Martin, P. Dallemagne, 2022, Molecules.

(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease.

E. M. García-Frutos, V. Andrisano, M. Bartolini, 2021, ACS chemical neuroscience.

New multipotent tetracyclic tacrines with neuroprotective activity.

R. León, Manuela G. López, J. Marco-Contelles, 2006, Bioorganic & medicinal chemistry.

Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels

J. Marco-Contelles, H. Martin, B. Refouvelet, 2020, Molecules.

Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.

R. León, Manuela G. López, Ignacio Moraleda, 2010, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

Oscar M. Bautista-Aguilera, B. Malawska, O. Soukup, 2016, Molecules.

PtCl2-mediated cycloisomerization of unsaturated propargylic carboxylates

J. Marco-Contelles, S. Anjum, 2005 .

Carbocycles from carbohydrates via free radical cyclizations: new synthetic approaches to glycomimetics

J. Marco-Contelles, Angeles Martínez-Grau, 1998 .

New insights on the mechanism of the transition-metal stereoselective olefin cyclopropanation.

E. Soriano, J. Marco-Contelles, 2008, Chemistry.

Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments

Oscar M. Bautista-Aguilera, I. Iriepa, J. Marco-Contelles, 2020, Chemical record.

New method for the synthesis of 4-aryl-3,4-dihydro-2H-benzo[g]chromene-2,5,10-triones

J. Marco-Contelles, L. Ismaili, Marwa Ncir, 2019, Synthetic Communications.

Automated Synthesis of New Quinoxalinetacrines

Oscar M. Bautista-Aguilera, F. López-Muñoz, C. D. Beadle, 2020 .

Metal-catalyzed cyclization of beta- and gamma-allenols derived from D-glyceraldehyde--synthesis of enantiopure dihydropyrans and tetrahydrooxepines: an experimental and theoretical study.

E. Soriano, J. Marco-Contelles, B. Alcaide, 2009, Chemistry.

β‐Lactam‐Synthese durch die Kinugasa‐Reaktion

J. Marco-Contelles, 2004 .

Regioselectivity control in the metal-catalyzed functionalization of gamma-allenols, part 2: Theoretical study.

E. Soriano, J. Marco-Contelles, B. Alcaide, 2009, Chemistry.

beta-Lactam synthesis by the Kinugasa reaction.

J. Marco-Contelles, 2004, Angewandte Chemie.

Synthesis of (E)-diethyl 6,6'-(diazene-1,2-diyl)bis(5-cyano-2-methyl-4-phenylnicotinates), a new type of 2,2'-azopyridine dyes

Abdelouahid Samadi, J. Marco-Contelles, M. Carreiras, 2010 .

Carbocycles from carbohydrates: Synthesis of some polyfunctionauzed cyclohexane derivatives. Preparation of useful chiral building blocks

J. Marco-Contelles, Angeles Martínez-Grau, 1991 .

Some Unexpected Reactivity of Propargyl 2,3-Dideoxy-2-en-α-D-glucopyranoside Derivatives

J. Marco-Contelles, G. Martin, G. Martin, 1997 .

Asymmetric Pauson-Khand Reaction. Cobalt-Mediated Cycloisomerization of 1,6-Enynes in Carbohydrate Templates: Synthesis of Bis-Heteroannulated Pyranosides.

J. Marco-Contelles, 1996, The Journal of organic chemistry.

The pauson-khand reaction on carbohydrate templates.I. Synthesis of bis-heteroannulated-pyranosides

J. Marco-Contelles, 1994 .

Selective transformations of differently functionalized 4-ethynyl-octa-1,7-dienes and 5-ethynyl-nona-1,8-dienes via intramolecular Pauson–Khand reaction: preparation of new and useful building blocks for the synthesis of angularly fused triquinanes

J. Marco-Contelles, L. Fensterbank, M. Malacria, 2002 .

A DFT-based theoretical investigation of the mechanism of the PtCl2-mediated cycloisomerization of allenynes.

E. Soriano, J. Marco-Contelles, 2005, Chemistry.

New Agents with Antimycobacterial Activity

J. Marco-Contelles, E. Gómez-Sánchez, 2005, Archiv der Pharmazie.

Microwave Irradiation–Assisted Amination of 2-Chloropyridine Derivatives with Amide Solvents

Abdelouahid Samadi, J. Marco-Contelles, M. Chioua, 2011 .

N-Arylmethyl-7-azabicyclo[2.2.1]heptane derivatives: synthesis and reaction mechanisms

E. Soriano, J. Marco-Contelles, M. Jimeno, 2009 .

Novel 5‐Nitroimidazole and 5‐Nitrothiazole Piperazine Derivatives and Their Antiparasitic Activity

Abdelouahid Samadi, J. Marco-Contelles, K. Goyal, 2017 .

Asymmetric and ‘anti’‐Selective Aldolisations of Acetates and Propionates. Preliminary Communication

J. Marco-Contelles, W. Oppolzer, 1986 .

Cyclohexane Epoxides − Chemistry and Biochemistry of (+)‐Cyclophellitol

J. Marco-Contelles, 2001 .

Carbocycles from carbohydrates via free radical cyclizations: new synthetic approaches to glycomimetics

J. Marco-Contelles, Angeles Martínez-Grau, 1998 .

The first analysis of the steric control of the 6-exo free-radical cyclization of acyclic sugar derivatives—MM3 transition state modelling 1 In memory of Dr. Eldiberto Fernández Alvarez 1

J. Marco-Contelles, C. Jaime, X. Sánchez-Ruiz, 1998 .

Synthesis of Polyfunctionalized Cyclohexanes by 6-Exo Free Radical Cyclization of Carbohydrate Precursors

J. Marco-Contelles, 1994 .

Carbocycles from carbohydrates: a free radical route to aminocyclitol derivatives

J. Marco-Contelles, M. Jimeno, Angeles Martínez-Grau, 1991 .

Carbocycles from carbohydrates. A free radical route to (1R, 2R, 3S, 4R)-4-Amino-1,2,3-cyclopentanetriol derivatives

J. Marco-Contelles, L. M. Martínez, A. M. Grau, 1991 .

Synthesis of chiral, densely functionalized medium-sized rings from carbohydrate precursors via regioselective exo/endo-primary alkyl radical cyclizations

J. Marco-Contelles, E. Opazo, 2000 .

Synthesis of polycyclic molecules via cascade radical carbocyclizations of dienynes: the first SnPh3 radical-mediated [2 + 2 + 2] formal cycloaddition of dodeca-1,6-dien-11-ynes

J. Marco-Contelles, 1996 .

Intramolecular reductive coupling of carbonyl-tethered oxime ethers promoted by samarium diiodide: A powerful method for the stereoselective synthesis of aminocyclopentitols

J. Marco-Contelles, N. Khiar, J. L. Chiara, 1995 .

Recent results in the free radical mediated synthesis of enantiomerically pure, highly functionalized carbocycles from carbohydrates

J. Marco-Contelles, M. Rodríguez-Fernández, 2001 .

Synthesis and transformations of (1R,2R,3S,4R)-4-O-benzylhydroxylamino-2,3-O-isopropylidene-1,2,3-cyclopentanetriol: synthesis of (1S,2R,3S,4R)-4-amino-2,3-O-isopropylidene-1,2,3-cyclopentanetriol

J. Marco-Contelles, Mamen Rodríguez-Fernández, 1997 .

A New Synthetic Approach to the Carbocyclic Core of Cyclopentane-Type Glycosidase Inhibitors: Asymmetric Synthesis of Aminocyclopentitols via Free Radical Cycloisomerization of Enantiomerically Pure Alkyne- Tethered Oxime Ethers Derived from Carbohydrates

J. Marco-Contelles, J. L. Chiara, M. Bernabé, 1996 .

6-Exo free radical cyclization of acyclic carbohydrate intermediates: a new synthetic route to enantiomerically pure polyhydroxylated cyclohexane derivatives

J. Marco-Contelles, M. Jimeno, Angeles Martínez-Grau, 1992 .

A new and extremely efficient, general strategy for the synthesis of enantiomerically pure iridoid aglycones

J. Marco-Contelles, J. Ruiz, 1998 .

Cleavage of N‐O Bonds Promoted by Samarium Diiodide: Reduction of Free or N‐Acylated O‐Alkylhydroxylamines.

J. Marco-Contelles, J. L. Chiara, C. Destabel, 1996 .

Free Radical Cyclization of Acyclic Sugar Dithioacetals: An Approach to Mannostatin A Analogues

J. Marco-Contelles, C. Destabel, P. Gallego, 1995 .

Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models

F. López-Muñoz, D. Hadjipavlou-Litina, I. Iriepa, 2020, Scientific Reports.

PtCl2- and PtCl4-catalyzed cycloisomerization of polyunsaturated precursors

J. Marco-Contelles, L. Fensterbank, M. Malacria, 2006 .

Free-radical reactions of some phenylthio-2,3-dideoxyhex-2-enopyranosides

J. Marco-Contelles, A. M. Gómez, N. Martin-Leon, 1990 .

CHIRAL, DENSELY FUNCTIONALIZED CYCLOHEPTANES FROM CARBOHYDRATES. I. THE NITRONE ROUTE

J. Marco-Contelles, E. Opazo, 1999 .

SOME UNEXPECTED RESULTS IN DONDONI'S ONE-CARBON HOMOLOGATION PROCEDURE[1]

J. Marco-Contelles, E. de Opazo, 2001 .

Synthesis of Higher‐Carbon Sugars by Addition of Organometallic Reagents to Aldehydes or Lactols Derived from Carbohydrates.

J. Marco-Contelles, E. Opazo, Nieves Arroyo, 2001 .

Synthesis and transformations of [1,2-O-isopropylidene-α-d-erythro (and α-d-ribo)furanose]-3-spiro-3′-(4′-amino-5′H-2′,3′-dihydroisothiazole-1′,1′-dioxide) derivatives

C. Len, J. Marco-Contelles, D. Postel, 2004 .

Asymmetric synthesis of cyclopentylamine derivatives, intermediates for carbocyclic nucleoside synthesis. Carbocyclization of 2-amino-5-hexenyl radicals

J. Marco-Contelles, M. Bernabé, 1994 .

Strategies and Tactics for Free Radical Carbocyclization: Synthesis of Polyfunctionalized Cyclopentanoid Molecules from Carbohydrates.

J. Marco-Contelles, Angeles Martínez-Grau, Luis A. Martínez, 1993 .

Synthesis of annulated furanoses by free-radical cyclization of haloalkenes derived from diacetone glucose

J. Marco-Contelles, C. Foces-Foces, M. Martínez-Ripoll, 1992 .

Synthesis and pharmacology of galantamine.

J. Marco-Contelles, C. Rodríguez, M. Villarroya, 2006, Chemical reviews.

Palladium-catalyzed reduction of a propargylic acetate derived from a sugar with SmI2. Some unexpected results

J. Marco-Contelles, J. L. Chiara, C. Destabel, 1996 .

Free radical cycloisomerization of enantiomerically pure alkyne-tethered oxime ethers: A new method for the asymmetric synthesis of aminocyclopentitols

J. Marco-Contelles, J. L. Chiara, M. Bernabé, 1995 .

Synthesis of branched chain cyclitols: preparation of some useful chiral building blocks

J. Marco-Contelles, C. Pozuelo, B. Sánchez, 1992 .

Iridoids from Carbohydrates via Pauson-Khand Reaction: Synthesis of Advanced Highly Oxygenated Cyclopentane-Annulated Pyranosides from D-Glucal Derivatives.

J. Marco-Contelles, J. Ruiz-Caro, 1999, The Journal of organic chemistry.

Synthesis of 4-amino-5-H-2,3-dihydroisothiazole-1,1-dioxide ring systems on sugar templates via carbanion-mediated sulfonamide intramolecular cyclization reactions (CSIC protocols) of glyco-alpha-sulfonamidonitriles.

C. Len, J. Marco-Contelles, A. N. Van Nhien, 2004, The Journal of organic chemistry.

GOLD-CATALYZED REACTIONS: A COMPUTATIONAL APPROACH

E. Soriano, J. Marco-Contelles, 2014 .

Computational mechanisms of Au and Pt catalyzed reactions

E. Soriano, J. Marco-Contelles, B. Alcaide, 2011 .

A theoretical analysis of the Ti(IV)-catalyzed glycoaminocyanation reaction.

E. Soriano, J. Marco-Contelles, H. Ducatel, 2008, Carbohydrate research.

First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.

E. De Clercq, C. Pannecouque, C. Len, 2005, Journal of medicinal chemistry.

Mechanistic analysis of intramolecular free radical reactions toward synthesis of 7-azabicyclo[2.2.1]heptane derivatives.

E. Soriano, J. Marco-Contelles, 2009, Journal of Organic Chemistry.

N-azole substituted carbohydrates. Synthesis and transformations of 1-(3′-deoxy-1′,2′:5′,6′-di-O-isopropylidene-α-D-glucofuranos-3′-yl)-azole derivatives

J. Marco-Contelles, C. A. Jiménez, 1999 .

Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.

G. Duverlie, S. Castelain, J. Balzarini, 2011, European journal of medicinal chemistry.

Synthesis and in vitro activity of novel N- 3 acylated TSAO-T compounds against HIV-1 and HCV European Journal of Medicinal Chemistry

G. Duverlie, S. Castelain, J. Balzarini, 2011 .

Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry.

Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry letters.

Branched-Chain Sugars: Improved Synthetic Approach to 3-O-Substituted Derivatives of 5,6-Dideoxy-5-C-hydroxymethyl-1,2-O-isopropylidene-α-D-xylo-hept-5-enofuranurono-7,5'-lactone and (1R, 2R, 4R)-4-(3-Furyl)-1,2-isopropylidenedioxytetrahydrofuran

J. Marco-Contelles, B. Fraser-Reid, N. Martin-Leon, 1990 .

Synthesis of 7‐azabicyclo[2.2.1]heptane derivatives by transformation of tropinone

J. Marco-Contelles, Elena Gómez‐Sénchez, 2006 .

Naturally occurring cyclohexane epoxides: sources, biological activities, and synthesis.

J. Marco-Contelles, S. Anjum, M. Molina, 2004, Chemical reviews.

Experimental and computational investigation of the unexpected formation of β-substituted polyoxygenated furans from conveniently functionalized carbohydrates

E. Soriano, J. Marco-Contelles, D. Postel, 2010 .

Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity.

S. Smaili, R. León, A. Caricati‐Neto, 2011, European journal of pharmacology.

5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5H-indolo[2,3-b]quinolin-11-amine: a highly potent human cholinesterase inhibitor.

M. Bartolini, F. López-Muñoz, Ignacio Moraleda, 2017, MedChemComm.

Synthesis of 5-Amino-3,3-dimethyl-7-phenyl-3H-[1,2]oxathiolo [4,3-b]pyridine-6-carbonitrile 1,1-Dioxides.

J. Balzarini, Abdelouahid Samadi, J. Marco-Contelles, 2014 .

A free radical approach to the synthesis of the 1,7-dioxaspiro[4,4]nonane ring system from carbohydrate templates

P. Ballesteros, E. Soriano, J. Marco-Contelles, 2003 .

Alzheimer's Disease, the "One-Molecule, One-Target" Paradigm, and the Multitarget Directed Ligand Approach.

J. Marco-Contelles, M. Oset-Gasque, 2018, ACS chemical neuroscience.

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

J. Kos, M. Denic, J. Marco-Contelles, 2023, Acta pharmaceutica Sinica. B.

Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer’s Disease

E. Martínez-Alonso, Alejandro Escobar-Peso, A. Alcázar, 2021, Pharmaceuticals.

Five-Membered-Ring-Fused Tacrines as Anti-Alzheimer’s Disease Agents

J. Marco-Contelles, M. Carreiras, 2021, Synlett.

Studies on the affinity of 6-[(n-(cyclo)aminoalkyl)oxy]-4H-chromen-4-ones for sigma 1/2 receptors.

F. López-Muñoz, M. Gütschow, I. Iriepa, 2021, RSC medicinal chemistry.

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy

Oscar M. Bautista-Aguilera, F. López-Muñoz, K. Musílek, 2020, International journal of molecular sciences.

Chromenones as Multineurotargeting Inhibitors of Human Enzymes

C. Müller, M. Gütschow, C. D. Beadle, 2019, ACS omega.

New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition.

K. Kieć‐Kononowicz, B. Malawska, O. Soukup, 2019, Journal of medicinal chemistry.

Synthesis, Monoamine Oxidase Inhibition and Computational Analysis of Diversely Substituted N‐Propargylated‐1,3,5‐triazines

J. Marco-Contelles, S. Alcaro, M. Yáñez, 2019, ChemistrySelect.

Facts, Results, and Perspectives of the Current Alzheimer's Disease Research.

J. Marco-Contelles, 2019, ACS chemical neuroscience.

Neuroinflammation Signaling Modulated by ASS234, a Multitarget Small Molecule for Alzheimer's Disease Therapy.

F. López-Muñoz, J. Marco-Contelles, J. del Pino, 2018, ACS chemical neuroscience.

In silico assessment of the metabolism and its safety significance of multitarget propargylamine ASS234

F. López-Muñoz, J. Marco-Contelles, A. Romero, 2018, CNS neuroscience & therapeutics.

"AβTau", Lobby or Religion?

J. Marco-Contelles, 2019, ACS medicinal chemistry letters.

In‐vitro and in‐vivo evaluation of the modulatory effects of the multitarget compound ASS234 on the monoaminergic system

I. Smolders, P. Sun, G. Esteban, 2017, The Journal of pharmacy and pharmacology.

Wnt Signaling Pathway, a Potential Target for Alzheimer's Disease Treatment, is Activated by a Novel Multitarget Compound ASS234

J. Marco-Contelles, O. Aguilera, A. Romero, 2014, CNS neuroscience & therapeutics.

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro.

C. Pérez, Irene Bolea, Abdelouahid Samadi, 2013, Current Alzheimer research.

Recent Developments on Multi-Target-Directed Tacrines for Alzheimer's Disease. I. The Pyranotacrines.

Alejandro Romero, J. Marco-Contelles, Jose Marco-Contelles, 2018, Current topics in medicinal chemistry.

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget‐Directed Ligands for the Treatment of Alzheimer's Disease

K. Kuča, D. Jun, K. Musílek, 2016, ChemMedChem.

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

P. Agostinho, C. Pérez, Ignacio Moraleda, 2013, ACS chemical neuroscience.

Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.

V. Andrisano, M. Bartolini, R. León, 2011, European journal of medicinal chemistry.

A reinvestigation of the acid-promoted heterocyclization of 2-(2-oxo-2-arylethyl)malononitriles in the presence of amines

R. León, Abdelouahid Samadi, E. Soriano, 2009, Molecular Diversity.

Synthesis and Friedlander reactions of 5-amino-4-cyano-1,3-oxazoles

J. Marco-Contelles, D. Brites, M. Carreiras, 2007 .

New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( Z)- N- tert-Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment.

J. Montaner, D. Hadjipavlou-Litina, M. I. Ayuso, 2019, Journal of medicinal chemistry.

Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia.

Abdelouahid Samadi, M. Unzeta, J. Marco-Contelles, 2014, Current pharmaceutical design.

The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti‐Alzheimer Multitarget Profile of Dimebon

V. Andrisano, M. Bartolini, M. Rosini, 2013, ChemMedChem.

1,6‐C‐H and 1,5‐O‐Si Insertion Reactions of Alkylidenecarbene Derivatives of Monosaccharides

R. León, J. Marco-Contelles, A. N. Van Nhien, 2005 .

Synthesis of fused azole-piperidinoses

J. Marco-Contelles, C. A. Jiménez, 2001 .

Synthesis of AZA Analogues of TSAO

C. Len, J. Marco-Contelles, A. Nguyen Van Nhien, 2003, Nucleosides, Nucleotides & Nucleic Acids.

Nucleobase-Derived Nitrones: Synthesis and Antioxidant and Neuroprotective Activities in an In Vitro Model of Ischemia–Reperfusion

F. López-Muñoz, D. Hadjipavlou-Litina, Rafał Gulej, 2022, International journal of molecular sciences.

Intramolecular alkylation of ε-iodo, α-alkoxy aldehydes

J. Marco-Contelles, E. Opazo, 2000 .

Modification of conditions for the selective preparation of 2-amino-3-cyano-4-phenylpyridines

J. Marco-Contelles, Mónica Álvarez-Pérez, 2011 .

6-Exo Free Radical Cyclization of Acyclic Carbohydrate Intermediates: A New Synthetic Route to Enantiomerically Pure Polyhydroxylated Cyclohexane Derivatives.

J. Marco-Contelles, M. Jimeno, Angeles Martínez-Grau, 1992 .

Ischemic brain injury: New insights on the protective role of melatonin.

R. Reiter, J. Marco-Contelles, E. Gil-Martín, 2017, Free radical biology & medicine.

Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine.

Yagamare Fall, José Marco-Contelles, P. De Deurwaerdère, 2017, ACS chemical neuroscience.

Nitrones, Old Fellows for New Therapies in Ischemic Stroke

E. Martínez-Alonso, A. Alcázar, J. Marco-Contelles, 2017 .

Toxicity induced by chemical warfare agents: insights on the protective role of melatonin.

J. Marco-Contelles, J. del Pino, R. Pita, 2013, Chemico-biological interactions.

Stereoelectronic effects in the 6-exo free radical cyclization of acyclic sugar derivatives: synthesis of branched chain cyclitols

J. Marco-Contelles, B. Sánchez, 1993 .

A new annulated furanoses: a new free-radical isomerization of an S-methyl hex-5-enylxanthate to an S-(cyclopentylmethyl) S-methyl dithiocarbonate

J. Marco-Contelles, B. Sánchez, Pilar Ruiz-Fernandez, 1993 .

Naturally Occurring Diazo Compounds: The Kinamycins

J. Marco-Contelles, M. Molina, 2003 .

Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease.

Irene Bolea, G. Esteban, Ignacio Moraleda, 2011, European journal of medicinal chemistry.

PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.

Manuela G. López, Abdelouahid Samadi, J. Marco-Contelles, 2013, ACS chemical neuroscience.

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids

Katarina Nikolic, Isabel Iriepa, Elena Soriano, 2014, Drug design, development and therapy.

Synthesis and Biological Evaluation of Novel Chromone+Donepezil Hybrids for Alzheimer's Disease Therapy.

K. Musílek, I. Iriepa, J. Marco-Contelles, 2019, Current Alzheimer research.

Novel Tacrine‐Grafted Ugi Adducts as Multipotent Anti‐Alzheimer Drugs: A Synthetic Renewal in Tacrine–Ferulic Acid Hybrids

V. Andrisano, M. Bartolini, M. Bolognesi, 2015, ChemMedChem.

N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists.

F. Sala, S. Sala, M. Criado, 2016, ACS chemical neuroscience.

Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease.

Ignacio Moraleda, I. Iriepa, J. Marco-Contelles, 2016, European journal of medicinal chemistry.

2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.

J. Čapek, J. Pejchal, M. Valko, 2020, European journal of medicinal chemistry.

Neuroprotective Effects of the MAO‐B Inhibitor, PF9601N, in an In Vivo Model of Excitotoxicity

C. Ballini, M. A. Colivicchi, L. Della Corte, 2014, CNS neuroscience & therapeutics.

Therapeutic Potential of Melatonin in Combination with Other Drugs Against Neurodegeneration

R. Cacabelos, J. Marco-Contelles, A. Romero, 2016 .

Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.

M. Bartolini, M. Bolognesi, J. Menéndez, 2018, European journal of medicinal chemistry.

Melatonin as potential candidate to prevent the toxicity induced by chemical warfare agents

J. Marco-Contelles, R. Pita, A. Romero, 2013, Archives of Toxicology.

Protective effect of the multitarget compound DPH‐4 on human SSAO/VAP‐1‐expressing hCMEC/D3 cells under oxygen–glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia

P. Couraud, I. Romero, B. Weksler, 2015, British journal of pharmacology.

Melatonin as a Novel Therapeutic Agent Against Chemical Warfare Agents

J. Marco-Contelles, R. Pita, A. Romero, 2016 .

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

D. Jun, O. Soukup, J. Marco-Contelles, 2019, Biomolecules.

Neuroprotective and antioxidant properties of new quinolylnitrones in in vitro and in vivo cerebral ischemia models

F. López-Muñoz, J. Marco-Contelles, R. Martínez-Murillo, 2023, Scientific Reports.

Synthesis and Neuroprotective Properties of N-Substituted C-Dialkoxyphosphorylated Nitrones

F. López-Muñoz, D. Hadjipavlou-Litina, J. Marco-Contelles, 2019, ACS omega.

Synthesis and Biological Assessment of PyrimidoTacrines as Promising Agents for Alzheimer's Disease Therapy

Ignacio Moraleda, I. Iriepa, J. Marco-Contelles, 2021, ChemistrySelect.

Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges

I. Varela-Nieto, J. Marco-Contelles, L. Rodríguez-de la Rosa, 2021, Frontiers in Cellular Neuroscience.

The subthalamic dopamine D5 receptors in Parkinson’s disease

John B. O. Mitchell, L. Mavridis, D. Agbaba, 2014 .

N‐(furan‐2‐ylmethyl)‐N‐methylprop‐2‐yn‐1‐amine (F2MPA): A Potential Cognitive Enhancer with MAO Inhibitor Properties

P. De Deurwaerdère, I. García, Y. Fall, 2014, CNS neuroscience & therapeutics.

Regioselective Synthesis of Novel [1,2,4]Triazolo[1,5‐ a ]pyridine Derivatives

F. Masmoudi, J. Marco-Contelles, Manel Ben Hassen, 2021 .

Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.

C. Pérez, M. de la Fuente Revenga, Ignacio Moraleda, 2013, European journal of medicinal chemistry.

Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.

C. Pérez, Ignacio Moraleda, I. Iriepa, 2012, European journal of medicinal chemistry.

Multipotent MAO and Cholinesterase Inhibitors for the Treatment of Alzheimer′s Disease: Synthesis, Pharmacological Analysis and Molecular Modeling of Heterocyclic Substituted Alkyl and Cycloalkyl Propargyl Amine.

J. Marco-Contelles, 2012 .

Studies on the acetylation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile derivatives

Abdelouahid Samadi, E. Soriano, J. Marco-Contelles, 2010 .

Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones.

D. Hadjipavlou-Litina, I. Iriepa, J. Marco-Contelles, 2019, Bioorganic chemistry.

Multi-target 1,4-dihydropyridines showing calcium channel blockade and antioxidant capacity for Alzheimer's disease therapy.

Ignacio Moraleda, I. Iriepa, J. Marco-Contelles, 2019, Bioorganic chemistry.

Modulation of Heat Shock Response Proteins by ASS234, Targeted for Neurodegenerative Diseases Therapy.

F. López-Muñoz, J. Marco-Contelles, J. del Pino, 2018, Chemical research in toxicology.

Development of HuperTacrines as non-toxic, cholinesterase inhibitors for the potential treatment of Alzheimer's disease.

J. Borrell, Simone Brogi, S. Butini, 2015, Mini reviews in medicinal chemistry.

Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment

I. Iriepa, J. Marco-Contelles, R. Cornu, 2023, International journal of molecular sciences.

Computational analysis of the binding ability of heterocyclic and conformationally constrained epibatidine analogs in the neuronal nicotinic acetylcholine receptor

E. Soriano, J. Marco-Contelles, L. Gandía, 2010, Molecular Diversity.

The Proof-of-Concept of MBA121, a Tacrine–Ferulic Acid Hybrid, for Alzheimer’s Disease Therapy

J. Marco-Contelles, D. González-Nieto, R. Martínez-Murillo, 2023, International journal of molecular sciences.

Editorial [Hot Topic: The Medicinal Chemistry of Hybrid-Based Drugs Targeting Multiple Sites of Action (Guest Editors: Jose Marco-Contelles, & Elena Soriano)]

E. Soriano, J. Marco-Contelles, 2011 .

Branched Chain Cyclitols: Asymmetric Synthesis Of A 1α, 25-Dihydroxy-19-Nor-Vitamin D3 A-Ring Synthon

J. Marco-Contelles, P. Ruiz, B. Sánchez, 1992 .

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer′s Disease Therapy

V. Andrisano, M. Bartolini, Ignacio Moraleda, 2016, Molecules.

Novel Quinolylnitrones Combining Neuroprotective and Antioxidant Properties.

D. Hadjipavlou-Litina, E. Martínez-Alonso, A. Alcázar, 2019, ACS chemical neuroscience.

Quinolinyl Nitrone RP19 Induces Neuroprotection after Transient Brain Ischemia.

J. Montaner, M. I. Ayuso, E. Martínez-Alonso, 2017, ACS chemical neuroscience.

Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration.

J. Marco-Contelles, J. Egea, A. Romero, 2017, Future medicinal chemistry.

An update on the pharmacology of galantamine

Manuela G. López, J. Marco-Contelles, M. Villarroya, 2007, Expert opinion on investigational drugs.

The medicinal chemistry of hybrid-based drugs targeting multiple sites of action.

E. Soriano, J. Marco-Contelles, 2011, Current topics in medicinal chemistry.

Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease

R. León, J. Marco-Contelles, Antonio G. García, 2013, Medicinal research reviews.

Novel indanone derivatives as MAO B/H3R dual-targeting ligands for treatment of Parkinson's disease.

H. Stark, J. Marco-Contelles, S. Hagenow, 2018, European journal of medicinal chemistry.

Synthesis and transformations of new annulated pyranosides using the Pauson-Khand reaction.

J. Marco-Contelles, J. Ruiz-Caro, 2001, Carbohydrate research.

Synthesis of 7-azabicyclo[2.2.1]heptane and 2-oxa-4-azabicyclo[3.3.1]non-3-ene derivatives by base-promoted heterocyclization of alkyl N-(cis(trans)-3,trans(cis)-4-dibromocyclohex-1-yl)carbamates and N-(cis(trans)-3,trans(cis)-4-dibromocyclohex-1-yl)-2,2,2-trifluoroacetamides.

E. Soriano, J. Marco-Contelles, E. Gómez-Sánchez, 2007, The Journal of organic chemistry.

Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.

Simone Brogi, G. Campiani, S. Butini, 2016, European journal of medicinal chemistry.

D. Hadjipavlou-Litina, A. Alcázar, Abdelouahid Samadi, 2012, Journal of medicinal chemistry.

Neuroprotective and Antioxidant Properties of CholesteroNitrone ChN2 and QuinolylNitrone QN23 in an Experimental Model of Cerebral Ischemia: Involvement of Necrotic and Apoptotic Cell Death

J. Marco-Contelles, F. López-Muñoz, M. Chioua, 2023, Antioxidants.

Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.

E. De Clercq, C. Pannecouque, J. Balzarini, 2008, Bioorganic & medicinal chemistry letters.

PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.

Manuela G. López, Abdelouahid Samadi, J. Marco-Contelles, 2013, ACS chemical neuroscience.

Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke

J. Montaner, M. I. Ayuso, E. Martínez-Alonso, 2020, Antioxidants.

6-endo-dig Free-Radical Carbocyclizations: A New Strategy for the Synthesis of Cyclitols

J. Marco-Contelles, M. Bernabé, D. Ayala, 1994 .

Synthesis, antioxidant and neuroprotective analysis of diversely functionalized α-aryl-N-alkyl nitrones as potential agents for ischemic stroke therapy.

E. Martínez-Alonso, J. Marco-Contelles, A. Escobar-Peso, 2024, European journal of medicinal chemistry.

K. Nikolić, D. Agbaba, Irene Bolea, 2014, European journal of medicinal chemistry.

Structure, bonding, and reactivity of reactant complexes and key intermediates.

E. Soriano, J. Marco-Contelles, 2012, Topics in current chemistry.

Mechanistic insights on the cycloisomerization of polyunsaturated precursors catalyzed by platinum and gold complexes.

E. Soriano, J. Marco-Contelles, 2009, Accounts of chemical research.

Mechanism of the gold-catalyzed rearrangement of (3-acyloxyprop-1-ynyl)oxiranes: a dual role of the catalyst.

A. D. de Lera, E. Soriano, J. Marco-Contelles, 2009, The Journal of organic chemistry.

DFT-based mechanism for the unexpected formation of dienes in the PtCl2 isomerization of propargylic acetates: examples of inhibition of the Rautenstrauch process.

E. Soriano, J. Marco-Contelles, 2007, The Journal of organic chemistry.

Heterocyclization of allenes catalyzed by late transition metals: mechanisms and regioselectivity.

E. Soriano, J. Marco-Contelles, B. Alcaide, 2012, Topics in current chemistry.

α-Phenyl-N-tert-Butylnitrone and Analogous α-Aryl-N-alkylnitrones as Neuroprotective Antioxidant Agents for Stroke

J. Marco-Contelles, 2024, Antioxidants.

A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE

Irene Bolea, P. Sun, G. Esteban, 2013, Journal of Neural Transmission.

A step further towards multitarget drugs for Alzheimer and neuronal vascular diseases: targeting the cholinergic system, amyloid-β aggregation and Ca(2+) dyshomeostasis.

R. León, J. Marco-Contelles, 2011, Current medicinal chemistry.

Hydrazides as Inhibitors of Histone Deacetylases.

J. Marco-Contelles, M. Carreiras, 2024, Journal of medicinal chemistry.