Marco Pieroni

发表

A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.

K. Nikolić, J. Vučićević, D. Agbaba, 2016, Bioorganic & medicinal chemistry.

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.

A. Cavalli, M. Radi, E. Crespan, 2017, Journal of medicinal chemistry.

Preliminary structure-activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains.

Oluseye K. Onajole, W. Bishai, A. Kozikowski, 2013, Journal of medicinal chemistry.

6‐Hydrogen‐8‐Methylquinolones Active Against Replicating and Non‐replicating Mycobacterium tuberculosis

S. Franzblau, Marco Pieroni, S. Sabatini, 2012, Chemical biology & drug design.

Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents.

S. Parapini, M. Zółkiewski, Marco Pieroni, 2017, Journal of medicinal chemistry.

Synthesis, biological evaluation, and structure-activity relationships for 5-[(E)-2-arylethenyl]-3-isoxazolecarboxylic acid alkyl ester derivatives as valuable antitubercular chemotypes.

Annamaria Lilienkampf, A. Kozikowski, S. Franzblau, 2009, Journal of medicinal chemistry.

Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics.

Marco Pieroni, Elisa Azzali, G. Costantino, 2018, Future microbiology.

An Experimental Model for the Rapid Screening of Compounds with Potential Use Against Mycobacteria.

Marco Pieroni, Elisa Azzali, P. A. D. da Silva, 2016, Assay and drug development technologies.

Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy.

Marco Pieroni, Elisa Azzali, G. Costantino, 2015, Journal of medicinal chemistry.

Pyrido[1,2‐a]benzimidazole‐Based Agents Active Against Tuberculosis (TB), Multidrug‐Resistant (MDR) TB and Extensively Drug‐Resistant (XDR) TB

W. Bishai, A. W. Sturm, A. Kozikowski, 2011, ChemMedChem.

Rational design of 5-phenyl-3-isoxazolecarboxylic acid ethyl esters as growth inhibitors of Mycobacterium tuberculosis. a potent and selective series for further drug development.

Annamaria Lilienkampf, A. Kozikowski, S. Franzblau, 2010, Journal of medicinal chemistry.

Searching for innovative quinolone-like scaffolds: synthesis and biological evaluation of 2,1-benzothiazine 2,2-dioxide derivatives

G. Kaatz, Marco Pieroni, S. Sabatini, 2012 .

Efflux Activity Differentially Modulates the Levels of Isoniazid and Rifampicin Resistance among Multidrug Resistant and Monoresistant Mycobacterium tuberculosis Strains

Marco Pieroni, M. Viveiros, I. Couto, 2018, Antibiotics.

Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O-Acetylserine Sulfhydrylase as a Colistin Adjuvant.

A. Mozzarelli, S. Bettati, Marialaura Marchetti, 2021, ACS infectious diseases.

CYCLOSERINE ENANTIOMERS ARE REVERSIBLE INHIBITORS OF HUMAN ALANINE:GLYOXYLATE AMINOTRANSFERASE: IMPLICATIONS FOR PRIMARY HYPEROXALURIA TYPE 1.

F. Cutruzzolà, A. Faccini, Marco Pieroni, 2019, The Biochemical journal.

Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases

C. Supuran, C. Capasso, A. Angeli, 2018, Journal of enzyme inhibition and medicinal chemistry.

Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with Serine Acetyltransferase (SAT) inhibitory properties

E. Carosati, S. Bettati, Marialaura Marchetti, 2022, Results in Chemistry.

Biochemical Characterization of Aspergillus fumigatus AroH, a Putative Aromatic Amino Acid Aminotransferase

L. Romani, T. Zelante, N. Keller, 2018, Front. Mol. Biosci..

Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria

S. Bettati, Marialaura Marchetti, B. Campanini, 2022, Pharmaceuticals.

Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms

A. Mozzarelli, A. Jirgensons, S. Bettati, 2018, Journal of Enzyme Inhibition and Medicinal Chemistry.

Identification of Human Alanine–Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1

Marco Pieroni, G. Costantino, Mirco Dindo, 2022, Journal of medicinal chemistry.

Mutation of Rv2887, a marR-Like Gene, Confers Mycobacterium tuberculosis Resistance to an Imidazopyridine-Based Agent

W. Bishai, A. Kozikowski, K. Winglee, 2015, Antimicrobial Agents and Chemotherapy.

Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor.

A. Mozzarelli, S. Bettati, B. Campanini, 2020, ACS medicinal chemistry letters.

Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR

A. Mozzarelli, S. Bettati, B. Campanini, 2016, Journal of enzyme inhibition and medicinal chemistry.

Rational Design, Synthesis, and Preliminary Structure-Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase.

A. Mozzarelli, S. Bettati, B. Campanini, 2016, Journal of medicinal chemistry.

Towards the sustainable discovery and development of new antibiotics

H. Petković, I. Gilbert, M. Lindvall, 2021, Nature Reviews Chemistry.

Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania.

W. Witola, R. McLeod, A. Kozikowski, 2012, Journal of medicinal chemistry.

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

Marco Pieroni, Shichun Lun, Oluseye K. Onajole, 2013, Nature Communications.

From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters.

A. Kozikowski, R. V. van Breemen, S. Franzblau, 2009, Journal of medicinal chemistry.

NOC Chemistry for Tuberculosis—Further Investigations on the Structure–Activity Relationships of Antitubercular Isoxazole‐3‐carboxylic Acid Ester Derivatives

Annamaria Lilienkampf, A. Kozikowski, S. Franzblau, 2010, ChemMedChem.

Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents.

S. Franzblau, Marco Pieroni, G. Costantino, 2014, European journal of medicinal chemistry.

2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry.

Marco Pieroni, Elisa Azzali, G. Costantino, 2020, ACS medicinal chemistry letters.

Challenging the Drug-Likeness Dogma for New Drug Discovery in Tuberculosis

Marco Pieroni, M. Viveiros, M. Girardini, 2018, Front. Microbiol..

Antituberculosis agents: Beyond medicinal chemistry rules

Marco Pieroni, 2019, Annual Reports in Medicinal Chemistry.

From 6-aminoquinolone antibacterials to 6-amino-7-thiopyranopyridinylquinolone ethyl esters as inhibitors of Staphylococcus aureus multidrug efflux pumps.

E. Carosati, G. Kaatz, Marco Pieroni, 2010, Journal of medicinal chemistry.

Synthesis and Structure–Activity Relationships of Lansine Analogues as Antileishmanial Agents

G. Tan, B. Tekwani, Sisay Girmay, 2012, ChemMedChem.

Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design

M. Welch, A. Mozzarelli, A. Jirgensons, 2018, Journal of enzyme inhibition and medicinal chemistry.

Aspergillus fumigatus tryptophan metabolic route differently affects host immunity

A. Beauvais, J. Latgé, L. Boon, 2021, Cell reports.

A Competitive O-Acetylserine Sulfhydrylase Inhibitor Modulates the Formation of Cysteine Synthase Complex

A. Mozzarelli, S. Cannistraro, L. Ronda, 2021, Catalysts.

Spectinamides: a challenge, a proof, and a suggestion.

Marco Pieroni, M. Viveiros, 2014, Trends in microbiology.

Discovery of New Potential Anti‐Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target‐Focused Repurposing Approaches

C. Supuran, D. Vullo, C. Capasso, 2016, ChemMedChem.

Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation

U. Sauer, N. Pavelka, P. Hruz, 2018, Mucosal Immunology.

Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery.

G. Lamichhane, A. Kaushik, Marco Pieroni, 2017, Journal of medicinal chemistry.

In pursuit of natural product leads: synthesis and biological evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and its analogues: discovery of N-(2-benzoxazol-2-ylphenyl)benzamides as novel antileishmanial chemotypes.

A. Kozikowski, Marco Pieroni, R. Brun, 2008, Journal of medicinal chemistry.

Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds: a patent evaluation of US2019343869(A1)

Marco Pieroni, 2020, Expert opinion on therapeutic patents.

Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A.

C. Mercurio, M. Villa, M. Varasi, 2015, European journal of medicinal chemistry.

Novel N-Benzoyl-2-Hydroxybenzamide Disrupts Unique Parasite Secretory Pathway

D. Rice, S. Prigge, W. Witola, 2012, Antimicrobial Agents and Chemotherapy.

Sodium Hyaluronate Nanocomposite Respirable Microparticles to Tackle Antibiotic Resistance with Potential Application in Treatment of Mycobacterial Pulmonary Infections

F. Sonvico, Marco Pieroni, M. Viveiros, 2019, Pharmaceutics.

Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit-to-lead optimization and release of a novel antitubercular chemotype via scaffold derivatization.

T. Dick, Marco Pieroni, G. Costantino, 2022, European journal of medicinal chemistry.

Crystal structure of Aspergillus fumigatus AroH, an aromatic amino acid aminotransferase

F. Cutruzzolà, L. Romani, T. Zelante, 2021, Proteins.

Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.

B. P. Doctor, M. Nambiar, A. Kozikowski, 2013, Bioorganic & medicinal chemistry letters.

Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants

A. Mozzarelli, S. Bettati, B. Campanini, 2021, Pharmaceuticals.

Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets

Marco Pieroni, Gabriele Costantino, Agostino Bruno, 2018, J. Chem. Inf. Model..

Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy.

A. Mozzarelli, S. Bettati, B. Campanini, 2014, Current medicinal chemistry.

Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy.

Marco Pieroni, Elisa Azzali, G. Costantino, 2015, Journal of medicinal chemistry.

Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation

U. Sauer, P. Hruz, G. De Libero, 2018, Mucosal Immunology.

In vitro Digestion of Zingiber officinale Extract and Evaluation of Stability as a First Step to Determine its Bioaccesibility

A. Faccini, C. Falavigna, Marco Pieroni, 2018, Natural Product Communications.

Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target

A. Mozzarelli, Marialaura Marchetti, B. Campanini, 2016, Journal of enzyme inhibition and medicinal chemistry.