K. Nacro

发表

Correction to Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations.

Shi Hua Ang, C. Verma, S. Kannan, 2017, Biochemistry.

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.

Shi Hua Ang, Eldwin Sum Wai Tan, C. Chuah, 2018, Journal of medicinal chemistry.

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

I. Enyedy, Y. Tomita, P. Roller, 2001, Journal of medicinal chemistry.

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).

P. Blumberg, M. Nicklaus, M. Peach, 2003, Journal of medicinal chemistry.

Role of Hydrophobic Residues in the C1b Domain of Protein Kinase C δ on Ligand and Phospholipid Interactions*

Shaomeng Wang, P. Blumberg, V. Marquez, 2001, The Journal of Biological Chemistry.

The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.

B Bienfait, B. Bienfait, G. Milne, 1999, Pharmacology & therapeutics.

b 2-Chimaerin is a novel target for diacylglycerol : Binding properties and changes in subcellular localization mediated by ligand binding to its C 1 domain

E. Kremmer, B. Bienfait, H. Mischak, 1999 .

An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).

P. Blumberg, M. Nicklaus, S. Garfield, 2001, Journal of medicinal chemistry.

Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.

A. Poulsen, J. Cherian, Boping Liu, 2016, Journal of medicinal chemistry.

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma

P. Houghton, S. Gery, Ye Chen, 2021, Oncogene.

Restoration of oxytocin receptor signaling and social recognition in a mouse model of autism

Fulvio, E. Pérez-Garci, D. Schreiner, 2021 .

Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations.

Shi Hua Ang, C. Verma, S. Kannan, 2015, Biochemistry.

Influence of the Nature and Substitution of Chiral 2,3-Epoxy Alcohol Derivatives on the Enantiomeric Elution Order on Chiralcel OD Column

K. Nacro, R. Neier, M. Baltas, 1998 .

Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives.

K. Nacro, Denise Peace, T. Friedrich, 2007, Bioorganic & medicinal chemistry.

An efficient synthesis of (7S,10R)-2-bromo-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole: application in the preparation and structural confirmation of a potent 5-HT6 antagonist

M. M. Hsia, K. Nacro, B. Shimpukade, 2012 .

Stereoselective synthesis of five and/or six membered ring hydroxylactones obtained by Lewis acid mediated reaction of γ,δ-epoxy-β-hydroxyesters; access to 5-methylated 2-deoxysugars.

K. Nacro, M. Baltas, J. Escudier, 1997 .

Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

B Bienfait, B. Bienfait, P. Blumberg, 2000, Journal of medicinal chemistry.

Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors.

J. Macor, Shuang Liu, T. Molski, 2014, ACS medicinal chemistry letters.

Attempt to rationalize the diastereoselectivity in the addition of ester enolate to optically active α,β-epoxyaldehydes

K. Nacro, M. Baltas, L. Gorrichon, 1999 .

Lactonisation and lactone ether formation of nerol geraniol compounds. Use of 13C to identify the cyclisation process

J. Jaud, K. Nacro, M. Baltas, 1999 .

Enhanced diastereoselectivity in the addition of ester enolate to optically active α,β-epoxyaldehydes obtained from nerol and geraniol

K. Nacro, M. Baltas, J. Escudier, 1996 .

Synthesis of 2‐Deoxynucleosides Substituted at C‐5.

K. Nacro, M. Baltas, J. Escudier, 1996 .

Attempt to Rationalize the Diastereoselectivity in the Addition of Ester Enolate to Optically Active α,β-Epoxyaldehydes.

K. Nacro, M. Baltas, L. Gorrichon, 2010 .

Enhanced Diastereoselectivity in the Addition of Ester Enolate to Optically Active α,β-Epoxyaldehydes Obtained from Nerol and Geraniol.

K. Nacro, M. Baltas, J. Escudier, 1996 .

Conformationally constrained analogues of diacylglycerol (DAG). Part 19: Asymmetric syntheses of (3R)- and (3S)-3-hydroxy-4,4-disubstituted heptono-1,4-lactones as protein kinase C (PK-C) ligands with increased hydrophilicity

P. Blumberg, V. Marquez, K. Nacro, 2002 .

Stereochemistry Control in the Lewis Acid Mediated Lactonization Reaction of γ,δ-Epoxy-β-silyloxy Esters

K. Nacro, M. Baltas, J. Escudier, 2001 .

Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.

C. Chai, J. Xu, K. Nacro, 2011, ACS medicinal chemistry letters.

Topography of transcriptionally active chromatin in glioblastoma

H. Wakimoto, T. Tan, Shaomeng Wang, 2021, Science Advances.

Rescue of oxytocin response and social behavior in a rodent model of autism

E. Pérez-Garci, D. Schreiner, P. Scheiffele, 2020, Nature.

Update on the Development of MNK Inhibitors as Therapeutic Agents.

C. Verma, S. Kannan, K. Nacro, 2021, Journal of medicinal chemistry.

Identification of covalent active site inhibitors of dengue virus protease

S. Vasudevan, S. Gayen, A. Poulsen, 2015, Drug design, development and therapy.

Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

D. Fruman, C. Chuah, H. Fan, 2013, Proceedings of the National Academy of Sciences.

A facile synthesis of 4-aryl-1,2,3,4-tetrahydroisoquinolines

Shuang Liu, K. Nacro, P. Guzzo, 2012 .

Differential Localization of Protein Kinase C δ by Phorbol Esters and Related Compounds Using a Fusion Protein with Green Fluorescent Protein*

P. Blumberg, V. Marquez, K. Nacro, 1999, The Journal of Biological Chemistry.

Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones.

B. Bienfait, P. Blumberg, V. Marquez, 2000, Bioorganic & medicinal chemistry letters.

Structure-guided fragment-based in silico drug design of dengue protease inhibitors

Peter Güntert, Andreas Schüller, M. S. Madhusudhan, 2011, J. Comput. Aided Mol. Des..

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.

J. Kwiatkowski, A. Poulsen, Jeffrey Hill, 2020, Journal of medicinal chemistry.

Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases

Mohan R. Pradhan, C. Verma, S. Kannan, 2017, ACS omega.

Effect of Ser392 phosphorylation on the structure and dynamics of the polybasic domain of ADP ribosylation factor nucleotide site opener protein: a molecular simulation study.

Chandra S Verma, Gerhard Grüber, C. Verma, 2013, Biochemistry.

Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.

Rong Li, Jeffrey Hill, T. Keller, 2018, Structure.

beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain.

E. Kremmer, B. Bienfait, H. Mischak, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).

B. Bienfait, P. Blumberg, V. Marquez, 1998, Bioorganic & medicinal chemistry letters.

Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C.

B. Bienfait, P. Blumberg, H. Tamamura, 2000, Journal of medicinal chemistry.

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

I. Enyedy, Y. Tomita, P. Roller, 2001, Journal of medicinal chemistry.

Enabling Synthesis of Triple Reuptake Inhibitor (+)-BMS-820836, a Potential Therapeutic Agent for the Treatment of Depression

Paul C. Lobben, Shuang Liu, R. Olson, 2016 .

Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists.

K. Nacro, R. Pathak, Animesh Ghosh, 2012, Bioorganic & medicinal chemistry letters.

Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.

C. Chai, J. Xu, K. Nacro, 2011, ACS medicinal chemistry letters.