J. Joy

发表

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.

Shi Hua Ang, Eldwin Sum Wai Tan, C. Chuah, 2018, Journal of medicinal chemistry.

The crystal structure of the non-liganded 14-3-3σ protein: insights into determinants of isoform specific ligand binding and dimerization

H. Hermeking, T. Holak, G. Popowicz, 2005, Cell Research.

Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile virus NS2B/NS3 serine protease.

Jeffrey Hill, J. Joy, H. A. Lim, 2011, European journal of medicinal chemistry.

Lyso-myristoyl phosphatidylcholine micelles sustain the activity of Dengue non-structural (NS) protein 3 protease domain fused with the full-length NS2B.

J. Lescar, Jeffrey Hill, Qingxin Li, 2013, Protein expression and purification.

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.

Rong Li, Sugunavathi Sepramaniam, A. Poulsen, 2019, ACS medicinal chemistry letters.

Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19INK4d

T. Holak, N. Nalabothula, W. Machleidt, 2006, Biological chemistry.

Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.

A. Poulsen, J. Cherian, Boping Liu, 2016, Journal of medicinal chemistry.

Structure–activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase

H. Ford, Jeffrey Hill, T. Keller, 2021, Protein science : a publication of the Protein Society.

Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells

H. Ford, D. Ghosh, J. Marugan, 2019, Molecular Cancer Therapeutics.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

Hong Kee Tan, D. Tenen, Y. S. Tan, 2018, Proceedings of the National Academy of Sciences.

A Warhead Substitution Study on the Coronavirus Main Protease Inhibitor Nirmatrelvir

Boping Liu, Xiaoying Koh, J. Joy, 2022, ACS medicinal chemistry letters.

Solid‐phase synthesis and screening of a library of C‐terminal arginine peptide aldehydes against Murray Valley encephalitis virus protease

N. Ede, Jeffrey Hill, J. Joy, 2012, Journal of peptide science : an official publication of the European Peptide Society.

Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.

A. Poulsen, Boping Liu, Jeffrey Hill, 2021, Bioorganic & medicinal chemistry.

Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor

Jeffrey Hill, T. Keller, C. Kang, 2017, Biomolecular NMR Assignments.

A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides

F. Ng, Jeffrey Hill, J. Joy, 2014, Peptides.

Novel agmatine dipeptide inhibitors against the West Nile virus NS2B/NS3 protease: a P3 and N-cap optimization study.

A. Poulsen, Jeffrey Hill, Wen-Yang Wu, 2013, European journal of medicinal chemistry.

Identification of covalent active site inhibitors of dengue virus protease

S. Vasudevan, S. Gayen, A. Poulsen, 2015, Drug design, development and therapy.

Functional and structural studies on the signal transduction proteins involved in tumorigenesis: insulin-like growth factor binding proteins (IGFBPs), integrin linked kinase (ILK), and 14-3-3σ

J. Joy, 2006 .

Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.

J. Kwiatkowski, A. Poulsen, Jeffrey Hill, 2020, Journal of medicinal chemistry.

NMR and mass spectrometry studies of putative interactions of cell cycle proteins pRb and CDK6 with cell differentiation proteins MyoD and ID-2.

Mahavir Singh, T. Holak, Marcin Krajewski, 2005, Biochimica et biophysica acta.

Antiviral activities of 15 dengue NS2B-NS3 protease inhibitors using a human cell-based viral quantification assay.

J. Chu, Jeffrey Hill, C. S. Brian Chia, 2015, Antiviral research.

Strategic Design of Catalytic Lysine-Targeting Reversible Covalent BCR-ABL Inhibitors.

Rong Li, A. Poulsen, S. Yao, 2021, Angewandte Chemie.

Generation of Active Bovine Terminal Deoxynucleotidyl Transferase (TdT) in E.coli

Jeffrey Hill, H. Flotow, J. Joy, 2010 .

NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex*

Rong Li, P. Shi, S. Gayen, 2013, The Journal of Biological Chemistry.

Rational Design of Resorcylic Acid Lactone Analogues as Covalent MNK1/2 Kinase Inhibitors by Tuning the Reactivity of an Enamide Michael Acceptor

Jeffrey Hill, C. Chai, J. Xu, 2013, ChemMedChem.

A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors

J. Joy, Gang Wang, R. Karuna, 2021, Bioorganic & Medicinal Chemistry Letters.

Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor

Jeffrey Hill, T. Keller, C. Kang, 2017, Biomolecular NMR Assignments.

Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease

A. Poulsen, F. Ng, Jeffrey Hill, 2016, Journal of enzyme inhibition and medicinal chemistry.

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques.

Rong Li, E. Guccione, Jianhe Peng, 2014, The Biochemical journal.

Novel agmatine dipeptide inhibitors against the West Nile virus NS2B/NS3 protease: a P3 and N-cap optimization study.

Jeffrey Hill, Wen-Yang Wu, J. Joy, 2013, European journal of medicinal chemistry.

Discovery and characterisation of the automethylation properties of PRDM9.

Rong Li, E. Guccione, Jianhe Peng, 2017, The Biochemical journal.