O. Fjellström

发表

The Structure of Murine N1-Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism.

C. Wassvik, T. Yokota, T. Sjögren, 2017, Biochemistry.

Proton translocating nicotinamide nucleotide transhydrogenase from E. coli. Mechanism of action deduced from its structural and catalytic properties.

J. Rydström, O. Fjellström, J Rydström, 2000, Biochimica et biophysica acta.

Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia.

K. Hansson, O. Fjellström, D. Gustafsson, 2014, Bioorganic & medicinal chemistry letters.

GPR81 HTS Case Study

O. Fjellström, Eric Wellner, 2016 .

A serendipitously identified novel small molecule procoagulant compound giving rise to a high-throughput screening assay based on human plasma.

J. Ulander, O. Fjellström, J. Deinum, 2013, Thrombosis research.

Overexpressing cell systems are a competitive option to primary adipocytes when predicting in vivo potency of dual GPR81/GPR109A agonists

P. Gennemark, J. Almquist, O. Fjellström, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Creating Novel Activated Factor XI Inhibitors through Fragment Based Lead Generation and Structure Aided Drug Design

O. Fjellström, I. Nilsson, T. Olsson, 2015, PloS one.

Interactions between the soluble domain I of nicotinamide nucleotide transhydrogenase from Rhodospirillum rubrum and transhydrogenase from Escherichia coli. Effects on catalytic and H+-pumping activities.

J. Rydström, M. V. Ivanova, O. Fjellström, 2000, European journal of biochemistry.

Involvement of the metabolic sensor GPR81 in cardiovascular control.

O. Fjellström, N. Oakes, J. Björkman, 2017, JCI insight.

Hepatic patatin‐like phospholipase domain‐containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans

J. Schumi, A. Andréasson, M. Ekstedt, 2022, Hepatology communications.

Small molecule modulators of PCSK9 - A literature and patent overview.

O. Fjellström, D. Pettersen, 2018, Bioorganic & medicinal chemistry letters.

Recombinant Apyrase (AZD3366) Against Myocardial Reperfusion Injury

Y. Ye, Huan Chen, Y. Birnbaum, 2022, Cardiovascular Drugs and Therapy.

Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function

A. Sabirsh, Tomas Åkerud, S. Martinsson, 2020, The Journal of Biological Chemistry.

Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach.

A. Åstrand, Johan Cassel, Zhong-Qing Yuan, 2016, Bioorganic & medicinal chemistry letters.

Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 That Accelerates the Transition into the Latent Conformation*

S. Geschwindner, T. Sjögren, O. Fjellström, 2012, The Journal of Biological Chemistry.

Domains, specific residues and conformational states involved in hydride ion transfer and proton pumping by nicotinamide nucleotide transhydrogenase from Escherichia coli.

J. Rydström, O. Fjellström, J. Meuller, 1998, Biochimica et biophysica acta.

Human target validation of phosphoinositide 3‐kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor

B. Kull, O. Fjellström, T. Inghardt, 2012, Journal of thrombosis and haemostasis : JTH.

From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs.

Eric Therrien, Yafeng Xue, W. V. Otterlo, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs.

Eric Therrien, S. Hanessian, O. Fjellström, 2008, Bioorganic & medicinal chemistry letters.

Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure.

Stephen Hanessian, Ingemar Nilsson, Ola Fjellström, 2006, Bioorganic & medicinal chemistry letters.

Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin.

N. Blomberg, Yafeng Xue, J. D. Del Valle, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and Pharmacological Properties of Silicon‐Containing GPR81 and GPR109A Agonists

O. Fjellström, Eric Wellner, R. Tacke, 2015, ChemMedChem.

Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel.

G. Strandlund, A. Åstrand, Jonas Boström, 2014, Bioorganic & medicinal chemistry letters.

Molecular biology of nicotinamide nucleotide transhydrogenase--a unique proton pump.

J. Rydström, O. Fjellström, J. Meuller, 1995, Biochimica et biophysica acta.

Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid.

J. A. Grant, Jonas Boström, A. Thelin, 2013, Journal of medicinal chemistry.

Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents

R. Isaacs, S. Geschwindner, L. Benthem, 2015, PloS one.

Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors.

Christer Alstermark, Ola Fjellström, Karolina Nilsson, 2008, Journal of medicinal chemistry.

Identification of novel GPR81 agonist lead series for target biology evaluation.

C. Tyrchan, O. Fjellström, Eric Wellner, 2020, Bioorganic & medicinal chemistry letters.

Three‐dimensional structure prediction of the NAD binding site of proton‐pumping transhydrogenase from Escherichia coli

J. Rydström, Suhail Ahmad, O. Fjellström, 1995, Proteins.

Pharmacodynamic-pharmacokinetic integration as a guide to medicinal chemistry.

Michael Rowley, Johan Ulander, Johan Gabrielsson, 2011, Current topics in medicinal chemistry.

Analysis of selective regions in the active sites of human cytochromes P450, 2C8, 2C9, 2C18, and 2C19 homology models using GRID/CPCA.

T. Andersson, I. Zamora, O. Fjellström, 2001, Journal of medicinal chemistry.

Mapping of Residues in the NADP(H)-binding Site of Proton-translocating Nicotinamide Nucleotide Transhydrogenase fromEscherichia coli

J. Rydström, O. Fjellström, J. Meuller, 1999, The Journal of Biological Chemistry.

Recombinant Apyrase (AZD3366) Against Myocardial Reperfusion Injury

Y. Ye, Huan Chen, Y. Birnbaum, 2022, Cardiovascular Drugs and Therapy.