Y. Long

发表

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

I. Enyedy, Y. Tomita, P. Roller, 2001, Journal of medicinal chemistry.

A p21(Waf1/Cip1)carboxyl-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells.

R. Sikorski, P. O'Connor, M. Mutoh, 1999, Cancer research.

Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.

Y. Pommier, K. Krajewski, P. Roller, 2004, Bioorganic & medicinal chemistry letters.

Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues.

N. Neamati, Yong Wang, Y. Long, 2012, Organic & biomolecular chemistry.

Bifunctional Chimera That Coordinately Targets Human Immunodeficiency Virus 1 Envelope gp120 and the Host-Cell CCR5 Coreceptor at the Virus-Cell Interface.

M. Kutzler, I. Chaiken, Y. Long, 2018, Journal of medicinal chemistry.

Efficient synthesis and identification of novel propane-1,3-diamino bridged CCR5 antagonists with variation on the basic center carrier.

Y. Long, Xing Fan, Hu-Shan Zhang, 2010, European journal of medicinal chemistry.

Crystal structures of SIRT3 reveal that the α2‐α3 loop and α3‐helix affect the interaction with long‐chain acyl lysine

Hualiang Jiang, Dongxiang Liu, Y. Long, 2016, FEBS letters.

Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase.

R. Shoemaker, R. Dayam, T. Sanchez, 2004, Journal of medicinal chemistry.

Significant compensatory role of position Y-2 conferring high affinity to non-phosphorylated inhibitors of Grb2-SH2 domain.

P. Roller, J. Voigt, F. Lung, 1999, Bioorganic & medicinal chemistry letters.

Functional preference of the constituent amino acid residues in a phage-library-based nonphosphorylated inhibitor of the Grb2-SH2 domain.

P. Roller, F. Lung, X. Wu, 2001, The journal of peptide research : official journal of the American Peptide Society.

Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3'-substituted tyrosine derivatives.

Megan L. Peach, Shaomeng Wang, S. Qiu, 2006, Journal of medicinal chemistry.

Direct synthesis of 2-aryl-4-quinolones via transition-metal-free intramolecular oxidative C(sp(3))-H/C(sp(3))-H coupling.

Jian-Ping Lin, Y. Long, Li-Rui Song, 2015, Organic letters.

Investigation on the 1,6-naphthyridine motif: discovery and SAR study of 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one-based c-Met kinase inhibitors.

M. Geng, Jian-Ping Lin, Yong Wang, 2013, Organic & biomolecular chemistry.

Enantiospecific Synthesis of All Four Stereoisomers of Novel Bicyclic Arylacetamides as k -Opioid Agonists

Ruixia Wu, Y. Long, Dachuan Qiu, 2010 .

3-Pyrroline containing arylacetamides: a novel series of remarkably selective kappa-agonists.

Y. Long, Z. Chi, Jie Chen, 2002, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists.

Juan Wang, Xiaohua Liu, Gang Liu, 2016, Journal of medicinal chemistry.

Solvent/oxidant-switchable synthesis of multisubstituted quinazolines and benzimidazoles via metal-free selective oxidative annulation of arylamidines.

Jian-Ping Lin, Y. Long, Fenghua Zhang, 2014, Organic letters.

Transition metal-free one-pot synthesis of 2-substituted 3-carboxy-4-quinolone and chromone derivatives.

Jian-Ping Lin, Y. Long, 2013, Chemical communications.

Discovery of novel (S)-alpha-phenyl-gamma-amino butanamide containing CCR5 antagonists via functionality inversion approach.

Y. Long, D. Feng, Hu-Shan Zhang, 2010, Bioorganic & medicinal chemistry letters.

GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space.

Y. Long, He Li, Cheng Chen, 2016, Bioorganic & medicinal chemistry letters.

On-Demand Activation of a Bioorthogonal Prodrug of SN-38 with Fast Reaction Kinetics and High Releasing Efficiency In Vivo.

Y. Long, Shun Feng, Jujun Zhou, 2021, Journal of medicinal chemistry.

Forward- and reverse-synthesis of piperazinopiperidine amide analogs: a general access to structurally diverse 4-piperazinopiperidine-based CCR5 antagonists.

Y. Long, D. Feng, Li Chen, 2007, Organic & biomolecular chemistry.

Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties.

B. Hammock, C. Morisseau, Y. Long, 2010, Journal of medicinal chemistry.

The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase.

B. Hammock, C. Morisseau, Y. Long, 2006, Bioorganic & medicinal chemistry.

Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold.

Y. Long, Qi Huang, He-Yao Wang, 2017, Journal of medicinal chemistry.

Structural requirements for Tyr in the consensus sequence Y-E-N of a novel nonphosphorylated inhibitor to the Grb2-SH2 domain.

P. Roller, T. Burke, Z. Yao, 1999, Biochemical and biophysical research communications.

Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine.

Qiang Z Yu, Y. Long, Ting Xue, 2008, Journal of medicinal chemistry.

Development of l-3-aminotyrosine suitably protected for the synthesis of a novel nonphosphorylated hexapeptide with low-nanomolar Grb2-SH2 domain-binding affinity.

P. Roller, Y. Long, Yan-li Song, 2004, Bioorganic & medicinal chemistry letters.

Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.

N. Neamati, Jian Ding, Yong-tang Zheng, 2012, Journal of medicinal chemistry.

Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.

Erik Serrao, N. Neamati, Yong-tang Zheng, 2014, Bioorganic & medicinal chemistry.

4'-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3',4',5'-substituted)anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule agents.

Y. Long, Yi Jin, Wei Tian, 2006, Bioorganic & medicinal chemistry letters.

Studies toward the total synthesis of cyclodidemniserinol trisulfate. Part I: 3,5,7-Trisubstituted 6,8-dioxabicyclo [3.2.1] octane core structure construction via a convergent and a linear stereoselective synthesis

Y. Long, Jianhua Liu, Lai-Dong Song, 2009 .

Synthesis of the C5-C30 fragment of cyclodidemniserinol trisulfate via I2-mediated deprotection and ring closure tandem reaction

Y. Long, Yi Jin, Jianhua Liu, 2010 .

Metal-free TEMPO-promoted C(sp³)-H amination to afford multisubstituted benzimidazoles.

Y. Long, D. Xue, 2014, The Journal of organic chemistry.

Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation.

R. Dayam, N. Neamati, Li-Fan Zeng, 2008, Bioorganic & medicinal chemistry.

Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase.

R. Dickson, P. Roller, P. Li, 2007, Organic letters.

Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors.

Xiao-min Luo, Jian Ding, Y. Long, 2005, Bioorganic & medicinal chemistry.

Studies toward the total synthesis of cyclodidemniserinol trisulfate. Part II: 3,5,7-Trisubstituted 6,8-dioxabicyclo [3.2.1] octane core structure construction via I2-mediated deprotection and ring closure tandem reaction

Y. Long, Jianhua Liu, 2009 .

Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists.

Y. Long, Xiao-Hua Jiang, Yan-li Song, 2004, Bioorganic & medicinal chemistry letters.

Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase.

B. Hammock, C. Morisseau, Y. Long, 2012, MedChemComm.

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.

Erik Serrao, N. Neamati, Z. Debyser, 2013, Bioorganic & medicinal chemistry.

Study on the Aggregation and Deaggregation Behaviors of Phosphatidylcholines

Y. Long, Xi-kui Jiang, G. Ji, 2010 .

Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.

N. Neamati, Li-Fan Zeng, Y. Long, 2011, Bioorganic & medicinal chemistry.

Design and synthesis of dimeric HIV-1 integrase inhibitory peptides.

Y. Pommier, K. Krajewski, P. Roller, 2003, Bioorganic & medicinal chemistry letters.

Design and Discovery of Peptide‐Based HIV‐1 Integrase Inhibitors

N. Neamati, Y. Long, 2011 .

An Efficient and Practical Synthesis of the HIV Protease Inhibitor Atazanavir via a Highly Diastereoselective Reduction Approach

Y. Long, Xing Fan, Yan-li Song, 2008 .

Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrido[4,3-c]azepin-5-one-based novel chemotype CCR2 antagonists via scaffold hopping strategy.

Y. Long, Xin Xie, Zhilong Wang, 2018, Bioorganic & medicinal chemistry.

Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.

N. Neamati, Z. Debyser, Stéphanie De Houwer, 2013, Journal of medicinal chemistry.

Discovery of Novel 2‐N‐Aryl‐Substituted Benzenesulfonamidoacetamides: Orally Bioavailable Tubulin Polymerization Inhibitors with Marked Antitumor Activities

Long Yu, Y. Long, D. Xue, 2012, ChemMedChem.

A novel proteolysis-resistant cyclic helix B peptide ameliorates kidney ischemia reperfusion injury.

Y. Long, T. Zhu, Ming Xu, 2014, Biochimica et biophysica acta.

Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase.

I. Enyedy, P. Roller, Y. Long, 2001, Bioorganic & medicinal chemistry letters.

Bioorthogonal chemistry: Optimization and application updates during 2013–2017

Y. Long, Wei Hu, Li-Huai Qin, 2018, Tetrahedron Letters.

Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.

Zhon-Yin Zhang, Y. Long, Zhong-Yin Zhang, 2008, Journal of the American Chemical Society.

Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization.

M. Geng, Y. Long, Yingming Yao, 2015, Bioorganic & medicinal chemistry letters.

Potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics.

Dajun Yang, Megan L Peach, Manchao Zhang, 2003, Bioorganic & medicinal chemistry letters.

Global optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.

P. Roller, F. Lung, Y. Long, 2003, Bioorganic & medicinal chemistry.

Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors.

N. Neamati, Yong-tang Zheng, Li-Fan Zeng, 2008, Bioorganic & medicinal chemistry letters.

A simple and highly efficient preparation of structurally diverse aryl β‐diketoacids as hiv‐1 integrase inhibitors

Y. Long, Xiao-Hua Jiang, 2010 .

Highly efficient preparation of aryl beta-diketo acids with tert-butyl methyl oxalate.

Y. Long, Xiao-Hua Jiang, Lai-Dong Song, 2003, The Journal of organic chemistry.

Binding affinity difference induced by the stereochemistry of the sulfoxide bridge of the cyclic peptide inhibitors of Grb2-SH2 domain: NMR studies for the structural origin.

Yan-Li Song, P. Roller, Y. Long, 2005, Biochemical and biophysical research communications.

High affinity nonphosphorylated cyclic peptide inhibitors of Grb2-SH2/growth factor receptor interactions

Dajun Yang, P. Roller, T. Burke, 2002 .

Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency.

Y. Cheng, Jian-Ping Zuo, Y. Long, 2016, Bioorganic & medicinal chemistry letters.

The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential.

Y. Long, B. Cao, Ying-jun Zhou, 2018, European journal of medicinal chemistry.

Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction.

N. Neamati, Yong-tang Zheng, Y. Long, 2017, European journal of medicinal chemistry.

Bicyclic Peptide Inhibitors of an Epithelial Cell-Derived Transmembrane Protease, Matriptase

I. Enyedy, Shaomeng Wang, R. Dickson, 2001 .

LPK-26, a novel kappa-opioid receptor agonist with potent antinociceptive effects and low dependence potential.

Y. Long, Ya-Wen Ju, Z. Chi, 2008, European journal of pharmacology.

Crystal structures of SIRT3 reveal that the alpha 2-alpha 3 loop and alpha 3-helix affect the interaction with long-chain acyl lysine.

Honglin Li, Hualiang Jiang, Y. Long, 2016 .

Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein.

Chao-Yie Yang, Xiongwu Wu, Yipin Lu, 2004, Journal of medicinal chemistry.

Utilization of 3'-carboxy-containing tyrosine derivatives as a new class of phosphotyrosyl mimetics in the preparation of novel non-phosphorylated cyclic peptide inhibitors of the Grb2-SH2 domain.

Xiao-min Luo, Y. Long, Jin-zhi Tan, 2006, Organic & biomolecular chemistry.

Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.

Dajun Yang, Dajun Yang, P. Roller, 2003, Biochemical and biophysical research communications.

4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.

Y. Long, Li-xin Gao, Yi Jin, 2014, Bioorganic & medicinal chemistry.

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

I. Enyedy, Y. Tomita, P. Roller, 2001, Journal of medicinal chemistry.

Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.

Zhon-Yin Zhang, Y. Long, A. Gunawan, 2008, Journal of the American Chemical Society.

Discovery of Novel 2‐N‐Aryl‐Substituted Benzenesulfonamidoacetamides: Orally Bioavailable Tubulin Polymerization Inhibitors with Marked Antitumor Activities

Long Yu, Y. Long, D. Xue, 2012, ChemMedChem.

Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into β-position to the carboxylic acid.

Nan Hu, Shimeng Guo, Y. Long, 2023, European journal of medicinal chemistry.

Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.

N. Neamati, Y. Long, Lai-Dong Song, 2006, Journal of medicinal chemistry.