S. Wang

发表

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

I. Enyedy, Y. Tomita, P. Roller, 2001, Journal of medicinal chemistry.

Conformational changes of small molecules binding to proteins.

M C Nicklaus, G. Milne, M. Nicklaus, 1995, Bioorganic & medicinal chemistry.

Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth.

B. Roth, J. Flippen-Anderson, Shaomeng Wang, 2001, Bioorganic & medicinal chemistry letters.

The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.

B Bienfait, B. Bienfait, G. Milne, 1999, Pharmacology & therapeutics.

Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.

I. Enyedy, P. Blumberg, J. Stone, 2001, Journal of medicinal chemistry.

Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.

I. Enyedy, P. Blumberg, S. Wang, 2001, Journal of medicinal chemistry.

Protein kinase C. Modeling of the binding site and prediction of binding constants.

G. Milne, P. Blumberg, M. Nicklaus, 1994, Journal of medicinal chemistry.

Conformationally constrained analogues of diacylglycerol. 10. Ultrapotent protein kinase C ligands based on a racemic 5-disubstituted tetrahydro-2-furanone template.

G. Milne, P. Blumberg, V. Marquez, 1996, Journal of medicinal chemistry.

Conformationally constrained analogues of diacylglycerol. 11. Ultrapotent protein kinase C ligands based on a chiral 5-disubstituted tetrahydro-2-furanone template.

G. Milne, P. Blumberg, V. Marquez, 1996, Journal of medicinal chemistry.

Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists.

J. Wityak, S. Mousa, R. Olson, 1997, Journal of medicinal chemistry.

Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.

M C Nicklaus, Y. Pommier, N. Neamati, 1997, Journal of medicinal chemistry.

Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity.

R. Glazer, P. Blumberg, A. Kozikowski, 1997, Journal of medicinal chemistry.

Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives.

R. Clark, S. Wang, D. Chu, 2000, Bioorganic & Medicinal Chemistry Letters.

Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists.

J. Wityak, S. Mousa, R. Olson, 1997, Journal of medicinal chemistry.

Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.

G. Liapakis, G. Melacini, L. Prokai, 1997, Journal of medicinal chemistry.

Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity.

A. Kozikowski, S. Wang, K. Johnson, 1999, Bioorganic & medicinal chemistry letters.

Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

P. Lam, R. Knabb, R. Alexander, 2001, Journal of medicinal chemistry.

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.

R. Knabb, S. Wang, R. Wexler, 2001, Bioorganic & medicinal chemistry letters.

Coumarin-based inhibitors of HIV integrase.

Y. Pommier, N. Neamati, G. Milne, 1997, Journal of medicinal chemistry.

Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors.

I. Enyedy, S. Sakamuri, W. Zaman, 2001, Bioorganic & medicinal chemistry letters.

Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

W G Laver, S. Muchmore, V. Giranda, 2001, Journal of medicinal chemistry.

Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching.

M C Nicklaus, G. Milne, M. Nicklaus, 1996, Journal of medicinal chemistry.

Structure-based design and synthesis of small molecule protein-tyrosine phosphatase 1B inhibitors.

L. Wu, T. Burke, Z. Zhang, 1998, Bioorganic & medicinal chemistry.

Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.

T R Burke, Y. Pommier, N. Neamati, 1996, Journal of medicinal chemistry.

Synthesis and antimicrobial activity of 4H-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position.

S. Wang, C. S. Cooper, R. Flamm, 1999, Journal of medicinal chemistry.

Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring.

B. P. Doctor, G. Campiani, A. Kozikowski, 1998, Bioorganic & medicinal chemistry letters.

Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.

M. Mitten, R. Clark, S. Wang, 2000, Journal of medicinal chemistry.

Conformationally constrained analogues of diacylglycerol. 12. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4-lactone template.

Z. Szallasi, G. Milne, P. Blumberg, 1996, Journal of medicinal chemistry.

Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.

I. Enyedy, R. Dickson, S. Wang, 2001, Journal of medicinal chemistry.

Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.

J. Wroblewski, A. Kozikowski, S. Wang, 1998, Journal of medicinal chemistry.

Molecular modeling, structure--activity relationships and functional antagonism studies of 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketones as a novel class of dopamine transporter inhibitors.

I. Enyedy, S. Sakamuri, W. Zaman, 2001, Bioorganic & medicinal chemistry.

Pharmacophores in drug design and discovery.

M C Nicklaus, G. Milne, M. Nicklaus, 1998, SAR and QSAR in environmental research.

Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.

Suoming Zhang, S. Zhang, M. Mitten, 2001, Journal of medicinal chemistry.

Pharmacophore-based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors.

I. Enyedy, S. Sakamuri, W. Zaman, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase.

I. Enyedy, P. Roller, Y. Long, 2001, Bioorganic & medicinal chemistry letters.

Discovery of HIV-1 integrase inhibitors by pharmacophore searching.

M C Nicklaus, T R Burke, Y. Pommier, 1997, Journal of medicinal chemistry.

beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain.

E. Kremmer, B. Bienfait, H. Mischak, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Conformationally constrained analogues of diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2 carbonyls in DAG mimetics by isopharmacophore replacement.

P. Blumberg, V. Marquez, S. Wang, 1998, Bioorganic & medicinal chemistry letters.

Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.

R. Copeland, R. Magolda, J. Trzăskos, 1999, Bioorganic & medicinal chemistry letters.

Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies.

I. Enyedy, S. Sakamuri, W. Zaman, 2000, Journal of medicinal chemistry.

Synthesis and protein kinase C binding activity of benzolactam-V7.

P. Blumberg, A. Kozikowski, S. Wang, 1999, Bioorganic & medicinal chemistry letters.

Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).

B. Bienfait, P. Blumberg, V. Marquez, 1998, Bioorganic & medicinal chemistry letters.

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.

I. Enyedy, Y. Tomita, P. Roller, 2001, Journal of medicinal chemistry.