C. D’Amore

发表

Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity.

V. Sepe, A. Zampella, S. Fiorucci, 2011, Journal of medicinal chemistry.

Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.

G. Bifulco, V. Sepe, A. Zampella, 2012, Organic & biomolecular chemistry.

Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists

V. Sepe, A. Zampella, S. Fiorucci, 2014, Steroids.

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges.

E. Novellino, V. Sepe, A. Zampella, 2014, European journal of medicinal chemistry.

4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity

G. Bifulco, A. Zampella, S. Fiorucci, 2012, Steroids.

Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis

E. Perissutti, A. Carino, V. Sepe, 2013, Marine drugs.

Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands.

A. Carino, V. Sepe, C. Finamore, 2014, Journal of medicinal chemistry.

Discovery of sulfated sterols from marine invertebrates as a new class of marine natural antagonists of farnesoid-X-receptor.

Giuseppe Bifulco, G. Bifulco, V. Sepe, 2011, Journal of medicinal chemistry.

Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.

G. Bifulco, V. Sepe, A. Zampella, 2012, Journal of medicinal chemistry.

Polyhydroxylated sterols from the Indonesian soft coral Sinularia sp. and their effect on farnesoid X-activated receptor

S. Fiorucci, E. Fattorusso, O. Taglialatela‐Scafati, 2012, Steroids.

Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei

G. Bifulco, V. Sepe, A. Zampella, 2012, Marine drugs.

Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

G. Bifulco, A. Zampella, S. Fiorucci, 2012, Journal of medicinal chemistry.

Protein kinase CK2: a potential therapeutic target for diverse human diseases

M. Salvi, C. D’Amore, M. Ruzzene, 2021, Signal Transduction and Targeted Therapy.

FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents.

A. Carino, V. Sepe, E. Distrutti, 2013, Pharmacological research.

Farnesoid X receptor suppresses constitutive androstane receptor activity at the multidrug resistance protein-4 promoter.

Marco Migliorati, E. Distrutti, S. Fiorucci, 2011, Biochimica et biophysica acta.

Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

A. Carino, V. Sepe, A. Zampella, 2015, PloS one.

The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation

D. Francisci, A. Carino, E. Distrutti, 2013, PloS one.

Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists

G. Bifulco, A. Zampella, S. Fiorucci, 2013, Marine drugs.

Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoei.

A. Zampella, S. Fiorucci, O. Taglialatela‐Scafati, 2013, Bioorganic & medicinal chemistry.

How can a traffic light properly work if it is always green? The paradox of CK2 signaling

L. Cesaro, L. Pinna, M. Salvi, 2021, Critical reviews in biochemistry and molecular biology.

Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata

A. Carino, S. Fiorucci, C. D’Amore, 2016, Marine drugs.

Phallusiasterols A and B: Two New Sulfated Sterols from the Mediterranean Tunicate Phallusia fumigata and Their Effects as Modulators of the PXR Receptor

V. Sepe, S. Fiorucci, C. D’Amore, 2014, Marine drugs.

Targeting the E1 ubiquitin-activating enzyme (UBA1) improves elexacaftor/tezacaftor/ivacaftor efficacy towards F508del and rare misfolded CFTR mutants

N. Pedemonte, C. Castellani, M. Salvi, 2022, Cellular and Molecular Life Sciences.

The HIV Matrix Protein p17 Promotes the Activation of Human Hepatic Stellate Cells through Interactions with CXCR2 and Syndecan-2

D. Francisci, F. Baldelli, A. Carino, 2014, PloS one.

In vivo administration of ritonavir worsens intestinal damage caused by cyclooxygease inhibitors.

D. Francisci, F. Baldelli, E. Distrutti, 2014, European journal of pharmacology.

HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes

D. Francisci, F. Baldelli, A. Carino, 2012, BMC Infectious Diseases.

Ritonavir-Induced Lipoatrophy and Dyslipidaemia is Reversed by the Anti-Inflammatory Drug Leflunomide in a Ppar-Γ-Dependent Manner

D. Francisci, F. Baldelli, S. Fiorucci, 2012, Antiviral therapy.

FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity.

F. Baldelli, S. Fiorucci, G. Palladino, 2013, Nutrition, metabolism, and cardiovascular diseases : NMCD.

Dissociation of Intestinal and Hepatic Activities of FXR and LXRα Supports Metabolic Effects of Terminal Ileum Interposition in Rodents

E. Distrutti, S. Fiorucci, M. Monti, 2013, Diabetes.

Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons

L. Pinna, M. Salvi, A. Cariboni, 2019, International journal of molecular sciences.

Efficacy of Ccr5 Antagonist Maraviroc in Reducing the Early, Ritonavir Induced, Atherogenesis and the Advanced Plaque Progression in Mice

D. Francisci, F. Baldelli, S. Fiorucci, 2022 .

Deciphering the role of protein kinase CK2 in the maturation/stability of CFTR F508del.

A. Venerando, L. Pinna, M. Salvi, 2019, Biochimica et biophysica acta. Molecular basis of disease.

A N-terminally deleted form of the CK2α' catalytic subunit is sufficient to support cell viability.

T. Hirota, L. Cesaro, L. Pinna, 2020, Biochemical and biophysical research communications.

The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines

P. Mosci, A. Carino, S. Marchianò, 2016, Oncotarget.

An NBD Derivative of the Selective Rat Toxicant Norbormide as a New Probe for Living Cell Imaging

G. Miotto, F. Fusi, M. Brimble, 2016, Front. Pharmacol..

The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.

E. Distrutti, A. Zampella, S. Fiorucci, 2011, Biochimica et biophysica acta.

Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.

V. Sepe, A. Zampella, S. Fiorucci, 2014, Journal of medicinal chemistry.