J. Colacino

发表

Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses.

S. Larsen, J. Tang, J. Colacino, 1990, Antiviral research.

Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia

B. Ray, J. Colacino, A. Branstrom, 2022, Frontiers in Oncology.

PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally

X. Tong, Z. Gu, F. Lahser, 2016, Antimicrobial Agents and Chemotherapy.

Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein

S. Peltz, X. Tong, Z. Gu, 2013, Antimicrobial Agents and Chemotherapy.

Selection of influenza A and B viruses for resistance to 4-guanidino-Neu5Ac2en in cell culture.

G. Air, W. G. Laver, J. Colacino, 1997, The Journal of infectious diseases.

The in vitro anti-hepatitis B virus activity of FIAU [1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell.

C. D. Jones, J. Colacino, K. Staschke, 1994, Antiviral research.

P3.12 Small molecule compounds that correct alternative splicing of the SMN2 gene and restore SMN protein expression and function

S. Peltz, D. Kobayashi, S. Paushkin, 2011, Neuromuscular Disorders.

Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en.

G. Air, W. G. Laver, A. Bansal, 1995, Virology.

Progress in Drug Research

P. N. Kaul, T. Fujiwara, H. Horikoshi, 2000, Progress in Drug Research.

Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.

Z. Gu, A. Nomeir, F. Lahser, 2016, Bioorganic & medicinal chemistry letters.

Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.

Z. Gu, C. Espiritu, H. Ren, 2013, Bioorganic & Medicinal Chemistry Letters.

Enhanced antiviral effect in cell culture of type 1 interferon and ribozymes targeting HCV RNA

K. Jensen, D. Macejak, B. Heinz, 2001, Journal of viral hepatitis.

Fialuridine is phosphorylated and inhibits DNA synthesis in isolated rat hepatic mitochondria.

D. Horn, J. Colacino, F. Richardson, 1997, Antiviral research.

Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate.

J. Simpson, J. Colacino, F. Perrino, 1994, Biochemistry.

Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase*

K. Anderson, Kenneth A. Johnson, Z. Suo, 2001, The Journal of Biological Chemistry.

Discovery of a novel bicycloproline P2 bearing peptidyl alpha-ketoamide LY514962 as HCV protease inhibitor.

J. Glass, B. Heinz, Q. Wang, 2004, Bioorganic & medicinal chemistry letters.

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

S. Peltz, A. Jacobson, T. Davis, 2018, Molecular Cancer Therapeutics.

Drug discovery and development of antiviral agents for the treatment of chronic hepatitis B virus infection.

J. Colacino, K. Staschke, 2001, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress‐Regulated Protein Translation

S. Peltz, Thomas P. Davis, G. Elfring, 2016, Clinical pharmacology in drug development.

Differential effects of the incorporation of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) on the binding of the transcription factors, AP-1 and TFIID, to their cognate target DNA sequences.

J. Colacino, K. Staschke, W. Smith, 1996, Nucleic acids research.

Stable Transformed Human Cell Lines Exhibiting tat‐Directed Expression of Tissue Plasminogen Activator

J. Colacino, S. Jaskunas, P. A. Heffernan, 1990 .

Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase.

Xin-Lai Sun, Q. Wang, J. Colacino, 2002, The Biochemical journal.

Evaluation of the anti-influenza virus activities of 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and its sodium salt

J. Colacino, W. Spitzer, J. Nelson, 1990, Antimicrobial Agents and Chemotherapy.

The Intracellular Formation of a Mononucleotide of the Anti-Influenza Agent 1,3,4-thiadiazol-2-ylcyanamide (LY217896)

J. Balzarini, J. Colacino, W. Ehlhardt, 1995 .

Incorporation of fialuridine (FIAU) into mitochondrial DNA and effects of FIAU on the morphology of mitochondria in human hepatoblastoma cells.

D. Horn, J. Colacino, J. Horn, 1996, Toxicology in vitro : an international journal published in association with BIBRA.

Priming of duck hepatitis B virus reverse transcription in vitro: premature termination of primer DNA induced by the 5'-triphosphate of fialuridine

J. Colacino, K. Staschke, 1994, Journal of virology.

Ataluren metabolism: Ataluren-O-1β-acyl glucuronide is a stable circulating metabolite in mouse, rat, dog and human.

J. Colacino, Ronald Kong, M. Weetall, 2021, Drug metabolism and pharmacokinetics.

In vitro metabolism, reaction phenotyping, enzyme kinetics, CYP inhibition and induction potential of ataluren

J. Colacino, Ronald Kong, Elizabeth Goodwin, 2020, Pharmacology research & perspectives.

6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B.

Z. Gu, H. Ren, A. Nomeir, 2015, Bioorganic & medicinal chemistry letters.

Synthesis and pharmacokinetics of potent carbamate HIV-1 protease inhibitors containing novel high affinity hydroxyethylamine isosteres

J. Colacino, M. Muesing, T. Shepherd, 1995 .

The PETT series, a new class of potent nonnucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase

L. Vrang, T. Unge, J. Deeter, 1995, Antimicrobial agents and chemotherapy.

The identification and development of antiviral agents for the treatment of chronic hepatitis B virus infection.

J. Colacino, K. Staschke, 1998, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

Potent, orally bioavailable HIV-1 protease inhibitors containing noncoded D-amino acids

J. Colacino, M. Muesing, T. Shepherd, 1995 .

The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines

S. Peltz, J. Luban, C. Strambio-De-Castillia, 2020, Virus Research.

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

S. Peltz, J. Luban, C. Strambio-De-Castillia, 2020, bioRxiv.

HIV Type-1 Latency: Targeted Induction of Proviral Reservoirs

S. Peltz, J. Dougherty, Z. Gu, 2009, Antiviral chemistry & chemotherapy.

Efficacy and selectivity of some nucleoside analogs as anti-human cytomegalovirus agents

J. Colacino, C. López, 1983, Antimicrobial Agents and Chemotherapy.

Enzymology and pathogenicity in mice of a herpes simplex virus type 1 mutant resistant to 2'-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodocytosine

J. Colacino, C. López, N. Greenberg, 1986, Antimicrobial Agents and Chemotherapy.

Cytopathogenicity, drug susceptibility, and thymidine kinase activity of a retinovirulent herpes simplex virus type 2

J. Ganley, J. Colacino, R. Kaiwar, 1990, Journal of medical virology.

Structure-activity relationship (SAR) optimization of 6-(indol-2-yl)pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B.

Ramesh Kakarla, Guangming Chen, Song Huang, 2014, Journal of medicinal chemistry.

Approaches and Strategies for the Treatment of Influenza Virus Infections

W. G. Laver, J. Colacino, K. Staschke, 1999, Antiviral chemistry & chemotherapy.

Cellular Metabolism and Anti-Influenza Activity of 1,3,4-Thiadiazol-2-Ylcyanamide (LY217896)

J. Tang, J. Colacino, G. Birch, 1993 .

Hepatitis Prevention and Treatment

B. Heinz, J. Colacino, 2004, Milestones in Drug Therapy.

Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform

Jean Hedrick, S. Peltz, T. Davis, 2016, PloS one.

The search for antiinfluenza compounds with specific reference to LY217896 and its sodium salt

J. Tang, J. Colacino, 1992 .

Physical structure and molecular cloning of equine cytomegalovirus DNA.

D. O’Callaghan, J. Colacino, J. Staczek, 1989, Virology.

Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection

H. Erb, B. Tennant, J. Gerin, 1998, Hepatology.

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.

E. Levine, K. Watanabe, K. O. Tankersley, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The nucleoside analog clitocine is a potent and efficacious readthrough agent.

S. Peltz, T. Davis, J. Leszyk, 2017, RNA.

Mechanisms for the anti-hepatitis B virus activity and mitochondrial toxicity of fialuridine (FIAU).

J. Colacino, 1996, Antiviral research.

PTC124 targets genetic disorders caused by nonsense mutations

Meenal Patel, Feng He, Masataka Kawana, 2007, Nature.

Inhibition of duck hepatitis B virus replication by hypericin.

T. Wu, J. Tang, J. Colacino, 1993, Antiviral research.

in vitro metabolism of 1-β-d-arabinofuranosylcytosine and 1-β-2'-fluoro-arabino-5-iodocytosine in normal and herpes simplex type 1 virus-infected cells

J. Colacino, C. López, W. Kreis, 1982 .

Detection of thymidine kinase activity using an assay based on the precipitation of nucleoside monophosphates with lanthanum chloride.

J. Colacino, R. Wolcott, Joseph M. Colacino, 1989, Analytical biochemistry.

Antiviral activity of 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl-5-iodocytosine against human cytomegalovirus in human skin fibroblasts

J. Colacino, C. López, 1985, Antimicrobial Agents and Chemotherapy.

Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA Polymerase

K. Kirkegaard, Faming Zhang, J. Lu, 2002, Journal of Virology.

The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential

S. Peltz, Jairo L. Sierra, H. Ren, 2018, PloS one.

Synthesis of 4-Amino-8-(2, 2-Difluoro-2-Deoxy-β-D-Ribo Furanosyl Amino)Pyrimido [5, 4-D]Pyrimidine (dFARPP). Stability and Cellular Cytotoxicity

J. Colacino, G. Grindey, H. Pearce, 1994 .

Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture

J. Colacino, S. Jaskunas, S. Jaskunas, 1994, Antimicrobial Agents and Chemotherapy.

Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent

M. Steinmetz, A. Prota, M. Pykett, 2021, Molecular Cancer Therapeutics.

Pharmacokinetics and Safety of PTC596, a Novel Tubulin‐Binding Agent, in Subjects With Advanced Solid Tumors

G. Shapiro, Philippe Bédard, J. Infante, 2021, Clinical pharmacology in drug development.

Metabolite V, an epoxide species is a minor circulating metabolite in humans following a single oral dose of deflazacort

J. Colacino, Ronald Kong, Elizabeth Goodwin, 2020, Pharmacology research & perspectives.

SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

Anirvan Ghosh, Roland Schmucki, Hasane Ratni, 2014, Science.

Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid.

J. Tang, J. Colacino, K. Staschke, 1998, Virology.

A human monoclonal antibody to cytomegalovirus (CMV).

J. Colacino, U. Hámmerling, C. López, 1984, Journal of immunology.

Identification of benzazole compounds that induce HIV-1 transcription

Z. Gu, J. Colacino, Jason D Graci, 2017, PloS one.

RNA-Dependent RNA Polymerase Synthesis Activity of Hepatitis C Virus Oligomerization and Cooperative RNA

K. Kirkegaard, Faming Zhang, J. Lu, 2002 .

Discovery of N-(4'-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication.

Z. Gu, H. Ren, J. Colacino, 2013, Bioorganic & medicinal chemistry letters.

A single sequence change destabilizes the influenza virus neuraminidase tetramer.

N. Chirgadze, E. Garman, W. G. Laver, 1997, Virology.

Synthesis and antiviral activity of prodrugs of the nucleoside 1-[2',3'-dideoxy-3'-C-(hydroxymethyl)-beta-D-erythropentofuranosyl] cytosine.

L. Vrang, J. Colacino, K. Staschke, 1998, Bioorganic & medicinal chemistry.

Small molecule splicing modifiers with systemic HTT-lowering activity

S. Peltz, Kerstin A. Effenberger, J. Narasimhan, 2021, Nature Communications.

Abstract 5517: PTC596-induced Bmi1 hyper-phosphorylation via Cdk1/2 activation resulting in tumor stem cell depletion

T. Davis, J. Colacino, Josephine Sheedy, 2014 .

High-throughput Screening Uncovers a Compound That Activates Latent HIV-1 and Acts Cooperatively with a Histone Deacetylase (HDAC) Inhibitor*

S. Peltz, Y. Ron, J. Dougherty, 2011, The Journal of Biological Chemistry.