I. Fujii

发表

Emodin O-methyltransferase from Aspergillus terreus

U. Sankawa, Y. Ebizuka, Zhi-Gang Chen, 2004, Archives of Microbiology.

Evidence for involvement of two naphthol reductases in the first reduction step of melanin biosynthesis pathway of Colletotrichum lagenarium.

Y. Kubo, Y. Ebizuka, I. Fujii, 2003, Mycological research.

Genomic evidences for the existence of a phenylpropanoid metabolic pathway in Aspergillus oryzae.

K. Kitamoto, P. Juvvadi, I. Fujii, 2005, Biochemical and biophysical research communications.

Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides.

M. Hashimoto, E. Kodama, K. Gomi, 2015, Nature chemistry.

More Functions for Multifunctional Polyketide Synthases

A. Watanabe, Y. Ebizuka, I. Fujii, 2004 .

Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans.

A. Watanabe, U. Sankawa, Y. Ebizuka, 2001, Chemistry & biology.

Identification of csypyrone B2 and B3 as the minor products of Aspergillus oryzae type III polyketide synthase CsyB.

K. Kitamoto, M. Hashimoto, I. Fujii, 2013, Bioorganic & medicinal chemistry letters.

Aspergillus oryzae CsyB Catalyzes the Condensation of Two β-Ketoacyl-CoAs to Form 3-Acetyl-4-hydroxy-6-alkyl-α-pyrone*

K. Kitamoto, M. Hashimoto, I. Fujii, 2014, The Journal of Biological Chemistry.

Cloning, Sequencing, and Functional Analysis of an Iterative Type I Polyketide Synthase Gene Cluster for Biosynthesis of the Antitumor Chlorinated Polyenone Neocarzilin in “Streptomyces carzinostaticus”

Y. Ebizuka, I. Fujii, M. Otsuka, 2004, Antimicrobial Agents and Chemotherapy.

Hidden Function of Catalytic Domain in 6-Methylsalicylic Acid Synthase for Product Release*

T. Nonaka, Y. Ebizuka, I. Fujii, 2010, The Journal of Biological Chemistry.

Cloning and sequence characterization of a non-reducing polyketide synthase gene from the lichen Xanthoparmelia semiviridis.

D. Stalker, Y. Chooi, J. Elix, 2008, Mycological research.

Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics.

C. Hutchinson, I. Fujii, 1995, Annual review of microbiology.

1.16 – Polyketide Biosynthesis in Filamentous Fungi

I. Fujii, 1999 .

Anthracycline Biosynthesis in Streptomyces galilaeus.

Y. Ebizuka, I. Fujii, 1997, Chemical reviews.

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet‐induced adipose tissue inflammation

K. Tsuneyama, K. Takatsu, H. Hayashi, 2014, Journal of leukocyte biology.

Differential accumulation of hyperforin and secohyperforin in Hypericum perforatum tissue cultures.

G. Bringmann, T. Kutchan, Y. Ebizuka, 2007, Phytochemistry.

Identification of the Biosynthetic Gene Cluster for Himeic Acid A: A Ubiquitin‐Activating Enzyme (E1) Inhibitor in Aspergillus japonicus MF275

M. Hashimoto, S. Tsukamoto, H. Kato, 2018, Chembiochem : a European journal of chemical biology.

Hydrolytic Polyketide Shortening by Ayg1p, a Novel Enzyme Involved in Fungal Melanin Biosynthesis*

K. Kwon-Chung, Y. Ebizuka, I. Fujii, 2004, Journal of Biological Chemistry.

Cloning of the polyketide synthase gene atX from Aspergillus terreus and its identification as the 6-Methylsalicylic acid synthase gene by heterologous expression

K. Gomi, U. Sankawa, Y. Ebizuka, 1996, Molecular and General Genetics MGG.

Enzymatic synthesis of 1,3,6,8-tetrahydroxynaphthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase PKS1.

Y. Kubo, A. Watanabe, Y. Ebizuka, 2000, Biochemistry.

An iterative type I polyketide synthase PKSN catalyzes synthesis of the decaketide alternapyrone with regio-specific octa-methylation.

H. Oikawa, Y. Ebizuka, I. Fujii, 2005, Chemistry & biology.

Functional analysis of fungal polyketide biosynthesis genes

I. Fujii, 2010, The Journal of Antibiotics.

Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression.

K. Gomi, Y. Oshima, I. Fujii, 2013, Organic letters.

Genetic Safeguard against Mycotoxin Cyclopiazonic Acid Production in Aspergillus oryzae

Shunji Takahashi, K. Kitamoto, Y. Koyama, 2011, Chembiochem : a European journal of chemical biology.

Rationalization of supramolecular chirality in a bisporphyrin system.

A. Ceulemans, Y. Inoue, G. Hembury, 2004, Angewandte Chemie.

Separation of the two reactions, oxidation and isomerization, catalyzed by Streptomyces cholesterol oxidase.

M. Yamashita, Y. Murooka, I. Fujii, 1998, Protein engineering.

The AMI1 gene family: indole-3-acetamide hydrolase functions in auxin biosynthesis in plants.

Masashi Suzuki, T. Muranaka, H. Seki, 2010, Journal of experimental botany.

Heterologous expression and product identification of Colletotrichum lagenarium polyketide synthase encoded by the PKS1 gene involved in melanin biosynthesis.

Y. Kubo, A. Watanabe, Y. Ebizuka, 1999, Bioscience, biotechnology, and biochemistry.

Synthesis, structure, and photochemical reaction of 9,10-dihydro-9-silaanthracene derivatives carrying bulky substituents

M. Oba, T. Okutsu, Hiroaki Horiuchi, 2000 .

Expression, purification and crystallization of a fungal type III polyketide synthase that produces the csypyrones.

I. Abe, M. Hashimoto, T. Matsui, 2014, Acta crystallographica. Section F, Structural biology communications.

Characterization of a glycyrrhizin-deficient strain of Glycyrrhiza uralensis.

H. Hayashi, M. Iinuma, Hitoshi Watanabe, 2013, Biological & pharmaceutical bulletin.

Cloning of aklavinone biosynthesis genes from Streptomyces galilaeus.

U. Sankawa, Y. Ebizuka, I. Fujii, 1992, The Journal of antibiotics.

Aspergillus fumigatus alb1 encodes naphthopyrone synthase when expressed in Aspergillus oryzae.

K. Kwon-Chung, A. Watanabe, Y. Ebizuka, 2000, FEMS microbiology letters.

HIV inhibitor from Thai bitter gourd.

Y. Ebizuka, I. Fujii, C. Wiwat, 2001, Planta medica.

Producing the sulfur-containing metabolite asparaptine in Asparagus calluses and a suspension cell line.

Tetsuya Mori, Kazuki Saito, T. Asano, 2019, Plant biotechnology.

Crystal Structure of Naptalam

I. Fujii, Y. Mano, Keiichirou Nemoto, 2008 .

Analysis of Subunit Interactions in the Iterative Type I Polyketide Synthase ATX from Aspergillus terreus

Y. Ebizuka, I. Fujii, Tomomi Moriguchi, 2006, Chembiochem : a European journal of chemical biology.

Cloning of modular type I polyketide synthase genes from salinomycin producing strain of Streptomyces albus.

M. Izumikawa, Y. Ebizuka, K. Tachibana, 2003, Bioorganic & medicinal chemistry.

Re-identification of Aspergillus nidulans wA gene to code for a polyketide synthase of naphthopyrone

W. Timberlake, A. Watanabe, U. Sankawa, 1999 .

Crystal Structure of 1-{2-[(p-Chloro-α-phenylbenzyl)oxy]ethyl}piperidine Fendizoate (Cloperastine Fendizoate)

I. Fujii, N. Hirayama, N. Marubayashi, 1999 .

4-Chloro-3-nitrocoumarin: an unusual non-bonding C—Cl⋯O=C interaction

I. Fujii, N. Hirayama, Y. Mano, 2005 .

Product identification of polyketide synthase coded by Aspergillus nidulans wA gene

W. Timberlake, A. Watanabe, U. Sankawa, 1998 .

Crystal Structures of 3-Nitrocoumarin Derivatives

I. Fujii, N. Hirayama, Y. Mano, 2006 .

Production of ‘hybrid’ antibiotics by genetic engineering

H. Ikeda, S. Ōmura, B. Rudd, 1985, Nature.

New Biosynthetic Step in the Melanin Pathway of Wangiella (Exophiala) dermatitidis: Evidence for 2-Acetyl-1,3,6,8-Tetrahydroxynaphthalene as a Novel Precursor

P. J. Szaniszlo, L. Puckhaber, Y. Ebizuka, 2008, Eukaryotic Cell.

Genome screening for reducing type I polyketide synthase genes in tropical fungi associated with medicinal plants

S. Lumyong, J. Peberdy, I. Fujii, 2011 .

Molecular Cloning and Heterologous Expression of the Gene Encoding Dihydrogeodin Oxidase, a Multicopper Blue Enzyme from Aspergillus terreus(*)

K. Gomi, U. Sankawa, Y. Ebizuka, 1995, The Journal of Biological Chemistry.

Solanapyrone Synthase, a Possible Diels–Alderase and Iterative Type I Polyketide Synthase Encoded in a Biosynthetic Gene Cluster from Alternaria solani

H. Oikawa, Y. Ebizuka, I. Fujii, 2010, Chembiochem : a European journal of chemical biology.

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases.

Takayuki Itoh, Ikuro Abe, Isao Fujii, 2010, Nature chemistry.

Shimalactone Biosynthesis Involves Spontaneous Double Bicyclo‐Ring Formation with 8π‐6π Electrocyclization

T. Asano, M. Hashimoto, I. Fujii, 2020, Angewandte Chemie.

Biosynthesis of steroidal antibiotic fusidanes: Functional analysis of oxidosqualene

Isao Fujii, Y. Ebizuka, I. Fujii, 2016 .

Two new 9,10-seco-cycloartanes from the seeds of Sphaerophysa salsula

Y. Ebizuka, I. Fujii, X. Li, 2006, Journal of Asian natural products research.

Inhibitory effect of aflastatin A on melanin biosynthesis by Colletotrichum lagenarium.

H. Nagasawa, Y. Kubo, S. Sakuda, 2001, Microbiology.

Pentaketide Melanin Biosynthesis in Aspergillus fumigatus Requires Chain-length Shortening of a Heptaketide Precursor*

K. Kwon-Chung, A. Watanabe, Y. Ebizuka, 2001, The Journal of Biological Chemistry.

Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae

K. Ehrlich, I. Fujii, P. Chang, 2009, Toxins.

Fungal type III polyketide synthases.

T. Nonaka, M. Hashimoto, I. Fujii, 2014, Natural product reports.

Aspergillus oryzae type III polyketide synthase CsyB uses a fatty acyl starter for the biosynthesis of csypyrone B compounds.

K. Kitamoto, M. Hashimoto, I. Fujii, 2013, Bioorganic & medicinal chemistry letters.

Novel angular naphthopyrone formation by Arp1p dehydratase involved in Aspergillus fumigatus melanin biosynthesis.

Tomoki Yoshida, K. Kwon-Chung, Y. Ebizuka, 2021, Environmental microbiology reports.

Convergent strategies in biosynthesis.

M. Nishiyama, T. Dairi, T. Kuzuyama, 2011, Natural product reports.

Architecture and Functional Analysis of Fungal Polyketide Synthases

A. Watanabe, U. Sankawa, Y. Ebizuka, 2002 .

A new pathway for polyketide synthesis in microorganisms

Isao Fujii, S. Horinouchi, Y. Ebizuka, 1999, Nature.

Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid.

K. Kitamoto, P. Juvvadi, Y. Koyama, 2009, Bioorganic & medicinal chemistry letters.

Identification of a novel polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) gene required for the biosynthesis of cyclopiazonic acid in Aspergillus oryzae.

K. Kitamoto, Y. Koyama, I. Fujii, 2008, Fungal genetics and biology : FG & B.

Domain–Domain Interactions in the Iterative Type I Polyketide Synthase ATX from Aspergillus terreus

Y. Ebizuka, I. Fujii, Tomomi Moriguchi, 2008, Chembiochem : a European journal of chemical biology.

Flavonoids from the seeds of sphaerophysa salsula

Y. Ebizuka, Zhongjun Ma, I. Fujii, 2004, Journal of Asian natural products research.

Terretonin Biosynthesis Requires Methylation as Essential Step for Cyclization

I. Abe, T. Wakimoto, Y. Ebizuka, 2012, Chembiochem : a European journal of chemical biology.

Structural Studies of Mitomycins. IX. 6-Demethyl-6-(phenylthiomethyl)mitomycin C

I. Fujii, N. Hirayama, M. Kasai, 1997 .

Identification of a Key Prenyltransferase Involved in Biosynthesis of the Most Abundant Fungal Meroterpenoids Derived from 3,5‐Dimethylorsellinic Acid.

I. Abe, E. Radhakrishnan, Y. Ebizuka, 2012, Chembiochem : a European journal of chemical biology.

Structural Studies of Mitomycins. Part 9. 6-Demethyl-6-( phenylthiomethyl)-mitomycin C.

I. Fujii, N. Hirayama, M. Kasai, 1997 .

Aspergillus oryzae type III polyketide synthase CsyA is involved in the biosynthesis of 3,5-dihydroxybenzoic acid.

T. Nonaka, K. Kitamoto, P. Juvvadi, 2010, Bioorganic & medicinal chemistry letters.

Identification and Heterologous Expression of the Topopyrone Nonaketide Synthase Gene from Phoma sp.

Y. Ebizuka, I. Fujii, N. Kashiwa, 2016, Chemical & pharmaceutical bulletin.

Identification of csypyrone B1 as the novel product of Aspergillus oryzae type III polyketide synthase CsyB.

K. Kitamoto, P. Juvvadi, Y. Ebizuka, 2010, Bioorganic & medicinal chemistry.

Expression, Purification, and Characterization of AknX Anthrone Oxygenase, Which Is Involved in Aklavinone Biosynthesis in Streptomyces galilaeus

U. Sankawa, Y. Ebizuka, I. Fujii, 2002, Journal of bacteriology.

Chiral Space Formed by (+)‐(1S)‐1,1′‐Binaphthalene‐2,2′‐diyl Phosphate: Recognition of Aliphatic L‐α‐Amino Acids

I. Fujii, N. Hirayama, 2002 .

Purification and characterization of emodinanthrone oxygenase from Aspergillus terreus

U. Sankawa, Y. Ebizuka, Zhi-Gang Chen, 1995 .

Functional expression of a highly-reducing polyketide synthase of Emericella variecolor IFM42010, an asteltoxin-producing strain, resulted in production of two polyenoic β-ketolactones with opposite stereochemistry.

M. Hashimoto, I. Fujii, Y. Goda, 2019, Bioorganic & medicinal chemistry letters.

Field Survey of Glycyrrhiza Plants in Central Asia (5). Chemical Characterization of G. bucharica Collected in Tajikistan.

H. Hayashi, I. Fujii, M. Saidov, 2019, Chemical & pharmaceutical bulletin.

Field Survey of Glycyrrhiza Plants in Central Asia (4). Characterization of G. glabra and G. bucharica Collected in Tajikistan.

H. Hayashi, I. Fujii, N. Yoshikawa, 2016, Biological & pharmaceutical bulletin.

Structural Basis for the Formation of Acylalkylpyrones from Two β-Ketoacyl Units by the Fungal Type III Polyketide Synthase CsyB*

I. Abe, M. Hashimoto, T. Matsui, 2015, The Journal of Biological Chemistry.

Discovery of a novel superfamily of type III polyketide synthases in Aspergillus oryzae.

K. Kitamoto, P. Juvvadi, I. Fujii, 2005, Biochemical and biophysical research communications.

PARTIAL PURIFICATION AND SOME PROPERTIES OF EMODIN-O-METHYLTRANSFERASE FROM (+)-GEODIN PRODUCING STRAIN OF ASPERGILLUS TERREUS

U. Sankawa, Y. Ebizuka, I. Fujii, 1982 .

Improvement of thermal stability of Streptomyces cholesterol oxidase by random mutagenesis and a structural interpretation.

S. Teshima, M. Yamashita, Y. Murooka, 1997, Protein engineering.

Heterologous expression systems for polyketide synthases.

I. Fujii, 2009, Natural product reports.

Biosynthesis of riboflavin. Enzymatic formation of 6,7-dimethyl-8-ribityllumazine from pentose phosphates.

A. Bacher, I. Fujii, H. Floss, 1984, The Journal of biological chemistry.

Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll‐like receptor 4/MD‐2 complex signaling in a different manner

K. Takatsu, H. Hayashi, Y. Nagai, 2012, Journal of leukocyte biology.

Reconstitution of biosynthetic machinery of fungal polyketides: unexpected oxidations of biosynthetic intermediates by expression host

A. Minami, K. Gomi, H. Oikawa, 2016, Bioscience, biotechnology and biochemistry.

Multiple Oxidative Modifications in the Ophiobolin Biosynthesis: P450 Oxidations Found in Genome Mining.

A. Minami, K. Gomi, H. Oikawa, 2016, Organic letters.

Cycloartane-type triterpenoids from Sphaerophysa salsula

Wei Li, Y. Ebizuka, Zhongjun Ma, 2004, Journal of Asian natural products research.

Field Survey of Ephedra Plants in Central Asia (1). Characterization of Ephedra equisetina, Ephedra intermedia, and Their Putative Hybrids Collected in the Zaravshan Mountains of Tajikistan.

H. Hayashi, I. Fujii, H. Hisoriev, 2019, Biological & pharmaceutical bulletin.

Convergent Strategies in Biosynthesis

Isao Fujii, Makoto Nishiyama, M. Nishiyama, 2011 .

Discovery of a Fungal Multicopper Oxidase That Catalyzes the Regioselective Coupling of a Tricyclic Naphthopyranone To Produce Atropisomers.

S. Ohte, H. Tomoda, I. Fujii, 2018, Angewandte Chemie.

Monapinone Coupling Enzyme Produces Non-Natural Heterodimers

S. Ohte, H. Tomoda, I. Fujii, 2021, Catalysts.

Cloning of chalcone-flavanone isomerase cDNA from Pueraria lobata and its overexpression in Escherichia coli.

U. Sankawa, Y. Ebizuka, I. Fujii, 1996, Protein expression and purification.

Identification of emodinanthrone oxygenase in fungus Aspergillus terreus.

U. Sankawa, Y. Ebizuka, I. Fujii, 1991, Biochemistry international.

Crystal structures of racemic and enantiopure synephrine correlated with physicochemical properties from IR spectroscopy and thermal analysis.

I. Fujii, 2018, Acta crystallographica. Section C, Structural chemistry.

Product identification of non-reducing polyketide synthases with C-terminus methyltransferase domain from Talaromyces stipitatus using Aspergillus oryzae heterologous expression.

M. Hashimoto, I. Fujii, Y. Goda, 2015, Bioorganic & medicinal chemistry letters.

Transformations of Penicillium islandicum and Penicillium frequentans that produce anthraquinone-related compounds

U. Sankawa, Y. Ebizuka, I. Fujii, 1995, Current Genetics.

Crystal structure of (1S,2R)-2-hydroxy-1,2-diphenylethan-1-aminium (S)-2-azaniumylbutanedioate monohydrate

I. Fujii, 2017, Acta crystallographica. Section E, Crystallographic communications.

Crystal structure of racemic cis-2-amino-1,2-diphenylethanol (ADE)

I. Fujii, 2015, Acta crystallographica. Section E, Crystallographic communications.

3-{[(Benzyloxy)carbonyl]amino}butanoic acid

Taira Kimino, Isao Fujii, I. Fujii, 2011, Acta crystallographica. Section E, Structure reports online.

pH-dependent production of himeic acid A and its non-enzymatic conversions to himeic acids B and C.

M. Hashimoto, S. Tsukamoto, H. Kato, 2018, Bioorganic & medicinal chemistry.

Functional Analysis of a Biosynthetic Gene Cluster Demonstrates Role of Spontaneous Double Bicyclo-ring Formation Including 8π-6π Electrocyclization in Shimalactone Biosynthesis.

T. Asano, M. Hashimoto, I. Fujii, 2020, Angewandte Chemie.

Structure of R—(1-Naphtyl)ethylamine Hydrochloride Monohydrate

I. Fujii, N. Hirayama, 2000 .

Expression of Alternaria solani PKSF Generates a Set of Complex Reduced‐Type Polyketides with Different Carbon‐Lengths and Cyclization

Ken Kasahara, H. Oikawa, Y. Ebizuka, 2006, Chembiochem : a European journal of chemical biology.

Nucleotide sequence of the aknA region of the aklavinone biosynthetic gene cluster of Streptomyces galilaeus

U. Sankawa, Y. Ebizuka, I. Fujii, 1994, Journal of bacteriology.