K. Langer

发表

Doxorubicin-loaded PLGA nanoparticles - a systematic evaluation of preparation techniques and parameters∗

S. Pieper, K. Langer, Sebastian Pieper, 2017 .

Delivery of Loperamide Across the Blood-Brain Barrier with Polysorbate 80-Coated Polybutylcyanoacrylate Nanoparticles

D. A. Kharkevich, J. Kreuter, K. Langer, 1997, Pharmaceutical Research.

Reversion of arterial calcification by elastin-targeted DTPA-HSA nanoparticles.

K. Langer, F. Rutsch, J. Keuth, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Tumour cell delivery of antisense oligonuclceotides by human serum albumin nanoparticles.

K. Strebhardt, J. Kreuter, K. Langer, 2004, Journal of controlled release : official journal of the Controlled Release Society.

The impact of gastrointestinal mucus on nanoparticle penetration – in vitro evaluation of mucus‐penetrating nanoparticles for photodynamic therapy

K. Langer, D. Mulac, Laura Mahlert, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Covalent Modification of Human Serum Albumin by the Natural Sesquiterpene Lactone Parthenolide

K. Langer, T. Schmidt, M. Plöger, 2015, Molecules.

Optimization of the preparation process for human serum albumin (HSA) nanoparticles.

H von Briesen, V. Vogel, D. Schubert, 2003, International journal of pharmaceutics.

A new preparation strategy for surface modified PLA nanoparticles to enhance uptake by endothelial cells.

K. Langer, D. Mulac, B. Raudszus, 2018, International journal of pharmaceutics.

Detection and analysis of human serum albumin nanoparticles within phagocytic cells at the resolution of individual live cell or single 3D multicellular spheroid

N. Zurgil, M. Deutsch, K. Langer, 2015, Journal of Nanoparticle Research.

Tracking of Magnetite Labeled Nanoparticles in the Rat Brain Using MRI

S. Ropele, F. Fazekas, H. von Briesen, 2014, PloS one.

Albumin nanoparticles with predictable size by desolvation procedure

K. Langer, B. von Storp, A. Engel, 2012, Journal of microencapsulation.

Targeted human serum albumin nanoparticles for specific uptake in EGFR-Expressing colon carcinoma cells.

H. von Briesen, K. Langer, Sylvia Wagner, 2011, Nanomedicine : nanotechnology, biology, and medicine.

Enhanced drug targeting by attachment of an anti alphav integrin antibody to doxorubicin loaded human serum albumin nanoparticles.

I. Riemann, M. Michaelis, J. Cinatl, 2010, Biomaterials.

Physico-chemical characterisation of PLGA nanoparticles after freeze-drying and storage.

V. Vogel, W. Mäntele, K. Langer, 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Effect of trastuzumab-modified antisense oligonucleotide-loaded human serum albumin nanoparticles prepared by heat denaturation.

K. Strebhardt, K. Langer, B. Spänkuch, 2008, Biomaterials.

Human serum albumin (HSA) nanoparticles: reproducibility of preparation process and kinetics of enzymatic degradation.

V. Vogel, S. Faust, K. Langer, 2008, International journal of pharmaceutics.

Trastuzumab-modified nanoparticles: optimisation of preparation and uptake in cancer cells.

K. Strebhardt, K. Langer, B. Spänkuch, 2006, Biomaterials.

Preparation of surface modified protein nanoparticles by introduction of sulfhydryl groups.

K. Langer, C. Weber, S. Reiß, 2000, International journal of pharmaceutics.

Discrete spatio-temporal regulation of tyrosine phosphorylation directs influenza A virus M1 protein towards its function in virion assembly

M. Schmidt, S. Ludwig, G. Seebohm, 2020, PLoS pathogens.

Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes.

H. von Briesen, J. Kreuter, K. Langer, 2005, Biomaterials.

Light-responsive polymeric nanoparticles based on a novel nitropiperonal based polyester as drug delivery systems for photosensitizers in PDT.

D. Kuckling, K. Langer, D. Mulac, 2021, International journal of pharmaceutics.

Methylmethacrylate sulfopropylmethacrylate copolymer nanoparticles for drug delivery. Part I: Preparation and physicochemical characterization

K. Langer, J. Kreuter, A. Berthold, 1996 .

Thermophoretic immunoassay based on autodisplayed Z-domains for the diagnosis of C-reactive protein

Min Park, Min‐Jung Kang, K. Langer, 2018 .

Backbone-Degradable (Co-)Polymers for Light-Triggered Drug Delivery

D. Kuckling, K. Langer, Timo Schoppa, 2021, ACS Applied Polymer Materials.

Preparation of Light-Responsive Aliphatic Polycarbonate via Versatile Polycondensation for Controlled Degradation

D. Kuckling, K. Langer, Juliane Anderski, 2019, Macromolecular Chemistry and Physics.

Identification of main influencing factors on the protein corona composition of PLGA and PLA nanoparticles.

H. Humpf, K. Langer, D. Mulac, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Quantitative bioimaging of platinum group elements in tumor spheroids.

U. Karst, H. von Briesen, M. Sperling, 2016, Analytica chimica acta.

Nanoparticle albumin-bound mTHPC for photodynamic therapy: Preparation and comprehensive characterization of a promising drug delivery system.

K. Langer, Jörg Fabian, D. Mulac, 2020, International journal of pharmaceutics.

Reaction of human macrophages on protein corona covered TiO₂ nanoparticles.

H. Fuchs, Yuliang Zhao, Chunying Chen, 2015, Nanomedicine : nanotechnology, biology, and medicine.

Characterization of polybutyleyanoacrylate nanoparticles. Part II: Determination of polymer content by NMR-analysis

A. Zimmer, C. Noe, K. Langer, 1996 .

Lecithin coating as universal stabilization and functionalization strategy for nanosized drug carriers to overcome the blood-brain barrier.

K. Langer, D. Mulac, A. Wünsch, 2020, International journal of pharmaceutics.

Lipoprotein imitating nanoparticles: Lecithin coating binds ApoE and mediates non-lysosomal uptake leading to transcytosis over the blood-brain barrier.

K. Langer, D. Mulac, A. Wünsch, 2020, International journal of pharmaceutics.

Preparation of avidin-labelled gelatin nanoparticles as carriers for biotinylated peptide nucleic acid (PNA).

H. von Briesen, K. Langer, J. Kreuter, 2000, International journal of pharmaceutics.

Preparation of Sesquiterpene Lactone-Loaded PLA Nanoparticles and Evaluation of Their Antitrypanosomal Activity

J. Matasyoh, K. Langer, M. Kaiser, 2019, Molecules.

Desolvation process and surface characteristics of HSA-nanoparticles.

K. Langer, J. Kreuter, C. Weber, 2000, International journal of pharmaceutics.

Characterisation of PEGylated PLGA nanoparticles comparing the nanoparticle bulk to the particle surface using UV/vis spectroscopy, SEC, 1H NMR spectroscopy, and X-ray photoelectron spectroscopy

M. Schaefer, K. Langer, S. Spek, 2015 .

Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain.

J. Kreuter, K. Langer, S. Gelperina, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro

H. Humpf, K. Langer, D. Mulac, 2022, PloS one.

Characterisation and cellular uptake of polysorbate 80-coated PLA nanoparticles

K. Langer, D. Mulac, B. Raudszus, 2017 .

Cytotoxicity of aphidicolin and its derivatives against neuroblastoma cells in vitro: synergism with doxorubicin and vincristine

M. Michaelis, J. Cinatl, J. Cinatl, 2000, Anti-cancer drugs.

Methylmethacrylate sulfopropylmethacrylate copolymer nanoparticles for drug delivery: Part III: Evaluation as drug delivery system for ophthalmic applications

K. Langer, J. Kreuter, E. Mutschler, 1997 .

Modifying plasmid-loaded HSA-nanoparticles with cell penetrating peptides - Cellular uptake and enhanced gene delivery.

K. Langer, D. Mulac, A. Iltzsche, 2017, International journal of pharmaceutics.

Polymeric nanoparticles - Influence of the glass transition temperature on drug release.

K. Langer, D. Mulac, Svenja Lappe, 2017, International journal of pharmaceutics.

Different dissolution conditions affect stability and dissolution profiles of bioequivalent levodopa-containing oral dosage forms.

K. Langer, Olaf Rose, Johanna Weitzel, 2022, International journal of pharmaceutics.

Photophysical evaluation of mTHPC-loaded HSA nanoparticles as novel PDT delivery systems.

S. Hackbarth, B. Röder, K. Langer, 2010, Journal of photochemistry and photobiology. B, Biology.

Novel photosensitizer-protein nanoparticles for photodynamic therapy: photophysical characterization and in vitro investigations.

S. Hackbarth, A. Preuß, B. Röder, 2009, Journal of photochemistry and photobiology. B, Biology.

Desolvation process and surface characterisation of protein nanoparticles.

K. Langer, J. Kreuter, C. Weber, 2000, International journal of pharmaceutics.

Effect of nanoparticle size and PEGylation on the protein corona of PLGA nanoparticles.

H. Humpf, K. Langer, D. Mulac, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Gelatin nanoparticles by two step desolvation--a new preparation method, surface modifications and cell uptake.

J. Kreuter, K. Langer, J. Kreuter, 2000, Journal of microencapsulation.

Human serum albumin-polyethylenimine nanoparticles for gene delivery.

H. von Briesen, J. Kreuter, K. Langer, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Mucus‐penetrating nanoparticles: Promising drug delivery systems for the photodynamic therapy of intestinal cancer

K. Langer, D. Mulac, Laura Mahlert, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Didodecyldimethylammonium bromide (DMAB) stabilized poly(lactic-co-glycolic acid) (PLGA) nanoparticles: Uptake and cytotoxic potential in Caco-2 cells

K. Langer, D. Mulac, S. Spek, 2018 .

Nanoparticulate carriers for photodynamic therapy of cholangiocarcinoma: In vitro comparison of various polymer-based nanoparticles.

K. Langer, D. Mulac, Jonas Grünebaum, 2015, International journal of pharmaceutics.

Crystal Engineering of Pharmaceutical Co-crystals: “NMR Crystallography” of Niclosamide Co-crystals

G. Brunklaus, K. Langer, R. Gossmann, 2016 .

Specific targeting of HER2 overexpressing breast cancer cells with doxorubicin-loaded trastuzumab-modified human serum albumin nanoparticles.

Sylvia Wagner, Hagen von Briesen, H. von Briesen, 2008, Bioconjugate chemistry.

Light-Responsive Serinol-Based Polycarbonate and Polyester as Degradable Scaffolds.

D. Kuckling, K. Langer, D. Mulac, 2019, ACS applied bio materials.

Covalent Linkage of Apolipoprotein E to Albumin Nanoparticles Strongly Enhances Drug Transport into the Brain

M. Michaelis, K. Langer, R. Alyautdin, 2006, Journal of Pharmacology and Experimental Therapeutics.

Coupling of the antitumoral enzyme bovine seminal ribonuclease to polyethylene glycol chains increases its systemic efficacy in mice

M. Michaelis, J. Cinatl, J. Matoušek, 2002, Anti-cancer drugs.

Bovine seminal ribonuclease attached to nanoparticles made of polylactic acid kills leukemia and lymphoma cell lines in vitro

M. Michaelis, J. Cinatl, J. Vogel, 2000, Anti-cancer drugs.

Freeze drying of human serum albumin (HSA) nanoparticles with different excipients.

K. Langer, Marion G Anhorn, M. Anhorn, 2008, International journal of pharmaceutics.

Rhombic organization of microvilli domains found in a cell model of the human intestine

F. Rehfeldt, K. Langer, Jonas Franz, 2018, PloS one.

Identification of flubendazole as potential anti-neuroblastoma compound in a large cell line screen

F. Westermann, M. Wass, S. Fulda, 2015, Scientific Reports.

Synthesis and pharmacokinetic properties of novel cPLA2α inhibitors with 1-(carboxyalkylpyrrolyl)-3-aryloxypropan-2-one structure.

D. Bettenworth, M. Lehr, K. Langer, 2023, Bioorganic & medicinal chemistry.

Uptake of plasmid-loaded nanoparticles in breast cancer cells and effect on Plk1 expression

K. Strebhardt, K. Langer, B. Spänkuch, 2009, Journal of drug targeting.

Downregulation of Plk1 expression by receptor-mediated uptake of antisense oligonucleotide-loaded nanoparticles.

K. Langer, B. Spänkuch, K. Strebhardt, 2008, Neoplasia.

Incorporation of biodegradable nanoparticles into human airway epithelium cells-in vitro study of the suitability as a vehicle for drug or gene delivery in pulmonary diseases.

T. Wagner, S. Loitsch, K. Langer, 2004, Biochemical and biophysical research communications.

Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: focus on cardio- and testicular toxicity.

J. Kreuter, K. Langer, S. Gelperina, 2007, International journal of pharmaceutics.

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells

M. Wass, M. Michaelis, S. Pieper, 2019, Beilstein journal of nanotechnology.

Preparation, characterisation and maintenance of drug efficacy of doxorubicin-loaded human serum albumin (HSA) nanoparticles.

M. Michaelis, J. Cinatl, J. Kreuter, 2007, International journal of pharmaceutics.

Methylmethacrylate sulfopropylmethacrylate copolymer nanoparticles for drug delivery: Part II: arecaidine propargyl ester and pilocarpine loading and in vitro release

K. Langer, J. Kreuter, E. Mutschler, 1997 .

Characterisation of polybutylcyanoarylate nanoparticles: I. Quantification of PCBA polymer and dextrans

K. Langer, J. Kreuter, A. Zimmer, 1994 .

Highly Specific HER2-mediated Cellular Uptake of Antibody-modified Nanoparticles in Tumour Cells

K. Strebhardt, J. Kreuter, K. Langer, 2004, Journal of drug targeting.

Characterization of serum albumin nanoparticles by sedimentation velocity analysis and electron microscopy

Vitali Vogel, Peter Schuck, V. Vogel, 2002 .

Comparison of cellular effects of starch-coated SPIONs and poly(lactic-co-glycolic acid) matrix nanoparticles on human monocytes

Harald Fuchs, Kristina Riehemann, Guiscard Seebohm, 2016, International journal of nanomedicine.

Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance in drug-adapted cancer cells

M. Wass, M. Michaelis, J. Cinatl, 2019, bioRxiv.

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

M. Wass, M. Michaelis, J. Cinatl, 2018, bioRxiv.

Preparation of avidin-labeled protein nanoparticles as carriers for biotinylated peptide nucleic acid.

H von Briesen, H. von Briesen, K. Langer, 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Photosensitizer loaded HSA nanoparticles II: in vitro investigations.

Matthias G. Wacker, Steffen Hackbarth, Beate Röder, 2011, International journal of pharmaceutics.

Comprehensive in vitro investigations on biodegradable photosensitizer-nanoparticle delivery systems.

S. Hackbarth, A. Preuß, B. Röder, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Flurbiprofen-loaded Nanoparticles Can Cross a Primary Porcine In vitroBlood-brain Barrier Model to Reduce Amyloid-ÃÂ²42 Burden

K. Langer, Sylvia Wagner, C. Pietrzik, 2016 .

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

Hans-Ulrich Humpf, H. Humpf, K. Langer, 2019, Beilstein journal of nanotechnology.

Selective targeting of antibody-conjugated nanoparticles to leukemic cells and primary T-lymphocytes.

Hagen von Briesen, H. von Briesen, J. Kreuter, 2005, Biomaterials.

Use of Light-Degradable Aliphatic Polycarbonate Nanoparticles As Drug Carrier for Photosensitizer.

D. Kuckling, K. Langer, D. Mulac, 2018, Biomacromolecules.

Pharmacological activity of DTPA linked to protein-based drug carrier systems.

H. Doerr, M. Michaelis, J. Cinatl, 2004, Biochemical and biophysical research communications.

Ligand-Modified Human Serum Albumin Nanoparticles for Enhanced Gene Delivery.

H. von Briesen, K. Langer, N. Noske, 2015, Molecular pharmaceutics.

Light‐responsive nanoparticles based on new polycarbonate polymers as innovative drug delivery systems for photosensitizers in PDT

D. Kuckling, K. Langer, D. Mulac, 2019, International journal of pharmaceutics.

Spacer length and serum protein adsorption affect active targeting of trastuzumab-modified nanoparticles

H. Humpf, K. Langer, D. Mulac, 2021, Biomaterials and biosystems.

Comparative examination of adsorption of serum proteins on HSA- and PLGA-based nanoparticles using SDS-PAGE and LC-MS.

K. Langer, D. Mulac, J. Brockmeyer, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Asymmetrical flow field-flow fractionation for the analysis of PEG-asparaginase.

G. Hempel, J. Boos, K. Langer, 2016, Talanta.

Conversion of indomethacin nanosuspensions into solid dosage forms via fluid bed granulation and compaction.

K. Langer, F. Sahnen, J. Kamps, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

PEGylated human serum albumin (HSA) nanoparticles: preparation, characterization and quantification of the PEGylation extent

K. Langer, E Fahrländer, S Schelhaas, 2015, Nanotechnology.

Nanoparticulate flurbiprofen reduces amyloid-β42 generation in an in vitro blood–brain barrier model

S. Ropele, R. Schmidt, S. Weggen, 2013, Alzheimer's Research & Therapy.

In vitro Antiviral Activity of Aphidicolin and its Derivates

H. Doerr, M. Michaelis, J. Cinatl, 2002, Arzneimittelforschung.

Stimuli Accelerated Polymeric Drug Delivery Systems

D. Kuckling, K. Langer, Dimitri Jung, 2022, Polymer International.

Photosensitizer loaded HSA nanoparticles. I: Preparation and photophysical properties.

Matthias Wacker, Annegret Preuss, A. Preuß, 2010, International journal of pharmaceutics.

New Perspective in the Formulation and Characterization of Didodecyldimethylammonium Bromide (DMAB) Stabilized Poly(Lactic-co-Glycolic Acid) (PLGA) Nanoparticles

K. Langer, D. Mulac, R. Gossmann, 2015, PloS one.

Asymmetric flow field-flow fractionation (AF4) for the quantification of nanoparticle release from tablets during dissolution testing.

K. Langer, D. Mulac, M. Plöger, 2014, International journal of pharmaceutics.

Conversion of PLGA nanoparticle suspensions into solid dosage forms via fluid bed granulation and tableting

K. Langer, Alexander Bernhardt, Lutz Horster, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

M. Schönhoff, K. Langer, M. Häuser, 2015, Beilstein journal of nanotechnology.

Laihunitization as a mechanism of olivine oxidation

K. Langer, D. Khramov, N. Khisina, 1998 .

Comparison of intracellular accumulation and cytotoxicity of free mTHPC and mTHPC-loaded PLGA nanoparticles in human colon carcinoma cells

T. Knobloch, K. Langer, Sylvia Wagner, 2011, Nanotechnology.

Development of a Lyophilization Process for Long-Term Storage of Albumin-Based Perfluorodecalin-Filled Artificial Oxygen Carriers

K. Langer, S. Eitner, K. Ferenz, 2021, Pharmaceutics.

A FRET-Based Assay for the Identification of PCNA Inhibitors

K. Langer, J. Jose, S. Schreiber, 2023, International journal of molecular sciences.

In vitro evaluation of innovative light-responsive nanoparticles for controlled drug release in intestinal PDT.

D. Kuckling, K. Langer, D. Mulac, 2019, International journal of pharmaceutics.

Backbone vs. side-chain: two light-degradable polyurethanes based on 6-nitropiperonal

D. Kuckling, K. Langer, Timo Schoppa, 2021, Polymer Chemistry.

Optimization of the preparation process for human serum albumin (HSA) nanoparticles.

V. Vogel, D. Schubert, K. Langer, 2003, International journal of pharmaceutics.

Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Properties

M. Lehr, K. Langer, M. Barth, 2022, ChemMedChem.