A. Prat

J. Weiner, B. Engelhardt, F. Sallusto, 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Immune Functions of Brain Endothelial Cells

J. Antel, A. Prat, K. Biernacki, 2005 .

Focal disturbances in the blood–brain barrier are associated with formation of neuroinflammatory lesions

C. Larochelle, J. I. Alvarez, A. Prat, 2015, Neurobiology of Disease.

Antigen and superantigen presentation in the human CNS

J. Antel, A. Prat, 2000, Journal of Neuroimmunology.

Laquinimod enhances central nervous system barrier functions

D. Lodygin, A. Flügel, F. Odoardi, 2017, Neurobiology of Disease.

This information is current as Sclerosis Patients Cytotoxicity and Is Increased in Multiple B Cell-Derived IL-15 Enhances CD 8 T Cell

A. Mohebiany, P. Duquette, A. Prat, 2011 .

Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis

J. Newcombe, A. Prat, N. Arbour, 2011, Journal of Neuroinflammation.

B Cell-Derived IL-15 Enhances CD8 T Cell Cytotoxicity and Is Increased in Multiple Sclerosis Patients

A. Mohebiany, P. Duquette, A. Prat, 2011, The Journal of Immunology.

Functional Consequences of Neuromyelitis Optica-IgG Astrocyte Interactions on Blood-Brain Barrier Permeability and Granulocyte Recruitment1

A. Bar-Or, J. Antel, A. Prat, 2008, The Journal of Immunology.

Granulocyte Recruitment Blood-Brain Barrier Permeability and Optica-IgG Astrocyte Interactions on Functional Consequences of Neuromyelitis

J. Antel, A. Prat, R. Cayrol, 2008 .

Role of ninjurin‐1 in the migration of myeloid cells to central nervous system inflammatory lesions

M. Prinz, A. Fontana, A. Bouthillier, 2011, Annals of neurology.

Differential effects of Th1 and Th2 lymphocyte supernatants on human microglia

A. Bar-Or, J. Antel, A. Prat, 2003, Glia.

Interferon‐γ secretion by peripheral blood T‐cell subsets in multiple sclerosis: Correlation with disease phase and interferon‐β therapy

B. Becher, D. Pelletier, A. Prat, 1999 .

Interferon-gamma secretion by peripheral blood T-cell subsets in multiple sclerosis: correlation with disease phase and interferon-beta therapy.

D. Pelletier, J. Antel, A. Prat, 1999, Annals of neurology.

Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases

Y. de Koninck, B. Engelhardt, D. Côté, 2014, The Journal of Immunology.

Pathogenesis of multiple sclerosis

J. Antel, A. Prat, 2005, Current opinion in neurology.

Epstein-Barr virus-associated immune reconstitution inflammatory syndrome as possible cause of fulminant multiple sclerosis relapse after natalizumab interruption

B. Serafini, F. Aloisi, S. D'alfonso, 2018, Journal of Neuroimmunology.

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10

A. Bar-Or, S. Baranzini, S. Zamvil, 2019, Cell.

IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes

Elie Haddad, P. Duquette, C. Larochelle, 2022, Journal of neuroinflammation.

Regulation of Th1 and Th2 Lymphocyte Migration by Human Adult Brain Endothelial Cells

J. Antel, A. Prat, M. Blain, 2001, Journal of neuropathology and experimental neurology.

Inflammatory potential and migratory capacities across human brain endothelial cells of distinct glatiramer acetate-reactive T cells generated in treated multiple sclerosis patients.

A. Bar-Or, J. Antel, H. Kim, 2004, Clinical immunology.

Characterization of T cell lines derived from glatiramer-acetate-treated multiple sclerosis patients

J. Antel, A. Prat, Yufen Qin, 2000, Journal of Neuroimmunology.

A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4+ T cell profile

V. Martel-Laferrière, D. Kaufmann, C. Tremblay, 2022, bioRxiv.

Confirmed disability progression as a marker of permanent disability in multiple sclerosis

M. Sormani, L. Kappos, J. Lechner-Scott, 2022, European journal of neurology.

Regulation of Cellular and Molecular Trafficking across Human Brain Endothelial Cells by Th1‐ and Th2‐Polarized Lymphocytes

J. Antel, A. Prat, M. Blain, 2004, Journal of neuropathology and experimental neurology.

CLMP Promotes Leukocyte Migration Across Brain Barriers in Multiple Sclerosis

P. Duquette, A. Bouthillier, C. Larochelle, 2022, Neurology: Neuroimmunology & Neuroinflammation.

Blood–Brain Barrier Promotes Differentiation of Human Fetal Neural Precursor Cells

M. Pandolfo, J. Antel, A. Prat, 2009, Stem cells.

Regulation of cardiovascular sympathetic neurons by substance P and gamma-aminobutyric acid in the rat spinal cord.

J. de Champlain, A. Prat, R. Couture, 1991, European journal of pharmacology.

Neuroinflammatory Diseases Barrier Disruption in Demyelinating Spinal Cord − Neutrophils Mediate Blood

Y. Koninck, B. Engelhardt, D. Côté, 2014 .

Cyclophosphamide modulates arachidonic acid metabolism by peritoneal macrophages.

M. Isturiz, M. Palermo, A. Prat, 1988, International journal of immunopharmacology.

An optimized method to process mouse CNS to simultaneously analyze neural cells and leukocytes by flow cytometry

A. Prat, N. Arbour, Camille L. Pittet, 2015, Journal of Neuroscience Methods.

Preferential recruitment of interferon‐γ–expressing TH17 cells in multiple sclerosis

P. Duquette, J. I. Alvarez, A. Prat, 2009, Annals of neurology.

Sex-dependent factors encoded in the immune compartment dictate relapsing or progressive phenotype in demyelinating disease.

A. Prat, Marc-André Lécuyer, Stephanie E. J. Zandee, 2019, JCI insight.

EphrinB1 and EphrinB2 regulate T cell chemotaxis and migration in experimental autoimmune encephalomyelitis and multiple sclerosis

W. Jin, C. Larochelle, A. Prat, 2016, Neurobiology of Disease.

Comparing switch to ocrelizumab, cladribine or natalizumab after fingolimod treatment cessation in multiple sclerosis

J. Lechner-Scott, M. Onofrj, M. Slee, 2022, Journal of Neurology, Neurosurgery, and Psychiatry.

Natalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts

E. Leray, J. Lechner-Scott, M. Onofrj, 2021, CNS Drugs.

Determinants of Human B Cell Migration Across Brain Endothelial Cells1

M. Duddy, A. Bar-Or, J. Antel, 2003, The Journal of Immunology.

Cardiovascular and behavioural effects of centrally administered neuropeptide K in the rat: receptor characterization

A. Prat, R. Couture, P. Picard, 1994, British journal of pharmacology.

Characterization of the cardiovascular and behavioral effects of centrally administered neuropeptide K in the conscious rat

A. Prat, R. Couture, P. Picard, 1993, Regulatory Peptides.

Early predictors of disability in paediatric multiple sclerosis: evidence from a multi-national registry

M. Onofrj, E. Havrdová, S. Khoury, 2022, Journal of Neurology, Neurosurgery, and Psychiatry.

MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes

A. Bouthillier, C. Larochelle, A. Prat, 2022, Brain : a journal of neurology.

Firategrast—natalizumab in a pill?

A. Prat, O. Stüve, 2012, The Lancet Neurology.

Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10

A. Bar-Or, S. Baranzini, S. Zamvil, 2019, Cell.

NG2 immunoreactivity on human brain endothelial cells

A. Olivier, J. Antel, A. Prat, 2001, Acta Neuropathologica.

Oncostatin M triggers brain inflammation by compromising blood–brain barrier integrity

R. Thoelen, H. D. de Vries, H. Schroten, 2022, Acta Neuropathologica.

Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS

C. Vandevert, T. Yednock, W. Zago, 2012, PloS one.

Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis: An International Registry Study.

J. Lechner-Scott, M. Onofrj, M. Slee, 2022, Neurology.

Tau seeding in cases of multiple sclerosis

O. Stuve, M. Diamond, Ping Shang, 2022, Acta Neuropathologica Communications.

Human brain endothelial cells supply support for monocyte immunoregulatory functions

J. Antel, A. Prat, K. Biernacki, 2003, Journal of Neuroimmunology.

3-Dimensional Immunostaining and Automated Deep-Learning Based Analysis of Nerve Degeneration

Etienne J. P. Maes, A. Fournier, A. Prat, 2022, International journal of molecular sciences.

Subungueal-Splinter Hemorrhage an Early Sign of Thromboangitis Obliterans

D. Gossard, A. Prat, J.G. Quenneville, 1981, Angiology.

Single-Cell Transcriptomics Identifies Brain Endothelium Inflammatory Networks in Experimental Autoimmune Encephalomyelitis

J. Ragoussis, C. Larochelle, A. Prat, 2022, Neurology: Neuroimmunology & Neuroinflammation.

How safe is natalizumab during pregnancy?

P. Duquette, A. Prat, 2015, Multiple sclerosis.

Granulocyte–macrophage colony‐stimulating factor–stimulated human macrophages demonstrate enhanced functions contributing to T‐cell activation

P. Duquette, C. Larochelle, A. Prat, 2022, Immunology and cell biology.

Disruption of central nervous system barriers in multiple sclerosis.

A. Prat, R. Cayrol, Jorge I Alvarez, 2011, Biochimica et biophysica acta.

MicroRNA-223 protects neurons from degeneration in Experimental Autoimmune Encephalomyelitis

A. Bar-Or, A. Fournier, Y. Zhang, 2018, bioRxiv.

Treatment Optimization in MS: Canadian MS Working Group Updated Recommendations

Douglas L Arnold, Yves Lapierre, D. Arnold, 2013, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

F. Charron, H. D. de Vries, A. Prat, 2011, Science.

Effect of Disease Modifying Therapy on Disability in Relapsing-Remitting Multiple Sclerosis Over 15 Years.

J. Lechner-Scott, M. Slee, A. Kermode, 2020, Neurology.

Immunotherapy prevents long-term disability in relapsing multiple sclerosis over 15 years

J. Lechner-Scott, M. Slee, A. Kermode, 2019, bioRxiv.

Multiple sclerosis-associated uveitis

A. Prat, K. Biernacki, L. Jaworski, 2017 .

Use of selective antagonists to dissociate the central cardiovascular and behavioural effects of tachykinins on NK1 and NK2 receptors in the rat

C. Tschöpe, T. Unger, A. Prat, 1992 .

In vivo characterization of tachykinin receptors responsible for the central cardiovascular effects of substance P and neurokinin A

C. Tschöpe, T. Unger, A. Prat, 1993, Regulatory Peptides.

Characterization of the tachykinin receptors involved in spinal and supraspinal cardiovascular regulation.

A. Prat, R. Couture, P. Picard, 1995, Canadian journal of physiology and pharmacology.

Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

B. Becher, F. Quintana, D. Rosene, 2021, Nature.

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

A. Abate, F. Quintana, J. Antel, 2021, Science.

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor

N. Pochet, Steffen Jung, C. Clish, 2016, Nature Medicine.

Therapeutic decisions in multiple sclerosis: moving beyond efficacy.

L. Weiner, M. Tintoré, W. Brück, 2013, JAMA neurology.

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

G. Getz, Hailei Zhang, H. Weiner, 2019, Nature Neuroscience.

Assessing the risk of multiple sclerosis disease-modifying therapies

P. Duquette, C. Larochelle, A. Prat, 2019, Expert review of neurotherapeutics.

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology

D. Geerts, H. D. de Vries, A. Prat, 2019, Cell Death & Disease.

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

V. Yong, S. Whitehead, A. Prat, 2021, Nature Neuroscience.

MAFG-driven astrocytes promote CNS inflammation

J. Ragoussis, B. Becher, D. Weitz, 2020, Nature.

Glial influence on the Blood Brain Barrier

A. Prat, Jorge I Alvarez, Takahiro Katayama, 2013, Glia.

Isolation of endothelial cells, pericytes and astrocytes from mouse brain

V. Roullin, A. Prat, Marc-André Lécuyer, 2019, PloS one.

Heterogeneity of T‐lymphocyte function in primary progressive multiple sclerosis: Relation to magnetic resonance imaging lesion volume

D. Arnold, D. Pelletier, J. Antel, 2000, Annals of neurology.

Interleukin-26, preferentially produced by TH17 lymphocytes, regulates CNS barrier function

P. Duquette, A. Bouthillier, A. Prat, 2020, Neurology: Neuroimmunology & Neuroinflammation.

Frailty in ageing persons with multiple sclerosis

M. Keezer, É. Roger, P. Duquette, 2020, Multiple sclerosis.

Managing Multiple Sclerosis: Treatment Initiation, Modification, and Sequencing

M. Freedman, A. Prat, P. Giacomini, 2018, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

IL-1β enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells

A. Fournier, S. Lévesque, A. Prat, 2018, Proceedings of the National Academy of Sciences.

IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation

H. Weiner, A. Madi, H. Lassmann, 2016, Brain : a journal of neurology.

Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis

S. Akira, V. Yong, A. Prat, 2012, Glia.

Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system

Danica Stanimirovic, Nathalie Arbour, Burkhard Becher, 2008, Nature Immunology.

Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

D. Begley, B. Engelhardt, Richard J Smeyne, 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Angiotensin II Controls Occludin Function and Is Required for Blood–Brain Barrier Maintenance: Relevance to Multiple Sclerosis

A. Bouthillier, A. Prat, R. Cayrol, 2007, The Journal of Neuroscience.

Inflammation at the Blood–Brain Barrier in Multiple Sclerosis

H. D. de Vries, A. Prat, H. Vries, 2013 .

One more role for the gut: microbiota and blood brain barrier.

L. Michel, A. Prat, 2016, Annals of translational medicine.

Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis

J. Lechner-Scott, O. Pearson, M. Slee, 2019, JAMA.

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

H. Weiner, R. Bakshi, P. Kivisäkk, 2014, Nature Medicine.

Early clinical markers of aggressive multiple sclerosis.

M. Slee, M. Trojano, F. Grand'Maison, 2019, Brain : a journal of neurology.

Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system.

T. Yednock, P. Duquette, C. Larochelle, 2012, Brain : a journal of neurology.

Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality

J. Richards, D. Kaufmann, A. Dyachenko, 2021, medRxiv.

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology

D. Geerts, H. D. de Vries, A. Prat, 2019, Cell Death & Disease.

B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation

A. Bar-Or, J. Gommerman, L. Michel, 2015, Front. Immunol..

Functions of lipid raft membrane microdomains at the blood–brain barrier

B. Engelhardt, J. Greenwood, A. Prat, 2009, Journal of Molecular Medicine.

Targeting the GM-CSF receptor for the treatment of CNS autoimmunity.

S. Miller, M. Sleeman, A. Prat, 2017, Journal of autoimmunity.

Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on α4 integrin

Nathalie Arbour, Josée Poirier, P. Talbot, 2011, Brain : a journal of neurology.

QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis.

S. Richard, S. Rivest, D. Gosselin, 2020, Cell reports.

Brain‐immune connection: Immuno‐regulatory properties of CNS‐resident cells

Burkhard Becher, B. Becher, J. Antel, 2000, Glia.

Statins reduce human blood–brain barrier permeability and restrict leukocyte migration: Relevance to multiple sclerosis

P. Duquette, A. Bouthillier, A. Prat, 2006, Annals of neurology.

How Do Immune Cells Support and Shape the Brain in Health, Disease, and Aging?

M. Schwartz, J. Kipnis, S. Rivest, 2013, The Journal of Neuroscience.

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells.

A. Prat, R. Cayrol, Monique Bernard, 2008, Brain : a journal of neurology.

Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites

G. Tóth, Peggy Taylor, N. Hattori, 2020, bioRxiv.

Th1 Polarization of CD4+ T Cells by Toll-Like Receptor 3-Activated Human Microglia

J. Antel, A. Prat, U. Meier, 2007, Journal of neuropathology and experimental neurology.

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

C. Clish, F. Quintana, J. Antel, 2019, Cell.

MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

H. D. de Vries, A. V. van Zonneveld, I. Romero, 2013, The Journal of Neuroscience.

Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy

A. Bar-Or, J. Gommerman, Ellen Hilgenberg, 2015, Science Translational Medicine.

Identification of astrocyte regulators by nucleic acid cytometry

A. Abate, E. Boritz, D. Douek, 2023, Nature.

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation.

S. Ludwin, A. Bar-Or, L. Boon, 2015, Immunity.

Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology?

F. Zipp, C. Larochelle, A. Prat, 2016, Trends in Neurosciences.

USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation

M. Lathrop, K. Knobeloch, J. Berghout, 2016, Nature Immunology.

Glial regulation of the blood-brain barrier in health and disease

A. Prat, B. Broux, E. Gowing, 2015, Seminars in Immunopathology.

Cytotoxic NKG2C+ CD4 T Cells Target Oligodendrocytes in Multiple Sclerosis

S. Ludwin, J. Newcombe, J. Antel, 2013, The Journal of Immunology.

Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases

H. Wiendl, C. Gross, R. Liblau, 2021, Nature Reviews Neurology.

Update on treatments in multiple sclerosis.

L. Michel, C. Larochelle, A. Prat, 2015, Presse medicale.

Successful Management of Natalizumab-Associated Primary Central Nervous System Lymphoma through Autologous Stem Cell Transplant

A. Prat, F. Berthelet, L. Létourneau-Guillon, 2020, Current oncology.

Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis.

D. Arnold, J. Antel, S. Narayanan, 2005, Archives of neurology.

Bradykinin B1 receptor expression and function on T lymphocytes in active multiple sclerosis

P. Duquette, A. Prat, J. Poirier, 1999, Neurology.

A Novel MicroRNA-132-Surtuin-1 Axis Underlies Aberrant B-cell Cytokine Regulation in Patients with Relapsing-Remitting Multiple Sclerosis

A. Bar-Or, J. Antel, J. Gommerman, 2014, PloS one.

The IL‐27/IL‐27R axis is altered in CD4+ and CD8+ T lymphocytes from multiple sclerosis patients

P. Duquette, C. Larochelle, A. Prat, 2021, Clinical & translational immunology.

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system

M. Mori, F. Zipp, L. Steinman, 2009, Nature Medicine.

Overcoming the Brain Barriers: From Immune Cells to Nanoparticles.

A. Prat, M. Charabati, J. Rabanel, 2019, Trends in pharmacological sciences.

Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis

A. Bar-Or, J. Gommerman, A. Prat, 2016, Front. Immunol..

Interleukin-15 enhances proinflammatory T-cell responses in patients with MS and EAE

P. Duquette, C. Larochelle, A. Prat, 2020, Neurology: Neuroimmunology & Neuroinflammation.

Cladribine versus fingolimod, natalizumab and interferon β for multiple sclerosis

J. Lechner-Scott, M. Slee, A. Kermode, 2018, Multiple sclerosis.

Association of Inflammation and Disability Accrual in Patients With Progressive-Onset Multiple Sclerosis

M. Slee, M. Trojano, F. Grand'Maison, 2018, JAMA neurology.

DICAM promotes TH17 lymphocyte trafficking across the blood-brain barrier during autoimmune neuroinflammation

F. Quintana, J. Antel, A. Flügel, 2022, Science Translational Medicine.

Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers

A. Bar-Or, J. Gommerman, P. Duquette, 2019, Science Translational Medicine.

Immunological and pathological characterization of fatal rebound MS activity following natalizumab withdrawal

W. Brück, C. Larochelle, A. Prat, 2017, Multiple sclerosis.

TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types

H. Durham, A. Prat, Yousra Khalfallah, 2018, Scientific Reports.

A roadmap to precision medicine for multiple sclerosis

T. Chitnis, A. Prat, 2020, Multiple sclerosis.

Anti-inflammatory disease modifying treatment does not attenuate disability progression in secondary progressive multiple sclerosis

J. Lechner-Scott, M. Trojano, F. Grand'Maison, 2016 .

Droplet-based forward genetic screening of astrocyte–microglia cross-talk

A. Abate, V. Kuchroo, Michael A. Wheeler, 2023, Science.

The effectiveness of natalizumab vs fingolimod-A comparison of international registry studies.

E. Leray, J. Lechner-Scott, M. Onofrj, 2021, Multiple sclerosis and related disorders.

Employment status, productivity loss, and associated factors among people with multiple sclerosis

L. Lynd, A. Traboulsee, S. Kolind, 2023, Multiple sclerosis.

Myeloid cell transmigration across the CNS vasculature triggers IL-1β–driven neuroinflammation during autoimmune encephalomyelitis in mice

S. Lévesque, A. Prat, Marc-André Lécuyer, 2016, The Journal of experimental medicine.

JAML mediates monocyte and CD8 T cell migration across the brain endothelium

C. Larochelle, A. Prat, Hania Kebir, 2015, Annals of clinical and translational neurology.

The Blood-Brain Barrier and Its Microenvironment : Basic Physiology to Neurological Disease

A. Prat, E. D. Vries, 2005 .

Kinin B1 Receptor Expression and Function on Human Brain Endothelial Cells

J. Antel, A. Prat, R. Couture, 2000, Journal of neuropathology and experimental neurology.

Switching to natalizumab or fingolimod in multiple sclerosis: Comparative effectiveness and effect of pre-switch disease activity.

J. Lechner-Scott, M. Onofrj, F. Grand'Maison, 2022, Multiple sclerosis and related disorders.

Comparative efficacy of first-line natalizumab vs IFN-&bgr; or glatiramer acetate in relapsing MS

L. Kappos, J. Lechner-Scott, M. Trojano, 2016, Neurology. Clinical practice.

Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis.

V. Yong, A. Prat, K. Patel, 2013, Brain : a journal of neurology.

B7 Expression and Antigen Presentation by Human Brain Endothelial Cells: Requirement for Proinflammatory Cytokines

B. Becher, J. Antel, A. Prat, 2000, Journal of neuropathology and experimental neurology.

Death receptor expression and function at the human blood brain barrier

A. Prat, K. Biernacki, K. Wosik, 2007, Journal of the Neurological Sciences.

EGFL7 reduces CNS inflammation in mouse

F. Zipp, Mirko H. H. Schmidt, L. Michel, 2018, Nature Communications.

Stress Signal ULBP4, an NKG2D Ligand, Is Upregulated in Multiple Sclerosis and Shapes CD8+ T-Cell Behaviors

E. Haddad, A. Levert, P. Duquette, 2021, Neurology: Neuroimmunology & Neuroinflammation.

The Canadian prospective cohort study to understand progression in multiple sclerosis (CanProCo): rationale, aims, and study design

L. Lynd, S. Patten, A. Traboulsee, 2021, BMC Neurology.

Disability outcomes of early cerebellar and brainstem symptoms in multiple sclerosis

J. Lechner-Scott, M. Slee, M. Trojano, 2020, Multiple sclerosis.

From Baló's concentric sclerosis to multiple sclerosis: a series of 6 patients.

P. Duquette, C. Larochelle, A. Prat, 2020, Multiple sclerosis and related disorders.

Treatment effectiveness of alemtuzumab compared with natalizumab, fingolimod, and interferon beta in relapsing-remitting multiple sclerosis: a cohort study

J. Lechner-Scott, O. Pearson, M. Slee, 2017, The Lancet Neurology.

Disease Reactivation After Cessation of Disease-Modifying Therapy in Patients With Relapsing-Remitting Multiple Sclerosis.

L. Kappos, E. Leray, J. Lechner-Scott, 2022, Neurology.

Delay from treatment start to full effect of immunotherapies for multiple sclerosis.

L. Kappos, P. Vermersch, E. Leray, 2020, Brain : a journal of neurology.

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner

D. Geerts, B. Hof, A. Prat, 2017, Brain, Behavior, and Immunity.

CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis

P. Duquette, A. Bouthillier, C. Larochelle, 2019, Cellular & Molecular Immunology.

Association of Sustained Immunotherapy With Disability Outcomes in Patients With Active Secondary Progressive Multiple Sclerosis.

M. Trojano, F. Grand'Maison, E. Havrdová, 2020, JAMA neurology.

The efficacy of diflunisal in osteoarthritis of the knee. A Canadian Multicenter Study.

A. Prat, P. Davis, P. Lee, 1985, The Journal of rheumatology.

Oxidative Modifications of Parkin Underlie its Selective Neuroprotection in Adult Human Brain

G. Tóth, Peggy Taylor, N. Hattori, 2020, bioRxiv.

Roles of CD4 and CD8 T Lymphocytes in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

A. Prat, N. Arbour, 2015 .

Comparison Between Dimethyl Fumarate, Fingolimod, and Ocrelizumab After Natalizumab Cessation.

J. Lechner-Scott, M. Slee, A. Kermode, 2023, JAMA neurology.

Anti‐inflammatory disease‐modifying treatment and disability progression in primary progressive multiple sclerosis: a cohort study

L. Kappos, J. Lechner-Scott, M. Slee, 2018, European journal of neurology.

Risk of requiring a wheelchair in primary progressive multiple sclerosis: Data from the ORATORIO trial and the MSBase registry

X. Montalban, L. Kappos, M. Onofrj, 2021, European journal of neurology.

Neuronal microRNA regulation in Experimental Autoimmune Encephalomyelitis

A. Bar-Or, A. Fournier, Y. Zhang, 2018, Scientific Reports.

Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis

L. Kappos, J. Lechner-Scott, M. Onofrj, 2023, European journal of neurology.

Effectiveness of multiple disease-modifying therapies in relapsing-remitting multiple sclerosis: causal inference to emulate a multiarm randomised trial

E. Stuart, L. Kappos, J. Lechner-Scott, 2023, Journal of Neurology, Neurosurgery, and Psychiatry.

Anti-inflammatory disease-modifying treatment and short-term disability progression in SPMS

Pierre Grammond, Patrizia Sola, Murat Terzi, 2017, Neurology.

Neuropeptide K potently stimulates the hydrolysis of phosphatidylinositol in the rat spinal cord

A. Prat, R. Couture, H. Hasséssian, 1993, Neuroscience Letters.

CCR6 Expression on B Cells Is Not Required for Clinical or Pathological Presentation of MOG Protein–Induced Experimental Autoimmune Encephalomyelitis despite an Altered Germinal Center Response

A. Bar-Or, J. Gommerman, L. Ward, 2021, The Journal of Immunology.

Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis

Y. Itoyama, A. Bar-Or, J. Antel, 2018, Journal of Neuroinflammation.

[Neutrophil-dependent inflammatory reactions in systemic lupus erythematosus].

A. Llera, A. Prat, A. Boveris, 1989, Medicina.

Endo-MitoEGFP Mice: A Novel Transgenic Mouse with Fluorescently Marked Mitochondria in Microvascular Endothelial Cells

P. Cossette, A. Prat, Marc-André Lécuyer, 2013, PloS one.

Mechanisms of metabolic stress induced cell death of human oligodendrocytes: relevance for progressive multiple sclerosis

J. A. Stratton, Moses Rodriguez, T. Kuhlmann, 2023, Acta Neuropathologica Communications.

Comparative effectiveness in multiple sclerosis: A methodological comparison

J. Lechner-Scott, M. Onofrj, A. Al-Asmi, 2023, Multiple sclerosis.

Induction of B7.1 and B7.2 co-stimulatory molecule on the surface of human brain endothelial cells

J. Antel, A. Prat, M. Blain, 1998, Journal of Neuroimmunology.

Bradykinin B1 receptor regulates the migration of lymphocytes in multiple sclerosis

J. Antel, P. Duquette, A. Prat, 1998, Journal of Neuroimmunology.

Regulation and Functional Effects of Monocyte Migration across Human Brain‐Derived Endothelial Cells

J. Antel, A. Prat, R. Rotondo, 2003, Journal of neuropathology and experimental neurology.

Review: Leucocyte–endothelial cell crosstalk at the blood–brain barrier: A prerequisite for successful immune cell entry to the brain

B. Engelhardt, J. Greenwood, R. Lyck, 2011, Neuropathology and applied neurobiology.

Aggressive form of multiple sclerosis can be predicted early after disease onset

M. Slee, M. Trojano, F. Grand'Maison, 2019 .

Risk of secondary progressive multiple sclerosis after early worsening of disability

M. Onofrj, H. Butzkueven, F. Patti, 2023, Journal of Neurology, Neurosurgery, and Psychiatry.

Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS

B. Michalke, A. Prat, S. David, 2023, Acta Neuropathologica Communications.

JAML mediates monocyte and CD8 T cell migration across the brain endothelium

C. Larochelle, A. Prat, Jorge I Alvarez, 2015, Annals of clinical and translational neurology.

Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability.

Charles R G Guttmann, Jack P Antel, C. Guttmann, 2005, Archives of neurology.

TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types

H. Durham, A. Prat, Yousra Khalfallah, 2018, Scientific Reports.

Anaesthetic doses of pentobarbital antagonize phosphatidylinositol hydrolysis induced by substance P or carbachol in the spinal cord and cerebral cortex of the rat.

A. Prat, R. Couture, H. Hasséssian, 1992, European Journal of Pharmacology.

Clinical course, imaging, and pathological features of 45 adult and pediatric cases of myelin oligodendrocyte glycoprotein antibody-associated disease.

C. Nguyen, E. Rossignol, M. Oskoui, 2023, Multiple sclerosis and related disorders.

Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

G. Getz, Hailei Zhang, H. Weiner, 2019, Nature Neuroscience.

Retinoic Acid Induces Blood–Brain Barrier Development

E. Aronica, D. Geerts, H. D. de Vries, 2013, The Journal of Neuroscience.

Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites

G. Tóth, Peggy Taylor, N. Hattori, 2021, Acta Neuropathologica.

Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis

S. Akira, V. Yong, A. Prat, 2012, Glia.

Review: Leucocyte–endothelial cell crosstalk at the blood–brain barrier: A prerequisite for successful immune cell entry to the brain

B. Engelhardt, J. Greenwood, R. Lyck, 2011, Neuropathology and applied neurobiology.

Focal disturbances in the blood–brain barrier are associated with formation of neuroinflammatory lesions

C. Larochelle, A. Prat, Jorge I Alvarez, 2015, Neurobiology of Disease.

Glial influences on BBB functions and molecular players in immune cell trafficking.

A. Prat, Marc-André Lécuyer, Hania Kebir, 2016, Biochimica et biophysica acta.

Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis

J. Lechner-Scott, O. Pearson, M. Slee, 2019, JAMA.

B Cell-Derived IL-15 Enhances CD8 T Cell Cytotoxicity and Is Increased in Multiple Sclerosis Patients

A. Mohebiany, P. Duquette, A. Prat, 2011, The Journal of Immunology.

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

G. Getz, Hailei Zhang, H. Weiner, 2019, Nature Neuroscience.

Antibody-Independent Function of Human B Cells Contributes to Antifungal T Cell Responses

A. Bar-Or, J. Gommerman, Hulun Li, 2017, The Journal of Immunology.

Diminished Th 17 ( not Th 1 ) responses underlie MS disease abrogation after HSCT

D. Arnold, H. Atkins, M. Duddy, 2012 .

IL-1β enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells

A. Fournier, S. Lévesque, A. Prat, 2018, Proceedings of the National Academy of Sciences.

Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in relapsing-remitting multiple sclerosis patients on high-dose interferon β

F. Grand'Maison, M. Latour, J. Cailhier, 2014, Multiple sclerosis.

Roles of the kallikrein/kinin system in the adaptive immune system.

F. Zipp, A. Prat, M. Bader, 2008, International immunopharmacology.

CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis

P. Duquette, A. Bouthillier, C. Larochelle, 2019, Cellular & Molecular Immunology.

Long-term disability trajectories in primary progressive MS patients: A latent class growth analysis

M. Sormani, J. Lechner-Scott, M. Slee, 2018, Multiple sclerosis.

Determinants of therapeutic lag in multiple sclerosis

E. Leray, J. Lechner-Scott, M. Onofrj, 2021, Multiple sclerosis.

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier

J. Weiner, B. Engelhardt, F. Sallusto, 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Oligodendrocytes in Multiple Sclerosis CD4 T Cells Target + Cytotoxic NKG2C

S. Ludwin, J. Antel, A. Prat, 2013 .