N. Asada

发表

The use of many-body expansions and geometry optimizations in fragment-based methods.

K. Kitaura, D. Fedorov, I. Nakanishi, 2014, Accounts of chemical research.

Structure-activity relationships of carboline and carbazole derivatives as a novel class of ATP-competitive kinesin spindle protein inhibitors.

K. Kitaura, K. Matsuno, A. Asai, 2011, Journal of medicinal chemistry.

Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2.

D. Moechars, K. Kusakabe, N. Asada, 2019, Journal of medicinal chemistry.

Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization.

Y. Kusumoto, N. Asada, K. Hayashi, 2022, ACS medicinal chemistry letters.

Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial.

L. Tritsmans, K. Kusakabe, M. Timmers, 2021, Journal of medicinal chemistry.

Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2.

D. Moechars, K. Kusakabe, Shinji Suzuki, 2021, Journal of medicinal chemistry.

An Efficient Method to Evaluate Intermolecular Interaction Energies in Large Systems Using Overlapping Multicenter ONIOM and the Fragment Molecular Orbital Method.

Kenneth M Merz, Kazuo Kitaura, Dmitri G Fedorov, 2012, The journal of physical chemistry letters.

Pocket-to-Lead: Structure-Based De Novo Design of Novel Non-peptidic HIV-1 Protease Inhibitors Using the Ligand Binding Pocket as a Template.

N. Asada, Yusuke Sako, S. Arita, 2022, Journal of medicinal chemistry.

Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop Interactions.

D. Moechars, K. Kusakabe, Frederik J. R. Rombouts, 2021, Journal of medicinal chemistry.

Discovery of an Extremely Potent Thiazine-Based β-Secretase (BACE1) Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.

K. Kusakabe, Shinji Suzuki, N. Asada, 2019, Journal of medicinal chemistry.

Origin of the kinetic HDAC2‐selectivity of an HDAC inhibitor

Yukihiro Itoh, Takayoshi Suzuki, K. Kusakabe, 2023, J. Comput. Chem..

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization.

Kenji Nakahara, Takahiko Yamamoto, K. Kusakabe, 2018, Journal of medicinal chemistry.