J. Bowyer

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The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water.

R. Delongchamp, J. Latendresse, D. Doerge, 2009, Toxicology and applied pharmacology.

Multiple‐Testing Strategy for Analyzing cDNA Array Data on Gene Expression

James J. Chen, R. Kodell, R. Delongchamp, 2004, Biometrics.

Microglial activation and responses to vasculature that result from an acute LPS exposure.

J. O'Callaghan, S. Sarkar, J. Hess, 2020, Neurotoxicology.

Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure

T. Patterson, J. Bowyer, Monzy Thomas, 2010, Synapse.

High doses of methamphetamine that cause disruption of the blood‐brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus

J. Bowyer, Syed F. Ali, 2006, Synapse.

Modification of the anticonvulsant efficacy of diazepam by Ro-15-1788 in the kindled amygdaloid seizure model.

M. Paule, T. Albertson, J. Bowyer, 1982, Life sciences.

K+ channel and adenylate cyclase involvement in regulation of Ca2+-evoked release of [3H]dopamine from synaptosomes.

N. Weiner, J. Bowyer, 1989, The Journal of pharmacology and experimental therapeutics.

A threshold neurotoxic amphetamine exposure inhibits parietal cortex expression of synaptic plasticity-related genes

K. Vrana, W. Freeman, J. O'Callaghan, 2007, Neuroscience.

Neuronal degeneration in the limbic system of weanling rats exposed to saline, hyperthermia or d-amphetamine

J. Bowyer, 2000, Brain Research.

d-Fenfluramine produces neuronal degeneration in localized regions of the cortex, thalamus, and cerebellum of the rat.

L. Schmued, J. Bowyer, P. Clausing, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature

T. Patterson, J. Bowyer, Monzy Thomas, 2009, Synapse.

Development of dopamine and N-methyl-D-aspartate systems in rat brain: the effect of prenatal phencyclidine exposure.

W. Slikker, R. Holson, J. Bowyer, 1993, Brain research. Developmental brain research.

Comparison of Glutamine‐Enhanced Glutamate Release from Slices and Primary Cultures of Rat Brain

A. Scallet, J. Bowyer, D. Davies, 1995, Annals of the New York Academy of Sciences.

Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity.

J. Bowyer, K. Davis, J. Hanig, 2013, Neurotoxicology.

Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype.

J. Casida, J. Bergquist, D. Doerge, 2005, Biochimica et biophysica acta.

Determination of d-amphetamine in biological samples using high-performance liquid chromatography after precolumn derivatization with o-phthaldialdehyde and 3-mercaptopropionic acid.

J. Bowyer, P. Clausing, G. Newport, 1995, Journal of chromatography. B, Biomedical applications.

Ketamine-induced changes in kindled amygdaloid seizures

W. D. Winters, R. Baselt, T. Albertson, 1983, Neuropharmacology.

Cortical Kindled Seizures: Modification by Excitant and Depressant Drugs

W. D. Winters, T. Albertson, J. Bowyer, 1983, Epilepsia.

Changes in mRNA Levels for Heat‐Shock/Stress Proteins (Hsp) and a Secretory Vesicle Associated Cysteine‐String Protein (Csp1) after Amphetamine (AMPH) Exposure

J. Bowyer, D. Davies, 1999, Annals of the New York Academy of Sciences.

A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during the waking (lights off) cycle.

D. Doerge, J. Bowyer, B. Divine, 2012, Neurotoxicology and teratology.

Aminophylline and kindled seizures

R. M. Joy, T. Albertson, J. Bowyer, 1983, Experimental Neurology.

The effects of pentylenetetrazol, bicuculline and strychnine on the development of kindled seizures

T. Albertson, J. Bowyer, 1982, Neuropharmacology.

Phencyclidine inhibition of the rate of development of amygdaloid kindled seizures

J. Bowyer, 1982, Experimental Neurology.

The effects of various anesthetics on amygdaloid kindled seizures

W. D. Winters, J. Bowyer, 1981, Neuropharmacology.

Modification of dopaminergic receptor sensitivity in rat brain after amygdaloid kindling

K. Gee, J. Bowyer, M. Hollinger, 1979, Experimental Neurology.

Neurovascular changes in acute, sub-acute and chronic mouse models of Parkinson's disease.

L. Schmued, M. Paule, S. Sarkar, 2014, Current neurovascular research.

An evaluation of l-ephedrine neurotoxicity with respect to hyperthermia and caudate/putamen microdialysate levels of ephedrine, dopamine, serotonin, and glutamate.

W. Slikker, S. Ferguson, J. Bowyer, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

L. Schmued, J. Bowyer, Syed F. Ali, 2008, Synapse.

Further studies of the role of hyperthermia in methamphetamine neurotoxicity.

W. Slikker, L. Schmued, R. Holson, 1994, The Journal of pharmacology and experimental therapeutics.

Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?

J. O'Callaghan, D. Miller, S. Sarkar, 2016, Journal of Neuroinflammation.

Microglial activation and vascular responses that are associated with early thalamic neurodegeneration resulting from thiamine deficiency

S. Sarkar, J. Bowyer, J. Hanig, 2018, Neurotoxicology.

Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response.

W. Slikker, J. Bowyer, H. Broening, 1995, The Journal of pharmacology and experimental therapeutics.

Pentylenetetrazol augmentation of developing kindled amygdaloid seizures

W. D. Winters, T. Albertson, J. Bowyer, 1981, Neuropharmacology.

The anticonvulsant effects of diazepam and phenobarbital in prek1ndled and kindled cortical seizures

T. Albertson, J. Bowyer, 1981, Neuropharmacology.

The kindled seizure: production of and modification by dieldrin in rats.

R. M. Joy, T. Albertson, J. Bowyer, 1980, Neurobehavioral toxicology.

Metabolomic analysis of urine from rats chronically dosed with acrylamide using NMR and LC/MS

S. Bhattacharyya, R. Beger, Jinchun Sun, 2010, Metabolomics.

Quantification of rat brain neurotransmitters and metabolites using liquid chromatography/electrospray tandem mass spectrometry and comparison with liquid chromatography/electrochemical detection.

D. Doerge, J. Bowyer, E. Tareke, 2007, Rapid communications in mass spectrometry : RCM.

Phosphorylation and activation of tyrosine hydroxylase in PC18 cells: a cell line derived from rat pheochromocytoma PC12 cells

N. Weiner, H. Houchi, J. Bowyer, 1992, Brain Research.

Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats.

L. Muskhelishvili, J. Latendresse, D. Doerge, 2012, Toxicology letters.

Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity

J. Bowyer, J. Hanig, 2014, Temperature.

The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatum.

W. Slikker, R. Holson, J. Bowyer, 1992, The Journal of pharmacology and experimental therapeutics.

Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood

J. Bowyer, R. Schleimer, J. Hanig, 2015, PloS one.

Classification of cDNA array genes that have a highly significant discriminative power due to their unique distribution in four brain regions.

Weida Tong, Leming Shi, Hong Fang, 2004, DNA and cell biology.

Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model.

L. Schmued, M. Paule, R. Beger, 2014, Neurotoxicology.

Amphetamine levels in brain microdialysate, caudate/putamen, substantia nigra and plasma after dosage that produces either behavioral or neurotoxic effects.

W. Slikker, R. Holson, J. Bowyer, 1995, The Journal of pharmacology and experimental therapeutics.

Low environmental temperatures or pharmacologic agents that produce hypothermia decrease methamphetamine neurotoxicity in mice

W. Slikker, R. Holson, J. Bowyer, 1994, Brain Research.

Regions of the basal ganglia and primary olfactory system are most sensitive to neurodegeneration after extended sevoflurane anesthesia in the perinatal rat.

J. Talpos, J. Bowyer, S. Burks, 2020, Neurotoxicology and teratology.

Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat.

M. Paule, S. Sarkar, J. Bowyer, 2016, Neurotoxicology.

Biomarkers of adult and developmental neurotoxicity.

W. Slikker, J. Bowyer, 2005, Toxicology and applied pharmacology.

Individual differences in dopamine release but not rotational behavior correlate with extracellular amphetamine levels in caudate putamen in unlesioned rats

W. Slikker, R. Holson, J. Bowyer, 1996, Psychopharmacology.

Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterations.

John F. Young, Merle G Paule, William Slikker, 2003, Neurotoxicology.

Neuronal degeneration in the forebrain produced by amphetamine, methamphetamine and fenfluramine

J. Bowyer, S. Peterson, 2002 .

Effects of a cold environment or age on methamphetamine-induced dopamine release in the caudate putamen of female rats

W. Slikker, R. Holson, J. Bowyer, 1993, Pharmacology Biochemistry and Behavior.

Elevated environmental temperatures can induce hyperthermia during d-fenfluramine exposure and enhance 5-hydroxytryptamine (5-HT) depletion in the brain.

W. Slikker, J. Bowyer, C. Stewart, 1997, The Journal of pharmacology and experimental therapeutics.

Nitric oxide regulation of methamphetamine-induced dopamine release in caudate/putamen

W. Slikker, R. Holson, J. Bowyer, 1995, Brain Research.

Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine

J. O'Callaghan, D. Miller, S. Sarkar, 2017, Journal of neurochemistry.

Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine

J. O'Callaghan, D. Miller, K. Kelly, 2012, Journal of neurochemistry.

Brain Region–Specific Neurodegenerative Profiles Showing the Relative Importance of Amphetamine Dose, Hyperthermia, Seizures, and the Blood–Brain Barrier

L. Schmued, J. Bowyer, Monzy Thomas, 2008, Annals of the New York Academy of Sciences.

Parenterally administered 3-nitropropionic acid and amphetamine can combine to produce damage to terminals and cell bodies in the striatum

W. Slikker, L. Schmued, A. Scallet, 1996, Brain Research.

Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats

J. Bowyer, R. Schleimer, J. Hanig, 2019, PloS one.

Low Environmental Temperatures or Pharmacologic Agents That Produce Hypothermia Decrease Methamphetamine Neurotoxicity in Mice

W. Slikker, R. Holson, J. Bowyer, 1995, Annals of the New York Academy of Sciences.

A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain

T. Patterson, J. Bowyer, Monzy Thomas, 2012, Journal of visualized experiments : JoVE.

Seizure activity and hyperthermia potentiate the increases in dopamine and serotonin extracellular levels in the amygdala during exposure to d-amphetamine.

B. Yamamoto, J. Bowyer, J. Tor-Agbidye, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

An Iterative Leave-One-Out Approach to Outlier Detection in RNA-Seq Data

Ching-Wei Chang, J. Bowyer, N. George, 2015, PloS one.

Individual differencs in dopamine release but not rotational behavior correlate with extracellular amphetamine levels in caudate putament in unlesioned rats

W. Slikker, R. Holson, J. Bowyer, 2008, Psychopharmacology.

Determination of D-fenfluramine, D-norfenfluramine and fluoxetine in plasma, brain tissue and brain microdialysate using high-performance liquid chromatography after precolumn derivatization with dansyl chloride.

J. Bowyer, P. Clausing, G. Newport, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Parvalbumin neuron circuits and microglia in three dopamine-poor cortical regions remain sensitive to amphetamine exposure in the absence of hyperthermia, seizure and stroke

R. Jakab, J. Bowyer, 2002, Brain Research.

Methamphetamine exposure can produce neuronal degeneration in mouse hippocampal remnants

L. Schmued, J. Bowyer, 1997, Brain Research.

Systemic administration of fluoro-gold for the histological assessment of vascular structure, integrity and damage.

L. Schmued, S. Sarkar, J. Raymick, 2014, Current neurovascular research.

Modulation of the Ca++-evoked release of [3H]dopamine from striatal synaptosomes by dopamine (D2) agonists and antagonists.

N. Weiner, J. Bowyer, 1987, The Journal of pharmacology and experimental therapeutics.

Introducing Black-Gold II, a highly soluble gold phosphate complex with several unique advantages for the histochemical localization of myelin

John Bowyer, L. Schmued, M. Paule, 2008, Brain Research.

Methamphetamine-stimulated striatal dopamine release declines rapidly over time following microdialysis probe insertion

R. Holson, J. Bowyer, P. Clausing, 1996, Brain Research.

Ca2(+)-evoked [3H]dopamine release from synaptosomes is dependent on neuronal type Ca2+ channels and is not mediated by acetylcholine, glutamate or aspartate release.

N. Weiner, J. Bowyer, 1990, The Journal of pharmacology and experimental therapeutics.

Alpha-2 adrenergic inhibition of Ca(++)-evoked [3H]norepinephrine release from synaptosomes is blocked by depolarization.

N. Weiner, J. Bowyer, 1990, Journal of Pharmacology and Experimental Therapeutics.

Modulation of the Ca2+-evoked Release of Dopamine from Synaptosomes

N. Weiner, J. Bowyer, J. Masserano, 1991 .

Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?

J. O'Callaghan, D. Miller, S. Sarkar, 2016, Journal of Neuroinflammation.

Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity

James J. Chen, T. Patterson, J. Bowyer, 2013, BMC Genomics.

Fluoro-Ruby labeling prior to an amphetamine neurotoxic insult shows a definitive massive loss of dopaminergic terminals and axons in the caudate-putamen

L. Schmued, J. Bowyer, 2006, Brain Research.

Neuronal degeneration in rat forebrain resulting from d-amphetamine-induced convulsions is dependent on seizure severity and age

J. Bowyer, S. Peterson, G. Wang, 1998, Brain Research.

Inhibitory effects of amphetamine on potassium-stimulated release of [3H]dopamine from striatal slices and synaptosomes.

N. Weiner, J. Bowyer, J. Masserano, 1987, The Journal of pharmacology and experimental therapeutics.

Multi-class computational evolution: development, benchmark evaluation and application to RNA-Seq biomarker discovery

J. Bowyer, N. George, J. Moore, 2017, BioData Mining.

Application of the Technique of Brain Microdialysis in Determining the Mechanisms of Action of Neurotoxicants

J. Bowyer, 1995 .

Selective changes in gene expression in cortical regions sensitive to amphetamine during the neurodegenerative process.

A. R. Little, J. O'Callaghan, R. Jakab, 2004, Neurotoxicology.

Effects of phencyclidine, amphetamine and related compounds on dopamine release from and uptake into striatal synaptosomes.

N. Weiner, J. Bowyer, K. Spuhler, 1984, The Journal of pharmacology and experimental therapeutics.

L-ephedrine-induced neurodegeneration in the parietal cortex and thalamus of the rat is dependent on hyperthermia and can be altered by the process of in vivo brain microdialysis.

S. Ferguson, J. Bowyer, K. Hopkins, 2001, Toxicology letters.

Interactions of MK-801 with glutamate-, glutamine- and methamphetamine-evoked release of [3H]dopamine from striatal slices.

W. Slikker, A. Scallet, R. Holson, 1991, Journal of Pharmacology and Experimental Therapeutics.

Age and Dietary Factors in Hippocampal Sensitivity to Trimethyltin

W. Slikker, A. Scallet, J. Lipscomb, 1992, Annals of the New York Academy of Sciences.

Long-term effects of amphetamine neurotoxicity on tyrosine hydroxylase mRNA and protein in aged rats.

J. Bowyer, P. Clausing, K. Nagamoto-Combs, 1998, The Journal of pharmacology and experimental therapeutics.

Long-term Effects of Amphetamine Neurotoxicity on Tyrosine Hydroxylase mRNA and Protein in Aged Rats 1

J. Bowyer, P. Clausing, K. Nagamoto-Combs, 1998 .

Phenobarbital and dizocilpine can block methamphetamine-induced neurotoxicity in mice by mechanisms that are independent of thermoregulation

J. O'Callaghan, D. Miller, R. Holson, 2001, Brain Research.

The time course of blood brain barrier leakage and its implications on the progression of methamphetamine‐induced seizures

S. Sarkar, J. Bowyer, J. Hanig, 2018, Neurotoxicology.

A Statistical Approach in Using cDNA Array Analysis to Determine Modest Changes in Gene Expression in Several Brain Regions after Neurotoxic Insult

R. Delongchamp, J. Bowyer, A. Harris, 2003, Annals of the New York Academy of Sciences.

Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity

James J. Chen, T. Patterson, J. Bowyer, 2013, BMC Genomics.

Time Course of Brain Temperature and Caudate/Putamen Microdialysate Levels of Amphetamine and Dopamine in Rats after Multiple Doses of d‐Amphetamine

J. Bowyer, P. Clausing, 1999, Annals of the New York Academy of Sciences.

Introducing Black-Gold II, a highly soluble gold phosphate complex with several unique advantages for the histochemical localization of myelin

L. Schmued, M. Paule, J. Bowyer, 2008, Brain Research.

The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 rats.

L. Muskhelishvili, R. Delongchamp, J. Latendresse, 2008, Toxicology and applied pharmacology.

The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking water.

R. Delongchamp, J. Latendresse, D. Doerge, 2009, Toxicology and applied pharmacology.

Glutamate N-methyl-d-aspartate and dopamine receptors have contrasting effects on the limbic versus the somatosensory cortex with respect to amphetamine-induced neurodegeneration

R. Jakab, R. Delongchamp, J. Bowyer, 2004, Brain Research.