M. Shimazawa

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Progranulin, a Major Secreted Protein of Mouse Adipose‐Derived Stem Cells, Inhibits Light‐Induced Retinal Degeneration

T. Iwama, H. Hara, M. Shimazawa, 2014, Stem cells translational medicine.

The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage.

T. Iwama, H. Hara, M. Shimazawa, 2013, Experimental eye research.

The conditioned medium of murine and human adipose-derived stem cells exerts neuroprotective effects against experimental stroke model

T. Iwama, S. Yoshimura, H. Hara, 2012, Brain Research.

Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish.

Y. Nishimura, H. Hara, M. Shimazawa, 2016, Journal of pharmacological sciences.

The Changes in Blood Flow Seen in the Eye after Foot Acupuncture Treatment in Mice

H. Hara, T. Seki, M. Shimazawa, 2020, Evidence-based complementary and alternative medicine : eCAM.

TheChanges inBloodFlowSeen in the Eye after FootAcupuncture Treatment in Mice

H. Hara, T. Seki, M. Shimazawa, 2020 .

Increased Expression of Tight Junctions in ARPE-19 Cells Under Endoplasmic Reticulum Stress

H. Hara, Kanji Takahashi, M. Shimazawa, 2011, Current eye research.

Brazilian Green Propolis Protects against Retinal Damage In Vitro and In Vivo

H. Hara, M. Shimazawa, S. Mishima, 2006, Evidence-based complementary and alternative medicine : eCAM.

The protective effects of bilberry and lingonberry extracts against UV light-induced retinal photoreceptor cell damage in vitro.

H. Hara, M. Shimazawa, K. Tsuruma, 2013, Journal of agricultural and food chemistry.

Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen‐glucose deprivation Stress, with a gene‐expression analysis

H. Hara, M. Shimazawa, S. Mishima, 2009, Phytotherapy research : PTR.

Blockade of phosphodiesterase-III protects against oxygen-glucose deprivation in endothelial cells by upregulation of VE-cadherin.

T. Iwama, H. Hara, M. Shimazawa, 2011, Current neurovascular research.

Photobiomodulation with 670 nm light increased phagocytosis in human retinal pigment epithelial cells

H. Hara, M. Shimazawa, K. Tsuruma, 2015, Molecular vision.

Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, Journal of neuroinflammation.

Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury.

T. Iwama, H. Hara, T. Iwawaki, 2014, Free radical biology & medicine.

EP300 Protects from Light-Induced Retinopathy in Zebrafish

Y. Nishimura, H. Hara, M. Shimazawa, 2016, Front. Pharmacol..

Oral administration of NSP-116, a free radical scavenger, suppresses the symptoms of retinal vein occlusion in the murine model.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, Experimental eye research.

Protective effects of fluoroquinolones on UV‐induced damage of cultured ocular cell lines

H. Hara, Tetsuya Yamamoto, K. Mochizuki, 2017, European journal of pharmacology.

Effect of hypoxia on susceptibility of RGC-5 cells to nitric oxide.

H. Hara, M. Shimazawa, K. Tsuruma, 2010, Investigative ophthalmology & visual science.

An Inducer of VGF Protects Cells against ER Stress-Induced Cell Death and Prolongs Survival in the Mutant SOD1 Animal Models of Familial ALS

Hitoshi Takahashi, H. Hara, M. Yamada, 2010, PloS one.

The involvement of ATF4 and S-opsin in retinal photoreceptor cell damage induced by blue LED light

H. Hara, M. Shimazawa, K. Tsuruma, 2017, Molecular vision.

Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2020, Biochemical and biophysical research communications.

Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2018, Molecular vision.

Role of endoplasmic reticulum stress in light‐induced photoreceptor degeneration in mice

T. Kudo, H. Hara, M. Shimazawa, 2013, Journal of neurochemistry.

Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo.

H. Hara, M. Iinuma, M. Shimazawa, 2012, Molecular nutrition & food research.

Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity.

H. Hara, M. Shimazawa, K. Tsuruma, 2011, European journal of pharmacology.

Protective effects of Chinese propolis and its component, chrysin, against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells.

H. Hara, M. Shimazawa, Y. Araki, 2008, Journal of agricultural and food chemistry.

Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice

Y. Oida, H. Hara, M. Shimazawa, 2007, Neuroscience.

Restraint-Induced Expression of Endoplasmic Reticulum Stress-Related Genes in the Mouse Brain

T. Kudo, H. Hara, M. Shimazawa, 2011 .

Brazilian green propolis promotes the cytoprotective expression of heme oxygenase-1 against oxidative stress injury in murine myoblast cells

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2020, Functional Foods in Health and Disease.

Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia–reperfusion injury

T. Iwama, H. Hara, M. Shimazawa, 2014, Neuroscience.

Rifampicin attenuates the MPTP-induced neurotoxicity in mouse brain

Y. Oida, H. Hara, K. Kitaichi, 2006, Brain Research.

Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase.

N. Nakayama, T. Iwama, H. Hara, 2016, Biochemical and biophysical research communications.

Effects of lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits.

H. Hara, M. Shimazawa, T. Sugiyama, 2001, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Effect of lomerizine, a new Ca(2+)channel blocker, on the microcirculation in the optic nerve head in conscious rabbits: a study using a laser speckle technique.

M. Araie, H. Hara, M. Shimazawa, 1999, Experimental eye research.

Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons

T. Iwama, K. Yamashita, S. Nakashima, 2007, Brain Research.

Tissue kallikrein (kallidinogenase) protects against retinal ischemic damage in mice.

H. Hara, M. Shimazawa, K. Tsuruma, 2014, European journal of pharmacology.

Glycoprotein nonmetastatic melanoma protein B ameliorates skeletal muscle lesions in a SOD1G93A mouse model of amyotrophic lateral sclerosis

G. Sobue, H. Hara, M. Katsuno, 2015, Journal of neuroscience research.

[Retinal neovascularization and its therapeutic agents].

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2010, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[Current therapeutic approaches and involvement of amyloid-beta in retinal diseases].

H. Hara, M. Shimazawa, 2009, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Potential effects of progranulin and granulins against retinal photoreceptor cell degeneration

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2019, Molecular vision.

The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis

G. Sobue, Hitoshi Takahashi, H. Hara, 2012, Scientific Reports.

Apoptosis‐Inducing Factor and Cyclophilin A Cotranslocate to the Motor Neuronal Nuclei in Amyotrophic Lateral Sclerosis Model Mice

H. Hara, M. Shimazawa, K. Tsuruma, 2011, CNS neuroscience & therapeutics.

Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice

Hitoshi Takahashi, H. Hara, T. Inuzuka, 2009, Neurobiology of Disease.

VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush

H. Hara, M. Shimazawa, Yuki Inoue, 2018, Scientific Reports.

Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil

Y. Oida, H. Hara, M. Shimazawa, 2008, Neuroscience.

Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease

Y. Oida, H. Hara, M. Shimazawa, 2008, Brain Research.

Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, Scientific Reports.

Thalidomide protects against ischemic neuronal damage induced by focal cerebral ischemia in mice

H. Hara, M. Shimazawa, T. Yamamoto, 2009, Neuroscience.

Neutrophil accumulation promotes intimal hyperplasia after photochemically induced arterial injury in mice.

H. Hara, M. Nakashima, M. Shimazawa, 2005, European journal of pharmacology.

Metallothionein-III deficiency exacerbates light-induced retinal degeneration.

H. Hara, M. Shimazawa, K. Tsuruma, 2012, Investigative ophthalmology & visual science.

Degenerative alterations in the visual pathway after NMDA-induced retinal damage in mice

M. Araie, H. Hara, H. Fukumitsu, 2008, Brain Research.

Progranulin deficiency causes the retinal ganglion cell loss during development

H. Hara, M. Shimazawa, K. Tsuruma, 2017, Scientific Reports.

Purple rice extract and anthocyanidins of the constituents protect against light-induced retinal damage in vitro and in vivo.

H. Shimoda, H. Hara, M. Shimazawa, 2011, Journal of agricultural and food chemistry.

Neuroprotection by Brazilian Green Propolis against In vitro and In vivo Ischemic Neuronal Damage

H. Hara, M. Shimazawa, H. Nagai, 2005, Evidence-based complementary and alternative medicine : eCAM.

Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia

H. Hara, T. Inuzuka, I. Hozumi, 2007, Neuroscience.

Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2

H. Hara, T. Inuzuka, I. Hozumi, 2006, Brain Research.

1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of bee products and their constituents determined by ESR.

H. Hara, M. Shimazawa, S. Kondo, 2009, Biological & pharmaceutical bulletin.

Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo.

H. Hara, M. Shimazawa, T. Hashizume, 2015, European journal of pharmacology.

Induction of amyloid precursor protein by the neurotoxic peptide, amyloid‐beta 25–35, causes retinal ganglion cell death

H. Hara, M. Shimazawa, K. Tsuruma, 2010, Journal of neurochemistry.

Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells

H. Hara, M. Shimazawa, Y. Mashima, 2009, Brain Research.

Comparison of bee products based on assays of antioxidant capacities

H. Hara, M. Shimazawa, K. Tsuruma, 2009, BMC complementary and alternative medicine.

Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood–brain barrier

T. Iwama, H. Hara, O. Kozawa, 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

The effects of valproate and olanzapine on the abnormal behavior of diacylglycerol kinase β knockout mice

H. Hara, M. Shimazawa, K. Tsuruma, 2015, Pharmacological reports : PR.

Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models

H. Hara, M. Shimazawa, Takahiko Imai, 2020, Naunyn-Schmiedeberg's Archives of Pharmacology.

Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage

H. Hara, T. Hirayama, H. Nagasawa, 2019, Scientific Reports.

Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model

H. Hara, Leo Thomas, M. Shimazawa, 2022, Investigative ophthalmology & visual science.

Triamcinolone Acetonide Suppresses Inflammation and Facilitates Vascular Barrier Function in Human Retinal Microvascular Endothelial Cells.

H. Hara, M. Shimazawa, Tomohiro Otsuka, 2017, Current neurovascular research.

Establishment of a pigmented murine model abundant with characteristics of retinal vein occlusion.

H. Hara, T. Kitaoka, M. Shimazawa, 2021, Experimental eye research.

Oral and ocular administration of crocetin prevents retinal edema in a murine retinal vein occlusion model

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2019, Molecular vision.

Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion.

H. Hara, M. Shimazawa, Yuki Inoue, 2018, Investigative ophthalmology & visual science.

Nerve Fiber Layer Measurement Using Scanning Laser Polarimetry with Fixed Corneal Compensator in Normal Cynomolgus Monkey Eyes

H. Hara, M. Shimazawa, M. Sasaoka, 2005, Ophthalmic Research.

Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo

H. Hara, M. Shimazawa, M. Nishi, 2008, Brain Research.

SMN Protein Contributes to Skeletal Muscle Cell Maturation Via Caspase-3 and Akt Activation

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2020, In Vivo.

Combination Treatment with Normobaric Hyperoxia and Cilostazol Protects Mice against Focal Cerebral Ischemia-Induced Neuronal Damage Better Than Each Treatment Alone

T. Iwama, H. Hara, M. Shimazawa, 2009, Journal of Pharmacology and Experimental Therapeutics.

Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice

T. Iwama, H. Hara, M. Shimazawa, 2008, Neuroscience Letters.

Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice.

H. Hara, M. Shimazawa, K. Tsuruma, 2013, European journal of pharmacology.

Journal of Complementary and Integrative Medicine Antiangiogenic Effects of Chinese Medicines ( Hachimijiogan and Kogikujiogan ) on Vascular Endothelial Growth Factor-A-Induced Tube Formation in Human Umbilical Vein Endothelial Cells Co-Cultured with Fibroblasts

H. Hara, M. Shimazawa, N. Matsunaga, 2011 .

A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase

H. Hara, M. Shimazawa, Takahiko Imai, 2018, Brain Research.

The effect of GPNMB on muscular atrophy caused by ALS

H. Hara, M. Shimazawa, K. Tsuruma, 2015 .

Extracellular SOD and VEGF are increased in vitreous bodies from proliferative diabetic retinopathy patients

H. Hara, M. Shimazawa, T. Adachi, 2009, Molecular vision.

VGF and striatal cell damage in in vitro and in vivo models of Huntington’s disease

H. Hara, M. Shimazawa, K. Tsuruma, 2015, Pharmacology research & perspectives.

Riluzole enhances the antitumor effects of temozolomide via suppression of MGMT expression in glioblastoma.

N. Nakayama, T. Iwama, H. Hara, 2020, Journal of neurosurgery.

Proteomic approach with LCMS-IT-TOF identified an increase of Rab33B after transient focal cerebral ischemia in mice

H. Hara, M. Shimazawa, K. Tsuruma, 2010, Experimental & Translational Stroke Medicine.

GPNMB ameliorates mutant TDP‐43‐induced motor neuron cell death

A. Kakita, Hitoshi Takahashi, H. Hara, 2017, Journal of neuroscience research.

Glutamatergic dysfunction is associated with phenotypes of VGF-overexpressing mice

H. Hara, M. Shimazawa, M. Shinohara, 2022, Experimental Brain Research.

Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022.

M. Nakashima, M. Shimazawa, Y. Takiguchi, 1997, European journal of pharmacology.

Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo.

H. Hara, T. Iwawaki, M. Shimazawa, 2016, European journal of pharmacology.

Effects of ticagrelor in a mouse model of ischemic stroke

T. Iwama, H. Hara, M. Shimazawa, 2017, Scientific Reports.

Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia

T. Iwama, Y. Hirose, H. Hara, 2012, Scientific Reports.

The Mitochondria-targeted Peptide, Bendavia, Attenuated Ischemia/Reperfusion-induced Stroke Damage

H. Hara, M. Shimazawa, Takahiko Imai, 2020, Neuroscience.

Acorus calamus extract and its component α-asarone attenuate murine hippocampal neuronal cell death induced by l-glutamate and tunicamycin.

H. Hara, Tatsuji Takahashi, M. Shimazawa, 2021, Bioscience, biotechnology, and biochemistry.

Protective effects of the astaxanthin derivative, adonixanthin, on brain hemorrhagic injury

M. Hayashi, H. Hara, M. Shimazawa, 2018, Brain Research.

SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells.

Y. Nishimura, H. Hara, M. Shimazawa, 2012, Investigative ophthalmology & visual science.

Established Stem Cell Model of Spinal Muscular Atrophy Is Applicable in the Evaluation of the Efficacy of Thyrotropin‐Releasing Hormone Analog

H. Hara, Z. Kato, M. Shimazawa, 2016, Stem cells translational medicine.

Therapeutic Effects of Iron Chelation in Atorvastatin-Induced Intracranial Hemorrhage of Zebrafish Larvae.

Y. Nishimura, H. Hara, M. Shimazawa, 2020, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2020, Journal of pharmacological sciences.

Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil

T. Kudo, Y. Oida, H. Hara, 2008, Brain Research.

Distribution and function of hyaluronan binding protein involved in hyaluronan depolymerization (HYBID, KIAA1199) in the mouse central nervous system

Y. Okada, H. Hara, M. Shimoda, 2017, Neuroscience.

SELECTIVE EFFECTS OF LOMERIZINE, A NOVEL DIPHENYLMETHYLPIPERAZINE Ca2+ CHANNEL BLOCKER, ON CEREBRAL BLOOD FLOW IN RATS AND DOGS

T. Yamaguchi, M. Shimazawa, M. Hashimoto, 1999, Clinical and experimental pharmacology & physiology.

Lomerizine, a Ca2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rat retina.

H. Hara, A. Akaike, Y. Honda, 2000, Experimental eye research.

Preferential involvement of Na⁺/Ca²⁺ exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice.

I. Komuro, H. Hara, A. Baba, 2012, Biochemical and biophysical research communications.

Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.

H. Hara, Y. Nozawa, T. Kojima, 2009, Biochemical and biophysical research communications.

Propofol Exerts Greater Neuroprotection with Disodium Edetate than without It

T. Iwama, H. Hara, H. Nagase, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Effects of propofol with EDTA on cell damage induced by oxygen and glucose deprivation (OGD) in PC12 cell cultures and middle cerebral artery (MCA) occlusion in mice: A-597

H. Hara, M. Shimazawa, Y. Kotani, 2006 .

Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells

H. Hara, M. Shimazawa, K. Tsuruma, 2009, BMC complementary and alternative medicine.

Protective effect of SUN N8075, a free radical scavenger, against excessive light-induced retinal damage in mice.

H. Hara, M. Shimazawa, K. Tsuruma, 2014, Biological & pharmaceutical bulletin.

A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells.

H. Hara, M. Shimazawa, K. Tsuruma, 2013, Biochemical and biophysical research communications.

Lomerizine, a Ca2+ Channel Blocker, Protects against Neuronal Degeneration within the Visual Center of the Brain after Retinal Damage in Mice

M. Araie, H. Hara, Yasushi Ito, 2010, CNS neuroscience & therapeutics.

Progranulin increases phagocytosis by retinal pigment epithelial cells in culture

H. Hara, M. Shimazawa, K. Tsuruma, 2017, Journal of neuroscience research.

Protective Effects of Astaxanthin from Paracoccus carotinifaciens on Murine Gastric Ulcer Models

H. Hara, M. Shimazawa, K. Tsuruma, 2012, Phytotherapy research : PTR.

Sulfatides, L- and P-selectin ligands, exacerbate the intimal hyperplasia occurring after endothelial injury.

H. Hara, M. Nakashima, M. Shimazawa, 2005, European journal of pharmacology.

Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation

H. Hara, M. Shimazawa, K. Tsuruma, 2015, BMC Complementary and Alternative Medicine.

Impairment of oligodendrocyte lineages in spinal muscular atrophy model systems

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2019, Neuroreport.

Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors

T. Inuzuka, I. Hozumi, Yasushi Ito, 2009, Neuroscience Letters.

A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N‐methyl‐D‐aspartate injection and ischemia–reperfusion

I. Komuro, M. Araie, H. Hara, 2009, Journal of neuroscience research.

Hydroxyl radicals cause fluctuation in intracellular ferrous ion levels upon light exposure during photoreceptor cell death.

H. Hara, T. Hirayama, H. Nagasawa, 2014, Experimental eye research.

Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice.

H. Hara, M. Shimazawa, K. Tsuruma, 2012, European journal of pharmacology.

Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects via antioxidant actions.

H. Hara, M. Shimazawa, S. Mishima, 2007, Life sciences.

Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina

H. Hara, M. Shimazawa, K. Tsuruma, 2016, Scientific Reports.

Involvement of cannabinoid receptor type 2 in light‐induced degeneration of cells from mouse retinal cell line in vitro and mouse photoreceptors in vivo

H. Hara, M. Shimazawa, K. Tsuruma, 2018, Experimental eye research.

Endothelin-1 impairs retrograde axonal transport and leads to axonal injury in rat optic nerve.

H. Hara, M. Shimazawa, M. Sasaoka, 2006, Current neurovascular research.

Survival motor neuron protein regulates oxidative stress and inflammatory response in microglia of the spinal cord in spinal muscular atrophy.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2020, Journal of pharmacological sciences.

TUDCA Promotes Phagocytosis by Retinal Pigment Epithelium via MerTK Activation.

H. Hara, M. Shimazawa, K. Tsuruma, 2015, Investigative ophthalmology & visual science.

The Effects of Rufinamide on in Vitro Spinal Muscular Atrophy Model

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2019, Pharmacology & Pharmacy.

A comparative study of the antithrombotic effect of aurintricarboxylic acid on arterial thrombosis in rats and guinea‐pigs

M. Nakashima, M. Shimazawa, Y. Takiguchi, 1996, British journal of pharmacology.

Inhibitory effect of epinastine on the type II-IV allergic reactions in mice, rats and guinea pigs.

M. Shimazawa, C. Kamei, K. Tasaka, 1991, Arzneimittel-Forschung.

Agarwood (Aquilaria Crassna) Extracts Decrease High-protein High-fat Diet-induced Intestinal Putrefaction Toxins in Mice

H. Hara, M. Shimazawa, K. Tsuruma, 2012 .

Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye.

H. Takeuchi, H. Hara, M. Shimazawa, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Granulin 1 Promotes Retinal Regeneration in Zebrafish

H. Hara, M. Shimazawa, K. Tsuruma, 2018, Investigative ophthalmology & visual science.

Evaluation of Bleb Characteristics after Trabeculectomy and Glaucoma Implant Surgery in the Rabbit

H. Hara, Tetsuya Yamamoto, K. Kawase, 2020, Ophthalmic Research.

Proliferative diabetic retinopathy and relations among antioxidant activity, oxidative stress, and VEGF in the vitreous body

H. Hara, M. Shimazawa, T. Sugiyama, 2010, Molecular vision.

The Experimental and Clinical Pharmacology of Propofol, an Anesthetic Agent with Neuroprotective Properties

Toru Iwama, Masamitsu Shimazawa, Hideaki Hara, 2008, CNS neuroscience & therapeutics.

Bunazosin, a selective alpha1-adrenoceptor antagonist, as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage.

Makoto Araie, Masamitsu Shimazawa, Hideaki Hara, 2006, Cardiovascular drug reviews.

Laxative Effect of Agarwood Leaves and Its Mechanism

H. Hara, M. Iinuma, M. Shimazawa, 2008, Bioscience, biotechnology, and biochemistry.

Glucagon-like peptide-1 protects the murine hippocampus against stressors via Akt and ERK1/2 signaling.

H. Hara, M. Shimazawa, Y. Yoshino, 2015, Biochemical and biophysical research communications.

Laxative effects of agarwood on low-fiber diet-induced constipation in rats

H. Hara, M. Shimazawa, K. Tsuruma, 2010, BMC complementary and alternative medicine.

Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation.

H. Hara, M. Shimazawa, K. Tsuruma, 2012, Current neurovascular research.

Lig-8, a highly bioactive lignophenol derivative from bamboo lignin, exhibits multifaceted neuroprotective activity.

Y. Akao, H. Hara, Y. Nozawa, 2007, CNS drug reviews.

Water extract of Brazilian green propolis attenuates high glucose-induced vascular morphological abnormality in zebrafish

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2018, Journal of Functional Foods.

Intravitreal injection of endothelin-1 caused optic nerve damage following to ocular hypoperfusion in rabbits.

H. Hara, M. Shimazawa, M. Sasaoka, 2006, Experimental eye research.

RS9, a novel Nrf2 activator, attenuates light‐induced death of cells of photoreceptor cells and Müller glia cells

H. Hara, Y. Nakagami, M. Shimazawa, 2017, Journal of neurochemistry.

Protective effects of a dietary carotenoid, astaxanthin, against light-induced retinal damage.

H. Hara, M. Shimazawa, K. Tsuruma, 2013, Journal of pharmacological sciences.

Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice.

H. Takeuchi, H. Hara, M. Shimazawa, 2011, Investigative ophthalmology & visual science.

Purple Rice (Oryza sativa L.) Extract and its Constituents Inhibit VEGF‐induced Angiogenesis

H. Shimoda, H. Hara, M. Shimazawa, 2012, Phytotherapy research : PTR.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Induced by Repeated Forced Swimming in Mice.

H. Hara, M. Shimazawa, Miyu Tanaka, 2019, Biological & pharmaceutical bulletin.

Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage

H. Hara, T. Hirayama, H. Nagasawa, 2019, Scientific Reports.

10-Hydroxy-2-decenoic Acid, a Major Fatty Acid from Royal Jelly, Inhibits VEGF-induced Angiogenesis in Human Umbilical Vein Endothelial Cells

H. Hara, M. Shimazawa, Yuichi Chikaraishi, 2007, Evidence-based complementary and alternative medicine : eCAM.

Toll-like receptor 4 inhibitor protects against retinal ganglion cell damage induced by optic nerve crush in mice.

H. Hara, M. Shimazawa, K. Tsuruma, 2017, Journal of pharmacological sciences.

Diabetes Mellitus Aggravates Hemorrhagic Transformation after Ischemic Stroke via Mitochondrial Defects Leading to Endothelial Apoptosis

H. Hara, Y. Oumi, M. Shimazawa, 2014, PloS one.

Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.

H. Hara, M. Shimazawa, K. Tsuruma, 2012, Journal of pharmacological sciences.

Platelet-Derived Growth Factor-BB Lessens Light-Induced Rod Photoreceptor Damage in Mice.

H. Hara, M. Shimazawa, Yuki Inoue, 2017, Investigative ophthalmology & visual science.

Retinal Degeneration and Microglial Dynamics in Mature Progranulin-Deficient Mice

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, International journal of molecular sciences.

Canagliflozin Inhibits Glioblastoma Growth and Proliferation by Activating AMPK

N. Nakayama, T. Iwama, K. Shoda, 2022, Cellular and Molecular Neurobiology.

Progranulin Insufficiency Affects Lysosomal Homeostasis in Retinal Pigment Epithelium

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2022, In Vivo.

Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo.

H. Hara, M. Shimazawa, Y. Inokuchi, 2008, The Journal of pharmacy and pharmacology.

Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis

H. Hara, M. Takata, M. Shimazawa, 2013, British journal of pharmacology.

Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death.

T. Kudo, M. Araie, H. Hara, 2009, Investigative ophthalmology & visual science.

Metallothionein, an endogenous antioxidant, protects against retinal neuron damage in mice.

H. Hara, H. Nagase, Tetsuya Yamamoto, 2006, Investigative ophthalmology & visual science.

NMDA receptor signaling induces the chemoresistance of temozolomide via upregulation of MGMT expression in glioblastoma cells

N. Nakayama, T. Iwama, K. Shoda, 2022, Journal of Neuro-Oncology.

Efficacy of Prednisolone in Generated Myotubes Derived From Fibroblasts of Duchenne Muscular Dystrophy Patients

I. Nishino, H. Hara, S. Takeda, 2018, Front. Pharmacol..

Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage.

Takuya Fujisawa, Kazuhiro Tsuruma, Masamitsu Shimazawa, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Agarwood Induced Laxative Effects via Acetylcholine Receptors on Loperamide-Induced Constipation in Mice

Tetsuro Ito, H. Hara, M. Iinuma, 2010, Bioscience, biotechnology, and biochemistry.

Neuropeptide VGF-Derived Peptide LQEQ-19 has Neuroprotective Effects in an In Vitro Model of Amyotrophic Lateral Sclerosis

H. Hara, M. Shimazawa, S. Nakamura, 2019, Neurochemical Research.

Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light

H. Hara, M. Shimazawa, K. Tsuruma, 2014, Scientific Reports.

Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase

H. Hara, M. Takata, M. Shimazawa, 2016, Scientific Reports.

Effects of progranulin on the pathological conditions in experimental myocardial infarction model

H. Hara, Takahiro Sasaki, S. Minatoguchi, 2020, Scientific Reports.

Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo.

Y. Akao, H. Hara, Y. Nozawa, 2006, Journal of pharmacological sciences.

The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment

T. Iwama, H. Hara, Y. Azuma, 2013, Journal of Neuroinflammation.

Contribution of platelet-derived growth factor signaling to retina regeneration in zebrafish

H. Hara, M. Shimazawa, A. Yamaguchi, 2020, Neuroscience Letters.

Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation.

H. Hara, M. Shimazawa, Yuki Inoue, 2018, Investigative ophthalmology & visual science.

Tissue Kallikrein Inhibits Retinal Neovascularization via the Cleavage of Vascular Endothelial Growth Factor-165

H. Hara, M. Shimazawa, K. Tsuruma, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

S. Akira, H. Hara, S. Uematsu, 2010, Neuroscience.

Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability.

H. Hara, Y. Nakagami, M. Shimazawa, 2019, Investigative ophthalmology & visual science.

Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular Neovascularization

H. Hara, S. Higashiyama, M. Shimazawa, 2018, Arteriosclerosis, thrombosis, and vascular biology.

New quantitative analysis, using high-resolution images, of oxygen-induced retinal neovascularization in mice.

H. Hara, M. Shimazawa, Yuichi Chikaraishi, 2007, Experimental eye research.

Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke

H. Hara, M. Shimazawa, K. Tsuruma, 2013, Scientific Reports.

The Protective Effects of Levetiracetam on a Human iPSCs-Derived Spinal Muscular Atrophy Model

H. Hara, H. Nishio, Toshio Saito, 2019, Neurochemical Research.

Notch Signaling Mediates Astrocyte Abnormality in Spinal Muscular Atrophy Model Systems

H. Hara, H. Nishio, Toshio Saito, 2019, Scientific Reports.

Edaravone is a candidate agent for spinal muscular atrophy: In vitro analysis using a human induced pluripotent stem cells‐derived disease model

H. Hara, M. Shimazawa, K. Tsuruma, 2017, European journal of pharmacology.

A longitudinal comparison in cynomolgus macaques of the effect of brimonidine on optic nerve neuropathy using diffusion tensor imaging magnetic resonance imaging and spectral domain optical coherence tomography

A. Hama, H. Hara, M. Shimazawa, 2021, Heliyon.

Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma

H. Onoe, Takuya Hayashi, H. Watabe, 2013, Molecular Neurodegeneration.

A Docosahexaenoic Acid-Derived Pro-resolving Agent, Maresin 1, Protects Motor Neuron Cells Death

H. Hara, M. Shimazawa, K. Tsuruma, 2018, Neurochemical Research.

VGF has Roles in the Pathogenesis of Major Depressive Disorder and Schizophrenia: Evidence from Transgenic Mouse Models

H. Hara, M. Shimazawa, Takahiro Mizoguchi, 2019, Cellular and Molecular Neurobiology.

Distribution of Carotenoids and Protective Effects of Zeaxanthin on Retina of Ayu Sweetfish (Plecoglossus altivelis).

T. Maoka, H. Hara, M. Shimazawa, 2020, Journal of oleo science.

Carteolol hydrochloride reduces visible light-induced retinal damage in vivo and BSO/glutamate-induced oxidative stress in vitro.

M. Tanito, H. Hara, M. Shimazawa, 2019, Journal of pharmacological sciences.

Protective Effects of Antiplacental Growth Factor Antibody Against Light-Induced Retinal Damage in Mice.

H. Hara, M. Shimazawa, K. Tsuruma, 2015, Investigative ophthalmology & visual science.

Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina.

H. Hara, M. Shimazawa, K. Tsuruma, 2010, European journal of pharmacology.

Edaravone is a free radical scavenger that protects against laser-induced choroidal neovascularization in mice and common marmosets.

H. Hara, M. Shimazawa, K. Tsuruma, 2016, Experimental eye research.

HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth

Y. Okada, H. Hara, M. Shimazawa, 2021, Brain Research.

Diacylglycerol Kinase β Knockout Mice Exhibit Lithium-Sensitive Behavioral Abnormalities

Naoaki Saito, Kazuhiro Tsuruma, Masamitsu Shimazawa, 2010, PloS one.

Vaccinium myrtillus (Bilberry) Extracts Reduce Angiogenesis In Vitro and In Vivo

H. Hara, M. Shimazawa, Yuichi Chikaraishi, 2007, Evidence-based complementary and alternative medicine : eCAM.

Phosphatidylinositol inhibits vascular endothelial growth factor-A--induced migration of human umbilical vein endothelial cells.

H. Hara, M. Shimazawa, N. Matsunaga, 2008, Journal of pharmacological sciences.

Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration.

M. Hayashi, T. Maoka, H. Hara, 2017, Journal of pharmacological sciences.

Free-Radical Scavenger NSP-116 Protects the Corneal Epithelium against UV-A and Blue LED Light Exposure.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, Biological & pharmaceutical bulletin.

Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice

H. Hara, M. Shimazawa, Yuki Inoue, 2018, Experimental eye research.

Effects of ripasudil, a ROCK inhibitor, on retinal edema and nonperfusion area in a retinal vein occlusion murine model.

H. Hara, M. Shimazawa, Yuki Inoue, 2018, Journal of pharmacological sciences.

Effects of kallidinogenase on retinal edema and size of non-perfused areas in mice with retinal vein occlusion.

H. Hara, M. Shimazawa, Yuki Inoue, 2017, Journal of pharmacological sciences.

Retinal Diseases Associated with Oxidative Stress and the Effects of a Free Radical Scavenger (Edaravone)

H. Hara, M. Shimazawa, Tomomi Masuda, 2017, Oxidative medicine and cellular longevity.

Protective effects of NSP-116, a novel imidazolyl aniline derivative, against light-induced retinal damage in vitro and in vivo.

H. Hara, M. Shimazawa, K. Tsuruma, 2016, Free radical biology & medicine.

Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models

H. Hara, M. Shimazawa, K. Tsuruma, 2016, Current eye research.

Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage.

H. Hara, M. Shimazawa, K. Tsuruma, 2015, Experimental eye research.

Protective effects of placental growth factor on retinal neuronal cell damage

H. Hara, M. Shimazawa, K. Tsuruma, 2014, Journal of neuroscience research.

The Effects of Brazilian Green Propolis against Excessive Light-Induced Cell Damage in Retina and Fibroblast Cells

H. Hara, M. Shimazawa, K. Tsuruma, 2013, Evidence-based complementary and alternative medicine : eCAM.

Cilostazol prevents retinal ischemic damage partly via inhibition of tumor necrosis factor-α-induced nuclear factor-kappa B/activator protein-1 signaling pathway

H. Hara, M. Shimazawa, K. Tsuruma, 2013, Pharmacology research & perspectives.

Toll-like receptor 4 mediates retinal ischemia/reperfusion injury through nuclear factor-κB and spleen tyrosine kinase activation.

H. Hara, M. Shimazawa, K. Tsuruma, 2013, Investigative ophthalmology & visual science.

Role of heparin-binding epidermal growth factor-like growth factor in light-induced photoreceptor degeneration in mouse retina.

H. Hara, M. Shimazawa, K. Tsuruma, 2013, Investigative ophthalmology & visual science.

Retina Toll-Like Receptor 4 Mediates Retinal Ischemia / Reperfusion Injury Through Nuclear Factor-j B and Spleen Tyrosine Kinase Activation

H. Hara, M. Shimazawa, K. Tsuruma, 2013 .

Edaravone, a Free Radical Scavenger, Protects against Retinal Damage in Vitro and in Vivo

M. Araie, H. Hara, M. Aihara, 2009, Journal of Pharmacology and Experimental Therapeutics.

The Novel cPLA2 Inhibitor AK106-001616 Has a Protective Effect on SOD1 G93A -Induced Cell Death in NSC34 Murine Motor Neuron-Like Cell

H. Hara, M. Shimazawa, K. Tsuruma, 2016 .

Diacylglycerol Kinase β Knockout Mice Exhibit Attention-Deficit Behavior and an Abnormal Response on Methylphenidate-Induced Hyperactivity

H. Hara, K. Kitaichi, M. Shimazawa, 2012, PloS one.

Discovery of a CNS penetrant small molecule SMN2 splicing modulator with improved tolerability for spinal muscular atrophy

H. Hara, M. Shimazawa, Shoichi Okubo, 2020, Scientific Reports.

Inhibitory Actions of Bilberry Anthocyanidins on Angiogenesis

H. Hara, M. Shimazawa, K. Tsuruma, 2010 .

A Docosahexaenoic Acid-Derived Pro-resolving Agent, Maresin 1, Protects Motor Neuron Cells Death

H. Hara, M. Shimazawa, K. Tsuruma, 2018, Neurochemical Research.

Memantine, an NMDA receptor antagonist, improves working memory deficits in DGKβ knockout mice

H. Hara, M. Shimazawa, K. Tsuruma, 2016, Neuroscience Letters.

Reduced retinal function in amyloid precursor protein‐over‐expressing transgenic mice via attenuating glutamate‐N‐methyl‐d‐aspartate receptor signaling

T. Kudo, M. Takeda, H. Hara, 2008, Journal of neurochemistry.

Reduced Cholinergic Activity in the Hippocampus of Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein Knockout Mice

H. Hara, C. Borlongan, N. Matsukawa, 2019, International journal of molecular sciences.

Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathy.

H. Hara, K. Kiuchi, M. Inatani, 2006, Molecular vision.

CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure

H. Hara, M. Shimazawa, K. Tsuruma, 2017, Front. Pharmacol..

Colored lenses suppress blue light-emitting diode light-induced damage in photoreceptor-derived cells

Kaho Hiromoto, Yoshiki Kuse, Kazuhiro Tsuruma, 2016, Journal of biomedical optics.

Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.

H. Hara, M. Shimazawa, K. Tsuruma, 2010, Experimental eye research.

Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression.

H. Hara, M. Shimazawa, K. Tsuruma, 2012, European journal of pharmacology.

Excess adiponectin in eyes with progressive ocular vascular diseases

H. Hara, M. Shimazawa, Yuki Inoue, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Physiological Roles of Metallothioneins in Central Nervous System Diseases.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2018, Biological & pharmaceutical bulletin.

Central Changes in Glaucoma: Neuroscientific Study Using Animal Models

H. Onoe, K. Imamura, Yasuyoshi Watanabe, 2011 .

Molecular imaging reveals unique degenerative changes in experimental glaucoma

Yasuyoshi Watanabe, Kazuyuki Imamura, Shigeru Tanaka, 2009, Neuroreport.

Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model.

Makoto Araie, Katsuki Nakamura, Masamitsu Shimazawa, 2008, Experimental eye research.

Generation and Characterization of Conditional Heparin-Binding EGF-Like Growth Factor Knockout Mice

K. Fukunaga, Y. Oida, H. Hara, 2009, PloS one.

Protective effects of Huperzia serrata and its components against oxidative damage and cognitive dysfunction

Y. Hayashi, H. Hara, M. Shimazawa, 2020 .

Induction of amyloid-β1-42 in the retina and optic nerve head of chronic ocular hypertensive monkeys

H. Onoe, C. Mayama, M. Araie, 2012, Molecular vision.

Cilostazol Ameliorates Warfarin-Induced Hemorrhagic Transformation After Cerebral Ischemia in Mice

H. Hara, Hideki Ito, M. Shimazawa, 2013, Stroke.

Crocetin Prevents Amyloid β 1-42 -Induced Cell Death in Murine Hippocampal Cells

H. Hara, M. Shimazawa, K. Tsuruma, 2014 .

Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation

H. Hara, M. Shimazawa, T. Takagi, 2016, Neurobiology of Disease.

Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in‐vitro and in mice in‐vivo

H. Hara, M. Shimazawa, Y. Inokuchi, 2008 .

SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models

H. Hara, I. Hozumi, M. Takata, 2014, Neuroscience Letters.

Imipramine protects mouse hippocampus against tunicamycin-induced cell death.

H. Hara, M. Shimazawa, K. Tsuruma, 2012, European journal of pharmacology.

Central Nervous System Migration of Astaxanthin and Adonixanthin Following Their Oral Administration in Cynomolgus Monkeys.

M. Hayashi, T. Maoka, H. Hara, 2020, Journal of nutritional science and vitaminology.

Neuroprotective Effect of Ocular Hypotensive Drugs: Latanoprost/Timolol in Combination Are More Effective than Each as Monotherapy in RGC-5.

H. Hara, M. Shimazawa, K. Tsuruma, 2016, Biological & pharmaceutical bulletin.

Histamine-induced production of interleukin-1 alpha from murine bone marrow stromal cells and its inhibition by H2 blockers.

M. Shimazawa, K. Tasaka, M. Mio, 1993, Molecular Pharmacology.

Effects of timolol-related ophthalmic solutions on cultured human conjunctival cells

H. Hara, Tetsuya Yamamoto, K. Kawase, 2010, Japanese Journal of Ophthalmology.

Piezo1 activation induces fibronectin reduction and PGF2α secretion via arachidonic acid cascade.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, Experimental eye research.

Luteolin shows an antidepressant-like effect via suppressing endoplasmic reticulum stress.

Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara, 2011, Biological & pharmaceutical bulletin.

Rimonabant, a selective cannabinoid1 receptor antagonist, protects against light‐induced retinal degeneration in vitro and in vivo

H. Hara, M. Shimazawa, K. Tsuruma, 2017, European journal of pharmacology.

Neuroprotective effects of minocycline against in vitro and in vivo retinal ganglion cell damage

T. Yamashima, H. Hara, N. Agarwal, 2005, Brain Research.

Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage

T. Yamashima, H. Hara, M. Shimazawa, 2005, Brain Research.

Pharmacological inhibition of mitochondrial fission attenuates oxidative stress-induced damage of retinal pigmented epithelial cells.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, Journal of pharmacological sciences.

Increased Seizure Susceptibility in a Mouse with Diacylglycerol Kinase β Deficiency

H. Hara, Y. Shirai, N. Saito, 2013 .

Physicochemical properties affecting retinal drug/coumarin-6 delivery from nanocarrier systems via eyedrop administration.

Takuya Fujisawa, Kazuhiro Tsuruma, Masamitsu Shimazawa, 2010, Investigative ophthalmology & visual science.

Phosphoethanolamine Elevation in Plasma of Spinal Muscular Atrophy Type 1 Patients.

H. Hara, H. Nishio, N. Harahap, 2020, The Kobe journal of medical sciences.

Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/ KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation.

Y. Okada, H. Hara, M. Shimoda, 2018, Biochemical and biophysical research communications.

Differentiation of Induced Pluripotent Stem Cells ( iPSCs ) into Retinal Ganglion Cells ( RGCs ) in Culture

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2019 .

Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma.

H. Hara, Tetsuya Yamamoto, K. Kawase, 2020, Investigative ophthalmology & visual science.

A pharmacological approach in newly established retinal vein occlusion model

H. Hara, M. Kondo, M. Shimazawa, 2017, Scientific Reports.

Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, Journal of Pharmacological Sciences.

A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice

M. Shimazawa, K. Tsuruma, H. Hara, 2012, Neuroscience.

Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model

Yasuyoshi Watanabe, Makoto Aihara, Kazuyuki Imamura, 2011, The European journal of neuroscience.

Microglia increases the proliferation of retinal precursor cells during postnatal development

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2018, Molecular vision.

The extracellular fragment of GPNMB (Glycoprotein nonmelanosoma protein B, osteoactivin) improves memory and increases hippocampal GluA1 levels in mice

K. Fukunaga, H. Hara, S. Moriguchi, 2015, Journal of neurochemistry.

Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation

K. Fukunaga, Y. Oida, H. Hara, 2011, Brain Research.

Anti-diabetic effects of astaxanthin-rich extract derived from Paracoccus carotinifaciens on pancreatic β cells

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2022, Journal of Functional Foods.

Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma

M. Hayashi, T. Maoka, H. Hara, 2020, Marine drugs.

The antianxiety‐like effect of astaxanthin extracted from Paracoccus carotinifaciens

H. Hara, M. Shimazawa, K. Tsuruma, 2011, BioFactors.

Role of metallothioneins 1 and 2 in ocular neovascularization.

H. Hara, Yasushi Ito, M. Shimazawa, 2014, Investigative ophthalmology & visual science.

Mitochondria dynamics in the aged mice eye and the role in the RPE phagocytosis.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, Experimental eye research.

Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro

H. Hara, M. Shimazawa, K. Tsuruma, 2014, BMC Complementary and Alternative Medicine.

Effect of KB-2796, a new diphenylpiperazine Ca2+ antagonist, on glutamate-induced neurotoxicity in rat hippocampal primary cell cultures.

K. Yokota, M. Shimazawa, H. Hara, 1993, Japanese journal of pharmacology.

ALK5 inhibitor acts on trabecular meshwork cell and reduces intraocular pressure.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2023, Experimental eye research.

The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment.

H. Hara, Tatsuji Takahashi, M. Shimazawa, 2021, Journal of Pharmacological Sciences.

An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys: In vivo Positron Emission Tomography Imaging of Glial Activation

Yasuyoshi Watanabe, Kazuyuki Imamura, Makoto Araie, 2012, PloS one.

Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF

H. Hara, M. Shimazawa, K. Tsuruma, 2017, Scientific Reports.

Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice

T. Tabira, H. Hara, M. Shimazawa, 2015, Bioscience, biotechnology, and biochemistry.

Morphological and Functional Changes in the Retina after Chronic Oxygen-Induced Retinopathy

Shinsuke Nakamura, Kazuhiro Tsuruma, Masamitsu Shimazawa, 2012, PloS one.

GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response

H. Hara, M. Takata, M. Shimazawa, 2017, Scientific Reports.

An arylidene-thiazolidinedione derivative, GPU-4, without PPARγ activation, reduces retinal neovascularization.

H. Hara, H. Nagasawa, M. Shimazawa, 2011, Current neurovascular research.

Laxative effects and mechanism of action of Brazilian green propolis

H. Hara, M. Shimazawa, K. Tsuruma, 2012, BMC Complementary and Alternative Medicine.

Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia

H. Hara, T. Inuzuka, I. Hozumi, 2009, Brain Research.

Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury

H. Hara, M. Shimazawa, K. Tsuruma, 2011, Neuroscience.

A Novel Calpain Inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic Acid 5-Methoxy-3-oxapentyl Ester (SNJ-1945), Reduces Murine Retinal Cell Death In Vitro and In Vivo

H. Hara, Tetsuya Yamamoto, M. Shimazawa, 2010, Journal of Pharmacology and Experimental Therapeutics.

Exposure to Blue LED Light at Subjective Daytime Does not Affect Brain Function in Pigmented Mice

H. Hara, M. Shimazawa, Tomohiro Yako, 2017 .

Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery

H. Hara, M. Shimazawa, K. Hyakkoku, 2012, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization.

H. Hara, K. Kawase, K. Mochizuki, 2017, Investigative ophthalmology & visual science.

Impaired Cerebellar Development in Mice Overexpressing VGF

H. Hara, M. Shimazawa, Takahiro Mizoguchi, 2018, Neurochemical Research.

Importance of CBF measurement to exclude concomitant cerebral infarction in the murine endovascular perforation SAH model.

T. Iwama, H. Hara, M. Shimazawa, 2020, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice.

N. Nakayama, T. Iwama, H. Hara, 2021, Journal of pharmacological sciences.

Comparison of the therapeutic indexes of different molecular forms of botulinum toxin type A.

Masanori Kato, H. Hara, S. Yoneda, 2005, European journal of pharmacology.

BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing

K. Yoshino, M. Hatano, H. Hara, 2023 .

The kallikrein system in retinal damage/protection.

H. Hara, M. Shimazawa, Tomomi Masuda, 2015, European journal of pharmacology.

Identification of VGF nerve growth factor inducible-producing cells in human spinal cords and expression change in patients with amyotrophic lateral sclerosis

A. Kakita, H. Hara, M. Shimazawa, 2020, International Journal of Medical Sciences.

The Protective Effects of Levetiracetam on a Human iPSCs-Derived Spinal Muscular Atrophy Model

H. Hara, H. Nishio, Toshio Saito, 2019, Neurochemical Research.

ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis

Hitoshi Takahashi, H. Hara, T. Inuzuka, 2013, Journal of Neurology.

The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment

T. Iwama, H. Hara, Y. Azuma, 2013, Journal of Neuroinflammation.

Temozolomide has anti-tumor effects through the phosphorylation of cPLA2 on glioblastoma cells

T. Iwama, H. Hara, M. Saio, 2019, Brain Research.

Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina.

H. Hara, M. Shimazawa, K. Tsuruma, 2011, Investigative ophthalmology & visual science.

Calpain Inhibitor Protects Cells against Light-Induced Retinal Degeneration

H. Hara, M. Shimazawa, K. Tsuruma, 2010, Journal of Pharmacology and Experimental Therapeutics.

Establishment and Effects of Ginger and Kikyoto of a Haloperidol-Induced Dysphagia Model in Guinea Pigs

H. Hara, Y. Nishioka, M. Shimazawa, 2016 .

Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo.

H. Hara, M. Shimazawa, Y. Araki, 2009, Molecular nutrition & food research.

The Protective Effect of Blue Light Cutting Particles Mixed Optical Material against Blue LED Light-Induced Photoreceptor and Cornea Cell Death

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2019, Journal of Science and Technology in Lighting.

TRPV4 channels promote vascular permeability in retinal vascular disease.

H. Hara, E. Sugaru, M. Shimazawa, 2023, Experimental eye research.

AN EXPERIMENTAL MODEL OF MIGRAINE WITH AURA: CORTICAL HYPOPERFUSION FOLLOWING SPREADING DEPRESSION IN THE AWAKE AND FREELY MOVING RAT

H. Hara, M. Shimazawa, 1996, Clinical and experimental pharmacology & physiology.

Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, Journal of pharmacological sciences.

Role of Activating Transcription Factor 4 in Murine Choroidal Neovascularization Model

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, International journal of molecular sciences.

Zeaxanthin, a Retinal Carotenoid, Protects Retinal Cells against Oxidative Stress

H. Hara, M. Shimazawa, Y. Nakajima, 2009, Current eye research.

Intravitreal aflibercept protects photoreceptors of mice against excessive light exposure.

H. Hara, M. Shimazawa, Yuki Inoue, 2018, Journal of pharmacological sciences.

Fluorescence investigation of the retinal delivery of hydrophilic compounds via liposomal eyedrops.

Hitoshi Sasaki, Takuya Fujisawa, Kazuhiro Tsuruma, 2011, Biological & pharmaceutical bulletin.

Piezo 1 is involved in intraocular pressure regulation.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2021, Journal of pharmacological sciences.

Anti-VEGFR2 antibody-modified micelle for triggered drug delivery and effective therapy of choroidal neovascularization.

H. Hara, M. Shimazawa, Kenichiro Naito, 2019, Current neurovascular research.

VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush

H. Hara, M. Shimazawa, Yuki Inoue, 2018, Scientific Reports.

SUN N8075, a novel radical scavenger, protects against retinal cell death in mice

H. Hara, M. Shimazawa, K. Tsuruma, 2011, Neuroscience Letters.

Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF

H. Hara, M. Shimazawa, K. Tsuruma, 2017, Scientific Reports.

Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c‐Fos‐like immunoreactivity after cortical spreading depression in rats

M. Shimazawa, H. Hara, T. Sukamoto, 1995, British journal of pharmacology.

Role of heparin-binding epidermal growth factor-like growth factor in light-induced photoreceptor degeneration in mouse retina.

H. Hara, M. Shimazawa, K. Tsuruma, 2013, Investigative ophthalmology & visual science.

Involvement of brain-derived neurotrophic factor in time-dependent neurodegeneration in the murine superior colliculus after intravitreal injection of N-methyl-D-aspartate

H. Hara, Yasushi Ito, M. Shimazawa, 2009, Molecular vision.

Creation of retinal vein occlusion model in cynomolgusmonkeys and determination of its pathological features.

H. Hara, M. Shimazawa, Tomoaki Araki, 2020, Current Neurovascular Research.

Involvement of endoplasmic reticulum stress in optic nerve degeneration after chronic high intraocular pressure in DBA/2J mice

H. Hara, M. Shimazawa, K. Tsuruma, 2015, Journal of neuroscience research.

Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models

H. Hara, M. Shimazawa, Takahiko Imai, 2020, Naunyn-Schmiedeberg's Archives of Pharmacology.

REVIEW: An Approach for Neuroprotective Therapies of Secondary Brain Damage after Excitotoxic Retinal Injury in Mice

H. Hara, Yasushi Ito, M. Shimazawa, 2010, CNS neuroscience & therapeutics.

Movement of retinal vessels toward the optic nerve head after increasing intraocular pressure in monkey eyes with experimental glaucoma

H. Onoe, H. Hara, G. Tomita, 2017, Experimental eye research.

A novel calpain inhibitor, SNJ-1945, reduces murine retinal cell death in vitro and in vivo

Yoshimi, H. Hara, M. Shimazawa, 2009 .

Memantine Protects Against Secondary Neuronal Degeneration in Lateral Geniculate Nucleus and Superior Colliculus after Retinal Damage in Mice

M. Araie, H. Hara, Yasushi Ito, 2008, CNS neuroscience & therapeutics.

Notch Signaling Mediates Astrocyte Abnormality in Spinal Muscular Atrophy Model Systems

H. Hara, H. Nishio, Toshio Saito, 2019, Scientific Reports.

CB-12181, a new azasugar-based matrix metalloproteinase/tumor necrosis factor-alpha converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo.

Koichiro Yoshino, H. Hara, M. Shimazawa, 2009, Current Neurovascular Research.

VGF has Roles in the Pathogenesis of Major Depressive Disorder and Schizophrenia: Evidence from Transgenic Mouse Models

H. Hara, M. Shimazawa, Takahiro Mizoguchi, 2019, Cellular and Molecular Neurobiology.

Impaired Cerebellar Development in Mice Overexpressing VGF

H. Hara, M. Shimazawa, Takahiro Mizoguchi, 2018, Neurochemical Research.

Protective effects of alpha-mangostin encapsulated in cyclodextrin-nanoparticle on cerebral ischemia.

H. Hara, Shota Fujii, K. Sakurai, 2022, Journal of controlled release : official journal of the Controlled Release Society.

Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization.

H. Hara, K. Kawase, K. Mochizuki, 2017, Investigative ophthalmology & visual science.

Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression.

H. Hara, M. Shimazawa, K. Tsuruma, 2012, European journal of pharmacology.

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

S. Akira, H. Hara, S. Uematsu, 2010, Neuroscience.

Physiological Roles of Metallothioneins in Central Nervous System Diseases.

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2018, Biological & pharmaceutical bulletin.

BCL6B Contributes to Ocular Vascular Diseases via Notch Signal Silencing

K. Yoshino, M. Hatano, H. Hara, 2023, Arteriosclerosis, thrombosis, and vascular biology.

Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia–reperfusion injury

H. Hara, M. Shimazawa, K. Tsuruma, 2014, Neuroscience.

Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage.

H. Hara, Yasushi Ito, M. Shimazawa, 2007, Investigative ophthalmology & visual science.

Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys.

T. Yamashima, M. Araie, H. Hara, 2009, Experimental eye research.

Molecular imaging reveals unique degenerative changes in experimental glaucoma

H. Onoe, Shigeru Tanaka, K. Imamura, 2009, Neuroreport.

Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice.

H. Hara, M. Shimazawa, K. Tsuruma, 2012, European journal of pharmacology.

Survival Motor Neuron Protein Modulates Lysosomal Function Through the Expression of Transcription Factor EB in Motoneurons

S. Kamiya, H. Hara, M. Shimazawa, 2020 .

Progranulin deficiency causes the retinal ganglion cell loss during development

H. Hara, M. Shimazawa, K. Tsuruma, 2017, Scientific Reports.

Lomerizine, a Ca2+ Channel Blocker, Protects against Neuronal Degeneration within the Visual Center of the Brain after Retinal Damage in Mice

M. Araie, H. Hara, Yasushi Ito, 2010, CNS neuroscience & therapeutics.

Irreversible Photoreceptors and RPE Cells Damage by Intravenous Sodium Iodate in Mice Is Related to Macrophage Accumulation.

H. Hara, M. Shimazawa, Yuki Inoue, 2018, Investigative ophthalmology & visual science.

Angiostatic effects of Brazilian green propolis and its chemical constituents.

H. Hara, M. Shimazawa, Yuichi Chikaraishi, 2010, Molecular nutrition & food research.

Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice

T. Kudo, Y. Oida, H. Hara, 2010, Neuroscience Letters.

Nrf2 Activator RS9 Suppresses Pathological Ocular Angiogenesis and Hyperpermeability.

H. Hara, Y. Nakagami, M. Shimazawa, 2019, Investigative ophthalmology & visual science.

Bimatoprost protects retinal neuronal damage via Akt pathway.

H. Hara, M. Shimazawa, K. Tsuruma, 2013, European journal of pharmacology.

Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death.

T. Kudo, M. Araie, H. Hara, 2009, Investigative ophthalmology & visual science.

Optic disc topographic parameters measured in the normal cynomolgus monkey by confocal scanning laser tomography

M. Shimazawa, M. Sasaoka, T. Taniguchi, 2005, British Journal of Ophthalmology.

Sphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies.

H. Hara, M. Shimazawa, Yuki Inoue, 2024, Scientific reports.

Analysis and characterization of anthocyanins and carotenoids in Japanese blue tomato

H. Hara, M. Shimazawa, K. Tsuruma, 2016, Bioscience, biotechnology, and biochemistry.

GPR35, A New Therapeutic Target for Atrophic Age-Related Macular Degeneration

M. Shimazawa, Shinsuke Nakamura, Tomohiro Yako, 2024, BPB Reports.

Combination Treatment with Normobaric Hyperoxia and Cilostazol Protects Mice against Focal Cerebral Ischemia-Induced Neuronal Damage Better Than Each Treatment Alone

T. Iwama, H. Hara, M. Shimazawa, 2009, Journal of Pharmacology and Experimental Therapeutics.

Investigation into the usefulness of cynomolgus monkeys with spontaneously elevated intraocular pressure as a model for glaucoma treatment research.

H. Hara, M. Shimazawa, Tomoaki Araki, 2023, Journal of pharmacological sciences.

Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage

T. Iwama, H. Hara, M. Shimazawa, 2009, Neuroscience Letters.

H-151, a Selective STING Inhibitor, Has Potential as a Treatment for Neovascular Age-Related Macular Degeneration

M. Shimazawa, Shinsuke Nakamura, Miruto Tanaka, 2024, Investigative ophthalmology & visual science.

The role of progranulin in macrophages of a glioblastoma model.

M. Shimazawa, Shinsuke Nakamura, Shohei Tsuji, 2024, Journal of neuro-oncology.

Progranulin-deficient macrophages cause cardiotoxicity under hypoxic conditions.

M. Shimazawa, Shinsuke Nakamura, Yoshiki Kuse, 2023, Biochemical and biophysical research communications.

Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction

H. Hara, M. Shimazawa, Shinsuke Nakamura, 2023, FASEB bioAdvances.

GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response

H. Hara, M. Takata, M. Shimazawa, 2017, Scientific Reports.

Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells

H. Hara, M. Shimazawa, K. Tsuruma, 2009, BMC complementary and alternative medicine.

Linagliptin decreased the tumor progression on glioblastoma model.

K. Shoda, M. Shimazawa, Shinsuke Nakamura, 2024, Biochemical and biophysical research communications.

Protective effects of Chinese propolis and its component, chrysin, against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells.

H. Hara, M. Shimazawa, Y. Araki, 2008, Journal of agricultural and food chemistry.