D. Smyth

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Peptide amidation.

A. F. Bradbury, D. Smyth, 1991, Trends in biochemical sciences.

Contents

Prescott, Š., D., 2010, Neurobiology of Aging.

Mechanism of C-terminal amide formation by pituitary enzymes

M. Finnie, A. F. Bradbury, D. Smyth, 1982, Nature.

The glycopeptide moiety of vasopressin-neurophysin precursor is neurohypophysial prolactin releasing factor.

J. D. Neill, D. Smyth, J. Mulchahey, 1988, Biochemical and biophysical research communications.

Large and infinite extra dimensions

Prescott, Š., D., 2001, hep-ph/0104152.

Some Reactions of N-Ethylmaleimide1

D. Smyth, J. Fruton, A. Nagamatsu, 1960 .

Dependence creating properties of lipotropin C-fragment (beta-endorphin): evidence for its internal control of behavior.

J. V. van Ree, D. Smyth, F. Colpaert, 1979, Life sciences.

Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen.

D. Smyth, Z. Khan, 1993, European journal of biochemistry.

A. Aitken, J. Morrell, D. Smyth, 1989, FEBS letters.

Selective processing of β-endorphin in regions of porcine pituitary

D. Smyth, S. Zakarian, Derek G. Smyth, 1980, Nature.

Induction of tolerance to the analgesic action of lipotropin C-Fragment

E. Hulme, C. Snell, A. F. Bradbury, 1976, Nature.

A new glycopeptide in pig, ox and sheep pituitary.

D. Smyth, D. Massey, 1979, Biochemical and biophysical research communications.

Metabolism of the analgesic peptide lipotropin C‐Fragment in rat striatal slices

C. Snell, D. Smyth, 1977, FEBS letters.

Preparation and properties of lipotropin C‐Fragment with anionic substituents attached to the lysine residues

M. Geisow, D. Smyth, M.J. Geisow, 1977, FEBS letters.

Specific cleavage of lipotropin C-fragment by endopeptidases; evidence for a preferred conformation.

B. Austen, D. Smyth, 1977, Biochemical and biophysical research communications.

Beta-endorphin-related peptides in the pituitary gland: isolation, identification and distribution.

J. Deakin, D. Smyth, S. Zakarian, 1981, Ciba Foundation symposium.

Isolation of the C-fragment and C'-fragment of lipotropin from pig pituitary and C-fragment from brain.

C. Snell, D. Smyth, D. Massey, 1978, The Biochemical journal.

β-Endorphin is processed differently in specific regions of rat pituitary and brain

D. Smyth, S. Zakarian, 1982, Nature.

Influence of N-terminal acetylation and C-terminal proteolysis on the analgesic activity of beta-endorphin.

J. Deakin, D. Smyth, J. O. Doströvsky, 1980, The Biochemical journal.

Chronic stimulation of anterior pituitary cell cultures with CRF leads to the secretion of lipotropin.

D. Smyth, J. Ham, 1986, Neuroendocrinology.

The amino acid sequence of the C-peptide of human proinsulin.

D. Smyth, F. Sundby, A. Ko, 1971, European journal of biochemistry.

On the sequence of residues 11 to 18 in bovine pancreatic ribonuclease.

S. Moore, W. Stein, D. Smyth, 1962, The Journal of biological chemistry.

Lipotropin and beta-endorphin : a perspective

D. Smyth, 2016 .

60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective.

D. Smyth, Derek Smyth, 2016, Journal of molecular endocrinology.

PRIMARY STRUCTURE AND SPECIFICITY IN ENDOGENOUS OPIOID PEPTIDES

D. Smyth, 1980 .

Proton magnetic resonance studies on [methionine]-enkephalin and beta-endorphin in aqueous solution.

R. J. Williams, D. Smyth, D. Rabenstein, 1979, Biochimica et biophysica acta.

Analgesic activity of lipotropin C fragment depends on carboxyl terminal tetrapeptide

J. Dostrovsky, J. Deakin, J. Deakin, 1977, Nature.

γ Endorphin, α endorphin and Met-enkephalin are formed extracellularly from lipotropin C fragment

B. Austen, C. Snell, D. Smyth, 1977, Nature.

Prohormones of beta-melanotropin (beta-melanocyte-stimulating hormone, beta-MSH) and corticotropin (adrenocorticotropic hormone, ACTH): structure and activation.

C. Snell, A. F. Bradbury, D. Smyth, 1976, Ciba Foundation symposium.

Preparation of human C-peptide.

D. Smyth, J. Markussen, F. Sundby, 1971, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Reactions of N-ethylmaleimide with peptides and amino acids.

O. Blumenfeld, W. Konigsberg, D. Smyth, 1964, The Biochemical journal.

Biosynthesis of the C-terminal amide in peptide hormones

A. F. Bradbury, D. Smyth, 1987, Bioscience reports.

Glycyl glutamine, an inhibitory neuropeptide derived from β-endorphin

D. Smyth, J. Normanton, J. Wolstencroft, 1983, Nature.

β-ENDORPHIN IN THE BRAIN AND PITUITARY; EVIDENCE FOR TWO SPECIFIC PROCESSING PATTERNS

D. Smyth, S. Zakarian, 1981 .

The Importance of Defined Tracers in RIA

D. Silver, D. Smyth, M. R. Harris, 1986 .

The oligosaccharide units of rabbit immunoglobulin G. Multiple carbohydrate attachment sites.

D. Smyth, M. Fanger, 1972, The Biochemical journal.

Specific processing of the thyrotropin-releasing prohormone in rat brain and spinal cord.

D. Smyth, S. M. Cockle, 1987, European journal of biochemistry.

Distribution of active and inactive forms of endorphins in rat pituitary and brain.

D. Smyth, S. Zakarian, 1979, Proceedings of the National Academy of Sciences of the United States of America.

[24] Techniques in enzymic hydrolysis

D. Smyth, 1967 .

The amino acid sequence of guinea pig C-peptide

D. Smyth, J. Markussen, F. Sundby, 1974, Nature.

The effect of acylation on the molecular size of insulin.

D. Smyth, D. Massey, 1972, European journal of biochemistry.

Purification of a cysteine endopeptidase which is secreted with bioactive peptides from the epidermal glands of Xenopus laevis.

N. Darby, D. Smyth, D. Lackey, 1991, European journal of biochemistry.

Carbamylation of Oxytocin and Arginine-Vasopressin

D. Smyth, G. Bisset, A. Poisner, 1963, Nature.

The use of cyanate for the determination of NH2-terminal residues in proteins.

G. Stark, D. Smyth, 1963, The Journal of biological chemistry.

Vasopressin coexists in half of the corticotropin-releasing factor axons present in the external zone of the median eminence in normal rats.

H. Gainer, M. Whitnall, D. Smyth, 1987, Neuroendocrinology.

Bovine proinsulin: amino acid sequence of the C-peptide isolated from pancreas.

D. Smyth, J. Markussen, F. Sundby, 1971, European journal of biochemistry.

Hallucinations after propofol

D. Smyth, P.J. Collins‐Howgill, 1988 .

4-Phenyl-3-butenoic acid, an in vivo inhibitor of peptidylglycine hydroxylase (peptide amidating enzyme).

B. Roos, A. F. Bradbury, D. Smyth, 1990, European journal of biochemistry.

Peptide amidation: evidence for multiple molecular forms of the amidating enzyme.

A. F. Bradbury, D. Smyth, 1988, Biochemical and biophysical research communications.

Processing reactions in the later stages of hormone activation.

N. Darby, A. F. Bradbury, D. Smyth, 1988, Biochimie.

Immunocytochemical localization of ß-endorphin (lipotropin c-fragment) in the developing rat spinal cord and hypothalamus

D. Smyth, L. Haynes, S. Zakarian, 1982, Brain Research.

gamma endorphin, alpha endorphin and Met-enkephalin are formed extracellularly from lipotropin C fragment.

B. Austen, C. Snell, D. Smyth, 1977, Nature.

C‐FRAGMENT OF LIPOTROPIN—AN ENDOGENOUS POTENT ANALGESIC PEPTIDE

W. Feldberg, D. Smyth, 1977, British journal of pharmacology.

Constructing semisynthetic polypeptides

D. Smyth, 1975, Nature.

Endorphins are stored in biologically active and inactive forms: isolation of α-N-acetyl peptides

M. Finnie, D. Smyth, S. Zakarian, 1979, Nature.

The processing of β-endorphin and α-melanotrophin in the pars intermedia of Xenopus laevis is influenced by background adaptation

D. Smyth, K. Maruthainar, Y. Peng-Loh, 1992 .

Unequivocal assignments of NH proton magnetic resonance bands in oxytocin using 2H‐ and 15N‐substituted molecules

J. Feeney, G. Roberts, A. Burgen, 1974, FEBS letters.

The use of 3-bromopropionic acid for the determination of protein thiol groups.

A. F. Bradbury, D. Smyth, 1973, The Biochemical journal.

Studies on the Bohr Effect of Sheep Hemoglobin

G. Meschia, F. Battaglia, D. Smyth, 1961, The Journal of general physiology.

The determination of glucosamine and galactosamine.

D. Smyth, M. Fanger, D. G. Smyth, 1970, Analytical biochemistry.

Studies on the asymmetrically attached oligosaccharide of rabbit immunoglobulin-G. I. Biosynthesis and stability of the C2-oligosaccharide.

W. Hinrichs, D. Smyth, 1970, Immunology.

Isolation and characterization of endogenous [α]-n-acyl derivatives of the C and C′ of lph

D. Smyth, S. Zakarian, 1979 .

The synthesis of tritiovaline and its incorporation into rat-visceral proteins.

D. Smyth, J. Crawhall, 1958, The Biochemical journal.

Induction of excessive grooming in the rat by fragments of lipotropin

W. Gispen, E. Hulme, C. Snell, 1976, Nature.

Substrate recognition by UDP-N-acetyl-α-d-galactosamine: polypeptide N-acetyl-α-d-galactosaminyltransferase. Effects of chain length and disulphide bonding of synthetic peptide substrates

A. F. Bradbury, D. Smyth, R. Hughes, 1988 .

The oligosaccharide units of rabbit immunoglobulin G. Asymmetric attachment of C2-oligosaccharide.

D. Smyth, M. Fanger, 1972, The Biochemical journal.

Evidence for the Neurotrophic Regulation of Collagen‐Tailed Acetylcholinesterase in Immature Skeletal Muscle by β‐Endorphin

D. Smyth, L. Haynes, Margaret E. Smith, 1984, Journal of neurochemistry.

Lipotropin C-fragment has a COOH-terminal sequence with high intrinsic resistance to the action of exopeptidases.

M. Geisow, D. Smyth, 1977, Biochemical and biophysical research communications.

The NH2-terminus of C-fragment is resistant to the action of aminopeptidases.

B. Austen, D. Smyth, 1977, Biochemical and biophysical research communications.

β-endrophin: modulation of acute tolerance and antagonism by endogenous brain systems

D. Smyth, W. Klee, Y. Jacquet, 1978, Brain Research.

Biogenesis and metabolism of opiate active peptides

B. Austen, M. Geisow, C. Snell, 1978 .

C fragment of lipotropin has a high affinity for brain opiate receptors

E. Hulme, C. Snell, A. F. Bradbury, 1976, Nature.

Lipotropin: precursor to two biologically active peptides.

C. Snell, A. F. Bradbury, D. Smyth, 1976, Biochemical and biophysical research communications.

Substrate specificity of an amidating enzyme in porcine pituitary.

A. F. Bradbury, D. Smyth, 1983, Biochemical and biophysical research communications.

Isolation and identification of two neutral thyrotropin releasing hormone-like peptides, pyroglutamylphenylalanineproline amide and pyroglutamylglutamineproline amide, from human seminal fluid.

A. Aitken, D. Smyth, J. R. García, 1992, The Journal of biological chemistry.

Molecular Changes in Exchange Labelling with Tritium

D. Smyth, P. Jellinck, 1958, Nature.

The sequence of amino acid residues in bovine pancreatic ribonuclease: revisions and confirmations.

S. Moore, W. Stein, D. Smyth, 1963, The Journal of biological chemistry.

Susceptibility of neuroactive peptides to aminopeptidase digestion is related to molecular size.

B. Austen, C. Evans, D. Smyth, 1979, Biochemical and biophysical research communications.

Endopeptidases and prohormone processing

N. Darby, D. Smyth, 1990, Bioscience reports.

Distribution of beta-endorphin-related peptides in rat pituitary and brain.

D. Smyth, S. Zakarian, 1982, The Biochemical journal.

On the molecular mechanism of oxytocin action.

D. Smyth, 1970, Biochimica et biophysica acta.

Acetylation of amino and tyrosine hydroxyl groups. Preparation of inhibitors of oxytocin with no intrinsic activity on the isolated uterus.

D. Smyth, 1967, The Journal of biological chemistry.

Carbamylation of amino and tyrosine hydroxyl groups. Preparation of an inhibitor of oxytocin with no intrinsic activity on the isolated uterus.

D. Smyth, 1967, The Journal of biological chemistry.

Characterization of a proteolytic enzyme in the skin secretions of Xenopus laevis.

N. Darby, D. Smyth, 1988, Biochemical and biophysical research communications.

The peptide hormones: molecular and cellular aspects

D. Smyth, 1975, Nature.

Continuous infusion of propofol in dystrophia myotonica

D. Smyth, D. White, 1989, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Exaggerated physiological responses to propofol in myotonic dystrophy.

D. Smyth, D. White, 1990, British journal of anaesthesia.

Antigenicity of the β-Chain of Human Hæmoglobin

D. Smyth, B. Askonas, B. A. ASKONAS, 1964, Nature.

A novel peptide, pyroglutamylglutamylproline amide, in the rabbit prostate complex, structurally related to thyrotrophin-releasing hormone.

A. Aitken, D. Smyth, S. M. Cockle, 1989, The Journal of biological chemistry.

Enzyme‐catalysed peptide amidation

A. F. Bradbury, D. Smyth, Derek G. Smyth, 1987 .

The thyrotropin-releasing hormone-like peptides pGlu-Phe-Pro amide and pGlu-Glu-Pro amide increase plasma triiodothyronine levels in the mouse; the activity is sensitive to testosterone.

D. Smyth, R. Peñafiel, J. del Rio-García, 1998, European Journal of Pharmacology.

Characterization of neutral TRH-like peptides in mammary gland, mammary tumors and milk.

D. Smyth, M. Ghilchik, J. del Rio-García, 2000, Biochimica et biophysica acta.

Identification of the TRH-like peptides pGlu–Glu–Pro amide and pGlu–Phe–Pro amide in rat thyroid: regulation by thyroid status

H. Fraser, D. Smyth, J. D. Rio-Garcia, 1999, Regulatory Peptides.

Molecular cloning in the marmoset shows that semenogelin is not the precursor of the TRH-like peptide pGlu-Glu-Pro amide.

H. Fraser, G. Kreil, D. Smyth, 1998, Biochimica et biophysica acta.

Distribution of pyroglutamylpeptide amides related to thyrotrophin-releasing hormone in the central nervous system and periphery of the rat.

D. Smyth, J. del Rio-García, 1990, The Journal of endocrinology.

The TRH‐like peptides in rabbit testis are different from the TRH‐like peptide in the prostate

G. Kreil, D. Smyth, A. Huber, 1996, FEBS letters.

Thyrotrophin-releasing hormone-related polypeptides in rabbit prostate and semen are different from those in rabbit hypothalamus.

J. Morrell, D. Smyth, S. M. Cockle, 1989, The Journal of endocrinology.

Beta-endorphin is present in active and inactive forms in rat gastric antrum.

D. Smyth, G. Rosenquist, K. Maruthainar, 1986, Biochemical and Biophysical Research Communications - BBRC.

Chromatography of peptides related to β-endorphin

D. Smyth, 1984 .

Regulation of bioactive β‐endorphin processing in rat pars intermedia

D. Smyth, J. Ham, 1984 .

beta-Endorphin and related peptides in pituitary, brain, pancreas and antrum.

D. Smyth, 1983, British medical bulletin.

Isolation of beta-endorphin-related peptides from ox pituitary.

D. Smyth, D. Massey, 1980, Biochemical Society transactions.

Some techniques in the assay of tritium.

D. Smyth, J. Crawhall, T. E. Banks, 1956, The Biochemical journal.

Comparison of the analgesic properties of lipotropin C-fragment and stabilized enkephalins in the rat.

S. Wendlandt, J. Deakin, C. Snell, 1977, Biochemical and biophysical research communications.

The thyrotrophin-releasing hormone (TRH)-like peptides in rat prostate are not formed by expression of the TRH gene but are suppressed by thyroid hormone.

B. Roos, D. Smyth, P. J. Gkonos, 1992, The Journal of endocrinology.

Sequential formation of beta-endorphin-related peptides in porcine pituitary.

N. Darby, D. Smyth, K. Maruthainar, 1988, Neuroendocrinology.

Biosynthesis and Targeting of β-Endorphin

D. Smyth, 1986 .

β‐Endorphin and ACTH related peptides in primary cultures of rat anterior pituitary cells: evidence for different intracellular pools

D. Smyth, J. Ham, 1985, FEBS Letters.

Differential Regulation of ACTH and β-Endorphin by Controlled Processing

D. Smyth, J. Ham, 1986 .

Influence of dopaminergic agents on beta-endorphin processing in rat pars intermedia.

D. Smyth, J. Ham, K. McFarthing, 1984, Biochemical Society transactions.

The C-terminal dipeptide of β-endorphin: A neuropeptide with inhibitory activity

D. Smyth, J. Normanton, J. Wolstencroft, 1983 .

β-Endorphin processing in pituitary and brain is sensitive to haloperidol stimulation

D. Smyth, J. Ham, 1985, Neuropeptides.

Studies on limited proteolysis and degradation of lipotropin C-fragment [proceedings].

B. Austen, D. Smyth, 1977, Biochemical Society transactions.

Biosynthetic origin and receptor conformation of methionine enkephalin

C. Snell, A. F. Bradbury, D. Smyth, 1976, Nature.

Guinea pig proinsulin. Primary structure of the C-peptide isolated from pancreas.

D. Smyth, D. Massey, 1975, The Journal of biological chemistry.

Enzyme-catalysed peptide amidation. Isolation of a stable intermediate formed by reaction of the amidating enzyme with an imino acid.

A. F. Bradbury, D. Smyth, 1987, European journal of biochemistry.

Glycyl glutamine, an inhibitory neuropeptide derived from beta-endorphin.

D. Smyth, J. Normanton, J. Wolstencroft, 1983, Nature.

The C-terminal dipeptide of beta-endorphin: a neuropeptide with inhibitory activity.

D. Smyth, J. Normanton, J. Wolstencroft, 1983, Life sciences.

[125I] Tyr27 β-endorphin: A radio-iodinated derivative of β-endorphin for the study of opiate receptors

E. Hulme, D. Smyth, K. McFarthing, 1984, Neuropeptides.

The use of cyanate for the determination of NH 2 -terminal residues in N-acylated proteins.

D. Smyth, A. Ko, 1973, Analytical biochemistry.

Quantitative blocking of amino groups in acid solution by carbamylation

G. Stark, D. Smyth, 1966 .

[47] Use of papain, pepsin, and subtilisin in sequence determination

D. Smyth, 1967 .

Catalysis of Slow C‐Terminal Processing Reactions by Carboxypeptidase H

L. Fricker, N. Darby, D. Smyth, 1989, Journal of neurochemistry.

Detection of TRH extended peptides in rat hypothalamus using an antibody raised to pGluHisProGlyLys

D. Smyth, S. M. Cockle, 1986, Bioscience reports.

Processing of the thyrotropin releasing hormone (TRH) precursor in Xenopus skin and bovine hypothalamus: evidence for the existence of extended forms of TRH

D. Smyth, S. M. Cockle, 1986, Regulatory Peptides.

Analgesia produced in cats by the C-fragment of lipotropin and by a synthetic pentapeptide [proceedings].

W. Feldberg, D. Smyth, 1977, The Journal of physiology.

The C-fragment of lipotropin - a potent analgesic [proceedings].

W. Feldberg, D. Smyth, 1976, The Journal of physiology.

Proinsulin: a proposed three-dimensional structure.

C. Snell, D. Smyth, 1975, The Journal of biological chemistry.

ANTIGENICITY OF THE BETA-CHAIN OF HUMAN HAEMOGLOBIN.

D. Smyth, B. Askonas, 1964, Nature.

Sequential processing reactions in the formation of hormone amides.

D. Smyth, A. Bleakman, 1987, European journal of biochemistry.