J. Hegemann

发表

Lasso peptides: an intriguing class of bacterial natural products.

M. Marahiel, J. Hegemann, M. Zimmermann, 2015, Accounts of chemical research.

The PqqD homologous domain of the radical SAM enzyme ThnB is required for thioether bond formation during thurincin H maturation

M. Marahiel, J. Hegemann, Beata M Wieckowski, 2015, FEBS letters.

Metal ions induced secondary structure rearrangements: mechanically interlocked lasso vs. unthreaded branched-cyclic topoisomers.

S. Zirah, F. Fernandez-Lima, S. Rebuffat, 2018, The Analyst.

Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase.

M. Marahiel, U. Linne, J. Hegemann, 2016, Angewandte Chemie.

Unexpected Methyllanthionine Stereochemistry in the Morphogenetic Lanthipeptide SapT

W. A. van der Donk, J. Hegemann, J. Z. Acedo, 2022, Journal of the American Chemical Society.

Signatures of Mechanically Interlocked Topology of Lasso Peptides by Ion Mobility–Mass Spectrometry: Lessons from a Collection of Representatives

M. Marahiel, S. Zirah, S. Rebuffat, 2017, Journal of The American Society for Mass Spectrometry.

Dual substrate‐controlled kinase activity leads to polyphosphorylated lasso peptides

M. Marahiel, J. Hegemann, C. Fage, 2016, FEBS letters.

Insights into the Unique Phosphorylation of the Lasso Peptide Paeninodin*

M. Marahiel, U. Linne, J. Hegemann, 2016, The Journal of Biological Chemistry.

Exploring structural signatures of the lanthipeptide prochlorosin 2.8 using tandem mass spectrometry and trapped ion mobility-mass spectrometry

F. Fernandez-Lima, W. A. van der Donk, J. Hegemann, 2021, Analytical and Bioanalytical Chemistry.

Caulosegnins I-III: a highly diverse group of lasso peptides derived from a single biosynthetic gene cluster.

M. Marahiel, J. Hegemann, M. Zimmermann, 2013, Journal of the American Chemical Society.

Xanthomonins I-III: a new class of lasso peptides with a seven-residue macrolactam ring.

M. Marahiel, H. Steuber, J. Hegemann, 2014, Angewandte Chemie.

Targeted Delivery of Proteasome Inhibitors to Somatostatin‐Receptor‐Expressing Cancer Cells by Octreotide Conjugation

A. Krüger, M. Groll, J. Hegemann, 2015, ChemMedChem.

Lasso peptides from proteobacteria: Genome mining employing heterologous expression and mass spectrometry.

M. Marahiel, J. Hegemann, M. Zimmermann, 2013, Biopolymers.

Combined thermal and carboxypeptidase Y stability assays for probing the threaded fold of lasso peptides.

J. Hegemann, 2022, Methods in enzymology.

Factors Governing the Thermal Stability of Lasso Peptides

J. Hegemann, 2020, Chembiochem : a European journal of chemical biology.

Mechanistic Studies of the Kinase Domains of Class IV Lanthipeptide Synthetases.

M. Gross, Liuqing Shi, W. A. van der Donk, 2019, ACS chemical biology.

X Lasso Peptides: Structure, Biosynthesis, Activities, and Beyond

J. Hegemann, Xiulan Xie, Kevin Jeanne Dit-Foque, 2019 .

Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters.

M. Marahiel, C. Robinson, A. De Simone, 2018, ACS chemical biology.

Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems.

W. A. van der Donk, J. Hegemann, 2018, Journal of the American Chemical Society.

The B1 Protein Guides the Biosynthesis of a Lasso Peptide

M. Marahiel, U. Linne, J. Hegemann, 2016, Scientific Reports.

Characterization of caulonodin lasso peptides revealed unprecedented N-terminal residues and a precursor motif essential for peptide maturation

M. Marahiel, J. Hegemann, M. Zimmermann, 2014 .

Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides.

E. Novellino, S. Zahler, M. Marahiel, 2014, Journal of medicinal chemistry.

Enterobacter bugandensis: a novel enterobacterial species associated with severe clinical infection

M. Marahiel, A. Goesmann, M. Suar, 2018, Scientific Reports.

A Bifunctional Leader Peptidase/ABC Transporter Protein Is Involved in the Maturation of the Lasso Peptide Cochonodin I from Streptococcus suis.

F. Fernandez-Lima, J. Hegemann, K. Jeanne Dit Fouque, 2021, Journal of natural products.

Structural signatures of the class III lasso peptide BI-32169 and the branched-cyclic topoisomers using trapped ion mobility spectrometry–mass spectrometry and tandem mass spectrometry

S. Zirah, F. Fernandez-Lima, S. Rebuffat, 2019, Analytical and Bioanalytical Chemistry.

Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-Based Production System.

U. Linne, Judit Tulla-Puche, F. Albericio, 2018, Journal of natural products.

Generation of Lasso Peptide-Based ClpP Binders

J. Hegemann, H. Brötz-Oesterhelt, I. Malik, 2021, International journal of molecular sciences.

Ion mobility-mass spectrometry of lasso peptides: signature of a rotaxane topology.

M. Marahiel, S. Zirah, S. Rebuffat, 2015, Analytical chemistry.

Fighting antibiotic resistance—strategies and (pre)clinical developments to find new antibacterials

T. Hesterkamp, J. Hegemann, A. Hirsch, 2022, EMBO reports.

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin.

Christopher J. Schwalen, D. Mitchell, W. A. van der Donk, 2018, Chemical communications.

Identification of Lasso Peptide Topologies Using Native Nanoelectrospray Ionization-Trapped Ion Mobility Spectrometry-Mass Spectrometry.

S. Zirah, F. Fernandez-Lima, S. Rebuffat, 2018, Analytical Chemistry.

The astexin-1 lasso peptides: biosynthesis, stability, and structural studies.

M. Marahiel, J. Hegemann, M. Zimmermann, 2013, Chemistry & biology.

General rules of fragmentation evidencing lasso structures in CID and ETD.

M. Marahiel, S. Zirah, S. Rebuffat, 2018, The Analyst.

Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications.

W. A. van der Donk, J. Hegemann, M. C. Walker, 2019, ACS synthetic biology.

Identification of the Catalytic Residues in the Cyclase Domain of the Class IV Lanthipeptide Synthetase SgbL

R. Süssmuth, J. Hegemann, 2021, Chembiochem : a European journal of chemical biology.

The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.

E. Novellino, M. Marahiel, L. Marinelli, 2016, Molecular bioSystems.

Enterobacter bugandensis: a novel enterobacterial species associated with severe clinical infection

M. Marahiel, A. Goesmann, M. Suar, 2018, Scientific Reports.

Genome Mining and Heterologous Expression Reveal Two Distinct Families of Lasso Peptides Highly Conserved in Endofungal Bacteria.

M. Marahiel, K. Ishida, C. Hertweck, 2019, ACS chemical biology.

Evidence of Cis/Trans-Isomerization at Pro7/Pro16 in the Lasso Peptide Microcin J25

S. Zirah, E. Lescop, F. Fernandez-Lima, 2019, Journal of The American Society for Mass Spectrometry.

Matters of class: coming of age of class III and IV lanthipeptides

R. Süssmuth, J. Hegemann, 2020, RSC chemical biology.

Current developments in antibiotic discovery

J. Hegemann, Sebastian Walesch, Joy Birkelbach, 2022, EMBO reports.

Light‐Controlled Tyrosine Nitration of Proteins

M. Uesugi, J. Hegemann, W. Yao, 2021, Angewandte Chemie.

Light-controlled Tyrosine Nitration of Proteins.

M. Uesugi, J. Hegemann, W. Yao, 2021, Angewandte Chemie.

MODELLING OF TEXTILE REINFORCED COMPOSITES USING FINITE ELEMENT TOOLS AND INVESTIGATION OF THE INFLUENCE OF POROSITY ON MECHANICAL PROPERTIES

Eads Deutschland, K. Hackl, J. Hegemann, 2007 .

Discovery of a Unique Structural Motif in Lanthipeptide Synthetases for Substrate Binding and Interdomain Interactions

J. Hegemann, Jiapeng Zhu, H. Yao, 2022, Angewandte Chemie.

Genome Mining, Isolation and Characterization of Novel Lasso Peptides and Their Utilization in Drug Development

Julian David Hegemann, J. Hegemann, 2014 .