G. Lauro

发表

Inverse Virtual Screening allows the discovery of the biological activity of natural compounds.

G. Bifulco, R. Riccio, G. Lauro, 2012, Bioorganic & medicinal chemistry.

Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E₂ synthase-1 enzyme (mPGES-1).

G. Bifulco, O. Werz, R. Riccio, 2014, European journal of medicinal chemistry.

Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors.

G. Bifulco, O. Werz, R. Riccio, 2015, ACS medicinal chemistry letters.

Structure‐Based Design of Microsomal Prostaglandin E2 Synthase‐1 (mPGES‐1) Inhibitors using a Virtual Fragment Growing Optimization Scheme

G. Bifulco, E. Novellino, O. Werz, 2016, ChemMedChem.

Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.

G. Bifulco, V. Sepe, A. Zampella, 2012, Organic & biomolecular chemistry.

Structural evidence of N6-isopentenyladenosine as a new ligand of farnesyl pyrophosphate synthase.

G. Bifulco, E. Novellino, M. Scrima, 2014, Journal of medicinal chemistry.

Elucidating the Relative and Absolute Configuration of Organic Compounds by Quantum Mechanical Approaches

G. Bifulco, G. Lauro, 2020 .

Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

G. Bifulco, A. Zampella, S. Fiorucci, 2012, Journal of medicinal chemistry.

Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.

Gianluigi Lauro, Giuseppe Bifulco, Raffaele Riccio, 2011, Journal of natural products.

Inverse Virtual Screening for the rapid re-evaluation of the presumed biological safe profile of natural products. The case of steviol from Stevia rebaudiana glycosides on farnesoid X receptor (FXR).

G. Bifulco, A. Carino, A. Zampella, 2021, Bioorganic chemistry.

Biological Profile of Two Gentiana lutea L. Metabolites Using Computational Approaches and In Vitro Tests

G. Bifulco, C. Finamore, G. Saviano, 2021, Biomolecules.

Glucopyranosylbianthrones from the Algerian Asphodelus tenuifolius: Structural Insights and Biological Evaluation on Melanoma Cancer Cells.

G. Bifulco, S. Terracciano, I. Bruno, 2018, Journal of natural products.

Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer

G. Bifulco, G. Sbardella, A. Tosco, 2017, Scientific Reports.

New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei.

G. Bifulco, W. Gerwick, R. Riccio, 2014, Organic letters.

Discovery and synthesis of namalide reveals a new anabaenopeptin scaffold and peptidase inhibitor.

G. Bifulco, C. Bewley, G. Lauro, 2012, Journal of medicinal chemistry.

Addressing the Target Identification and Accelerating the Repositioning of Anti‐Inflammatory/Anti‐Cancer Organic Compounds by Computational Approaches

G. Bifulco, G. Lauro, M. G. Chini, 2021 .

Giffonins, Antioxidant Diarylheptanoids from Corylus avellana, and Their Ability to Prevent Oxidative Changes in Human Plasma Proteins.

G. Bifulco, G. Lauro, M. Masullo, 2021, Journal of natural products.

Total synthesis of the potent anti-inflammatory natural product solomonamide A along with structural revision and biological activity evaluation.

G. Bifulco, M. Barthwal, G. Lauro, 2018, Organic & biomolecular chemistry.

Svetamycins A-G, Unusual Piperazic Acid-Containing Peptides from Streptomyces sp.

G. Bifulco, A. Vilcinskas, G. Lauro, 2017, The Journal of organic chemistry.

Bissubvilides A and B, Cembrane-Capnosane Heterodimers from the Soft Coral Sarcophyton subviride.

G. Bifulco, W. Gerwick, R. Riccio, 2016, Journal of natural products.

Hyalachelins A-C, unusual siderophores isolated from the terrestrial myxobacterium Hyalangium minutum.

G. Bifulco, R. Müller, G. Lauro, 2014, Organic letters.

Discovery of 3-hydroxy-3-pyrrolin-2-one-based mPGES-1 inhibitors using a multi-step virtual screening protocol.

G. Bifulco, O. Werz, A. Koeberle, 2018, MedChemComm.

A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4‐Thiazolidinedione‐Based Molecules as New Dual mPGES‐1/5‐LO Inhibitors

G. Bifulco, O. Werz, S. Terracciano, 2020, ChemMedChem.

Thiazolidin-4-one-based compounds interfere with the eicosanoid biosynthesis pathways by mPGES-1/sEH/5-LO multi-target inhibition

G. Bifulco, O. Werz, V. Sepe, 2022, European Journal of Medicinal Chemistry Reports.

Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge.

G. Bifulco, C. Bewley, M. Kelly, 2017, Journal of natural products.

Oxygenated Polyketides from Plakinastrella mamillaris as a New Chemotype of PXR Agonists

G. Bifulco, A. Zampella, S. Fiorucci, 2013, Marine drugs.

New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei.

G. Bifulco, W. Gerwick, R. Riccio, 2014, Organic letters.

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Simona De Vita, Gianluigi Lauro, Maria Giovanna Chini, 2020, RSC advances.

Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics.

G. Bifulco, R. Riccio, M. Turco, 2018, Chemical communications.

Hyalachelins A—C, Unusual Siderophores Isolated from the Terrestrial Myxobacterium Hyalangium minutum.

G. Bifulco, G. Lauro, A. Plaza, 2015 .

Phytochemical Analysis of the Methanolic Extract and Essential Oil from Leaves of Industrial Hemp Futura 75 Cultivar: Isolation of a New Cannabinoid Derivative and Biological Profile Using Computational Approaches

G. Bifulco, C. Finamore, G. Saviano, 2022, Plants.

Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation

Maria T. Potenza, G. Bifulco, O. Werz, 2022, Molecules.

New TRPM8 blockers exert anticancer activity over castration-resistant prostate cancer models.

G. Bifulco, A. Bertamino, I. Gomez-Monterrey, 2022, European journal of medicinal chemistry.

Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A₂, cyclooxygenases, lipoxygenase and proinflammatory cytokines.

G. Bifulco, S. N. Bukhari, M. Amjad, 2014, Bioorganic & medicinal chemistry.

Structural Refinement of 2,4-Thiazolidinedione Derivatives as New Anticancer Agents Able to Modulate the BAG3 Protein

G. Bifulco, S. Terracciano, I. Bruno, 2022, Molecules.

Identification of 2,4,5-trisubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one-based small molecules as selective BRD9 binders.

G. Bifulco, S. Terracciano, I. Bruno, 2022, European journal of medicinal chemistry.

Protein Preparation Automatic Protocol for High-Throughput Inverse Virtual Screening: Accelerating the Target Identification by Computational Methods

Simona De Vita, Gianluigi Lauro, Dafne Ruggiero, 2019, J. Chem. Inf. Model..

Scabiosa atropurpurea: A rich source of iridoids with α-glucosidase inhibitory activity evaluated by in vitro and in silico studies.

G. Bifulco, G. Lauro, M. Masullo, 2022, Phytochemistry.

DFT/NMR Approach for the Configuration Assignment of Groups of Stereoisomers by the Combination and Comparison of Experimental and Predicted Sets of Data

G. Bifulco, R. Riccio, G. Lauro, 2020, The Journal of organic chemistry.

Corylus avellana: A Source of Diarylheptanoids With α-Glucosidase Inhibitory Activity Evaluated by in vitro and in silico Studies

G. Bifulco, G. Lauro, M. Masullo, 2022, Frontiers in Plant Science.

Cyclic Diarylheptanoids from Corylus avellana Green Leafy Covers: Determination of Their Absolute Configurations and Evaluation of Their Antioxidant and Antimicrobial Activities.

G. Bifulco, G. Lauro, M. Masullo, 2017, Journal of natural products.

Chemistry and Selective Tumor Cell Growth Inhibitory Activity of Polyketides from the South China Sea Sponge Plakortis sp.

G. Bifulco, R. Riccio, Hua Tang, 2017, Marine drugs.

Immunomodulatory Biscembranoids and Assignment of Their Relative and Absolute Configurations: Data Set Modulation in the Density Functional Theory/Nuclear Magnetic Resonance Approach.

G. Bifulco, R. Riccio, A. Mándi, 2019, Journal of natural products.

In Silico, In Vitro and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

G. Bifulco, O. Werz, A. Koeberle, 2022, Biomolecules.

Discovery of a Secalonic Acid Derivative from Aspergillus aculeatus, an Endophyte of Rosa damascena Mill., Triggers Apoptosis in MDA-MB-231 Triple Negative Breast Cancer Cells

G. Bifulco, A. Chaubey, Shashank K Singh, 2020, ACS omega.

9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain

G. Bifulco, P. Filippakopoulos, S. Picaud, 2015, Journal of medicinal chemistry.

Identification of an indol-based multi-target kinase inhibitor through phenotype screening and target fishing using inverse virtual screening approach.

G. Bifulco, A. Bertamino, I. Gomez-Monterrey, 2019, European journal of medicinal chemistry.

Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells.

G. Bifulco, R. Cotugno, F. Dal Piaz, 2013, Journal of proteomics.

Discovery of noscapine derivatives as potential β-tubulin inhibitors.

G. Bifulco, P. Salehi, S. Terracciano, 2020, Bioorganic & medicinal chemistry letters.

Target identification by structure-based computational approaches: recent advances and perspectives.

G. Bifulco, G. Lauro, Simona De Vita, 2023, Bioorganic & medicinal chemistry letters.

Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening.

G. Bifulco, E. Novellino, O. Werz, 2017, European journal of medicinal chemistry.

Insights into the Ligand Binding to Bromodomain-Containing Protein 9 (BRD9): A Guide to the Selection of Potential Binders by Computational Methods

G. Bifulco, G. Lauro, Simona De Vita, 2021, Molecules.

Giffonins J-P, Highly Hydroxylated Cyclized Diarylheptanoids from the Leaves of Corylus avellana Cultivar "Tonda di Giffoni".

G. Bifulco, G. Lauro, M. Masullo, 2015, Journal of natural products.

Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer

G. Bifulco, G. Sbardella, A. Tosco, 2017, Scientific Reports.

Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors

G. Bifulco, O. Werz, S. Terracciano, 2022, ACS medicinal chemistry letters.

Isolation, Synthesis And Structure Determination Of Cannabidiol Derivatives And Their Cytotoxic Activities

G. Bifulco, Yedukondalu Nalli, Asif Ali, 2019, Natural product research.

Anti-inflammatory trends of new benzimidazole derivatives.

G. Bifulco, N. Rahman, S. N. Bukhari, 2016, Future medicinal chemistry.

Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization

G. Bifulco, A. Bertamino, I. Gomez-Monterrey, 2021, European Journal of Medicinal Chemistry.

Introducing structure-based three-dimensional pharmacophore models for accelerating the discovery of selective BRD9 binders.

G. Bifulco, S. Terracciano, I. Bruno, 2021, Bioorganic chemistry.

Ring-Fused Cyclic Aminals from Tetrahydro-β-carboline-Based Dipeptide Compounds.

G. Bifulco, A. Bertamino, I. Gomez-Monterrey, 2017, Journal of Organic Chemistry.

Exploration of TRPM8 Binding Sites by β-Carboline-Based Antagonists and Their In Vitro Characterization and In Vivo Analgesic Activities

G. Bifulco, A. Bertamino, I. Gomez-Monterrey, 2020, Journal of medicinal chemistry.

Reranking Docking Poses Using Molecular Simulations and Approximate Free Energy Methods

Gianni De Fabritiis, Matt J. Harvey, Simone Fulle, 2014, J. Chem. Inf. Model..

2-Substituted 1,5-benzothiazepine-based HDAC inhibitors exert anticancer activities on human solid and acute myeloid leukemia cell lines.

G. Bifulco, A. Nebbioso, S. Terracciano, 2023, Bioorganic & medicinal chemistry.