D. Sleat

发表

Mutational analysis of the tobacco mosaic virus 5'-leader for altered ability to enhance translation.

P. Turner, T. Wilson, D. Gallie, 1988, Nucleic acids research.

Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome*

Nan Wang, Jinchuan Xing, J. Everett, 2016, Molecular & Cellular Proteomics.

A comparison of eukaryotic viral 5'-leader sequences as enhancers of mRNA expression in vivo.

P. Turner, T. Wilson, D. Gallie, 1987, Nucleic acids research.

A Mouse Model of Classical Late-Infantile Neuronal Ceroid Lipofuscinosis Based on Targeted Disruption of the CLN2 Gene Results in a Loss of Tripeptidyl-Peptidase I Activity and Progressive Neurodegeneration

R. Sidman, Q. Mao, B. Davidson, 2004, The Journal of Neuroscience.

Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain.

R. Jenkins, K. Reuhl, G. Sarkar, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Ligand Binding Specificities of the Two Mannose 6-Phosphate Receptors*

D. Sleat, P. Lobel, 1997, The Journal of Biological Chemistry.

Mouse mutants lacking the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor are impaired in lysosomal enzyme transport: comparison of cation-independent and cation-dependent mannose 6-phosphate receptor-deficient mice.

D. Sleat, P. Lobel, T. Ludwig, 1998, The Biochemical journal.

Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis.

R. Donnelly, D. Sleat, P. Lobel, 1997, Science.

Identification of Sites of Mannose 6-Phosphorylation on Lysosomal Proteins*

D. Sleat, Meiqian Qian, Haiyan Zheng, 2006, Molecular & Cellular Proteomics.

Proteomic Analysis of Brain and Cerebrospinal Fluid from the Three Major Forms of Neuronal Ceroid Lipofuscinosis Reveals Potential Biomarkers.

Caifeng Zhao, K. Sims, D. Sleat, 2017, Journal of proteome research.

Tripeptidyl Peptidase I

D. Sleat, P. Lobel, I. Sohar, 2013 .

The human urine mannose 6-phosphate glycoproteome.

D. Sleat, Haiyan Zheng, P. Lobel, 2007, Biochimica et biophysica acta.

Rat Brain Contains High Levels of Mannose-6-phosphorylated Glycoproteins Including Lysosomal Enzymes and Palmitoyl-Protein Thioesterase, an Enzyme Implicated in Infantile Neuronal Lipofuscinosis*

J. Majercak, D. Sleat, P. Lobel, 1996, The Journal of Biological Chemistry.

alpha-Glucosidase and N-acetylglucosamine-6-sulphatase are the major mannose-6-phosphate glycoproteins in human urine.

S. Kraus, D. Sleat, P. Lobel, 1997, The Biochemical journal.

Loss of Niemann-Pick C1 or C2 Protein Results in Similar Biochemical Changes Suggesting That These Proteins Function in a Common Lysosomal Pathway

M. Jadot, D. Sleat, P. Lobel, 2011, PloS one.

Mutational analysis of the defective protease in classic late-infantile neuronal ceroid lipofuscinosis, a neurodegenerative lysosomal storage disorder.

T. Lerner, P. Uldall, R. Donnelly, 1999, American journal of human genetics.

Comparative Analysis of Quantitative Mass Spectrometric Methods for Subcellular Proteomics.

Caifeng Zhao, M. Jadot, D. Sleat, 2020, Journal of proteome research.

Genetic modulation of apoptotic pathways fails to alter disease course in tripeptidyl-peptidase 1 deficient mice

O. Bernard, D. Sleat, P. Lobel, 2009, Neuroscience Letters.

Intraventricular enzyme replacement improves disease phenotypes in a mouse model of late infantile neuronal ceroid lipofuscinosis.

B. Davidson, J. Cooper, Seng H. Cheng, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Niemann-Pick disease type C: spectrum of HE1 mutations and genotype/phenotype correlations in the NPC2 group.

K. Higaki, D. Sleat, P. Lobel, 2001, American journal of human genetics.

A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration

M. Baumann, D. Sleat, P. Lobel, 2000, The EMBO journal.

Intracranial Delivery of CLN2 Reduces Brain Pathology in a Mouse Model of Classical Late Infantile Neuronal Ceroid Lipofuscinosis

R. Crystal, Q. Mao, B. Davidson, 2006, The Journal of Neuroscience.

Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis.

D. Sleat, P. Lobel, C. Pham, 2008, The Biochemical journal.

Structural organization and sequence of CLN2, the defective gene in classical late infantile neuronal ceroid lipofuscinosis.

R. Donnelly, D. Sleat, P. Lobel, 1998, Genomics.

A Method to Estimate the Distribution of Proteins across Multiple Compartments Using Data from Quantitative Proteomics Subcellular Fractionation Experiments.

D. Sleat, D. Moore, P. Lobel, 2022, Journal of proteome research.

Characterisation of the 5'-leader sequence of tobacco mosaic virus RNA as a general enhancer of translation in vitro.

M. Bevan, P. Turner, T. Wilson, 1987, Gene.

Do mammalian NPC1 and NPC2 play a role in intestinal cholesterol absorption?

Ann M Stock, D. Sleat, P. Lobel, 2007, The Biochemical journal.

Selective encapsidation of CAT gene transcripts in TMV-infected transgenic tobacco inhibits CAT synthesis.

T. Wilson, D. Sleat, K. Plaskitt, 1988, Virology.

Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins

M. Jadot, M. Lecocq, D. Sleat, 2008, Proceedings of the National Academy of Sciences.

Timing of therapeutic intervention determines functional and survival outcomes in a mouse model of late infantile batten disease.

B. Davidson, R. Scheule, L. Shihabuddin, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Identification of HE1 as the second gene of Niemann-Pick C disease.

R. Wattiaux, M. Jadot, D. Sleat, 2000, Science.

Large-volume intrathecal enzyme delivery increases survival of a mouse model of late infantile neuronal ceroid lipofuscinosis.

Lingling Wang, D. Sleat, P. Lobel, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Restricted replication of vesicular stomatitis virus in T lymphocytes is coincident with a deficiency in a cellular protein kinase required for viral transcription.

S. Gautam, A. Banerjee, D. Sleat, 1992, The Journal of general virology.

Transcriptional activity and mutational analysis of recombinant vesicular stomatitis virus RNA polymerase

A. Banerjee, D. Sleat, 1993, Journal of virology.

Proteomics Analysis of Serum from Mutant Mice Reveals Lysosomal Proteins Selectively Transported by Each of the Two Mannose 6-Phosphate Receptors*S

D. Sleat, Meiqian Qian, Haiyan Zheng, 2008, Molecular & Cellular Proteomics.

Satellite RNAs of plant viruses: structures and biological effects

P. Palukaitis, M. Roossinck, D. Sleat, 1992 .

Specific alterations in levels of mannose 6-phosphorylated glycoproteins in different neuronal ceroid lipofuscinoses.

D. Sleat, P. Lobel, I. Sohar, 1998, The Biochemical journal.

Aminoglycoside-mediated suppression of nonsense mutations in late infantile neuronal ceroid lipofuscinosis.

D. Sleat, P. Lobel, I. Sohar, 2001, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

Biochemical Characterization of a Lysosomal Protease Deficient in Classical Late Infantile Neuronal Ceroid Lipofuscinosis (LINCL) and Development of an Enzyme‐Based Assay for Diagnosis and Exclusion of LINCL in HUman Specimens and Animal Models

M. Jadot, D. Sleat, P. Lobel, 1999, Journal of neurochemistry.

Analysis of large-scale whole exome sequencing data to determine the prevalence of genetically-distinct forms of neuronal ceroid lipofuscinosis.

Jinchuan Xing, Yeting Zhang, D. Sleat, 2016, Gene.

Prenatal testing for late infantile neuronal ceroid lipofuscinosis

R. Donnelly, E. Berry-Kravis, D. Sleat, 2000, Annals of neurology.

Glial fibrillary acidic protein is elevated in the lysosomal storage disease classical late-infantile neuronal ceroid lipofuscinosis, but is not a component of the storage material.

M. Jadot, D. Sleat, P. Lobel, 2010, The Biochemical journal.

Analysis of Brain and Cerebrospinal Fluid from Mouse Models of the Three Major Forms of Neuronal Ceroid Lipofuscinosis Reveals Changes in the Lysosomal Proteome*

Caifeng Zhao, D. Sleat, Haiyan Zheng, 2019, Molecular & Cellular Proteomics.

Lysosomal proteomics and disease

M. Jadot, D. Sleat, P. Lobel, 2007, Proteomics. Clinical applications.

Lysosomal protein thermal stability does not correlate with cellular half-life: Global observations and a case study of tripeptidyl-peptidase 1.

Vikas Nanda, D. Sleat, P. Lobel, 2020, The Biochemical journal.

Lysosomal enzyme tripeptidyl peptidase 1 plays a role in degradation of beta amyloid fibrils

F. Maxfield, D. Sleat, P. Lobel, 2019, bioRxiv.

Inducible transgenic expression of tripeptidyl peptidase 1 in a mouse model of late-infantile neuronal ceroid lipofuscinosis

D. Sleat, P. Lobel, Mukarram El-Banna, 2018, PloS one.

A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism.

W. Banks, K. Reuhl, R. Daneman, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease

J. Millonig, D. Sleat, D. Moore, 2017, Molecular therapy. Methods & clinical development.

Systemic Administration of Tripeptidyl Peptidase I in a Mouse Model of Late Infantile Neuronal Ceroid Lipofuscinosis: Effect of Glycan Modification

D. Sleat, P. Lobel, Y. Meng, 2012, PloS one.

Mass Spectrometry-based Protein Profiling to Determine the Cause of Lysosomal Storage Diseases of Unknown Etiology*

Caifeng Zhao, K. Sims, D. Sleat, 2009, Molecular & Cellular Proteomics.

Proteomics of the lysosome.

D. Sleat, P. Lobel, T. Lübke, 2009, Biochimica et biophysica acta.

Residual levels of tripeptidyl-peptidase I activity dramatically ameliorate disease in late-infantile neuronal ceroid lipofuscinosis.

S. Walkley, D. Sleat, P. Lobel, 2008, Molecular genetics and metabolism.

Demonstration of Lysosomal Localization for the Mammalian Ependymin-related Protein Using Classical Approaches Combined with a Novel Density Shift Method*

J. Pintar, M. Jadot, D. Sleat, 2006, Journal of Biological Chemistry.

The human brain mannose 6‐phosphate glycoproteome: A complex mixture composed of multiple isoforms of many soluble lysosomal proteins

Hong Li, D. Sleat, P. Lobel, 2005, Proteomics.

In vivo uncoating and efficient expression of foreign mRNAs packaged in TMV-like particles.

P. Turner, T. Wilson, D. Gallie, 1987, Science.

Satellite RNAs of plant viruses: structures and biological effects.

P. Palukaitis, M. Roossinck, D. Sleat, 1992, Microbiological reviews.

A single nucleotide change within a plant virus satellite RNA alters the host specificity of disease induction.

P. Palukaitis, D. Sleat, 1992, The Plant journal : for cell and molecular biology.

Mapping functional domains in cucumber mosaic virus and its satellite RNAs

P. Palukaitis, M. Roossinck, D. Sleat, 1991 .

Induction of tobacco chlorosis by certain cucumber mosaic virus satellite RNAs is specific to subgroup II helper strains.

P. Palukaitis, D. Sleat, 1990, Virology.

The 5'-leader sequence of tobacco mosaic virus RNA enhances the expression of foreign gene transcripts in vitro and in vivo.

J W Watts, P. Turner, T. Wilson, 1987, Nucleic acids research.

Identification and Validation of Mannose 6-Phosphate Glycoproteins in Human Plasma Reveal a Wide Range of Lysosomal and Non-lysosomal Proteins*S

Hong Li, D. Sleat, Haiyan Zheng, 2006, Molecular & Cellular Proteomics.

Structure and Function of the Vesicular Stomatitis Virus RNA-Dependent RNA Polymerase

S. Barik, A. Banerjee, D. Sleat, 1993 .

Using whole‐exome sequencing to investigate the genetic bases of lysosomal storage diseases of unknown etiology

Jinchuan Xing, Xiuping Liu, R. Donnelly, 2017, Human mutation.

Extending the Mannose 6-Phosphate Glycoproteome by High Resolution/Accuracy Mass Spectrometry Analysis of Control and Acid Phosphatase 5-Deficient Mice*

D. Sleat, Haiyan Zheng, D. Moore, 2013, Molecular & Cellular Proteomics.

The mannose 6-phosphate glycoprotein proteome.

D. Sleat, Haiyan Zheng, D. Moore, 2008, Journal of proteome research.

Elevated levels of tripeptidyl peptidase 1 do not ameliorate pathogenesis in a mouse model of Alzheimer disease

F. Maxfield, D. Sleat, P. Lobel, 2022, Neurobiology of Aging.

Potential Pitfalls and Solutions for Use of Fluorescent Fusion Proteins to Study the Lysosome

Vikas Nanda, Douglas Pike, D. Sleat, 2014, PloS one.

Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport.

M. Shen, S. Walkley, D. Sleat, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Proteomic analysis of mouse models of Niemann‐Pick C disease reveals alterations in the steady‐state levels of lysosomal proteins within the brain

D. Sleat, Haiyan Zheng, D. Moore, 2012, Proteomics.

Subcellular Localization of Mannose 6-Phosphate Glycoproteins in Rat Brain*

J. Pintar, R. Wattiaux, M. Jadot, 1999, The Journal of Biological Chemistry.

Studies on the mechanism of translational enhancement by the 5'-leader sequence of tobacco mosaic virus RNA.

P. Turner, T. Wilson, D. Sleat, 1988, European journal of biochemistry.

Packaging of recombinant RNA molecules into pseudovirus particles directed by the origin-of-assembly sequence from tobacco mosaic virus RNA.

J. Finch, P. Butler, P. Turner, 1986, Virology.

Mapping determinants within cucumber mosaic virus and its satellite RNA for the induction of necrosis in tomato plants.

P. Palukaitis, L. Zhang, D. Sleat, 1994, Molecular plant-microbe interactions : MPMI.

Nucleotide sequence of a new satellite RNA of cucumber mosaic virus.

D. Sleat, 1990, Nucleic acids research.

Site-directed mutagenesis of a plant viral satellite RNA changes its phenotype from ameliorative to necrogenic.

P. Palukaitis, D. Sleat, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Classification of Subcellular Location by Comparative Proteomic Analysis of Native and Density-shifted Lysosomes*

M. Jadot, D. Sleat, Haiyan Zheng, 2011, Molecular & Cellular Proteomics.

Increased levels of glycoproteins containing mannose 6-phosphate in human breast carcinomas.

K. Raška, D. Sleat, P. Lobel, 1995, Cancer research.

Selective recovery of foreign gene transcripts as virus-like particles in TMV-infected transgenic tobaccos.

R. Beachy, P. Turner, T. Wilson, 1988, Nucleic acids research.

A mouse mutant deficient in both neuronal ceroid lipofuscinosis‐associated proteins CLN3 and TPP1

J. Cooper, D. Sleat, P. Lobel, 2023, Journal of inherited metabolic disease.

Cerebrospinal Fluid Protein Biomarker Discovery in CLN3.

F. Porter, D. Sleat, Haiyan Zheng, 2023, Journal of proteome research.

Congenital ovine neuronal ceroid lipofuscinosis--a cathepsin D deficiency with increased levels of the inactive enzyme.

M. Baumann, R. Donnelly, D. Sleat, 2001, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

Effects of the 5′-Leader Sequence of Tobacco Mosaic Virus RNA, or Derivatives Thereof, on Foreign mRNA and Native Viral Gene Expression

A. Wilson, H. Trachsel, D. Sleat, 1990 .

Immunogold labeling locates the site of disassembly and transient gene expression of tobacco mosaic virus-like pseudovirus particles in vivo

T. Wilson, D. Gallie, J. Shaw, 1988 .

The mannose 6-phosphate glycoprotein proteome.

D. Sleat, Haiyan Zheng, D. Moore, 2008, Journal of proteome research.