E. Kostewicz

发表

Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.

D. Steinhilber, M. Schubert-Zsilavecz, M. Wurglics, 2013, Future medicinal chemistry.

Predicting the precipitation of poorly soluble weak bases upon entry in the small intestine

J. Dressman, T. Bock, E. Kostewicz, 2004, The Journal of pharmacy and pharmacology.

Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate.

B. Griffin, J. Dressman, M. Kuentz, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs.

Mark McAllister, René Holm, Christel A. S. Bergström, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In vitro models for the prediction of in vivo performance of oral dosage forms.

Anette Müllertz, Patrick Augustijns, Bertil Abrahamsson, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review

J. Dressman, N. Fotaki, E. Kostewicz, 2018, The Journal of pharmacy and pharmacology.

Model-Based Analysis of Biopharmaceutic Experiments To Improve Mechanistic Oral Absorption Modeling: An Integrated in Vitro in Vivo Extrapolation Perspective Using Ketoconazole as a Model Drug.

N. Patel, M. Jamei, E. Kostewicz, 2017, Molecular pharmaceutics.

Evaluating the predictability of the in vitro transfer model and in vivo rat studies as a surrogate to investigate the supersaturation and precipitation behaviour of different Albendazole formulations for humans

R. Holm, E. Kostewicz, Aaron Ruff, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Combining biorelevant in vitro and in silico tools to investigate the in vivo performance of the amorphous solid dispersion formulation of etravirine in the fed state.

J. Dressman, M. Kuentz, R. Holm, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Trypanothione Reductase High-Throughput Screening Campaign Identiﬁes Novel Classes of Inhibitors with Antiparasitic Activity (cid:1) †

A. Fairlamb, J. Baell, G. Holloway, 2009 .

Examination of two sustained release nifedipine preparations in humans and in pigs

L. Sansom, E. Kostewicz, T. Kuchel, 1996 .

Forecasting the Oral Absorption Behavior of Poorly Soluble Weak Bases Using Solubility and Dissolution Studies in Biorelevant Media

J. Dressman, E. Kostewicz, U. Brauns, 2002, Pharmaceutical Research.

Analysis of the enhanced oral bioavailability of fenofibrate lipid formulations in fasted humans using an in vitro-in silico-in vivo approach.

Jennifer B Dressman, Edmund S Kostewicz, J. Dressman, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Dissolution media simulating the intralumenal composition of the small intestine: physiological issues and practical aspects

Christos Reppas, Erika S. Stippler, Christian Leuner, 2004, The Journal of pharmacy and pharmacology.

PBPK models for the prediction of in vivo performance of oral dosage forms.

Martin Bergstrand, Xavier Pepin, Erik Sjögren, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Can the USP paddle method be used to represent in‐vivo hydrodynamics?

Bertil Abrahamsson, Jennifer B Dressman, Edmund Kostewicz, 2003, The Journal of pharmacy and pharmacology.

The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review

Niklas J. Koehl, B. Griffin, Joseph P O'Shea, 2019, The Journal of pharmacy and pharmacology.

Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth.

David M. Shackleford, T. Gonda, S. Charman, 2010, Journal of medicinal chemistry.

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

David M. Shackleford, D. Chalmers, D. Grobelny, 2011, Journal of medicinal chemistry.

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

Anette Müllertz, Filippos Kesisoglou, Christos Reppas, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

In vitro methods to assess drug precipitation in the fasted small intestine – a PEARRL review

Martin Kuentz, Christos Reppas, Jennifer B Dressman, 2018, The Journal of pharmacy and pharmacology.

Combining biorelevant in vitro and in silico tools to simulate and better understand the in vivo performance of a nano-sized formulation of aprepitant in the fasted and fed states.

N. Patel, J. Dressman, M. Kuentz, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Trypanothione Reductase High-Throughput Screening Campaign Identifies Novel Classes of Inhibitors with Antiparasitic Activity

A. Fairlamb, J. Baell, G. Holloway, 2009, Antimicrobial Agents and Chemotherapy.

Prediction of Ketoconazole absorption using an updated in vitro transfer model coupled to physiologically based pharmacokinetic modelling

Tom Fiolka, Edmund S Kostewicz, E. Kostewicz, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base Albendazole and its main metabolite Albendazole Sulfoxide.

M. Bolger, E. Kostewicz, Maximo Pettarin, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Jennifer Dressman - 40 years of oral drug absorption.

B. Abrahamsson, C. Reppas, E. Kostewicz, 2021, Journal of pharmaceutical sciences.

Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments.

Edmund S Kostewicz, B. Griffin, C. O’Driscoll, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Physiological Considerations and In Vitro Strategies for Evaluating the Influence of Food on Drug Release from Extended-Release Formulations

M. Koziolek, E. Kostewicz, M. Vertzoni, 2018, AAPS PharmSciTech.

In Vitro Biopredictive Methods: A Workshop Summary Report.

Amitava Mitra, Sandra Suarez-Sharp, Erik Sjögren, 2020, Journal of pharmaceutical sciences.

Influence of Hydrodynamics and Particle Size on the Absorption of Felodipine in Labradors

J. Dressman, A. Ungell, B. Abrahamsson, 2004, Pharmaceutical Research.

Physiological Considerations and In Vitro Strategies for Evaluating the Influence of Food on Drug Release from Extended-Release Formulations

M. Koziolek, E. Kostewicz, M. Vertzoni, 2018, AAPS PharmSciTech.

LEVERAGING THE USE OF IN VITRO AND COMPUTATIONAL METHODS TO SUPPORT THE DEVELOPMENT OF ENABLING ORAL DRUG PRODUCTS: AN INPHARMA COMMENTARY.

B. Griffin, M. Kuentz, Cordula Stillhart, 2023, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs.

Christel A. S. Bergström, Kung-I Feng, P. Artursson, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.

David M. Shackleford, D. Chalmers, D. Grobelny, 2011, Journal of medicinal chemistry.