M. Estacion

发表

Voltage-clamp and current-clamp recordings from mammalian DRG neurons

A. M. Rush, S. Dib-Hajj, S. Waxman, 2009, Nature Protocols.

Nonlinear effects of hyperpolarizing shifts in activation of mutant Nav1.7 channels on resting membrane potential.

S. Waxman, M. Estacion, 2017, Journal of neurophysiology.

NaV1.7 Gain-of-Function Mutations as a Continuum: A1632E Displays Physiological Changes Associated with Erythromelalgia and Paroxysmal Extreme Pain Disorder Mutations and Produces Symptoms of Both Disorders

S. Dib-Hajj, S. Waxman, J. Drenth, 2008, The Journal of Neuroscience.

Human TRPC6 expressed in HEK 293 cells forms non‐selective cation channels with limited Ca2+ permeability

M. Estacion, S. W. Jones, W. Schilling, 2006, The Journal of physiology.

Association of Immunophilins with Mammalian TRPC Channels*

M. Estacion, W. Schilling, M. Goel, 2004, Journal of Biological Chemistry.

Mutations causing achondroplasia and thanatophoric dysplasia alter bFGF-induced calcium signals in human diploid fibroblasts.

J. Gargus, M. Estacion, H. Nguyen, 1997, Human molecular genetics.

Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy

H. Smeets, S. Dib-Hajj, S. Waxman, 2020, Brain : a journal of neurology.

Maitotoxin-induced cell death cascade in bovine aortic endothelial cells: divalent cation specificity and selectivity.

M. Estacion, W. Schilling, Brian Wisnoskey, 2004, American journal of physiology. Cell physiology.

Blockade of maitotoxin-induced endothelial cell lysis by glycine and L-alanine.

M. Estacion, W. Schilling, W. Sinkins, 2003, American journal of physiology. Cell physiology.

A Novel Gain-of-Function Nav1.9 Mutation in a Child With Episodic Pain

S. Dib-Hajj, S. Waxman, I. Kurth, 2019, Front. Neurosci..

The Novel Activity of Carbamazepine as an Activation Modulator Extends from NaV1.7 Mutations to the NaV1.8-S242T Mutant Channel from a Patient with Painful Diabetic Neuropathy

David L. Bennett, Andreas C. Themistocleous, S. Dib-Hajj, 2018, Molecular Pharmacology.

Human Na(v)1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons.

S. Dib-Hajj, S. Waxman, M. Estacion, 2015, Journal of neurophysiology.

Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy.

S. Dib-Hajj, S. Waxman, G. Lauria, 2014, Brain : a journal of neurology.

Nav1.9, G‐proteins, and nociceptors

S. Waxman, M. Estacion, 2008, The Journal of physiology.

Maitotoxin-induced membrane blebbing and cell death in bovine aortic endothelial cells

M. Estacion, W. Schilling, 2001, BMC Physiology.

Ca2+ influx via T-type channels modulates PDGF-induced replication of mouse fibroblasts.

M. Estacion, L. Mordan, Z. Wang, 1993, The American journal of physiology.

Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Nav1.7 mutant channel

Yang Zhang, S. Dib-Hajj, S. Waxman, 2012, Nature Communications.

Expression of voltage-gated calcium channels correlates with PDGF-stimulated calcium influx and depends upon cell density in C3H 10T1/2 mouse fibroblasts.

M. Estacion, L. Mordan, 1993, Cell calcium.

Competence induction by PDGF requires sustained calcium influx by a mechanism distinct from storage-dependent calcium influx.

M. Estacion, L. Mordan, 1993, Cell calcium.

Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability

S. Dib-Hajj, S. Waxman, M. Estacion, 2010, Molecular pain.

Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability

S. Dib-Hajj, S. Waxman, M. Estacion, 2022, British journal of pharmacology.

Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of NaV1.7

S. Dib-Hajj, S. Waxman, G. Lauria, 2011, Molecular pain.

Maitotoxin activates a nonselective cation channel and a P2Z/P2X(7)-like cytolytic pore in human skin fibroblasts.

M. Estacion, W. Schilling, W. Sinkins, 1999, The American journal of physiology.

Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable

S. Dib-Hajj, S. Waxman, M. Lawden, 2008, Molecular pain.

Activation of Human TRPC6 Channels by Receptor Stimulation*

J. Westwick, M. Gosling, M. Estacion, 2004, Journal of Biological Chemistry.

Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore

H. Smeets, S. Dib-Hajj, S. Waxman, 2021, Frontiers in Pharmacology.

ResearchEffects of ranolazine on wild-type and mutant hNav 1 . 7 channels and on DRG neuron excitability

S. Dib-Hajj, S. Waxman, M. Estacion, 2015 .

Molecular Architecture of a Sodium Channel S6 Helix

S. Dib-Hajj, S. Waxman, M. Estacion, 2013, The Journal of Biological Chemistry.

Molecular architecture of a sodium channel S 6 helix : radial tuning of the Nav 1 . 7 activation gate

S. Dib-Hajj, S. Waxman, M. Estacion, 2013 .

Maitotoxin converts the plasmalemmal Ca(2+) pump into a Ca(2+)-permeable nonselective cation channel.

D. Kunze, V. Prasad, G. Shull, 2009, American journal of physiology. Cell physiology.

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

S. Dib-Hajj, S. Waxman, G. Lauria, 2012, Annals of neurology.

Acute electrophysiological responses of bradykinin‐stimulated human fibroblasts.

M. Estacion, 1991, The Journal of physiology.

A sodium channel gene SCN9A polymorphism that increases nociceptor excitability

S. Dib-Hajj, S. Waxman, T. Harty, 2009, Annals of neurology.

Ca2+ toxicity due to reverse Na+/Ca2+ exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav1.7 mutation.

S. Waxman, J. A. Black, G. Lauria, 2015, Journal of neurophysiology.

Ca 2 toxicity due to reverse Na / Ca 2 exchange contributes to degeneration of neurites of DRG neurons induced by a neuropathy-associated Nav 1 . 7 mutation

S. Waxman, J. A. Black, G. Lauria, 2015 .

Calcium is permeable through a maitotoxin-activated nonselective cation channel in mouse L cells.

J. Gargus, M. Estacion, H. Nguyen, 1996, The American journal of physiology.

Palytoxin-induced cell death cascade in bovine aortic endothelial cells.

M. Estacion, W. Schilling, W. Sinkins, 2006, American journal of physiology. Cell physiology.

Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy

Stef van Lieshout, M. Hammer, S. Dib-Hajj, 2014, Epilepsy Research.

A novel Nav1.7 mutation producing carbamazepine‐responsive erythromelalgia

S. Dib-Hajj, S. Waxman, Sean W. Taylor, 2009, Annals of neurology.

Functional expression of TrpC1: a human homologue of the Drosophila Trp channel.

M. Estacion, W. Schilling, W. Sinkins, 1998, The Biochemical journal.

Sodium Channels Contribute to Degeneration of Dorsal Root Ganglion Neurites Induced by Mitochondrial Dysfunction in an In Vitro Model of Axonal Injury

S. Waxman, Insil Kim, M. Estacion, 2013, The Journal of Neuroscience.

A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy

M. Hammer, S. Dib-Hajj, S. Waxman, 2014, Neurobiology of Disease.

Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons

S. Waxman, M. Estacion, F. Dib-Hajj, 2021, Scientific Reports.

KCNQ variants and pain modulation: a missense variant in Kv7.3 contributes to pain resilience

S. Dib-Hajj, S. Waxman, M. Estacion, 2021, Brain communications.

NaV1.7 as a Pharmacogenomic Target for Pain: Moving Toward Precision Medicine.

S. Dib-Hajj, S. Waxman, M. Estacion, 2018, Trends in pharmacological sciences.

A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons

S. Dib-Hajj, S. Waxman, M. Estacion, 2010, Experimental Neurology.

Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial

S. Waxman, D. Derjean, G. Cruccu, 2017, The Lancet Neurology.

Maitotoxin activates a nonselective cation channel and a P2Z/P2X7-like cytolytic pore in human skin fibroblasts.

M. Estacion, W. Schilling, W. Sinkins, 1999, American journal of physiology. Cell physiology.

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Sulayman D. Dib-Hajj, Stephen G. Waxman, R. Ian Storer, 2016, PloS one.

Dexpramipexole blocks Nav1.8 sodium channels and provides analgesia in multiple nociceptive and neuropathic pain models.

S. Dib-Hajj, S. Waxman, M. Estacion, 2019, Pain.

Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Nav1.7 mutation that massively hyperpolarizes activation

S. Dib-Hajj, S. Waxman, S. Walker, 2018, Scientific Reports.

The response of Na(V)1.3 sodium channels to ramp stimuli: multiple components and mechanisms.

S. Waxman, M. Estacion, 2013, Journal of neurophysiology.

A gain-of-function sodium channel β2-subunit mutation in painful diabetic neuropathy

S. Dib-Hajj, S. Waxman, G. Lauria, 2019, Molecular pain.

Inhibition of voltage-dependent Na+ current in cell-fusion hybrids containing activated c-Ha-ras

M. Estacion, 1990, The Journal of Membrane Biology.

Regulation of Drosophila TRPL Channels by Immunophilin FKBP59*

M. Estacion, W. Schilling, R. Garcia, 2001, The Journal of Biological Chemistry.

Regulation of Drosophila transient receptor potential‐like (TrpL) channels by phospholipase C‐dependent mechanisms

M. Estacion, W. Schilling, W. Sinkins, 2001, The Journal of physiology.

Characterization of ion channels seen in subconfluent human dermal fibroblasts.

M. Estacion, 1991, The Journal of physiology.

Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial. Lancet Neurol 2017;

D. Derjean, L. Bendtsen, M. Obermann, 2017 .

Identification and localization of TRPC channels in the rat kidney.

M. Estacion, W. Schilling, Cheng-Di Zuo, 2006, American journal of physiology. Renal physiology.

A 49-residue sequence motif in the C terminus of Nav1.9 regulates trafficking of the channel to the plasma membrane

S. Dib-Hajj, S. Waxman, D. Sizova, 2019, The Journal of Biological Chemistry.

Inhibition of sodium conductance by cannabigerol contributes to a reduction of neuronal dorsal root ganglion excitability

S. Dib-Hajj, S. Waxman, M. Estacion, 2021, bioRxiv.

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling.

S. Dib-Hajj, S. Waxman, A. Apkarian, 2016, JAMA neurology.

PDGF-stimulated calcium influx changes during in vitro cell transformation.

M. Estacion, L. Mordan, 1997, Cellular signalling.

Differential effect of D623N variant and wild-type Nav1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons

S. Dib-Hajj, S. Waxman, M. Estacion, 2013, Brain Research.

A novel gain-of-function Nav1.7 mutation in a carbamazepine-responsive patient with adult-onset painful peripheral neuropathy

S. Dib-Hajj, S. Waxman, M. Estacion, 2018, Molecular pain.

Alternating Electric Fields and Carcinogenesis: A New Paradigm to Avoid Missing the Elephant in the Room

Kim Sh, Daniel J. Clauw, Robert S. Katz, 2015 .

Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability

S. Dib-Hajj, S. Waxman, M. Estacion, 2023, Frontiers in Pharmacology.

A new Nav1.7 mutation in an erythromelalgia patient.

S. Dib-Hajj, S. Waxman, M. Estacion, 2013, Biochemical and biophysical research communications.

Maitotoxin induces biphasic interleukin-1beta secretion and membrane blebbing in murine macrophages.

G. Dubyak, M. Estacion, P. Verhoef, 2004, Molecular pharmacology.

P2X7 Receptor-Dependent Blebbing and the Activation of Rho-Effector Kinases, Caspases, and IL-1β Release1

G. Dubyak, M. Estacion, P. Verhoef, 2003, The Journal of Immunology.

Blockade of maitotoxin-induced oncotic cell death reveals zeiosis

M. Estacion, W. Schilling, 2002, BMC Physiology.

Nav1.7-A1632G Mutation from a Family with Inherited Erythromelalgia: Enhanced Firing of Dorsal Root Ganglia Neurons Evoked by Thermal Stimuli

S. Dib-Hajj, S. Waxman, M. Estacion, 2016, The Journal of Neuroscience.

Sodium Channels, Mitochondria, and Axonal Degeneration in Peripheral Neuropathy.

S. Waxman, M. Estacion, J. Hoeijmakers, 2016, Trends in molecular medicine.

Contribution of sodium channels to lamellipodial protrusion and Rac1 and ERK1/2 activation in ATP‐stimulated microglia

S. Waxman, M. Estacion, H. Ahn, 2014, Glia.

Erratum: Maitotoxin induces biphasic interleukin-1β secretion and membrane blebbing in murine macrophages (Molecular Pharmacology (2004) 66 (909-920))

G. Dubyak, M. Estacion, P. Verhoef, 2004 .

STIMULATION OF DROSOPHILA TRPL BY CAPACITATIVE CA2+ ENTRY

M. Estacion, W. Schilling, W. Sinkins, 1999 .

High-throughput combined voltage-clamp/current-clamp analysis of freshly isolated neurons

S. Dib-Hajj, S. Waxman, M. Estacion, 2023, Cell reports methods.

axons of small dorsal root ganglion neurons in vitro Membrane properties and electrogenesis in the distal

E. Fransén, S. Waxman, R. Carr, 2015 .

Cells: Combined Experimental and Modeling Study Current to Somatic Bursting in CA1 Pyramidal + K Current and M-Type + Contribution of Persistent Na

Y. Yaari, Maarten H. P. Kole, S. Waxman, 2015 .

Can robots patch‐clamp as well as humans? Characterization of a novel sodium channel mutation

S. Dib-Hajj, M. Estacion, L. Tyrrell, 2010, The Journal of physiology.

S. Dib-Hajj, S. Waxman, R. T. Morsche, 2008, The Journal of Neuroscience.

P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release.

G. Dubyak, M. Estacion, W. Schilling, 2003, Journal of immunology.

The response of Na(V)1.3 sodium channels to ramp stimuli: multiple components and mechanisms.

S. Waxman, M. Estacion, 2013, Journal of neurophysiology.

of Membrane Excitability Neurons Participate in Burst Generation and Control Persistent Sodium Currents in Mesencephalic V

G. Mato, B. Rudy, S. H. Chandler, 2015 .

Rostroventrolateral Medulla of the Rat Sodium Currents in Neurons From the

I. Rybak, N. Shevtsova, J. Paton, 2015 .

Release β and IL-1 Caspases , Activation of Rho-Effector Kinases , P 2 X 7 Receptor-Dependent Blebbing and the

G. Dubyak, M. Estacion, W. Schilling, 2003 .

Two independent mouse lines carrying the Nav1.7-I228M gain-of-function variant display DRG neuron hyperexcitability but a minimal pain phenotype.

Nivanthika K. Wimalasena, S. Waxman, C. Woolf, 2020, Pain.