Bruno Boulanger

Jérôme Mantanus, Philippe Hubert, Bruno Boulanger, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

A New Method for Quality by Design Robust Optimization in Liquid Chromatography

Roland Marini Djang'Eing'A, Jérémie Mbinze Kindenge, Benjamin Debrus, 2013 .

The Expected Design Space for analytical methods: a new perspective based on modeling and prediction

Benjamin Debrus, Bruno Boulanger, Pierre Lebrun, 2008 .

Analytical Procedure Validation and the Quality by Design Paradigm

Bruno Boulanger, Pierre Lebrun, Eric Rozet, 2015, Journal of biopharmaceutical statistics.

Design Space for Analytical Methods: Why ? What ? How ?

Benjamin Debrus, Philippe Hubert, Bruno Boulanger, 2015 .

Objectives of validation : the statistical rationale of the SFSTP

Philippe Hubert, Walthère Dewé, Bruno Boulanger, 2001 .

Total error and uncertainty: Friends or foes?

Eric Ziemons, Serge Rudaz, Philippe Hubert, 2011 .

Towards a new age of virtual ADME/TOX and multidimensional drug discovery

Bruno Boulanger, Sean Ekins, Maggie A. Z. Hupcey, 2002, J. Comput. Aided Mol. Des..

Validation of bioanalytical methods using total error

Roland Marini Djang'Eing'A, Serge Rudaz, Bruno Boulanger, 2009 .

Evaluation of decision methodologies for analytical method validation

Serge Rudaz, Philippe Hubert, Bruno Boulanger, 2009 .

Objectives of pre-study validation and decision rules

Philippe Hubert, Patrice Chiap, Walthère Dewé, 2000 .

Objectives and analytical methods and objectives of validation

Philippe Hubert, Patrice Chiap, Walthère Dewé, 2002 .

Validation for analytical methods : reducing the risk of decisions. Tutorial 04

Philippe Hubert, Bruno Boulanger, François Moonen, 2009 .

Chromatographic separation of a pharmaceutical formulation using Design of Experiment and Design Space.

Benjamin Debrus, Philippe Hubert, Bruno Boulanger, 2008 .

Conciliating objectives of analytical methods and objectives of validation : a statistical perspective

Philippe Hubert, Walthère Dewé, Bruno Boulanger, 2006 .

Analyse statistique des résultats de validation de méthodes d’analyse chromatographiques

Philippe Hubert, Walthère Dewé, Bruno Boulanger, 2000 .

Risk management for analytical methods based on the total error concept: Conciliating the objectives of the pre-study and in-study validation phases

Walthère Dewé, Bruno Boulanger, Myriam Maumy-Bertrand, 2007 .

SIMULTANEOUS ESTIMATION OF MEASUREMENT UNCERTAINTY AND IMPLEMENTATION OF CONTROL CHART USING QUALITY CONTROL STANDARDS

Eric Ziemons, Philippe Hubert, Walthère Dewé, 2006 .

Evaluating measurement uncertainty for dioxins in routine analysis by the accuracy profile approach

Bruno Boulanger, Guy Maghuin-Rogister, Philippe Hubert, 2005 .

Design Spaces for analytical methods

Benjamin Debrus, Philippe Hubert, Bruno Boulanger, 2013 .

Development of a new predictive modelling technique to find with confidence equivalence zone and design space of chromatographic analytical methods

Benjamin Debrus, Philippe Hubert, Bruno Boulanger, 2008 .

Statistical analysis of electroencephalograms: independent component analysis of event-related potentials

Bruno Boulanger, Céline Bugli, Philippe Lambert, 2004 .

Prediction-based Design Space as a general concept for drug development... and role for statisticians

Bruno Boulanger, Pierre Lebrun, 2009 .

Simultaneous improvement of the predictive character of the validation data and estimation of measurement uncertainty

Eric Ziemons, Philippe Hubert, Walthère Dewé, 2008 .

Statistical analysis of the validation results: diagnostic or decision tools

Philippe Hubert, Walthère Dewé, Bruno Boulanger, 2002 .

Intégration de la validation dans le concept AQbD

Philippe Hubert, Bruno Boulanger, Pierre Lebrun, 2017 .

A Quality By Design Approach For Longitudinal Quality Attributes

Bruno Boulanger, Pierre Lebrun, Eric Rozet, 2015, Journal of biopharmaceutical statistics.

The use of total error to validate analytical method : examples of applications

Philippe Hubert, Walthère Dewé, Bruno Boulanger, 2004 .

A BAYESIAN PREDICTIVE PROBABILITY CRITERION TO ASSESS ANALYTICAL METHODS VALIDITY

Roland Marini Djang'Eing'A, Eric Ziemons, Philippe Hubert, 2011 .

The Usefulness of Accuracy Profile to Validate Analytical Methods

Philippe Hubert, Walthère Dewé, Bruno Boulanger, 2005 .

Towards a better use of statistics in method validation

Philippe Hubert, Walthère Dewé, Bruno Boulanger, 2004 .

Development of robust analytical methods using design space methodology

Benjamin Debrus, Philippe Hubert, Bruno Boulanger, 2010 .

Use of ICA on HPCL-DAD data and high-order statistics to automatically achieve peak picking

Benjamin Debrus, Philippe Hubert, Bruno Boulanger, 2008 .

Validation of an automated method for the LC determination of atenolol in plasma : application of a new validation strategy

Patrice Chiap, Bruno Boulanger, Jacques Crommen, 1998 .

Guide for validation of analytical procedures

Philippe Hubert, Walthère Dewé, Bruno Boulanger, 2007 .

Evaluating analytical results reliability using a Bayesian probability criterion

Eric Ziemons, Philippe Hubert, Bruno Boulanger, 2010 .

Trial predictions vs. trial simulations in Model-based Drug Development: integrating uncertainties to evaluate the predictive probability of success.

Bruno Boulanger, Pierre Lebrun, Astrid Jullion, 2011 .

Expected Design Space: a Bayesian perspective based on modelling, prediction and multi-criteria decision method

Bruno Boulanger, Pierre Lebrun, 2009 .

A Bayesian Design Space for Analytical Methods Based on Multivariate Models and Predictions

Benjamin Debrus, Pierre Lebrun, Bruno Boulanger, 2013, Journal of biopharmaceutical statistics.

Numerical separation in HPLC-UV-DAD with Independent Component Analysis (ICA) using high order statistics for the automated identification of peaks.

Benjamin Debrus, Philippe Hubert, Bruno Boulanger, 2007 .

RISK MANAGMENT IN THE VALIDATION OF ANALYTICAL METHODS

Jérôme Mantanus, Eric Ziemons, Philippe Hubert, 2010 .

Statistical Modeling in Pharmaceutical Research and Development

Bruno Boulanger, Simona Panunzi, Andrea De Gaetano, 2006 .

Applying statistics recomended by regulatory documents.

Philippe Hubert, Walthère Dewé, Bruno Boulanger, 2006 .

Recent trends in the validation of bioanalytical methods

Philippe Hubert, Patrice Chiap, Walthère Dewé, 2005 .

Developing and optimizing analytical chromatographic method in a Quality by Design environment. Bayesian multi-criteria risk-based Design Space to guarantee future quality.

Roland Marini Djang'Eing'A, Benjamin Debrus, Philippe Hubert, 2010 .

Comparison of three approaches for doubt estimation

Serge Rudaz, Philippe Hubert, Patrice Chiap, 2006 .

Short Course on Method Validation

Philippe Hubert, Bruno Boulanger, 2007 .

Nonaqueous capillary electrophoresis method for the enantiomeric purity determination of S-timolol using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin: validation using the accuracy profile strategy and estimation of uncertainty.

Serge Rudaz, Philippe Hubert, Patrice Chiap, 2006, Journal of chromatography. A.

A Fast Exchange Algorithm for Designing Focused Libraries in Lead Optimization.

Bruno Boulanger, Bernadette Govaerts, Céline Le Bailly de Tilleghem, 2005 .

Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography.

Benjamin Debrus, Philippe Hubert, Bruno Boulanger, 2011, Analytica chimica acta.

Towards a new age of virtual ADME/TOX and multidimensional drug discovery

Bruno Boulanger, Sean Ekins, Peter W. Swaan, 2004, Molecular Diversity.

Synchronization of validation and estimation strategies of doubt associated as part of the accreditation in trial laboratories

Philippe Hubert, Walthère Dewé, Bruno Boulanger, 2006 .

A new statistical method for the automated detection of peaks in UV-DAD chromatograms of a sample mixture.

Benjamin Debrus, Philippe Hubert, Bruno Boulanger, 2009, Talanta.

Comparison of some chemometric tools for metabonomics biomarker identification

Michel Verleysen, Bruno Boulanger, Bernadette Govaerts, 2008 .

The SFSTP guide on the validation of chromatographic methods for drug bioanalysis: from the Washington Conference to the laboratory

Philippe Hubert, Patrice Chiap, Bruno Boulanger, 1999 .

Development of response models for optimising HPLC methods

Philippe Hubert, Patrice Chiap, Walthère Dewé, 2004 .

Analysis of recent pharmaceutical regulatory documents on analytical method validation.

Eric Ziemons, Serge Rudaz, Philippe Hubert, 2007, Journal of chromatography. A.

Example of application of the new strategy proposed for the validation of chromatographic bioanalytical methods

Philippe Hubert, Patrice Chiap, Bruno Boulanger, 2000 .

A risk-based analysis of the AAPS conference report on quantitative bioanalytical methods validation and implementation.

Serge Rudaz, Philippe Hubert, Bruno Boulanger, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Validation of an automated method for the liquid chromatographic determination of atenolol in plasma: application of a new validation protocol

Philippe Hubert, Patrice Chiap, Bruno Boulanger, 1999 .

Optimal designs for inverse prediction in univariate nonlinear calibration models

Bruno Boulanger, Bernadette Govaerts, B. Govaerts, 2004 .

Harmonization of strategies for the validation of quantitative analytical procedures

Patrice Chiap, Walthère Dewé, Bruno Boulanger, 2007 .

Total Error for the Valildation of Bioanalytical methods

Roland Marini Djang'Eing'A, Eric Ziemons, Serge Rudaz, 2009 .

Effect of a statistical outlier in potency bioassays

Bruno Boulanger, Binbing Yu, Steven J. Novick, 2018, Pharmaceutical statistics.

Validation and Routine of Ligand-Binding Assays, a Bayesian Perspective

Philippe Hubert, Bruno Boulanger, Pierre Lebrun, 2011 .