T. Wilkin

B. Metcalf, T. Wilkin, J. Hosking, 2011, International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity.

Evidence for energy conservation during pubertal growth. A 10-year longitudinal study (EarlyBird 71)

B. Metcalf, T. Wilkin, J. Hosking, 2016, International Journal of Obesity.

THE ACCELERATOR HYPOTHESIS – AN EVOLVING CONCEPT

T. Wilkin, 2016 .

Multinational, Placebo-Controlled, Randomized Trial of the Effects of Alendronate on Bone Density and Fracture Risk in Postmenopausal Women with Low Bone Mass: Results of the FOSIT Study

D. Felsenberg, H. Pols, D. Hanley, 1999, Osteoporosis International.

Changing perceptions in osteoporosis

T. Wilkin, 1999, BMJ.

BMI was right all along: taller children really are fatter (implications of making childhood BMI independent of height) EarlyBird 48

B. Metcalf, T. Wilkin, J. Hosking, 2011, International Journal of Obesity.

The gender insulin hypothesis: why girls are born lighter than boys, and the implications for insulin resistance

T. Wilkin, M. Murphy, Terence J. Wilkin, 2006, International Journal of Obesity.

The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes

T. Wilkin, 2001, Diabetologia.

Parents' awareness of overweight in themselves and their children: cross sectional study within a cohort (EarlyBird 21)

B. Metcalf, T. Wilkin, S. Alba, 2004, BMJ : British Medical Journal.

Changing perceptions in osteoporosis.

T. Wilkin, 1999 .

Early prevention of fracture in osteoporosis: new developments.

T. Wilkin, 1999, Hospital medicine.

Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene.

Richard W Jones, S. Ring, T. Frayling, 2005, Diabetes.

Lack of support for a role of the insulin gene variable number of tandem repeats minisatellite (INS-VNTR) locus in fetal growth or type 2 diabetes-related intermediate traits in United Kingdom populations.

T. Frayling, A. Hattersley, B. Knight, 2004, The Journal of clinical endocrinology and metabolism.

Adiponectin in childhood.

B. Metcalf, N. Sattar, P. English, 2008, International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity.

Obesity-linked insulin resistance in children - an emerging problem

B. Metcalf, T. Wilkin, J. Hosking, 2006 .

Preventable Factors in Childhood that Lead to Insulin Resistance, Diabetes Mellitus and the Metabolic Syndrome: The EarlyBird Diabetes Study I

B. Metcalf, T. Wilkin, A. Jeffery, 2003, Journal of pediatric endocrinology & metabolism : JPEM.

Resting energy expenditure, adiponectin and changes in body composition of young children (EarlyBird 34).

B. Metcalf, D. Gardner, T. Wilkin, 2008, International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity.

Gender‐assortative waist circumference in mother–daughter and father–son pairs, and its implications. An 11‐year longitudinal study in children (EarlyBird 59)

T. Wilkin, A. Jeffery, L. Voss, 2014, Pediatric obesity.

Raised plasminogen activator inhibitor‐1 (PAI‐1) is not an independent risk factor in the polycystic ovary syndrome (PCOS)

R. Fox, J. Friend, T. Wilkin, 2000, Clinical endocrinology.

Girls at five are intrinsically more insulin resistant than boys: The Programming Hypotheses Revisited--The EarlyBird Study (EarlyBird 6).

B. Metcalf, T. Wilkin, J. Kirkby, 2004, Pediatrics.

Trends, associations and predictions of insulin resistance in prepubertal children (EarlyBird 29)

B. Metcalf, D. Gardner, T. Wilkin, 2008, Pediatric diabetes.

Physical activity attenuates the mid-adolescent peak in insulin resistance but by late adolescence the effect is lost: a longitudinal study with annual measures from 9–16 years (EarlyBird 66)

W. Henley, B. Metcalf, T. Wilkin, 2015, Diabetologia.

Behavior of Insulin Resistance and Its Metabolic Correlates in Prepubertal Children

B. Metcalf, D. Gardner, N. Sattar, 2007, Diabetes Care.

Testing the accelerator hypothesis: a new approach to type 1 diabetes prevention (adAPT 1)

S. Greene, R. McCrimmon, T. Wilkin, 2016, Diabetes, obesity & metabolism.

Diabetes mellitus: Type 1 or type 2? The accelerator hypothesis.

T. Wilkin, 2002, The Journal of pediatrics.

The great weight gain experiment, accelerators, and their implications for autoantibodies in diabetes

T. Wilkin, 2006, Archives of Disease in Childhood.

Objectively Measured Physical Activity and Its Association With Adiponectin and Other Novel Metabolic Markers

B. Metcalf, N. Sattar, T. Wilkin, 2009, Diabetes Care.

Chronic fatigue: is it endocrinology?

D. Flanagan, T. Wilkin, K. Evans, 2009, Clinical medicine.

Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission

E. Bonifacio, M. Knip, H. Kolb, 2007, Diabetic medicine : a journal of the British Diabetic Association.

Little Evidence for Early Programming of Weight and Insulin Resistance for Contemporary Children: EarlyBird Diabetes Study Report 19

B. Metcalf, T. Wilkin, J. Hosking, 2006, Pediatrics.

The seeds are sown in childhood

T. Wilkin, 2003 .

Distinct idiotypes of insulin autoantibody in autoimmune polyendocrine syndrome type 2 and childhood onset type 1 diabetes.

M. Knip, T. Galloway, D. Devendra, 2004, The Journal of clinical endocrinology and metabolism.

Poor growth in school entrants as an index of organic disease: the Wessex growth study.

T. Wilkin, P. Betts, J. Mulligan, 1992, BMJ.

PGC1α Promoter Methylation in Blood at 5–7 Years Predicts Adiposity From 9 to 14 Years (EarlyBird 50)

K. Godfrey, B. Metcalf, K. Lillycrop, 2014, Diabetes.

Response to Comment on: Jeffery et al. Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty: A 9-Year Longitudinal Study (EarlyBird 26). Diabetes Care 2012;35:536–541

B. Metcalf, T. Wilkin, J. Hosking, 2012, Diabetes Care.

Major increase in Type 1 diabetes: no support for the Accelerator Hypothesis

T. Wilkin, 2008, Diabetic medicine : a journal of the British Diabetic Association.

Metabolic risk in contemporary children is unrelated to socio‐economic status: longitudinal study of a UK urban population (EarlyBird 42)

B. Metcalf, T. Wilkin, J. Hosking, 2010, Pediatric diabetes.

Generational change in fasting glucose and insulin among children at ages 5-16y: Modelled on the EarlyBird study (2015) and UK growth standards (1990) (EarlyBird 69).

T. Wilkin, A. Jeffery, L. Voss, 2017, Diabetes research and clinical practice.

A microenzyme-linked immunosorbent assay for urinary albumin, and its comparison with radioimmunoassay.

B. Leatherdale, T. Wilkin, R. Davies, 1984, Journal of immunological methods.

Validation of foot-to-foot bioelectrical impedance analysis with dual-energy X-ray absorptiometry in the assessment of body composition in young children: the EarlyBird cohort

B. Metcalf, T. Wilkin, J. Hosking, 2006, British Journal of Nutrition.

The Behaviour of Insulin Resistance and its Metabolic Correlates in Pre-pubertal Children: a Longitudinal Study (EarlyBird 32)

B. Metcalf, D. Gardner, N. Sattar, 2007 .

Short Stature and School Performance ‐ the Wessex Growth Study

T. Wilkin, P. Betts, B. Bailey, 1991, Acta paediatrica Scandinavica. Supplement.

The reliability of height and height velocity in the assessment of growth (the Wessex Growth Study)

T. Wilkin, P. Betts, B. Bailey, 1991, Archives of disease in childhood.

Republished research: Effectiveness of intervention on physical activity of children: systematic review and meta-analysis of controlled trials with objectively measured outcomes (EarlyBird 54)

W. Henley, B. Metcalf, T. Wilkin, 2013, British Journal of Sports Medicine.

A young man with acute paraparesis

T. Wilkin, D. Footitt, H. Elasha, 2000, Postgraduate medical journal.

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes.

T. Frayling, S. Ellard, K. Docherty, 1999, The Journal of clinical investigation.

Contribution of timetabled physical education to total physical activity in primary school children: cross sectional study

B. Metcalf, T. Wilkin, J. Kirkby, 2003, BMJ : British Medical Journal.

Children from low-income families have less access to sports facilities, but are no less physically active: cross-sectional study (EarlyBird 35).

B. Metcalf, T. Wilkin, J. Hosking, 2008, Child: care, health and development.

Reply to Wardle J et al. School-based physical activity and changes in adiposity

T. Wilkin, 2008, International Journal of Obesity.

Islet-cell and insulin autoantibodies in first-degree relatives of type I diabetics: a 5-year follow-up study in a Swiss population.

T. Wilkin, L. Matter, W. Berger, 1988, Advances in experimental medicine and biology.

The reliability of height measurement (the Wessex Growth Study).

K. Cumming, T. Wilkin, P. Betts, 1990, Archives of disease in childhood.

Testing the Accelerator Hypothesis: Body Size, β-Cell Function, and Age at Onset of Type 1 (Autoimmune) Diabetes

T. Wilkin, 2006, Diabetes Care.

The Pharmacokinetics of Nicotinamide in Humans and Rodents

A. Renwick, A. Petley, T. Wilkin, 1995, Diabetes.

The central issue? Visceral fat mass is a good marker of insulin resistance and metabolic disturbance in women with polycystic ovary syndrome

T. Wilkin, R. Thomas, J. Lord, 2006, BJOG : an international journal of obstetrics and gynaecology.

Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom.

M. McCarthy, J. Levy, T. Frayling, 2001, American journal of human genetics.

Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis

T. Wilkin, 2008, Pediatric diabetes.

Chapter 5 Association of Interferon-γ and Interleukin 10 Genotypes and Serum Levels with Partial Clinical Remission in Type 1 Diabetes

P. H. Moghaddam, E. Bonifacio, M. Knip, 2011 .

Association of interferon‐γ and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes

E. Bonifacio, M. Knip, H. Kolb, 2006 .

Comment on: Gale EAM (2007) To boldly go—or to go too boldly? The accelerator hypothesis revisited. Diabetologia 50:1571–1575—a reply to the editor

T. Wilkin, 2007, Diabetologia.

Is the ‘Accelerator Hypothesis’ worthy of our attention?

T. Wilkin, 2005, Diabetic medicine : a journal of the British Diabetic Association.

Reference ranges of bone mineral density for women in southern England: the impact of local data on the diagnosis of osteoporosis.

C. Cooper, T. Wilkin, M. Cawley, 1996, The British journal of radiology.

Major increase in Type 1 diabetes—no support for the Accelerator Hypothesis—response to MA O’Connell and FJ Cameron

T. Wilkin, 2008 .

DO WE NEED NEW GROWTH CHARTS?

T. Wilkin, P. Betts, L. Voss, 1987, The Lancet.

Response of urinary albumin to submaximal exercise in newly diagnosed non-insulin dependent diabetes.

D. Rowe, B. Leatherdale, T. Wilkin, 1984, British medical journal.

Glucose allostasis: Emperor’s new clothes?

B. Metcalf, T. Wilkin, 2009, Diabetologia.

Developments in the prediction of type 1 diabetes mellitus, with special reference to insulin autoantibodies

T. Galloway, T. Wilkin, B. Franke, 2005, Diabetes/metabolism research and reviews.

A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.

D. Melzer, L. Ferrucci, D. Lawlor, 2006, American journal of human genetics.

Evidence of early beta‐cell deficiency among children who show impaired fasting glucose: 10‐yr cohort study (EarlyBird 56)

B. Metcalf, T. Wilkin, J. Hosking, 2013, Pediatric diabetes.

Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty

Linda D. Voss, Joanne Hosking, B. Metcalf, 2012, Diabetes Care.

Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B (SDH‐B) gene mutation carriers

D. Berney, U. Srirangalingam, R. Reznek, 2008, Clinical endocrinology.

Microproteinuria in children with vesicoureteric reflux.

T. Wilkin, J. D. Atwell, F. G. Bell, 1986, British journal of urology.

Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans

T. Frayling, M. Weedon, A. Hattersley, 2006, BMC Medical Genetics.

The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type I as well as type II diabetes

T. Wilkin, Terence J. Wilkin, 2009, International Journal of Obesity.

Increasing body weight predicts the earlier onset of insulin‐dependant diabetes in childhood: testing the ‘accelerator hypothesis’ (2)

T. Wilkin, P. Betts, J. Mulligan, 2005, Diabetic medicine : a journal of the British Diabetic Association.

Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes.

B. Metcalf, T. Wilkin, M. Kibirige, 2003, Diabetes care.

Hyperthyroidism and the heart

T. Wilkin, 1983, British medical journal.

Increased urinary dopamine excretion in association with bilateral carotid body tumours - clinical, biochemical and genetic findings

D. Devendra, T. Wilkin, M. Murphy, 2006, Annals of clinical biochemistry.

Polycystic ovary syndrome and fat distribution: The central issue?

T. Wilkin, J. Lord, 2002, Human fertility.

Metformin in polycystic ovary syndrome

T. Wilkin, J. Lord, 2004, Current opinion in obstetrics & gynecology.

Protein creatinine index and Albustix in assessment of proteinuria.

D. Rowe, T. Wilkin, W. Gatling, 1983, British medical journal.

Gender differences in the relationship between heart rate control and adiposity in young children: a cross‐sectional study (EarlyBird 33)

B. Metcalf, D. Flanagan, T. Wilkin, 2009, Pediatric diabetes.

Sex differences in resting energy expenditure and their relation to insulin resistance in children (EarlyBird 13).

B. Metcalf, T. Wilkin, J. Kirkby, 2004, The American journal of clinical nutrition.

Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58).

J. Pinkney, T. Wilkin, J. Hosking, 2014, The Journal of clinical endocrinology and metabolism.

A biological, latent variable model of health (EarlyBird 68)

M. Hyland, T. Wilkin, A. Jeffery, 2014, Brain, Behavior, and Immunity.

The relationship of height and body fat to gender-assortative weight gain in children. A longitudinal cohort study (EarlyBird 44).

B. Metcalf, O. Ajala, T. Wilkin, 2011, International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity.

Immunohistochemical detection of plasminogen activator inhibitor-1 in polycystic ovaries

R. Fox, W. Atiomo, J. Friend, 2000, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

Postpartum multifocal avascular necrosis: what are the possible etiologies?

T. Wilkin, P. Hickling, M. E. Brown, 2001, Journal of clinical rheumatology.

Causes of insulin resistance in childhood.

B. Metcalf, T. Wilkin, A. Jeffery, 2002, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

Distribution of adiponectin, leptin, and metabolic correlates of insulin resistance: a longitudinal study in British children; 1: Prepuberty (EarlyBird 15).

B. Metcalf, N. Sattar, T. Wilkin, 2008, Clinical chemistry.

Bone densitometry is not a good predictor of hip fracture.

T J Wilkin, D. Devendra, T. Wilkin, 2001, BMJ : British Medical Journal.

Insulin Resistance and Progression to Type 1 Diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT)

T. Wilkin, TERENCE J. WILKIN, Terence J. Wilkin, 2008, Diabetes Care.

Does lean rather than fat mass provide the link between birth weight, BMI, and metabolic risk? EarlyBird 23

B. Metcalf, T. Wilkin, A. Jeffery, 2006, Pediatric diabetes.

Physical activity at the government-recommended level and obesity-related health outcomes: a longitudinal study (Early Bird 37)

B. Metcalf, T. Wilkin, J. Hosking, 2008, Archives of Disease in Childhood.

Metabolic syndrome: maladaptation to a modern world.

T. Wilkin, L. Voss, 2004, Journal of the Royal Society of Medicine.

40th EASD Annual Meeting of the European Association for the Study of Diabetes

B. M. Rasmussen, A. M. Foster, S. Bandinelli, 2004, Diabetologia.

Metabolic risk in early childhood: the EarlyBird Study

B. Metcalf, T. Wilkin, S. Alba, 2004, International Journal of Obesity.

Fatness leads to inactivity, but inactivity does not lead to fatness: a longitudinal study in children (EarlyBird 45)

T J Wilkin, W. Henley, B. Metcalf, 2010, Archives of Disease in Childhood.

Technical reliability of the CSA activity monitor: The EarlyBird Study.

J. Curnow, B. Metcalf, T. Wilkin, 2002, Medicine and science in sports and exercise.

Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes.

E. Bonifacio, M. Knip, H. Kolb, 2006, Clinical and experimental immunology.

The impact of pregnancy weight and glucose on the metabolic health of mother and child in the south west of the UK.

B. Metcalf, T. Wilkin, A. Jeffery, 2004, Midwifery.

Mood and its association with metabolic health in adolescents: a longitudinal study, EarlyBird 65

M. Hyland, T. Wilkin, J. Hosking, 2014, Pediatric diabetes.

Awareness of body weight by mothers and their children: repeated measures in a single cohort (EarlyBird 64).

B. Metcalf, T. Wilkin, J. Hosking, 2015, Child: care, health and development.

The use of phage display to distinguish insulin autoantibody (IAA) from insulin antibody (IA) idiotypes

T. Galloway, U. Keller, A. Evenden, 2003, Diabetologia.

Authors’ reply to Symonds

W. Henley, B. Metcalf, T. Wilkin, 2012, BMJ : British Medical Journal.

Effect of growth hormone on short normal children

T. Wilkin, 1987 .

Metabolic Syndrome: Maladaptation to a Modern World

T. Wilkin, L. Voss, 2004 .

Is Autoimmunity or Insulin Resistance the Primary Driver of Type 1 Diabetes?

T. Wilkin, 2013, Current Diabetes Reports.

The impact of school-time activity on total physical activity: the activitystat hypothesis (EarlyBird 46)

T J Wilkin, B. Metcalf, T. Wilkin, 2011, International Journal of Obesity.

IOTF thresholds for overweight and obesity and their relation to metabolic risk in children (EarlyBird 20)

B. Metcalf, T. Wilkin, A. Jeffery, 2006, International Journal of Obesity.

The relative contributions of birth weight, weight change, and current weight to insulin resistance in contemporary 5-year-olds: the EarlyBird Study.

B. Metcalf, T. Wilkin, J. Kirkby, 2002, Diabetes.

Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome.

M. McCarthy, T. Frayling, A. Hattersley, 2002, The Journal of clinical endocrinology and metabolism.

Exploring the Adolescent Fall in Physical Activity: A 10-yr Cohort Study (EarlyBird 41).

W. Henley, B. Metcalf, T. Wilkin, 2015, Medicine and science in sports and exercise.

Divergence between HbA1c and fasting glucose through childhood: implications for diagnosis of impaired fasting glucose (EarlyBird 52)

B. Metcalf, T. Wilkin, J. Hosking, 2014, Pediatric diabetes.

Body fat in children does not adversely influence bone development: a 7‐year longitudinal study (EarlyBird 18)

B. Metcalf, T. Wilkin, J. Hosking, 2013, Pediatric obesity.

Can we modulate physical activity in children?No

T. Wilkin, T. Wilkin, 2011, International Journal of Obesity.

Hyperthyroidism and the heart.

T. Wilkin, 1983 .

Physical activity cost of the school run: impact on schoolchildren of being driven to school (EarlyBird 22)

Linda Voss, B. Metcalf, T. Wilkin, 2004, BMJ : British Medical Journal.

Consistency of children's dietary choices: annual repeat measures from 5 to 13 years (EarlyBird 49).

B. Metcalf, T. Wilkin, J. Hosking, 2011, British Journal of Nutrition.

Assortative weight gain in mother–daughter and father–son pairs: an emerging source of childhood obesity. Longitudinal study of trios (EarlyBird 43)

B. Metcalf, T. Wilkin, J. Hosking, 2009, International Journal of Obesity.

Reliability of energy expenditure prediction equations in the weight management clinic.

B. Metcalf, T. Wilkin, C. O'Riordan, 2010, Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.

Physical activity and BMI in adolescence

B. Metcalf, T. Wilkin, L. Voss, 2005, The Lancet.

Gender-assortative weight gain: reply to Leary, Smith and Ness

T. Wilkin, 2011, International Journal of Obesity.

Are women with polycystic ovary syndrome resistant to activated protein C?

W. Atiomo, J. Friend, T. Wilkin, 2000, Fertility and Sterility.

The contribution of parental BMI to the metabolic health of their offspring

B. Metcalf, O. Ajala, T. Wilkin, 2012, Pediatric obesity.

Fatness leads to inactivity, but inactivity does not lead to fatness: a longitudinal study in children (EarlyBird 45)

W. Henley, B. Metcalf, T. Wilkin, 2010, Archives of Disease in Childhood.

Testing the Accelerator Hypothesis: Body Size, β-Cell Function, and Age at Onset of Type 1 (Autoimmune) Diabetes

T. Wilkin, 2006, Diabetes Care.

Accelerometers identify inactive and potentially obese children (EarlyBird 3)

T J Wilkin, B. Metcalf, T. Wilkin, 2002, Archives of disease in childhood.

Contribution of Early Weight Gain to Childhood Overweight and Metabolic Health: A Longitudinal Study (EarlyBird 36)

B. Metcalf, D. Gardner, T. Wilkin, 2009, Pediatrics.

Hyperthyroidism and the heart.

T. Wilkin, 1983, British medical journal.

Physical activity in young children

T. Wilkin, L. Voss, 2004, The Lancet.

Changes in resting energy expenditure and their relationship to insulin resistance and weight gain: a longitudinal study in pre-pubertal children (EarlyBird 17).

W. Henley, B. Metcalf, T. Wilkin, 2010, Clinical nutrition.