Sic L. Chan

发表

Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior.

M. Mattson, Sic L. Chan, W. Duan, 2002, Physiological reviews.

Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress

Ming Zhan, Mark P. Mattson, M. Mattson, 2007, NeuroMolecular Medicine.

Erratum: Presenilin mutations and calcium signaling defects in the nervous and immune systems (BioEssay (2001) 23 (733-744))

Sic L. Chan, M. P. Mattson, S. Camandola, 2001 .

Calcium orchestrates apoptosis

M. Mattson, Sic L. Chan, 2003, Nature Cell Biology.

Deletion of TRPC 6 attenuates NMDA receptor-mediated Ca 2 + Entry and Ca 2 +-induced neurotoxicity following cerebral ischemia and oxygen-glucose deprivation

Sic L. Chan, R. Wurster, Qing-Hui Chen, 2018 .

Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness.

J. Rich, G. Kyriazis, J. Lathia, 2010, Cancer research.

Stress-induced Switch in Numb Isoforms Enhances Notch-dependent Expression of Subtype-specific Transient Receptor Potential Channel*

G. Kyriazis, Sic L. Chan, Zelan Wei, 2009, The Journal of Biological Chemistry.

Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain

M. Mattson, Jaewon Lee, Sic L. Chan, 2007, NeuroMolecular Medicine.

Lifelong running reduces oxidative stress and degenerative changes in the testes of mice.

M. Mattson, T. Arumugam, G. Nagaraju, 2008, The Journal of endocrinology.

The Brain Uncoupling Protein UCP4 Attenuates Mitochondrial Toxin-Induced Cell Death: Role of Extracellular Signal-Regulated Kinases in Bioenergetics Adaptation and Cell Survival

Sic L. Chan, Zelan Wei, S. Chigurupati, 2009, Neurotoxicity Research.

A Synthetic Uric Acid Analog Accelerates Cutaneous Wound Healing in Mice

M. Mattson, Sung-Chun Tang, N. Greig, 2010, PloS one.

Mitochondrial Uncoupling Protein-4 Regulates Calcium Homeostasis and Sensitivity to Store Depletion-induced Apoptosis in Neural Cells*

M. Mattson, G. Kyriazis, Sic L. Chan, 2006, Journal of Biological Chemistry.

Presenilin-1 Mutations Sensitize Neurons to DNA Damage-Induced Death by a Mechanism Involving Perturbed Calcium Homeostasis and Activation of Calpains and Caspase-12

W. Klapper, C. Culmsee, M. Mattson, 2002, Neurobiology of Disease.

The Homocysteine-inducible Endoplasmic Reticulum Stress Protein Counteracts Calcium Store Depletion and Induction of CCAAT Enhancer-binding Protein Homologous Protein in a Neurotoxin Model of Parkinson Disease*

T. Arumugam, G. Kyriazis, Sic L. Chan, 2009, The Journal of Biological Chemistry.

Interferon‐γ is up‐regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity

M. Mattson, Jaewon Lee, Sic L. Chan, 2006, Journal of neuroscience research.

Evidence for altered Numb isoform levels in Alzheimer's disease patients and a triple transgenic mouse model.

M. Mattson, Sic L. Chan, E. Okun, 2011, Journal of Alzheimer's disease : JAD.

Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke

M. Mattson, Sung-Chun Tang, Suresh Poosala, 2006, Nature Medicine.

Evidence that γ-Secretase-Mediated Notch Signaling Induces Neuronal Cell Death via the Nuclear Factor-κB-Bcl-2-Interacting Mediator of Cell Death Pathway in Ischemic Stroke

Sung-Chun Tang, T. Arumugam, C. Sobey, 2011, Molecular Pharmacology.

Notch Activation Enhances the Microglia-Mediated Inflammatory Response Associated With Focal Cerebral Ischemia

T. Arumugam, D. Jo, He Li, 2011, Stroke.

p 38 MAP Kinase Mediates Nitric Oxide-induced Apoptosis of Neural Progenitor Cells *

M. Mattson, O. Milhavet, Sic L. Chan, 2001 .

Numb Endocytic Adapter Proteins Regulate the Transport and Processing of the Amyloid Precursor Protein in an Isoform-dependent Manner

M. Mattson, D. Jo, G. Kyriazis, 2008, Journal of Biological Chemistry.

Expression of Aquaporin 1 and 4 in a Congenital Hydrocephalus Rat Model

Sic L. Chan, M. Rammling, S. Chigurupati, 2011, Neurosurgery.

Good and Bad Amyloid Antibodies

M. Mattson, Sic L. Chan, 2003, Science.

p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults

M. Mattson, N. Greig, XiaoXiang Zhu, 2007, NeuroMolecular Medicine.

Neuroprotective actions of a histidine analogue in models of ischemic stroke

M. Mattson, Sung-Chun Tang, R. Cutler, 2007, Journal of neurochemistry.

Intravenous immunoglobulin protects neurons against amyloid beta‐peptide toxicity and ischemic stroke by attenuating multiple cell death pathways

M. Mattson, Sung-Chun Tang, D. Reutens, 2012, Journal of neurochemistry.

Numb modifies neuronal vulnerability to amyloid β-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis

M. Mattson, Sic L. Chan, W. A. Pedersen, 2002, NeuroMolecular Medicine.

A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78

M. Mattson, D. Ingram, D. Longo, 2002, Journal of neurochemistry.

Neuronal and glial calcium signaling in Alzheimer's disease.

Mark P Mattson, M. Mattson, Sic L. Chan, 2003, Cell calcium.

Chronic nicotine administration impairs activation of cyclic AMP-response element binding protein and survival of newborn cells in the dentate gyrus.

Sic L. Chan, Zelan Wei, N. Ameli, 2012, Stem cells and development.

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

M. M. Soundarapandian, Sic L. Chan, Yanfang Chen, 2010, Cell.

Prostate Apoptosis Response‐4 Mediates Trophic Factor Withdrawal‐Induced Apoptosis of Hippocampal Neurons

M. Mattson, S. Estus, Sic L. Chan, 1999, Journal of neurochemistry.

Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death

M. Mattson, Sung-Chun Tang, A. Vortmeyer, 2007, Proceedings of the National Academy of Sciences.

Oxidative lipid modification of nicastrin enhances amyloidogenic γ‐secretase activity in Alzheimer’s disease

M. Mattson, Sung-Chun Tang, W. Markesbery, 2012, Aging cell.

Selective localization of murine ApoSAA1/SAA2 in endosomes-lysosomes in activated macrophages and their degradation products

D. Laird, Sic L. Chan, Z. Ali-Khan, 1997 .

Dysregulation of cellular calcium homeostasis in Alzheimer’s disease

M. Mattson, Sic L. Chan, 2001, Journal of Molecular Neuroscience.

Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

C. Culmsee, M. Mattson, Zhihong Guo, 2000, The Journal of Neuroscience.

Effect of acetazolamide on aquaporin-1 and fluid flow in cultured choroid plexus.

Sic L. Chan, P. Ameli, S. Chigurupati, 2012, Acta neurochirurgica. Supplement.

New Therapeutic Strategies and Drug Candidates for Neurodegenerative Diseases: p53 and TNF‐α Inhibitors, and GLP‐1 Receptor Agonists

M. Mattson, N. Greig, T. Giordano, 2004 .

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

H. Jang, Jie Zhou, J. Egan, 2007, Proceedings of the National Academy of Sciences.

Numb isoforms containing a short PTB domain promote neurotrophic factor‐induced differentiation and neurotrophic factor withdrawal‐induced death of PC12 Cells

M. Mattson, Sic L. Chan, J. Verdi, 2002, Journal of neurochemistry.

Presenilins and APP in neuritic and synaptic plasticity

M. Mattson, K. Furukawa, Sic L. Chan, 2002, NeuroMolecular Medicine.

Altered Calcium Homeostasis and Mitochondrial Dysfunction in Cortical Synaptic Compartments of Presenilin‐1 Mutant Mice

M. Mattson, K. Duff, Sic L. Chan, 1999, Journal of neurochemistry.

Involvement of Notch signaling in hippocampal synaptic plasticity.

M. Mattson, D. Ingram, Yue Wang, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Neuronal Aquaporin 1 inhibits amyloidogenesis by suppressing the interaction between beta-secretase and amyloid precursor protein.

M. Mattson, D. Jo, Sic L. Chan, 2020, The journals of gerontology. Series A, Biological sciences and medical sciences.

Presenilin-1 mutation sensitizes oligodendrocytes to glutamate and amyloid toxicities, and exacerbates white matter damage and memory impairment in mice

M. Mattson, Sic L. Chan, Kirk Pak, 2007, NeuroMolecular Medicine.

Caspase and calpain substrates: Roles in synaptic plasticity and cell death

M. Mattson, Sic L. Chan, 1999, Journal of neuroscience research.

Cysteine Proteases, Synaptic Degeneration and Neuroodegenerative Disorders

M. Mattson, Sic L. Chan, 2002 .

p38 MAP Kinase Mediates Nitric Oxide-induced Apoptosis of Neural Progenitor Cells*

M. Mattson, O. Milhavet, Sic L. Chan, 2001, The Journal of Biological Chemistry.

The Bcl-2 family of proteins and their actions within the molecular machinery of cell death

Sic L. Chan, I. Kruman, Q. Guo, 2001 .

Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage

Roland N. Emokpae, M. Gorospe, M. Mattson, 2004, Neuron.

Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior

Wenzhen Duan, Mark P Mattson, Aiwu Cheng, 2002, Neurobiology of Aging.

Neutralization of Transthyretin Reverses the Neuroprotective Effects of Secreted Amyloid Precursor Protein (APP) in APPSw Mice Resulting in Tau Phosphorylation and Loss of Hippocampal Neurons: Support for the Amyloid Hypothesis

C. DeCarli, M. Mattson, Jeffrey A. Johnson, 2004, The Journal of Neuroscience.

TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14‐3‐3 protein binding ability

M. Mattson, Weiming Fu, Sic L. Chan, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mouse SAA1 and SAA2 bind avidly to heat denatured ubiquitin

Sic L. Chan, A. Bell, Z. Ali-Khan, 1995 .

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid β‐peptide

C. Culmsee, M. Mattson, N. Greig, 2001, Journal of neurochemistry.

Herp Stabilizes Neuronal Ca2+ Homeostasis and Mitochondrial Function during Endoplasmic Reticulum Stress*

M. Mattson, Jaewon Lee, Weiming Fu, 2004, Journal of Biological Chemistry.

Compromised respiratory adaptation and thermoregulation in aging and age-related diseases

Sic L. Chan, Zelan Wei, S. Chigurupati, 2010, Ageing Research Reviews.

The Lipid Peroxidation Product 4-Hydroxynonenal Facilitates Opening of Voltage-dependent Ca2+ Channels in Neurons by Increasing Protein Tyrosine Phosphorylation*

M. Mattson, Chengbiao Lu, Weiming Fu, 2002, The Journal of Biological Chemistry.

A Mechanism for the Neuroprotective Effect of Apolipoprotein E

M. Mattson, Sic L. Chan, W. A. Pedersen, 2000, Journal of neurochemistry.

Homocysteine and folate deficiency sensitize oligodendrocytes to the cell death-promoting effects of a presenilin-1 mutation and amyloid β-peptide

M. Mattson, Sic L. Chan, Kirk Pak, 2007, NeuroMolecular Medicine.

Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice.

M. Mattson, T. Arumugam, Sic L. Chan, 2011, Human molecular genetics.

Selective and biphasic effect of the membrane lipid peroxidation product 4‐hydroxy‐2,3‐nonenal on N‐methyl‐d‐aspartate channels

M. Mattson, Chengbiao Lu, Sic L. Chan, 2001, Journal of neurochemistry.

Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

M. Mattson, A. Nath, M. Rao, 2002, Journal of neurochemistry.

Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons*

M. Mattson, Sic L. Chan, J. Geiger, 2000, The Journal of Biological Chemistry.

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

Mark P Mattson, Frank M LaFerla, M. Mattson, 2000, Trends in Neurosciences.

Caspase-Mediated Degradation of AMPA Receptor Subunits: A Mechanism for Preventing Excitotoxic Necrosis and Ensuring Apoptosis

M. Mattson, Chengbiao Lu, G. Glazner, 2000, The Journal of Neuroscience.

Evidence for caspase‐mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease

M. Mattson, W. Griffin, Sic L. Chan, 1999 .

Neuronal apoptosis and the pathogenesis of Alzheimer's and Parkinson's diseases

M. Mattson, Sic L. Chan, Q. Guo, 2001 .

Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca2+ Entry and Ca2+-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation

Sic L. Chan, R. Wurster, Qing-Hui Chen, 2017, Front. Neurosci..

Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death

M. Mattson, Chengbiao Lu, E. Elmér, 2003, Journal of neurochemistry.

Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke

M. Mattson, T. Woodruff, T. Arumugam, 2010, Experimental Neurology.

Par-4

M. Mattson, Sic L. Chan, W. Duan, 1999, Journal of Molecular Neuroscience.

The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins.

Mark P Mattson, M. Mattson, B. Tyrberg, 2012, Human molecular genetics.

Involvement of Gadd153 in the pathogenic action of presenilin‐1 mutations

Mark P Mattson, Aiwu Cheng, M. Mattson, 2002, Journal of neurochemistry.

2‐deoxy‐d‐glucose protects hippocampal neurons against excitotoxic and oxidative injury: Evidence for the involvement of stress proteins

M. Mattson, A. Bruce-Keller, Jaewon Lee, 1999, Journal of neuroscience research.

Oral delivery of bioencapsulated proteins across blood-brain and blood-retinal barriers.

Neha Kohli, Henry Daniell, H. Daniell, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease.

M. Mattson, Sic L. Chan, W. A. Pedersen, 2002, Neuromolecular medicine.

New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists.

M. Mattson, N. Greig, T. Giordano, 2004, Annals of the New York Academy of Sciences.

Chapter 3 Cellular calcium dynamics

Yue Wang, K. Furukawa, Sic L. Chan, 2002 .

Electrophysiological and cerebrovascular effects of the α-secretase-derived form of amyloid precursor protein in young and middle-aged rats

M. Mattson, J. Criado, Sic L. Chan, 2007, Brain Research.

Phenformin Suppresses Calcium Responses to Glutamate and Protects Hippocampal Neurons against Excitotoxicity

M. Mattson, Jaewon Lee, Chengbiao Lu, 2002, Experimental Neurology.

Concentration- and cell type-specific effects of calbindin D28k on vulnerability of hippocampal neurons to seizure-induced injury.

M. Mattson, D. Gary, S. Christakos, 2000, Brain research. Molecular brain research.

Defects of immune regulation in the presenilin-1 mutant knockin mouse

M. Mattson, B. Osborne, D. Gary, 2007, NeuroMolecular Medicine.

Presenilin mutations and calcium signaling defects in the nervous and immune systems.

M. Mattson, Sic L. Chan, S. Camandola, 2001, BioEssays : news and reviews in molecular, cellular and developmental biology.

Ubiquitin and Alzheimer's amyloid ß precursor protein colocalize to endosomes‐lysosomes in cultured human cells

Sic L. Chan, Sonia S. Jung, Z. Ali-Khan, 1996, Neuroreport.

Calsenilin Enhances Apoptosis by Altering Endoplasmic Reticulum Calcium Signaling

J. Buxbaum, M. Mattson, W. Wasco, 2002, Molecular and Cellular Neuroscience.

Compromised respiratory adaptation and thermoregulation in aging and age-related diseases

Sic L. Chan, Zelan Wei, S. Chigurupati, 2010, Ageing Research Reviews.

C. DeCarli, M. Mattson, Jeffrey A. Johnson, 2004, The Journal of Neuroscience.

Ubiquitin (Ub) interacts non‐covalently with Alzheimer amyloid precursor protein (βPP): Isolation of Ub‐βPP conjugates from brain extracts

E. Master, Sic L. Chan, Z. Ali-Khan, 1997, Neuroreport.

Evidence that Par-4 participates in the pathogenesis of HIV encephalitis.

M. Mattson, V. Rangnekar, A. Nath, 1999, The American journal of pathology.