T. Talele

发表

Successful applications of computer aided drug discovery: moving drugs from concept to the clinic.

Santosh A. Khedkar, T. Talele, A. C. Rigby, 2010, Current topics in medicinal chemistry.

Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.

Maulik R. Patel, Maksim Chudayeu, Neerja Kaushik-Basu, 2010, Bioorganic & medicinal chemistry.

Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.

Bhargav A. Patel, S. Ambudkar, Zhe-Sheng Chen, 2017, Journal of medicinal chemistry.

3D QSAR studies of 1,3,4-benzotriazepine derivatives as CCK2 receptor antagonists.

Kirandeep Kaur, T. Talele, Kirandeep Kaur, 2008, Journal of molecular graphics & modelling.

3D-QSAR studies on malonyl coenzyme A decarboxylase inhibitors.

Maulik R. Patel, T. Talele, 2007, Bioorganic & medicinal chemistry.

Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.

Alan Ashworth, Bhargav A. Patel, A. Ashworth, 2019, Journal of medicinal chemistry.

Synthesis of 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxamide and 3-oxo-3,4-dihydrobenzo[b][1,4]oxazine-8-carboxamide derivatives as PARP1 inhibitors.

T. Talele, Uday Kiran Velagapudi, Xuwei Shao, 2020, Bioorganic chemistry.

Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.

Maulik R. Patel, Bhargav A. Patel, Neerja Kaushik-Basu, 2013, Bioorganic & medicinal chemistry.

Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance

Wen-Qi Jiang, Zhe-Sheng Chen, T. Talele, 2012, Anti-cancer drugs.

The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds.

Bhargav A. Patel, T. Talele, C. Ashby, 2013, Bioorganic & medicinal chemistry letters.

The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains.

T. Talele, C. Ashby, Shridhar S. Kulkarni, 2010, European journal of medicinal chemistry.

Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors

Paula F. Moraes, Raquel A. C. Leão, Maksim Chudayeu, 2013, Chemical biology & drug design.

Novel 4‐Thiazolidinones as Non‐Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA‐Dependent RNA Polymerase

Bhargav A. Patel, Neerja Kaushik-Basu, T. Talele, 2015, Archiv der Pharmazie.

Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna®) with the human ABC drug transporter P-glycoprotein

Damien Y. Duveau, M. Boxer, S. Ambudkar, 2014, Leukemia.

AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance.

Zhe-Sheng Chen, L. Fu, T. Talele, 2014, Cancer letters.

Molecular docking/dynamics studies of Aurora A kinase inhibitors.

T. Talele, M. McLaughlin, 2008, Journal of molecular graphics & modelling.

Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu.

Zhe-Sheng Chen, L. Fu, M. Zeng, 2011, Molecular pharmaceutics.

Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.

Maulik R. Patel, Pallav D. Patel, Jason C. Young, 2013, Chemistry & biology.

Synthesis and Characterization of Celecoxib Derivatives as Possible Anti-Inflammatory, Analgesic, Antioxidant, Anticancer and Anti-HCV Agents †

Neerja Kaushik-Basu, T. Talele, Ş. Küçükgüzel, 2013, Molecules.

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Y. Pommier, A. Tutt, J. Bartek, 2021, bioRxiv.

Structural basis for allosteric PARP-1 retention on DNA breaks

S. Pettitt, C. Lord, B. E. Black, 2020, Science.

Lamellarin O, a Pyrrole Alkaloid from an Australian Marine Sponge, Ianthella sp., Reverses BCRP Mediated Drug Resistance in Cancer Cells

Zhe-Sheng Chen, T. Talele, R. Capon, 2014, Marine drugs.

The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains.

T. Talele, C. Ashby, Shridhar S. Kulkarni, 2010, European journal of medicinal chemistry.

Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2

S. Bates, R. Robey, S. Ambudkar, 2014, Oncotarget.

Insertion of a peptide from MuLV RT into the connection subdomain of HIV-1 RT results in a functionally active chimeric enzyme in monomeric conformation

T. Talele, V. Pandey, N. Kaushik, 2001, Molecular and Cellular Biochemistry.

Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies

Zhe-Sheng Chen, T. Talele, Yun-kai Zhang, 2017, Oncotarget.

Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters

Bhargav A. Patel, Zhe-Sheng Chen, Dong-Hua Yang, 2016, Scientific Reports.

Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models.

Liwu Fu, Zhe-Sheng Chen, J. Gallo, 2013, Cancer letters.

Design and Synthesis of Human ABCB1 (P-Glycoprotein) Inhibitors by Peptide Coupling of Diverse Chemical Scaffolds on Carboxyl and Amino Termini of (S)-Valine-Derived Thiazole Amino Acid

Bhargav A. Patel, S. Ambudkar, Zhe-Sheng Chen, 2014, Journal of medicinal chemistry.

Identification of novel PARP-1 inhibitors by structure-based virtual screening.

S. Yarmoluk, T. Talele, Shridhar S. Kulkarni, 2013, Bioorganic & medicinal chemistry letters.

Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202.

Zhe-Sheng Chen, L. Fu, Yong‐ju Liang, 2012, Molecular pharmaceutics.

Saracatinib (AZD0530) is a potent modulator of ABCB1‐mediated multidrug resistance in vitro and in vivo

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2013, International journal of cancer.

Discovery of conjugated thiazolidinone-thiadiazole scaffold as anti-dengue virus polymerase inhibitors.

O. Cevik, Neerja Kaushik-Basu, T. Talele, 2016, Biochemical and biophysical research communications.

Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance.

S. Bates, R. Robey, S. Ambudkar, 2014, The international journal of biochemistry & cell biology.

CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function.

Zhe-Sheng Chen, F. Wang, K. To, 2014, Biochemical pharmacology.

Characterization of Aurintricarboxylic Acid as a Potent Hepatitis C Virus Replicase Inhibitor

Neerja Kaushik-Basu, P. Arora, T. Talele, 2009, Antiviral chemistry & chemotherapy.

Etodolac Thiosemicarbazides: A novel class of hepatitis C virus NS5B polymerase inhibitors.

Neerja Kaushik-Basu, P. Arora, T. Talele, 2013, Marmara pharmaceutical journal.

Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.

T. Talele, 2017, Journal of medicinal chemistry.

Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles*

R. Cetin-Atalay, Neerja Kaushik-Basu, P. Arora, 2015, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors.

T. Talele, Shridhar S. Kulkarni, Satyakam Singh, 2012, European journal of medicinal chemistry.

Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors

Frank R. Fronczek, Yves Pommier, Junko Murai, 2014, Journal of medicinal chemistry.

Chemical Space Exploration Around Thieno[3,2-d]pyrimidin-4(3H)-one Scaffold led to a Novel Class of Highly Active Clostridium difficile Inhibitors.

M. Seleem, T. Talele, Nader S. Abutaleb, 2019, Journal of medicinal chemistry.

Some Hydrazones of 2‐Aroylamino‐3‐methylbutanohydrazide: Synthesis, Molecular Modeling Studies, and Identification as Stereoselective Inhibitors of HIV‐1

E. De Clercq, C. Pannecouque, Neerja Kaushik-Basu, 2013, Archiv der Pharmazie.

Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles.

Maulik R. Patel, Pallav D. Patel, B. Kocsis, 2010, European journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of (S)‐Valine Thiazole‐Derived Cyclic and Noncyclic Peptidomimetic Oligomers as Modulators of Human P‐Glycoprotein (ABCB1)

Bhargav A. Patel, S. Ambudkar, T. Talele, 2014, Chembiochem : a European journal of chemical biology.

The "Cyclopropyl Fragment" is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules.

T. Talele, 2016, Journal of medicinal chemistry.

Opportunities for Tapping into Three-Dimensional Chemical Space Through a Quaternary Carbon.

T. Talele, 2020, Journal of medicinal chemistry.

2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase.

Neerja Kaushik-Basu, T. Talele, Esra Tatar, 2013, European journal of medicinal chemistry.

Design and Synthesis of N‐Substituted Indazole‐3‐Carboxamides as Poly(ADP‐ribose)polymerase‐1 (PARP‐1) Inhibitors †

Maulik R. Patel, K. Degenhardt, T. Talele, 2012, Chemical biology & drug design.

Synthesis and Crystallographic Characterization of 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole: A Crucial Intermediate for the Synthesis of Azole Antifungal Drugs

Pallav D. Patel, F. Fronczek, T. Talele, 2009 .

Three-dimensional quantitative structure-activity relationship (QSAR) and receptor mapping of cytochrome P-450(14 alpha DM) inhibiting azole antifungal agents.

V. Kulkarni, T. Talele, T T Talele, 1999, Journal of chemical information and computer sciences.

Docking analysis of a series of cytochrome P-450(14) alpha DM inhibiting azole antifungals.

V. Kulkarni, V. Hariprasad, T. Talele, 1998, Drug design and discovery.

Microwave assisted synthesis of some novel Flurbiprofen hydrazidehydrazones as anti-HCV NS5B and anticancer agents

Neerja Kaushik-Basu, P. Arora, T. Talele, 2013 .

Microwave assisted synthesis of some novel Flurbiprofen hydrazide-hydrazones as anti-HCV NS 5 B and anticancer agents

Neerja Kaushik-Basu, P. Arora, T. Talele, 2013 .

Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors

Neerja Kaushik-Basu, Paulo R. R. Costa, Tanaji T. Talele, 2008, Nucleic acids research.

Role of glutamine 151 of human immunodeficiency virus type-1 reverse transcriptase in substrate selection as assessed by site-directed mutagenesis.

T. Talele, V. Pandey, D. Harris, 2000, Biochemistry.

Neratinib Reverses ATP-Binding Cassette B1-Mediated Chemotherapeutic Drug Resistance In Vitro, In Vivo, and Ex Vivo

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2012, Molecular Pharmacology.

The beta7-beta8 loop of the p51 subunit in the heterodimeric (p66/p51) human immunodeficiency virus type 1 reverse transcriptase is essential for the catalytic function of the p66 subunit.

T. Talele, V. Pandey, N. Kaushik, 2001 .

The glutamine side chain at position 91 on the β5a-β5b loop of human immunodeficiency virus type 1 reverse transcriptase is required for stabilizing the dNTP binding pocket.

Neerja Kaushik-Basu, T. Talele, Alok K Upadhyay, 2011, Biochemistry.

The molluscum contagiosum virus death effector domain containing protein MC160 RxDL motifs are not required for its known viral immune evasion functions

T. Talele, Uday Kiran Velagapudi, Michael W. Beaury, 2017, Virus Genes.

The Phosphodiesterase-5 Inhibitor Vardenafil Is a Potent Inhibitor of ABCB1/P-Glycoprotein Transporter

X. An, P. Ding, S. Ambudkar, 2011, PloS one.

Recent development in the discovery of PARP inhibitors as anticancer agents: a patent update (2016-2020)

Bhargav A. Patel, T. Talele, D. Ferraris, 2021, Expert opinion on therapeutic patents.

Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.

S. Bates, R. Robey, S. Ambudkar, 2011, Cancer research.

Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains

T. Talele, Alok K Upadhyay, V. Pandey, 2009, Virology Journal.

Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo.

Zhe-Sheng Chen, Dong-Hua Yang, T. Talele, 2014, Biochemical pharmacology.

Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance

Zhe-Sheng Chen, T. Talele, C. Ashby, 2014, International journal of oncology.

GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance.

Zhe-Sheng Chen, A. Tiwari, T. Talele, 2012, Biochemical pharmacology.

WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2014, Cancer science.

Centrosomal kinase Nek2 cooperates with oncogenic pathways to promote metastasis

R. Cagan, J. Pendse, T. Talele, 2013, Oncogenesis.

Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2014, Biochemical pharmacology.

Vitro, in Vivo and ex Vivo

Liwu Fu, S. Ambudkar, Zhe-Sheng Chen, 2012 .

Nek2 Kinase Signaling in Malaria, Bone, Immune and Kidney Disorders to Metastatic Cancers and Drug Resistance: Progress on Nek2 Inhibitor Development

T. Talele, T. Das, Tirtha K. Das, 2022, Molecules.

Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1

Bhargav A. Patel, S. Ambudkar, Zhe-Sheng Chen, 2017, Scientific Reports.

Vemurafenib (PLX4032, Zelboraf®), a BRAF Inhibitor, Modulates ABCB1-, ABCG2-, and ABCC10-Mediated Multidrug Resistance

Zhe-Sheng Chen, T. Talele, C. Ashby, 2013, Journal of Cancer Research Updates.

Structure-based CoMFA and CoMSIA study of indolinone inhibitors of PDK1

Tanaji T. Talele, Kirandeep Kaur, T. Talele, 2009, J. Comput. Aided Mol. Des..

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Y. Pommier, A. Tutt, J. Bartek, 2022, Nature Cell Biology.

Characterization of Solid Dispersion of Itraconazole Prepared by Solubilization in Concentrated Aqueous Solutions of Weak Organic Acids and Drying

T. Talele, A. Serajuddin, H. Sandhu, 2016, Pharmaceutical Research.

β-Elemene, a compound derived from Rhizoma zedoariae, reverses multidrug resistance mediated by the ABCB1 transporter.

Zhe-Sheng Chen, T. Talele, C. Ashby, 2014, Oncology reports.

Characterization of Solid Dispersion of Itraconazole Prepared by Solubilization in Concentrated Aqueous Solutions of Weak Organic Acids and Drying

T. Talele, A. Serajuddin, H. Sandhu, 2016, Pharmaceutical Research.

Acetylene Group, Friend or Foe in Medicinal Chemistry.

T. Talele, 2020, Journal of medicinal chemistry.

Destabilization of tRNA3(Lys) from the primer-binding site of HIV-1 genome by anti-A loop polyamide nucleotide analog.

T. Talele, P. Palumbo, V. Pandey, 2001, Nucleic acids research.

BIRB796, the Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances the Efficacy of Chemotherapeutic Agents in ABCB1 Overexpression Cells

Zhe-Sheng Chen, L. Fu, Xiao-kun Wang, 2013, PloS one.

Thiazolidinones : a novel class of hepatitis C virus NS 5 B polymerase inhibitors

Neerja Kaushik-Basu, Tanaji T. Talele, Ye Chen, 2008 .

3D QSAR and Molecular Docking Studies of Benzimidazole Derivatives as Hepatitis C Virus NS5B Polymerase Inhibitors

Neerja Kaushik-Basu, Maulik R. Patel, Tanaji T. Talele, 2008, J. Chem. Inf. Model..

CoMFA and HQSAR studies on 6,7-dimethoxy-4-pyrrolidylquinazoline derivatives as phosphodiesterase10A inhibitors.

Maulik R. Patel, T. Talele, Shridhar S. Kulkarni, 2008, Bioorganic & medicinal chemistry.

Design, Synthesis, and Evaluation of 2‐(arylsulfonyl)oxiranes as Cell‐permeable Covalent Inhibitors of Protein Tyrosine Phosphatases

Kevin J. Mark, Sanjai Kumar, D. Ramai, 2012, Chemical biology & drug design.

Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors.

Neerja Kaushik-Basu, Volodymyr G Bdzhola, Jin-Ching Lee, 2012, European journal of medicinal chemistry.

Synthesis and SAR optimization of diketo acid pharmacophore for HCV NS5B polymerase inhibition.

Maulik R. Patel, Neerja Kaushik-Basu, T. Talele, 2011, European journal of medicinal chemistry.

ARRY‐334543 Reverses Multidrug Resistance by Antagonizing the Activity of ATP‐Binding Cassette Subfamily G Member 2

S. Ambudkar, Zhe-Sheng Chen, R. Xu, 2014, Journal of cellular biochemistry.

Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

S. Durell, S. Ambudkar, T. Talele, 2013, PloS one.

Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.

Tony Taldone, Tony Taldone, T. Talele, 2008, Bioorganic & medicinal chemistry letters.

2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

Haichao Wang, T. Talele, C. Ashby, 2021, Molecular medicine.

Revisiting Prochirality.

T. Talele, R. Ochs, 2019, Biochimie.

In Vitro Antibacterial Activity of Rhodanine Derivatives against Pathogenic Clinical Isolates

Bhargav A. Patel, M. Seleem, T. Talele, 2016, PloS one.

CoMSIA Study on Substituted Aryl Alkanoic Acid Analogs as GPR40 Agonists

Maulik R. Patel, Pallav D. Patel, T. Talele, 2011, Chemical biology & drug design.

Identification of a novel spirocyclic Nek2 inhibitor using high throughput virtual screening.

T. Talele, K. Fath, S. Ghoshal, 2023, Bioorganic & medicinal chemistry letters.

Pharmacophore Modeling of Nilotinib as an Inhibitor of ATP-Binding Cassette Drug Transporters and BCR-ABL Kinase Using a Three-Dimensional Quantitative Structure–Activity Relationship Approach

S. Ambudkar, S. Shukla, T. Talele, 2014, Molecular pharmaceutics.

Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles*

R. Cetin-Atalay, Neerja Kaushik-Basu, P. Arora, 2015, Journal of enzyme inhibition and medicinal chemistry.

Impact of template overhang-binding region of HIV-1 RT on the binding and orientation of the duplex region of the template-primer

Tanaji T. Talele, T. Talele, Alok K Upadhyay, 2010, Molecular and Cellular Biochemistry.

A single deletion at position 134, 135, or 136 in the beta 7–beta 8 loop of the p51 subunit of HIV‐1 RT disrupts the formation of heterodimeric enzyme

T. Talele, Alok K Upadhyay, V. Pandey, 2009, Journal of cellular biochemistry.

Neratinib Reverses ATP-Binding Cassette B1-Mediated Chemotherapeutic Drug Resistance In Vitro, In Vivo, and Ex Vivo

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2012, Molecular Pharmacology.

2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase.

Neerja Kaushik-Basu, T. Talele, Esra Tatar, 2013, European journal of medicinal chemistry.

Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo.

Zhe-Sheng Chen, Dong-Hua Yang, T. Talele, 2014, Biochemical Pharmacology.