Wendong Huang

发表

The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-κB Signaling Pathway

Yingjie Yu, Cong Guo, Hui Qi, 2015, Front. Pharmacol..

Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration

D. Moore, Wendong Huang, Ke Ma, 2006, Science.

Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice

B. M. Forman, Wendong Huang, Wei-Dong Chen, 2012, Hepatology.

Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway

Q. Gao, Wendong Huang, Meiling Su, 2015, International journal of molecular medicine.

The Constitutive Androstane Receptor and Pregnane X Receptor Function Coordinately to Prevent Bile Acid-induced Hepatotoxicity*

R. Evans, D. Moore, Wendong Huang, 2004, Journal of Biological Chemistry.

A Novel Compound Heterozygous CYP17A1 Variant Causes 17α-Hydroxylase/17, 20-Lyase Deficiency

Hong Chen, Wendong Huang, Yaping Sun, 2019, Front. Genet..

Adipocyte-derived PGE2 is required for intermittent fasting–induced Treg proliferation and improvement of insulin sensitivity

Xuexian O Yang, Wendong Huang, Yingmei Feng, 2022, JCI insight.

A New Long Form of c-Maf Cooperates with Sox9 to Activate the Type II Collagen Gene*

B. de Crombrugghe, Wendong Huang, H. Eberspaecher, 2002, The Journal of Biological Chemistry.

Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled bile acid receptor 1 (GP-BAR1, TGR5) agonists.

Nagarajan Vaidehi, N. Vaidehi, B. M. Forman, 2015, Bioorganic & medicinal chemistry.

Bile Acid–Mediated Activation of Brown Fat Protects From Alcohol-Induced Steatosis and Liver Injury in Mice

Senlin Xu, Eryun Zhang, W. Ding, 2021, Cellular and molecular gastroenterology and hepatology.

Bile acids and metabolic surgery

Wendong Huang, Lili Ding, H. Xue, 2021 .

Novel FXR (farnesoid X receptor) modulators: Potential therapies for cholesterol gallstone disease.

B. M. Forman, Donna D. Yu, Wendong Huang, 2016, Bioorganic & medicinal chemistry.

C‐Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia

Mark J. Murphy, A. Trumpp, D. Moore, 2008, Hepatology.

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

S. Wakil, L. Abu-Elheiga, P. Saha, 2009, Proceedings of the National Academy of Sciences.

miR-26a attenuates colitis and colitis-associated cancer by targeting the multiple intestinal inflammatory pathways

H. Pan, W. Han, Wendong Huang, 2021, Molecular therapy. Nucleic acids.

CAMK2γ Antagonizes mTORC1 Activation during Hepatocarcinogenesis

Dustin E. Schones, Juan Du, Z. Meng, 2016, Oncogene.

Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors.

B. Czerniak, B. de Crombrugghe, Wendong Huang, 2003, Human pathology.

The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor

Jonathan P. Jackson, D. Moore, C. Klaassen, 2008, Drug Metabolism and Disposition.

Alterations in xenobiotic metabolism in the long‐lived Little mice

D. Moore, K. Setchell, G. Darlington, 2007, Aging cell.

Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.

D. Moore, P. Wei, Wendong Huang, 2004, Molecular endocrinology.

Nuclear receptors and liver disease: Summary of the 2017 basic research symposium

Li Wang, Wendong Huang, Mélanie Tran, 2018, Hepatology communications.

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells

Hua Yu, Senlin Xu, Eryun Zhang, 2022, Nature communications.

Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.

B. M. Forman, Wendong Huang, Wei-Dong Chen, 2008, Molecular endocrinology.

Bile acid receptor and liver regeneration

Wendong Huang, Lili Ding, 2017 .

Bile Acid Receptors and Liver Regeneration

Wendong Huang, Lili Ding, Mingjie Fan, 2015 .

Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.

D. Moore, C. Klaassen, A. Slitt, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Nuclear bile acid receptor FXR in the hepatic regeneration.

Z. Meng, Wendong Huang, Wei-Dong Chen, 2011, Biochimica et biophysica acta.

Bile acid signaling and liver regeneration.

Wendong Huang, Xichun Wang, Qingfeng Yan, 2015, Biochimica et biophysica acta.

Erratum: Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase a enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer (Molecular and Cellular Biology (2000) 20:11 (p. 4149-4158))

V. Lefebvre, B. Crombrugghe, Wendong Huang, 2000 .

Mitochondrial dysfunction caused by m.2336T>C mutation with hypertrophic cardiomyopathy in cybrid cell lines.

Wendong Huang, Xufen Zhu, Aifu Lin, 2019, Mitochondrion.

Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obesity and insulin resistance in mice

Eryun Zhang, Li Yang, Zhengtao Wang, 2021, Acta pharmaceutica Sinica. B.

Acetylshikonin from Zicao Prevents Obesity in Rats on a High-Fat Diet by Inhibiting Lipid Accumulation and Inducing Lipolysis

Wendong Huang, Meiling Su, B. Zhu, 2016, PloS one.

CAMK2γ in Intestinal Epithelial Cells Modulates Colitis-Associated Colorectal Carcinogenesis via Enhancing STAT3 Activation

Hua Yu, Z. Meng, J. Shively, 2017, Oncogene.

PPARα alleviates iron overload‐induced ferroptosis in mouse liver

Shiyao Cao, Wendong Huang, Lisheng Zhang, 2022, EMBO reports.

Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis

A. Riggs, R. Natarajan, Eryun Zhang, 2021, Nature Communications.

Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression

D. Moore, U. Meyer, Wendong Huang, 2008, Molecular Pharmacology.

Phosphorylation of SOX9 by Cyclic AMP-Dependent Protein Kinase A Enhances SOX9's Ability To Transactivate aCol2a1 Chondrocyte-Specific Enhancer

V. Lefebvre, B. de Crombrugghe, Wendong Huang, 2000, Molecular and Cellular Biology.

A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.

D. Moore, Wendong Huang, Jun Zhang, 2004, The Journal of clinical investigation.

Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver

D. Moore, Wendong Huang, Wei-Dong Chen, 2012, Hepatology.

Insufficient bile acid signaling impairs liver repair in CYP27(-/-) mice.

B. M. Forman, Z. Meng, Wendong Huang, 2011, Journal of hepatology.

Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration.

D. Moore, Z. Meng, Wendong Huang, 2009, Molecular endocrinology.

The nuclear receptor CAR modulates alcohol-induced liver injury

Z. Meng, Xiaosong Chen, Wendong Huang, 2011, Laboratory Investigation.

Farnesoid X receptor alleviates age‐related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription

B. M. Forman, Donna D. Yu, Wendong Huang, 2009, Hepatology.

Sweroside ameliorates NAFLD in high-fat diet induced obese mice through the regulation of lipid metabolism and inflammatory response.

Li Yang, Li Yang, Zhengtao Wang, 2020, Journal of ethnopharmacology.

Bile Acid Receptors and Liver Cancer

Z. Meng, Wendong Huang, Xichun Wang, 2013, Current Pathobiology Reports.

Targeting Bile Acid-Activated Receptors in Bariatric Surgery.

Eryun Zhang, Li Yang, Zhengtao Wang, 2019, Handbook of experimental pharmacology.

GPBAR1/TGR5 Mediates Bile Acid-Induced Cytokine Expression in Murine Kupffer Cells

Z. Meng, Donna D. Yu, Wendong Huang, 2014, PloS one.

Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice

D. Moore, Eryun Zhang, Li Yang, 2020, Proceedings of the National Academy of Sciences.

Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma.

Jingfeng Liu, Wendong Huang, Xiong-fei Huang, 2012, American journal of physiology. Gastrointestinal and liver physiology.

Acetylshikonin from Zicao exerts antifertility effects at high dose in rats by suppressing the secretion of GTH.

Wendong Huang, Meiling Su, B. Zhu, 2016, Biochemical and biophysical research communications.

Myeloid adrenergic signaling via CaMKII forms a feedforward loop of catecholamine biosynthesis

Xuexian O Yang, Wendong Huang, Xuexian O. Yang, 2017, Journal of molecular cell biology.

Bile acid signaling and bariatric surgery.

Eryun Zhang, Wendong Huang, Lili Ding, 2017, Liver research.

A miRNA-mediated attenuation of hepatocarcinogenesis in both hepatocytes and Kupffer cells

Mingfeng Zhang, Chunyan Zhang, Wendong Huang, 2022, Molecular therapy. Nucleic acids.

Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism

Dustin E. Schones, Juan Du, Wen-Chi Huang, 2017, Scientific Reports.

Bile acids, gut microbiota and metabolic surgery

Wendong Huang, Yangmeng Wang, Lihua Jin, 2022, Frontiers in Endocrinology.

H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis

Jianguo Wu, Li Zhang, Wendong Huang, 2019, Cell Death & Disease.

The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway

Yanyan Li, Cong Guo, Jia Su, 2015, Oncotarget.

The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway

Yanyan Li, Cong Guo, Jia Su, 2015, Oncotarget.

Identification of a novel RNA giant nuclear body in cancer cells

Qi Dong, Shu Zheng, Xiaohua Xu, 2015, Oncotarget.

Genetic characterization and drug sensitivity study of newly derived HGBL double/triple-hit lymphoma cell lines

W. Chan, Senlin Xu, S. Alkan, 2022, Blood advances.

FXR protects lung from lipopolysaccharide-induced acute injury.

B. M. Forman, Donna D. Yu, Wendong Huang, 2012, Molecular endocrinology.

Targeting MYC and BCL2 by a natural compound for “double‐hit” lymphoma

W. Chan, Senlin Xu, Wendong Huang, 2022, Hematological oncology.

Loss of B7-H1 Expression by Recipient Parenchymal Cells Leads to Expansion of Infiltrating Donor CD8+ T Cells and Persistence of Graft-Versus-Host Disease

Lieping Chen, Z. Meng, Wei He, 2012, The Journal of Immunology.

Persistence of Graft-Versus-Host Disease T Cells and + Infiltrating Donor CD 8 Parenchymal Cells Leads to Expansion of Loss of B 7-H 1 Expression by Recipient

Lieping Chen, Z. Meng, Wei He, 2011 .

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

B. M. Forman, Donna D. Yu, Wendong Huang, 2008, Hepatology.

miR-379 mediates insulin resistance and obesity through impaired angiogenesis and adipogenesis regulated by ER stress

Mitsuo Kato, L. Lanting, Mei Wang, 2022, Molecular therapy. Nucleic acids.

miR-26a enhances autophagy to protect against ethanol-induced acute liver injury

H. Pan, Z. Meng, W. Han, 2015, Journal of Molecular Medicine.

CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine.

Z. Meng, Shu Zheng, Xiaohua Xu, 2012, Blood.

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

D. Moore, R. Granata, Wendong Huang, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.

David D Moore, D. Moore, Juan-Pablo Hernández, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

Wendong Huang, Mingjie Fan, Jiangling Peng, 2022, Basic & clinical pharmacology & toxicology.

Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II

Y. Yen, Z. Meng, Wendong Huang, 2013, Molecular Cancer Therapeutics.

Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca 2þ /Calmodulin-

Y. Yen, Z. Meng, Wendong Huang, 2013 .

FXR: a metabolic regulator and cell protector

D. Moore, Wendong Huang, Wei-Dong Chen, 2008, Cell Research.

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor.

Yun Yen, Fan Yang, David D Moore, 2007, Cancer research.

Modulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CAR

D. Moore, P. Wei, Wendong Huang, 2002, Science.

Farnesoid X receptor protects hepatocytes from injury by repressing miR-199a-3p, which increases levels of LKB1.

Young Woo Kim, Chan Gyu Lee, Z. Meng, 2012, Gastroenterology.

Gender Dictates the Nuclear Receptor-Mediated Regulation of CYP3A44

D. Moore, H. Strobel, Wendong Huang, 2007, Drug Metabolism and Disposition.

Andrographolide Prevents High-Fat Diet–Induced Obesity in C57BL/6 Mice by Suppressing the Sterol Regulatory Element-Binding Protein Pathway

Li Yang, Zhengtao Wang, Wendong Huang, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization

J. Deng, R. Behringer, W. Bi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis

Wei Liu, Jingling Xue, Jianjun Chen, 2022, Nature Cell Biology.

An Endoplasmic Reticulum Stress–MicroRNA‐26a Feedback Circuit in NAFLD

Wei Huang, Weiqiang Lin, Wendong Huang, 2020, Hepatology.

MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation

A. Riggs, Xianwu Zheng, Wendong Huang, 2013, Proceedings of the National Academy of Sciences.

miR‐194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice

R. Jove, Z. Meng, Xiaosong Chen, 2010, Hepatology.

Bile acid nuclear receptor FXR and digestive system diseases

Li Yang, Zhengtao Wang, Li Yang, 2015, Acta pharmaceutica Sinica. B.

Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines

H. Pan, Qin Pan, W. Han, 2015, Oncotarget.

Cellular transcriptomics: gelsolin negatively regulates the expression of apoptosis-associated genes and inhibits apoptosis in hepatocarcinoma cells.

Hongtao Li, Wendong Huang, N. Zang, 2015, International journal of clinical and experimental pathology.

Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

Dustin E. Schones, D. Moore, Li Yang, 2016, Hepatology.

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth.

Hua Yu, A. Herrmann, P. Chu, 2019, Cell metabolism.

Identification of the novel Np17 oncogene in human leukemia

Z. Meng, Wendong Huang, Bowen Wu, 2020, Aging.

Alternative approaches to target Myc for cancer treatment

Senlin Xu, Wendong Huang, Ying Gu, 2021, Signal Transduction and Targeted Therapy.

Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression.

Y. Yen, Xiyong Liu, B. M. Forman, 2012, Molecular endocrinology.

Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas‐induced murine liver injury by altering Bcl‐2 proteins

G. Gores, D. Moore, R. Craig, 2006, Hepatology.

Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle

S. Kay, Z. Jia, H. Lenz, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Phosphorylation of SOX9 by Cyclic AMP-Dependent Protein Kinase A Enhances SOX9's Ability To Transactivate aCol2a1 Chondrocyte-Specific Enhancer

V. Lefebvre, Wendong Huang, Xin Zhou, 2000, Molecular and Cellular Biology.

Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib

Xinbing Sui, H. Pan, W. Han, 2014, Scientific Reports.

Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue

Z. Meng, Xiaohua Xu, Wendong Huang, 2015, Oncotarget.

Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells

R. Jove, Fan Yang, Yan Wang, 2012, Molecular oncology.

The G‐Protein‐coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light‐chain enhancer of activated B cells (NF‐κB) in mice

B. M. Forman, Donna D. Yu, Wendong Huang, 2011, Hepatology.

Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation

Q. Ma, N. Zhou, Wendong Huang, 2018, Stem cell reports.

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.

D. Moore, G. Lozano, J. Parant, 2005, Molecular endocrinology.

Activating CAR and β-Catenin Induces Uncontrolled Liver Growth and Tumorigenesis

Ju-Seog Lee, D. Moore, Wendong Huang, 2014, Nature Communications.

Molecular mechanism of liver cancer.

H. Pan, Wendong Huang, Xianghui Fu, 2011, Anti-cancer agents in medicinal chemistry.

Gadd45β is induced through a CAR‐dependent, TNF‐independent pathway in murine liver hyperplasia

D. Moore, J. Locker, M. Pibiri, 2005, Hepatology.

FXR and liver carcinogenesis

Wendong Huang, Xiong-fei Huang, Wei-yu Zhao, 2014, Acta Pharmacologica Sinica.

The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling pathways.

Hui Qi, Qiqi Zhang, Jia Su, 2017, Oncotarget.

FXR regulates liver repair after CCl4-induced toxic injury.

H. Pan, B. M. Forman, Z. Meng, 2010, Molecular endocrinology.

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB

M. Kortylewski, A. Chow, Z. Meng, 2014, Scientific Reports.

Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.

W. Chan, Chao Guo, Xiwei Wu, 2017, Cancer cell.

Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway.

Li Yang, Zhengtao Wang, Wendong Huang, 2016, Toxicology and applied pharmacology.

Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3.

Yanyan Li, Hui Qi, Wendong Huang, 2015, Molecular endocrinology.

MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids.

R. Jove, F. Pattou, D. Moore, 2015, The Journal of clinical investigation.

Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice.

Hua Yu, Z. Meng, Wendong Huang, 2012, Journal of hepatology.

TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism

Z. Meng, Xiaosong Chen, Wendong Huang, 2011, Experimental diabetes research.

Pancreatic β cell microRNA-26a alleviates type 2 diabetes by improving peripheral insulin sensitivity and preserving β cell function

Yuquan Wei, N. Tong, Wendong Huang, 2020, PLoS biology.

Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury

Q. Gao, Wendong Huang, Meiling Su, 2016, Molecular medicine reports.

Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4

A. Chawla, Biao Wang, Wendong Huang, 2017, Diabetes.

Improving glucose and lipids metabolism: drug development based on bile acid related targets

Wendong Huang, Lili Ding, Jingyan Tian, 2021, Cell stress.

Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a

Wendong Huang, Bowen Wu, R. Xu, 2017, Oncotarget.

Pleiotropic roles of FXR in liver and colorectal cancers

Wendong Huang, Xiong-fei Huang, Mingjie Fan, 2022, Molecular and Cellular Endocrinology.

Deficiency of G‐protein‐coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis

B. M. Forman, Donna D. Yu, Wendong Huang, 2013, Hepatology.

Vertical sleeve gastrectomy reverses diet-induced gene-regulatory changes impacting lipid metabolism

Dustin E. Schones, Juan Du, Brian Xia, 2017, Scientific Reports.

Acetylshikonin stimulates glucose uptake in L6 myotubes via a PLC-β3/PKCδ-dependent pathway.

Wendong Huang, Meiling Su, Zhaochun Liu, 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

H19 Is Expressed in Hybrid Hepatocyte Nuclear Factor 4α+ Periportal Hepatocytes but Not Cytokeratin 19+ Cholangiocytes in Cholestatic Livers

J. Boyer, Jiajun Zhao, Kezhong Zhang, 2018, Hepatology communications.

Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila

Dustin E. Schones, J. S. de Belle, Brian Xia, 2016, Aging.

Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila

Dustin E. Schones, J. S. de Belle, Brian Xia, 2016, Aging.

Identification of miR-26a as a Target Gene of Bile Acid Receptor GPBAR-1/TGR5

Xiaosong Chen, Wendong Huang, G. Lou, 2015, PloS one.

FXR blocks the growth of liver cancer cells through inhibiting mTOR-s6K pathway.

Wendong Huang, Xinrui Wang, Xiong-fei Huang, 2016, Biochemical and biophysical research communications.

Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis

Xiangmei Chen, Xingxu Huang, Bian Hu, 2019, Molecular therapy. Nucleic acids.

Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

Xiwei Wu, Senlin Xu, Eryun Zhang, 2023, Communications Biology.

H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis

Jianguo Wu, Wendong Huang, Zhihong Yang, 2019, Cell Death & Disease.

Bile-ology: from bench to bedside

L. Jin, Wendong Huang, Mingjie Fan, 2019, Journal of Zhejiang University-SCIENCE B.

A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis

Wei Huang, R. Mukherjee, R. Sutton, 2022, Molecular therapy : the journal of the American Society of Gene Therapy.

FXR, a target for different diseases.

Wendong Huang, Wei-Dong Chen, Yan-Dong Wang, 2008, Histology and histopathology.

FXR, a target for different diseases.

Wendong Huang, Wei-Dong Chen, Yan-Dong Wang, 2008, Histology and histopathology.

Lgr5+ cell fate regulation by coordination of metabolic nuclear receptors during liver repair

Jing Zhang, Wendong Huang, S. Cao, 2022, Theranostics.

Design, Synthesis, Computational and Biological Evaluation of Novel Structure Fragments Based on Lithocholic Acid (LCA)

Senlin Xu, F. Kandeel, Wendong Huang, 2023, Molecules.

Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells

Senlin Xu, Eryun Zhang, Yang Xu, 2022, Nature Communications.

Metabolic nuclear receptors coordinate energy metabolism to regulate Sox9+ hepatocyte fate

Xiangmei Chen, Wendong Huang, Lisheng Zhang, 2021, iScience.

Mitochondrial ND5 12338T>C variant is associated with maternally inherited hypertrophic cardiomyopathy in a Chinese pedigree.

Wendong Huang, Xiaoyu Zhu, Pingping Jiang, 2012, Gene.

Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Wendong Huang, Lihua Jin, Linsen Shi, 2023, Cells.

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

P N Goodfellow, P. Goodfellow, V. Lefebvre, 1997, Molecular and cellular biology.

Enhanced nuclear translation is associated with proliferation and progression across multiple cancers

Weiqiang Lin, Wendong Huang, Xiang Gao, 2023, MedComm.

A gut feeling for drugs that have metabolic benefits

Eryun Zhang, Wendong Huang, Alon Agua, 2023, Nature Communications.

miR-26a deficiency is associated with bone loss and reduced muscle strength but does not affect severity of cartilage damage in osteoarthritis

M. Lotz, S. Miyaki, Y. Kato, 2023, Mechanisms of Ageing and Development.

The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones.

H. Kronenberg, U. Chung, B. Crombrugghe, 2001, Proceedings of the National Academy of Sciences of the United States of America.

miR-26a enhances autophagy to protect against ethanol-induced acute liver injury

H. Pan, Z. Meng, W. Han, 2015, Journal of Molecular Medicine.

miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis

R. Jove, Y. Yen, Z. Meng, 2014, Oncogene.

CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11

D. Moore, H. Strobel, A. Kalsotra, 2004, The Pharmacogenomics Journal.

Transcriptional mechanisms of chondrocyte differentiation.

V. Lefebvre, S. Murakami, R. Behringer, 2000, Matrix biology : journal of the International Society for Matrix Biology.

Ginsenoside Rb1 protects rat retinal ganglion cells against hypoxia and oxidative stress.

Wendong Huang, Zhi Zeng, Yongfei Yang, 2013, Molecular medicine reports.

MAP3K1 Variant Causes Hyperactivation of Wnt4/β-Catenin/FOXL2 Signaling Contributing to 46,XY Disorders/Differences of Sex Development

Hui Zhou, Wendong Huang, Hong Chen, 2022, Frontiers in Genetics.

Red ginseng extracts ameliorate high-fat diet-induced obesity and insulin resistance by activating the intestinal TGR5-mediated bile acids signaling pathway.

Wendong Huang, Wei Li, Linnan Li, 2023, Phytomedicine.