W. Skach

发表

Water transport across mammalian cell membranes.

A. Verkman, A. Mitra, J. Farinas, 1996, The American journal of physiology.

N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2

S. Shyng, W. Skach, Cathrin E. Bruederle, 2011, The Journal of general physiology.

Pharmacological chaperoning: two 'hits' are better than one.

W. Skach, 2007, The Biochemical journal.

Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events.

L. David, W. Skach, Brian J. Conti, 2015, Molecular cell.

Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28

A. Verkman, A. V. van Hoek, W. Skach, 1993, The Journal of cell biology.

Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum–associated degradation

L. David, W. Skach, Y. Matsumura, 2011, Molecular biology of the cell.

CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates

W. Skach, Zhongying Yang, H. Shishido, 2020, Nature Communications.

Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR☆

P. Haggie, D. Sheppard, M. Schlierf, 2020, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Translational tuning optimizes nascent protein folding in cells

Soo-Jung Kim, W. Skach, J. Barral, 2015, Science.

A small molecule high throughput screening platform to profile conformational properties of nascent, ribosome-bound proteins

W. Skach, H. Shishido, J. Yoon, 2022, Scientific Reports.

Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System

J. Brodsky, N. Bulleid, G. Demartino, 2007, Cell.

Patient-Centered Research Priorities for Pulmonary Nontuberculous Mycobacteria (NTM) Infection. An NTM Research Consortium Workshop Report.

A. Quittner, C. Daley, K. Winthrop, 2016, Annals of the American Thoracic Society.

The Cotranslational Contacts between Ribosome-bound Nascent Polypeptides and the Subunits of the Hetero-oligomeric Chaperonin TRiC Probed by Photocross-linking*

J. Frydman, W. Skach, S. Etchells, 2005, Journal of Biological Chemistry.

CFTR: New Members Join the Fold

W. Skach, 2006, Cell.

Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking.

A. Verkman, J. Crane, A. V. van Hoek, 2008, Molecular biology of the cell.

Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD water channels.

A. Verkman, A. Frigeri, W. Skach, 1993, Biochemical and biophysical research communications.

Endoplasmic Reticulum Protein Quality Control Is Determined by Cooperative Interactions between Hsp/c70 Protein and the CHIP E3 Ligase*

W. Skach, J. Sakai, Y. Matsumura, 2013, The Journal of Biological Chemistry.

Endoplasmic Reticulum Protein Quality Control is Determined by Cooperative Interactions Between Hsp / c 70 and the CHIP E 3 Ligase

W. Skach, J. Sakai, Y. Matsumura, 2013 .

Redundancy of mammalian proteasome beta subunit function during endoplasmic reticulum associated degradation.

W. Skach, J. Oberdorf, E. Carlson, 2001, Biochemistry.

Voltage-gated K+ Channels Contain Multiple Intersubunit Association Sites*

D. Pain, C. Deutsch, W. Skach, 1996, The Journal of Biological Chemistry.

Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum

A. Verkman, V. Lingappa, A. Frigeri, 1994, The Journal of cell biology.

Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences.

V. Lingappa, W. Skach, 1993, The Journal of biological chemistry.

A role for the ribosome-associated complex in activation of the IRE1 branch of UPR.

P. Thomas, Yi Liu, W. Skach, 2020, Cell reports.

Protein Export from Endoplasmic Reticulum to the Cytosol: In Vitro Methods

W. Skach, Y. Matsumura, 2009 .

The expanding role of the ER translocon in membrane protein folding

W. Skach, 2007, The Journal of cell biology.

Identification of a Human cDNA Clone for Lysosomal Type Ca2+-independent Phospholipase A2 and Properties of the Expressed Protein*

N. Nomura, T. Nagase, C. Dodia, 1997, The Journal of Biological Chemistry.

Novel mutations in 13 probands with galactokinase deficiency

D. Stambolian, R. Gitzelmann, W. Skach, 2000, Human mutation.

Transmembrane biogenesis of Kv1.3.

C. Deutsch, W. Skach, J. Wang, 2000, Biochemistry.

Evidence for interaction between transmembrane segments in assembly of Kv1.3.

C. Deutsch, W. Skach, Z. Sheng, 1997, Biochemistry.

Cooperativity and Flexibility of CFTR Transmembrane Segments Participate in Membrane Localization of a Charged Residue

W. Skach, Teresa M. Buck, K. Carveth, 2002 .

In vitro methods for CFTR biogenesis.

W. Skach, Y. Matsumura, L. Rooney, 2011, Methods in molecular biology.

Topology of P-glycoproteins.

W. Skach, 1998, Methods in enzymology.

Expression, functional analysis, and in situ hybridization of a cloned rat kidney collecting duct water channel.

A. Verkman, A. Frigeri, W. Skach, 1994, The American journal of physiology.

An Energy-dependent Maturation Step Is Required for Release of the Cystic Fibrosis Transmembrane Conductance Regulator from Early Endoplasmic Reticulum Biosynthetic Machinery*

W. Skach, J. Oberdorf, David G. Pitonzo, 2005, Journal of Biological Chemistry.

CFTR Folding Consortium: methods available for studies of CFTR folding and correction.

G. Lukács, H. Pollard, J. Brodsky, 2011, Methods in molecular biology.

Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues.

A. Verkman, M. Matthay, W. Skach, 1994, The Journal of biological chemistry.

Engineered transfer RNAs for suppression of premature termination codons

J. Lueck, D. Weiner, M. Behlke, 2018, Nature Communications.

In vitro incorporation of nonnatural amino acids into protein using tRNA(Cys)-derived opal, ochre, and amber suppressor tRNAs.

Soo-Jung Kim, W. Skach, J. Gubbens, 2010, RNA.

Chapter 5 Genetic and biophysical approaches to study water channel biology

G. Manley, A. Verkman, A. Mitra, 2001 .

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems.

J. Brodsky, W. Skach, 2011, Current opinion in cell biology.

CFTR modulator theratyping: Current status, gaps and future directions.

J. Wallenburg, J. Clancy, J. Nick, 2019, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

Garry R. Cutting, Harvey B. Pollard, Jeffrey L. Brodsky, 2016, Molecular biology of the cell.

Mechanisms of CFTR Folding at the Endoplasmic Reticulum

Soo-Jung Kim, W. Skach, 2012, Front. Pharmacol..

Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers.

A S Verkman, A. Verkman, W. Skach, 1994, The Journal of biological chemistry.

Evidence for stabilization of aquaporin-2 folding mutants by N-linked glycosylation in endoplasmic reticulum.

W. Skach, Teresa M. Buck, Joel Eledge, 2004, American journal of physiology. Cell physiology.

Cellular mechanisms of membrane protein folding

W. Skach, 2009, Nature Structural &Molecular Biology.

Sequential triage of transmembrane segments by Sec61α during biogenesis of a native multispanning membrane protein

W. Skach, H. Sadlish, A. Johnson, 2005, Nature Structural &Molecular Biology.

Cystic Fibrosis Transmembrane Conductance Regulator–associated ATP Release Is Controlled by a Chloride Sensor

Sreenivas Devidas, J. Kevin Foskett, John F. Engelhardt, 1998, The Journal of cell biology.

Coupled translocation events generate topological heterogeneity at the endoplasmic reticulum membrane.

W. Skach, Y. Lu, A. Helm, 1998, Molecular biology of the cell.

Kinetic Analysis of Ribosome-bound Fluorescent Proteins Reveals an Early, Stable, Cotranslational Folding Intermediate*

D. Kelkar, W. Skach, Devaki A Kelkar, 2011, The Journal of Biological Chemistry.

Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1).

V. Lingappa, W. Skach, 1994, Cancer research.

A 76-bp deletion in the Mip gene causes autosomal dominant cataract in Hfi mice.

P. Deen, D. Stambolian, W. Skach, 2001, Genomics.

Cotranslational Folding Inhibits Translocation from Within the Ribosome–Sec61 Translocon Complex

W. Skach, Brian J. Conti, U. Shinde, 2014, Nature Structural &Molecular Biology.

In vitro reconstitution of CFTR biogenesis and degradation.

W. Skach, J. Oberdorf, 2002, Methods in molecular medicine.

Ligand-driven vectorial folding of ribosome-bound human CFTR NBD1.

W. Skach, A. Johnson, Zhongying Yang, 2011, Molecular cell.

Molecular mechanisms of aquaporin biogenesis by the endoplasmic reticulum Sec61 translocon.

W. Skach, David G. Pitonzo, 2006, Biochimica et biophysica acta.

Reticulocyte lysate as a model system to study endoplasmic reticulum membrane protein degradation.

L. David, W. Skach, N. Bays, 2005, Methods in molecular biology.

Biogenesis of CFTR and other Polytopic Membrane Proteins: New Rolesfor the Ribosome-Translocon Complex

W. Skach, H. Sadlish, 2004, The Journal of Membrane Biology.

Co- and Posttranslational Translocation Mechanisms Direct Cystic Fibrosis Transmembrane Conductance Regulator N Terminus Transmembrane Assembly*

W. Skach, A. Bragin, X. Xiong, 1998, The Journal of Biological Chemistry.

Uncoupling proteasome peptidase and ATPase activities results in cytosolic release of an ER polytopic protein

W. Skach, J. Oberdorf, E. Carlson, 2006, Journal of Cell Science.

The Cytoplasmic Domain of Rhesus Cytomegalovirus Rh178 Interrupts Translation of Major Histocompatibility Class I Leader Peptide-Containing Proteins prior to Translocation

K. Früh, C. Powers, W. Skach, 2011, Journal of Virology.

Fine structure of the human galactokinase GALK1 gene.

D. Bergsma, D. Stambolian, S. Van Horn, 1996, Genome research.

A multifunctional aqueous channel formed by CFTR.

A. Verkman, V. Lingappa, W. Skach, 1992, Science.

Structural cues involved in endoplasmic reticulum degradation of G85E and G91R mutant cystic fibrosis transmembrane conductance regulator.

J. Widdicombe, J. Cohn, W. Skach, 1997, The Journal of clinical investigation.

Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulator.

W. Skach, W R Skach, 2000, Kidney international.

Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits.

A. McCormack, L. David, W. Skach, 2005, Biochemistry.

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

John R Yates, Gerard Manning, Yoshihiro Matsumura, 2010, Nature chemical biology.

Global organization and function of mammalian cytosolic proteasome pools: Implications for PA28 and 19S regulatory complexes.

A. McCormack, K. Früh, W. Skach, 2006, Molecular biology of the cell.

Erratum: Identification of a human cDNA clone for lysosomal type Ca2+- independent phospholipase A2 and properties of the expressed protein (Journal of Biological Chemistry (1997) 272 (2542-2550))

N. Nomura, T. Nagase, C. Dodia, 1997 .

Stepwise Insertion and Inversion of a Type II Signal Anchor Sequence in the Ribosome-Sec61 Translocon Complex

W. Skach, Brian J. Conti, A. Johnson, 2011, Cell.

Epstein-Barr Viral BNLF2a Protein Hijacks the Tail-anchored Protein Insertion Machinery to Block Antigen Processing by the Transport Complex TAP*

R. Tampé, J. Koch, P. Mayerhofer, 2011, The Journal of Biological Chemistry.

The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding*

W. Skach, Zhongying Yang, Prasanna K. Devaraneni, 2015, The Journal of Biological Chemistry.

Identification of Sequence Determinants That Direct Different Intracellular Folding Pathways for Aquaporin-1 and Aquaporin-4*

A. Verkman, Baoxue Yang, W. Skach, 2000, The Journal of Biological Chemistry.

Reorientation of aquaporin-1 topology during maturation in the endoplasmic reticulum.

A. Verkman, W. Skach, I. Turnbull, 2000, Molecular biology of the cell.

p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER‐associated degradation

W. Skach, E. Carlson, David G. Pitonzo, 2006, The EMBO journal.

Role of Hsp90 in Biogenesis of the β-Cell ATP-sensitive Potassium Channel Complex

Pei-Chun Chen, S. Shyng, F. Wang, 2010, Molecular biology of the cell.

Identification of a cDNA for Ca++-independent phospholipase A2 of lung lamellar bodies/lysosomes.

C. Dodia, A. Fisher, W. Skach, 1997, Chest.

Folding Biology of Cystic Fibrosis: A Consortium‐Based Approach to Disease

G. Lukács, H. Pollard, J. Brodsky, 2010 .

Differential Stability of Biogenesis Intermediates Reveals a Common Pathway for Aquaporin-1 Topological Maturation*

W. Skach, Teresa M. Buck, 2005, Journal of Biological Chemistry.

Thermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting channel activity.

Xuehong Liu, W. Skach, D. C. Dawson, 2012, Biochemistry.

Structure and function of kidney water channels.

A. Verkman, A. Mitra, J. Farinas, 1995, Kidney international.

Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon.

W. Skach, A. Johnson, Y. Matsumura, 2008, Molecular biology of the cell.

Control of Translocation through the Sec61 Translocon by Nascent Polypeptide Structure within the Ribosome*♦

Colin J. Daniel, W. Skach, Brian J. Conti, 2008, Journal of Biological Chemistry.

Evidence That Endoplasmic Reticulum (ER)-associated Degradation of Cystic Fibrosis Transmembrane Conductance Regulator Is Linked to Retrograde Translocation from the ER Membrane*

W. Skach, X. Xiong, Elaine Chong, 1999, The Journal of Biological Chemistry.

In Vitro Modulator Responsiveness of 655 CFTR Variants Found in People With CF

A. Sivachenko, G. Cutting, L. Millen, 2023, bioRxiv.

Mechanism of inhibition of cAMP-dependent epithelial chloride secretion by phorbol esters.

R. Mrsny, J. Widdicombe, D. Gruenert, 1993, The Journal of biological chemistry.

Cooperativity and Flexibility of Cystic Fibrosis Transmembrane Conductance Regulator Transmembrane Segments Participate in Membrane Localization of a Charged Residue*

W. Skach, Teresa M. Buck, K. Carveth, 2002, The Journal of Biological Chemistry.

Aberrant Folding of a Mutant Stat5b Causes Growth Hormone Insensitivity and Proteasomal Dysfunction*

V. Hwa, P. Rotwein, W. Skach, 2006, Journal of Biological Chemistry.

A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization

W. Skach, S. Grund, Teresa M. Buck, 2007, Nature Structural &Molecular Biology.

Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

V. Lingappa, W. Skach, M. Calayag, 1993, The Journal of biological chemistry.

Molecular mechanism of P-glycoprotein assembly into cellular membranes.

W. Skach, Victoria Anthony, 2002, Current protein & peptide science.

Distinct biogenesis mechanisms for the water channels MIWC and CHIP28 at the endoplasmic reticulum.

A. Verkman, W. Skach, T. Ma, 1995, Biochemistry.

Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System

J. Brodsky, N. Bulleid, G. Demartino, 2007, Cell.

Epstein-Barr Viral BNLF2a Protein Hijacks the Tail-anchored Protein Insertion Machinery to Block Antigen Processing by the Transport Complex TAP*

R. Tampé, J. Koch, P. Mayerhofer, 2011, The Journal of Biological Chemistry.

A role for the ribosome-associated complex in activation of the IRE1 branch of UPR

P. Thomas, Yi Liu, W. Skach, 2021, Cell reports.