J. Frölich

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Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study

C. Zoccali, I. Fermo, F. Mallamaci, 2001, The Lancet.

Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits.

S. Bode-Böger, J. Frölich, R. Böger, 1996, Biochemical and biophysical research communications.

Effects of caffeine on plasma renin activity, catecholamines and blood pressure.

D Robertson, J. Oates, D. Robertson, 1978, The New England journal of medicine.

Effects of diclofenac on lithium kinetics

J. Frölich, I. Reimann, 1981, Clinical pharmacology and therapeutics.

Diclofenac concentrations in synovial fluid and plasma after cutaneous application in inflammatory and degenerative joint disease.

M. Scholl, J. Frölich, J. Radermacher, 1991, British journal of clinical pharmacology.

Dietary L-arginine and alpha-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms.

R. Brandes, D. Tsikas, E. Schwedhelm, 1998, Atherosclerosis.

Measurement of nitrite and nitrate in plasma, serum and urine of humans by high-performance liquid chromatography, the Griess assay, chemiluminescence and gas chromatography-mass spectrometry: interferences by biogenic amines and N(G)-nitro-L-arginine analogs.

J. Frölich, F. Gutzki, D. Tsikas, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Effects of very low dose and enteric-coated acetylsalicylic acid on prostacyclin and thromboxane formation and on bleeding time in healthy subjects

S. Bode-Böger, J. Frölich, R. Böger, 1998, European Journal of Clinical Pharmacology.

Rapid and selective inhibition of platelet aggregation and thromboxane formation by intravenous low dose aspirin in man.

D. Tsikas, S. Bode-Böger, J. Frölich, 1993, Clinical science.

Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line

T. Thum, J. Frölich, J. Borlak, 2003, FEBS letters.

Renal prostaglandins and leukotrienes.

J. Frölich, L. Walker, 1987, Reviews of physiology, biochemistry and pharmacology.

Asymmetric Dimethylarginine, Blood Pressure, and Renal Perfusion in Elderly Subjects

D. Fliser, E. Ritz, H. Haller, 2003, Circulation.

L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship.

D. Tsikas, S. Bode-Böger, J. Frölich, 1998, British journal of clinical pharmacology.

Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease.

S. Bode-Böger, J. Frölich, R. Böger, 1998, Journal of the American College of Cardiology.

Oral L-arginine improves endothelial function in healthy individuals older than 70 years

G. Brabant, S. Bode-Böger, J. Frölich, 2003, Vascular medicine.

The L-arginine-nitric oxide pathway: role in atherosclerosis and therapeutic implications.

S. Bode-Böger, J. Frölich, R. Böger, 1996, Atherosclerosis.

NSAID: can renal side effects be avoided?

J. Frölich, D. Stichtenoth, 1996 .

Effects of meloxicam and indomethacin on cyclooxygenase pathways in healthy volunteers.

J. Frölich, D. Stichtenoth, B. Wagner, 1997, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS

D. Tsikas, J. Frölich, I. Probst, 2014, Oxidative medicine and cellular longevity.

Effects of acetylsalicylic acid and paracetamol alone and in combination on prostanoid synthesis in man.

J. Frölich, H. Bippi, 1990, British journal of clinical pharmacology.

Cigarette smoking stimulates cysteinyl leukotriene production in man

J. Frölich, J. Fauler, 1997, European journal of clinical investigation.

Dietary L-arginine decreases myointimal cell proliferation and vascular monocyte accumulation in cholesterol-fed rabbits.

A. Stan, S. Bode-Böger, J. Frölich, 1998, Atherosclerosis.

No effects of atorvastatin (10 mg/d or 80 mg/d) on nitric oxide, prostacyclin, thromboxane and oxidative stress in type 2 diabetes mellitus patients of the DALI study.

D. Tsikas, M. Huisman, J. Frölich, 2015, Pharmacological research.

The carcinoid flush. Provocation by pentagastrin and inhibition by somatostatin.

J. Oates, Z. Bloomgarden, J. Frölich, 1978, The New England journal of medicine.

Increased arachidonate in lipids after administration to man: Effects on prostaglandin biosynthesis

J. Oates, J. Frölich, M. Heimberg, 1975, Clinical pharmacology and therapeutics.

Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man.

J. Frölich, L. J. Küster, L. Küster, 1986, Prostaglandins.

Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia

A. Hingorani, K. Nicolaides, P. Vallance, 2003, The Lancet.

Knowledge on drug dosages of ward physicians

J. Frölich, D. Stichtenoth, J. Schnurrer, 2002, European Journal of Clinical Pharmacology.

Endogenous nitric oxide synthase inhibitors are responsible for the L‐arginine paradox

D. Tsikas, S. Bode-Böger, J. Frölich, 2000, FEBS letters.

Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease.

D. Fliser, E. Ritz, H. Haller, 2002, Journal of the American Society of Nephrology : JASN.

ADMA (asymmetric dimethylarginine): an atherosclerotic disease mediating agent in patients with renal disease?

D. Fliser, J. Frölich, J. Kielstein, 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Cardiovascular Effects of Systemic Nitric Oxide Synthase Inhibition With Asymmetrical Dimethylarginine in Humans

D. Tsikas, D. Fliser, H. Haller, 2004, Circulation.

Recombinant human erythropoietin enhances vasoconstrictor tone via endothelin-1 and constrictor prostanoids.

M. Kuhn, S. Bode-Böger, J. Frölich, 1996, Kidney international.

[Pathogenetic aspects of the L-arginine-NO metabolic pathway in arteriosclerosis and possible therapeutic aspects].

S. Bode-Böger, J. Frölich, R. Böger, 1996, VASA. Zeitschrift fur Gefasskrankheiten.

Urinary prostaglandins. Identification and origin.

J. Oates, J. Watson, J. Frölich, 1975, The Journal of clinical investigation.

Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease.

S. Bode-Böger, J. Frölich, R. Böger, 1997, Circulation.

Effects of intravenous aspirin on prostaglandin synthesis and kidney function in intensive care patients.

R. Ritz, J. Frölich, H. Bock, 1986, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Aortic thrombus and pulmonary embolism in a patient with hyperhomocysteinemia

A. Goette, H. Klein, S. Bode-Böger, 2006, Nature Clinical Practice Cardiovascular Medicine.

Asymmetric dimethylarginine plasma concentrations differ in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease.

S. Bode-Böger, J. Frölich, R. Böger, 1999, Journal of the American Society of Nephrology : JASN.

Gas chromatography-mass spectrometry of cis-9,10-epoxyoctadecanoic acid (cis-EODA). I. Direct evidence for cis-EODA formation from oleic acid oxidation by liver microsomes and isolated hepatocytes.

D. Tsikas, J. Frölich, F. Gutzki, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Gas chromatographic-tandem mass spectrometric quantification of free 3-nitrotyrosine in human plasma at the basal state.

E. Schwedhelm, J. Frölich, F. Gutzki, 1999, Analytical biochemistry.

Endothelium-dependent relaxation of human epicardial coronary arteries: frequent lack of effect of acetylcholine.

U. Förstermann, J. Frölich, A. Mügge, 1986, European journal of pharmacology.

1 Results , meta-analysis and a first evaluation of U NOx R , the urinary nitrate-to-nitrite molar ratio , as a measure of nitrite reabsorption in experimental and clinical settings

D. Tsikas, D. Wedekind, J. Huneau, 2019 .

Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers

D. Tsikas, J. Frölich, R. Böger, 2004, European Journal of Clinical Pharmacology.

Effect of selective inhibition of the inducible cyclooxygenase on renin release in healthy volunteers.

J. Frölich, D. Stichtenoth, B. Wagner, 1998, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

Lack of Oxidative Stress during Sustained Therapy with Isosorbide Dinitrate and Pentaerythrityl Tetranitrate in Healthy Humans: A Randomized, Double-Blind Crossover Study

D. Tsikas, J. Frölich, F. Gutzki, 2003, Journal of cardiovascular pharmacology.

Assessment of nitric oxide synthase activity in vitro and in vivo by gas chromatography-mass spectrometry.

D. Tsikas, B. Mayer, A. Savva, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Dietary L-arginine normalizes endothelin-induced vascular contractions in cholesterol-fed rabbits.

R. Brandes, S. Bode-Böger, J. Frölich, 1998, Journal of cardiovascular pharmacology.

Response of Human Coronary Arteries to Aggregating Platelets: Importance of Endothelium‐Derived Relaxing Factor and Prostanoids

U. Förstermann, J. Frölich, A. Mügge, 1988, Circulation research.

Endothelium-derived relaxing factor is likely to modulate the tone of resistance arteries in rabbit hindlimb in vivo.

U. Förstermann, J. Frölich, C. Dudel, 1987, The Journal of pharmacology and experimental therapeutics.

Advances in the analysis of eicosanoids by ELISA and GC/MS/MS.

J. Frölich, G. Bochmann, O. Oelz, 1986, Advances in prostaglandin, thromboxane, and leukotriene research.

Determination of S-nitrosoglutathione in human and rat plasma by high-performance liquid chromatography with fluorescence and ultraviolet absorbance detection after precolumn derivatization with o-phthalaldehyde.

M. Raida, D. Tsikas, P. Pantazis, 1999, Analytical biochemistry.

The kallikrein-kinin system in circulatory and metabolic homeostasis

J. Frölich, R. Mcconn, G. Haberland, 1981, World Journal of Surgery.

Specific and rapid quantification of 8-iso-prostaglandin F2alpha in urine of healthy humans and patients with Zellweger syndrome by gas chromatography-tandem mass spectrometry.

E. Mayatepek, E. Schwedhelm, J. Frölich, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Gas chromatographic-mass spectrometric discrimination between 8-iso-prostaglandin E2 and prostaglandin E2 through derivatization by O-(2,3,4,5,6-Pentafluorobenzyl)hydroxyl amine.

E. Schwedhelm, J. Frölich, F. Gutzki, 1998, Analytical biochemistry.

L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study.

D. Tsikas, S. Bode-Böger, J. Frölich, 1996, Circulation.

The second generation of COX-2 inhibitors: what advantages do the newest offer?

J. Frölich, D. Stichtenoth, 2003, Drugs.

Glutathione promotes prostaglandin H synthase (cyclooxygenase)‐dependent formation of malondialdehyde and 15(S)‐8‐iso‐prostaglandin F2α

D. Tsikas, J. Frölich, D. Stichtenoth, 2012, FEBS letters.

Enhanced synthesis of cysteinyl leukotrienes in psoriasis.

J. Frölich, J. Fauler, D. Tsikas, 1992, The Journal of investigative dermatology.

Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectrometry as methyl ester tri(N-pentafluoropropionyl) derivative.

D. Tsikas, J. Frölich, B. Schubert, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Antihypertensive inorganic nitrate and nitrite: what is the underlying mechanism?

D. Tsikas, J. Frölich, Jessica Y. Schneider, 2013, Hypertension.

Inhibitors of acyl-coenzyme A:lysolecithin acyltransferase activate the production of endothelium-derived vascular relaxing factor.

R. Busse, U. Förstermann, J. Frölich, 1986, The Journal of pharmacology and experimental therapeutics.

Relationship of asymmetric dimethylarginine to dialysis treatment and atherosclerotic disease.

S. Bode-Böger, J. Frölich, R. Böger, 2001, Kidney international. Supplement.

Glucocorticoid effect on arachidonic acid metabolism in vivo.

A. Náray-Fejes-Tóth, G. Fejes-Tóth, J. Frölich, 1988, Journal of steroid biochemistry.

Enhanced urinary excretion of leukotriene E4 by patients with multiple trauma with or without adult respiratory distress syndrome.

A. Seekamp, M. Nerlich, J. Frölich, 1991, Clinical science.

Cardiovascular effects of leukotrienes

J. Frölich, J. Fauler, 2005, Cardiovascular Drugs and Therapy.

[Cardiovascular effects of leukotrienes].

J. Frölich, J. Fauler, 1989, Zeitschrift fur Kardiologie.

Analysis of prostanoids by GC/MS measurement.

J. Frölich, C. Fischer, 1982, Advances in lipid research.

L-arginine stimulates NO-dependent vasodilation in healthy humans--effect of somatostatin pretreatment.

G. Brabant, D. Tsikas, S. Bode-Böger, 1999, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

W. Burchert, H. Hundeshagen, S. Schellong, 1997, Clinical science.

L-arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects.

D. Tsikas, S. Bode-Böger, J. Frölich, 1994, Clinical science.

Elevated urinary excretion of nitric oxide metabolites in young infants with Zellweger syndrome.

D. Tsikas, E. Mayatepek, J. Frölich, 2003, Clinica chimica acta; international journal of clinical chemistry.

Bartter's syndrome: a disorder characterized by high urinary prostaglandins and a dependence of hyperreninemia on prostaglandin synthesis.

A. A. Taylor, J. Oates, J. Gill, 1976, The American journal of medicine.

Vascular and renal effects of leukotriene C4 in conscious rats.

J. Frölich, J. Filep, B. Rigter, 1985, The American journal of physiology.

Analysis of Prostanoids and their Metabolites by Gas Chromatography-Mass Spectrometry

J. Frölich, C. Fischer, B. Rosenkranz, 1980 .

Endothelin Release and Shift in Prostaglandin Balance Are Involved in the Modulation of Vascular Tone by Recombinant Erythropoietin

M. Kuhn, S. Bode-Böger, J. Frölich, 1992, Journal of cardiovascular pharmacology.

URINARY NO3− EXCRETION AS AN INDICATOR OF NITRIC OXIDE FORMATION IN VIVO DURING ORAL ADMINISTRATION OF l‐ARGININE OR l‐NAME IN RATS

D. Tsikas, S. Bode-Böger, J. Frölich, 1996, Clinical and experimental pharmacology & physiology.

Evidence against a vasopressor role of ADH in malignant DOC-salt hypertension.

G. Fejes-Tóth, J. Frölich, J. Filep, 1985, Clinical and experimental hypertension. Part A, Theory and practice.

Clinical and Laboratory Investigations Comparison of different activity parameters in atopic dermatitis: correlation with clinical scores

J. Frölich, D. Stichtenoth, C. Neumann, 2002 .

Differential inhibition of human platelet aggregation and thromboxane A2 formation by L-arginine in vivo and in vitro

S. Bode-Böger, J. Frölich, R. Böger, 1998, Naunyn-Schmiedeberg's Archives of Pharmacology.

Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production.

R. Brandes, S. Bode-Böger, J. Frölich, 1995, Atherosclerosis.

Nebivolol decreases systemic oxidative stress in healthy volunteers.

D. Tsikas, E. Schwedhelm, J. Frölich, 2000, British journal of clinical pharmacology.

Deciduogenic effect of prostaglandins in the pseudopregnant rabbit.

J. Frölich, G. Davenport, L. Hoffman, 1977, Journal of reproduction and fertility.

Effects of a PAF-antagonist (BN 52063) on bronchoconstriction and platelet activation during exercise induced asthma.

H. Wilkens, J. Frölich, H. Fabel, 1990, British journal of clinical pharmacology.

Importance of Prostanoids for Bronchial Smooth Muscle Tone

D. Tsikas, A. Becker, J. Frölich, 1993 .

Increased urinary nitrate excretion in rats with adjuvant arthritis.

S. Bode-Böger, J. Frölich, R. Böger, 1994, Annals of the rheumatic diseases.

Prostacyclin metabolites in human plasma

J. Frölich, C. Fischer, B. Rosenkranz, 1981, Clinical pharmacology and therapeutics.

Enhanced synthesis of cysteinyl leukotrienes in atopic dermatitis

J. Frölich, J. Fauler, D. Tsikas, 1993, The British journal of dermatology.

Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis.

J. Frölich, J. Fauler, D. Tsikas, 1994, Arthritis and rheumatism.

Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets.

U. Förstermann, J. Frölich, U. Alheid, 1987, Thrombosis research.

of Analytical Chemistry in Nitric Oxide Clinical Research -Nitrosoalbumin Plasma Levels in Health and Disease: Facts or Artifacts? Value S

D. Tsikas, J. Frölich, 2011 .

Measurement of S-nitrosoalbumin by gas chromatography--mass spectrometry. III. Quantitative determination in human plasma after specific conversion of the S-nitroso group to nitrite by cysteine and Cu(2+) via intermediate formation of S-nitrosocysteine and nitric oxide.

D. Tsikas, J. Frölich, J. Sandmann, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

S-nitrosoalbumin plasma levels in health and disease: facts or artifacts? Value of analytical chemistry in nitric oxide clinical research.

D. Tsikas, J. Frölich, 2002, Circulation research.

Renal side effects of NSAIDs: role of COX-1 and COX-2

J. Frölich, D. Stichtenoth, 1998 .

Prostaglandin endoperoxide synthetase isoenzymes: the clinical relevance of selective inhibition.

J. Frölich, J. Frolich, 1995, Annals of the rheumatic diseases.

Catalytic hydrogenation of leukotriene B4 enhances sensitivity and specificity of gas chromatography-tandem mass spectrometry techniques and enables simultaneous analysis with cysteinyl leukotrienes in biological fluids.

J. Frölich, J. Fauler, F. Gutzki, 1996, Analytical biochemistry.

Determination of nitric oxide metabolites by means of the Griess assay and gas chromatography–mass spectrometry in the cavernous and systemic blood of healthy males and patients with erectile dysfunction during different functional conditions of the penis

D. Tsikas, U. Jonas, S. Ückert, 2000, Urological Research.

Mechanism of PAF-induced platelet aggregation in man.

J. Frölich, J. Filep, L. J. Küster, 1986, Thrombosis research.

Enzymatic synthesis of dioxygen‐18 labelled 8‐epi‐prostanglandin F2α and its use in quantitative GC‐tandem MS

D. Tsikas, O. Jahn, E. Schwedhelm, 1997 .

Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: comparison with lovastatin.

R. Brandes, S. Bode-Böger, J. Frölich, 1997, Circulation.

Vascular release of superoxide radicals is enhanced in hypercholesterolemic rabbits.

R. Brandes, P. Lichtlen, S. Bode-Böger, 1994, Journal of cardiovascular pharmacology.

Platelet-activating factor induces the production of leukotrienes by human monocytes.

J. Frölich, J. Fauler, G. Sielhorst, 1989, Biochimica et biophysica acta.

Accurate quantification of basal plasma levels of 3-nitrotyrosine and 3-nitrotyrosinoalbumin by gas chromatography-tandem mass spectrometry.

D. Tsikas, E. Schwedhelm, J. Frölich, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Vascular responses to leukotriene B4, C4 and D4 following FPL 55712, indomethacin, saralasin, phentolamine and verapamil in the conscious rat

J. Frölich, J. Filep, É. Földes‐Filep, 1987, British journal of pharmacology.

A new bioassay to study contractile and relaxant effects of PGE2 on perfused guinea pig trachea.

J. Frölich, G. Baersch, 1996, Journal of pharmacological and toxicological methods.

Regional differences in prostacyclin formation by the kidney. Prostacyclin is a major prostaglandin of renal cortex.

J. Oates, J. Frölich, M. Smigel, 1978, Biochimica et biophysica acta.

Analysis of renal prostaglandin synthesis by competitive protein binding assay and gas chromatography--mass spectrometry.

J. Oates, W. M. Williams, J. Frölich, 1976, Advances in prostaglandin and thromboxane research.

Hypercholesterolemia impairs basal nitric oxide synthase turnover rate: a study investigating the conversion of L-[guanidino-(15)N(2)]-arginine to (15)N-labeled nitrate by gas chromatography--mass spectrometry.

D. Tsikas, E. Schwedhelm, S. Bode-Böger, 2004, Nitric oxide : biology and chemistry.

Gas chromatographic-tandem mass spectrometric quantification of human plasma and urinary nitrate after its reduction to nitrite and derivatization to the pentafluorobenzyl derivative.

D. Tsikas, E. Schwedhelm, J. Frölich, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Interference by S-nitroso compounds with the measurement of nitrate in methods requiring reduction of nitrate to nitrite by cadmium.

J. Frölich, F. Gutzki, D. Tsikas, 1999, Journal of chromatography. B, Biomedical sciences and applications.

High-performance liquid chromatographic analysis of nitrite and nitrate in human plasma as S-nitroso-N-acetylcysteine with ultraviolet absorbance detection.

D. Tsikas, J. Frölich, J. Sandmann, 1999, Journal of chromatography. B, Biomedical sciences and applications.

The L-arginine/NO pathway in end-stage liver disease and during orthotopic liver and kidney transplantation: biological and analytical ramifications.

D. Tsikas, J. Klempnauer, A. M. zu Vilsendorf, 2009, Nitric oxide : biology and chemistry.

"Monitors" and European Community guideline on clinical trials

J. Frölich, E. Deutsch, B. Schneider, 1991, The Lancet.

Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers.

D. Tsikas, J. Frölich, D. Stichtenoth, 2005, Kidney international.

Identification of the major metabolite of prostacyclin and 6-ketoprostaglandin F1α in man

J. Frölich, C. Fischer, I. Reimann, 1980 .

Renal vascular effects of leukotriene C4 in the isolated perfused kidney of the rat

J. Frölich, M. Yoshizawa, M. Yoshizawa, 1987, British journal of pharmacology.

Urinary prostaglandins: site of entry into renal tubular fluid.

J. Oates, W. M. Williams, J. Frölich, 1977, Kidney international.

Renal prostaglandins

G. Fejes-Tóth, J. Frölich, 1982, Klinische Wochenschrift.

Nitric oxide and inflammatory joint diseases.

J. Frölich, D. Stichtenoth, 1998, British journal of rheumatology.

An increase in the ratio of thromboxane A2 to prostacyclin in association with increased blood pressure in patients on cyclosporine A.

U. Förstermann, R. Brunkhorst, J. Frölich, 1989, Prostaglandins.

Impaired degradation of leukotrienes in patients with peroxisome deficiency disorders.

W. Lehmann, R. Wanders, R. Schutgens, 1992 .

Different antioxidant mechanisms of α-tocopherol and L-arginine result in preserved endothelial function in hypercholesterolaemic rabbits.

J. Salonen, J. Kumpulainen, S. Bode-Böger, 1999 .

Effect of dexamethasone on in vivo prostanoid production in the rabbit.

A. Náray-Fejes-Tóth, G. Fejes-Tóth, J. Frölich, 1984, The Journal of clinical investigation.

INFLUENCE OF PROSTAGLANDIN INHIBITION ON DIHYDRALAZINE INDUCED ACUTE EFFECTS IN PATIENTS WITH ESSENTIAL HYPERTENSION *

J. Frölich, H. Wisser, D. Ratge, 1985, Clinical and experimental pharmacology & physiology.

Metabolic disposition of prostaglandin E1 in man.

J. Boeynaems, J. Frölich, C. Fischer, 1983, Biochimica et biophysica acta.

S-Transnitrosylation of albumin in human plasma and blood in vitro and in vivo in the rat.

A. Savva, J. Frölich, D. Stichtenoth, 2001, Biochimica et biophysica acta.

Investigations of S-transnitrosylation reactions between low- and high-molecular-weight S-nitroso compounds and their thiols by high-performance liquid chromatography and gas chromatography-mass spectrometry.

D. Tsikas, J. Frölich, F. Gutzki, 1999, Analytical biochemistry.

Measurement of S-nitrosoalbumin by gas chromatography-mass spectrometry. II. Quantitative determination of S-nitrosoalbumin in human plasma using S-[15N]nitrosoalbumin as internal standard.

D. Tsikas, J. Frölich, D. Stichtenoth, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Measurement of S-nitrosoalbumin by gas chromatography-mass spectrometry. I. Preparation, purification, isolation, characterization and metabolism of S-[15N]nitrosoalbumin in human blood in vitro.

D. Tsikas, J. Frölich, F. Gutzki, 1999, Journal of chromatography. B, Biomedical sciences and applications.

Measurement of nitrite and nitrate in biological fluids by gas chromatography-mass spectrometry and by the Griess assay: problems with the Griess assay--solutions by gas chromatography-mass spectrometry.

J. Frölich, F. Gutzki, D. Tsikas, 1997, Analytical biochemistry.

Effects of diclofenac on lithium kinetics

J. Frölich, I. Reimann, 1981, Clinical pharmacology and therapeutics.

Determination of dimethylated arginines in human plasma by high-performance liquid chromatography.

J. Frölich, W. Junker, D. Tsikas, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Metabolism of prostacyclin and 6-keto-prostaglandin F1 alpha in man.

J. Frölich, C. Fischer, I. Reimann, 1980, Artery.

Is circulating nitrite a directly acting vasodilator?

D. Tsikas, J. Frölich, 2002, Clinical science.

Endothelium-derived relaxing factor (EDRF): a defence mechanism against platelet aggregation and vasospasm in human coronary arteries.

U. Förstermann, J. Frölich, A. Mügge, 1989, European heart journal.

Prevention of postoperative swelling and pain by dexamethasone after operative removal of impacted third molar teeth

R. Schmelzeisen, J. Frölich, J.-C. Frflich, 2004, European Journal of Clinical Pharmacology.

Methods in prostaglandin research

J. Frölich, 1978 .

Determination of endothelium-derived nitrite/nitrate by gas chromatography/tandem mass spectrometry using (15N)NaNO2 as internal standard.

J. Frölich, F. Gutzki, D. Tsikas, 1992, Biological mass spectrometry.

Influence of intravenous acetylsalicylic acid and sodium salicylate on human renal function and lithium clearance

J. Frölich, C. Fischer, I. Reimann, 2004, European Journal of Clinical Pharmacology.

Indomethacin but not aspirin increases plasma lithium ion levels.

J. Frölich, U. Diener, I. Reimann, 1983, Archives of general psychiatry.

Effects of salicylic and acetylsalicylic acid alone and in combination on platelet aggregation and prostanoid synthesis in man.

J. Frölich, C. Fischer, B. Rosenkranz, 1986, British journal of clinical pharmacology.

Plasma concentrations and anti-platelet effects after low dose acetylsalicylic acid.

J. Frölich, B. Rosenkranz, 1985, Prostaglandins, leukotrienes, and medicine.

A competitive protein binding assay specific for prostaglandin E.

J. Oates, J. Frölich, T. Wilson, 1974, Biochimica et biophysica acta.

Gas chromatographic-tandem mass spectrometric determination of acetylsalicylic acid in human plasma after oral administration of low-dose aspirin and guaimesal.

E. Schwedhelm, J. Frölich, F. Gutzki, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Nitric oxide inhibits the secretion of T-helper 1- and T-helper 2-associated cytokines in activated human T cells.

J. Frölich, D. Stichtenoth, H. Bauer, 1997, Immunology.

Cardiac and microcirculatory effects of different doses of prostaglandin E1 in man

H. Wilkens, J. Frölich, A. Creutzig, 2004, European Journal of Clinical Pharmacology.

Artifactual-free analysis of S-nitrosoglutathione and S-nitroglutathione by neutral-pH, anion-pairing, high-performance liquid chromatography. Study on peroxynitrite-mediated S-nitration of glutathione to S-nitroglutathione under physiological conditions.

D. Tsikas, J. Frölich, K. Denker, 2001, Journal of chromatography. A.

Gas chromatographic-mass spectrometric determination of leukotriene E4 in human urine using deuterium-labelled leukotriene E4 standards.

T. Röder, J. Frölich, J. Fauler, 1993, Journal of chromatography.

Enzymic preparation of dioxygen-18 labelled leukotriene E4 and its use in quantitative gas chromatography-mass spectrometry.

J. Frölich, J. Fauler, D. Tsikas, 1992, Journal of chromatography.

Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.

R. Schmelzeisen, J. Frölich, S. Schultze–Mosgau, 1995, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

Endothelium-derived relaxing factor influences renal vascular resistance.

U. Förstermann, J. Frölich, J. Radermacher, 1990, The American journal of physiology.

COX-2 and the kidneys.

J. Frölich, D. Stichtenoth, 2000, Current pharmaceutical design.

Exercise increases systemic nitric oxide production in men.

S. Bode-Böger, J. Frölich, R. Böger, 1995, Journal of cardiovascular risk.

Chemical synthesis of dioxygen-18 labelled ω-/β-oxidized cysteinyl leukotrienes: analysis by gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry

J. Frölich, J. Fauler, D. Tsikas, 1995 .

Analysis of leukotriene B4 as free acid and its δ-lactone by high-performance liquid chromatography: a study on the stability and formation of leukotriene B4 δ-lactone

D. Tsikas, J. Frölich, J. Fauler, 1993 .

Human monocytes convert leukotriene B4 to two dihydro-leukotriene B4-metabolites.

J. Frölich, J. Fauler, V. Kaever, 1989, Prostaglandins, leukotrienes, and essential fatty acids.

LTB4 in nephrotoxic serum nephritis in rats.

J. Frölich, K. Koch, J. Fauler, 1989, Kidney international.

Long-term administration of L-arginine, L-NAME, and the exogenous NO donor molsidomine modulates urinary nitrate and cGMP excretion in rats.

S. Bode-Böger, J. Frölich, R. Böger, 1994, Cardiovascular research.

Capillary isotachophoretic determination of cysteinyl leukotrienes.

D. Tsikas, J. Frölich, J. Fauler, 1991, Journal of chromatography.

Nitric oxide synthesis in chronic renal failure. Are plasma S-nitrosothiol levels elevated?

D. Tsikas, J. Frölich, J. Kielstein, 2004, Clinica chimica acta; international journal of clinical chemistry.

Effect of captopril on prostacyclin and nitric oxide formation in healthy human subjects: interaction with low dose acetylsalicylic acid.

D. Tsikas, S. Bode-Böger, J. Frölich, 2003, British journal of clinical pharmacology.

Extraction and chromatographic procedures for purification of prostaglandins, thromboxanes, prostacyclin, and their metabolites.

M. Hamberg, B. Samuelsson, J. Frölich, 1978, Advances in prostaglandin and thromboxane research.

Gas chromatography-mass spectrometry of cis-9,10-epoxyoctadecanoic acid (cis-EODA). II. Quantitative determination of cis-EODA in human plasma.

D. Tsikas, J. Frölich, F. Gutzki, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Analysis of leukotrienes, prostaglandins, thromboxane B2 and their metabolites by capillary isotachophoresis

D. Tsikas, J. Frölich, J. Fauler, 1993, Electrophoresis.

Low dialysance of asymmetric dimethylarginine (ADMA)--in vivo and in vitro evidence of significant protein binding.

D. Fliser, G. Lonnemann, S. Bode-Böger, 2004, Clinical nephrology.

Measurement of prostaglandins, thromboxanes, prostacyclin and their metabolites by gas liquid chromatography--mass spectrometry.

M. Hamberg, B. Samuelsson, J. Frölich, 1978, Advances in prostaglandin and thromboxane research.

Determination, source, metabolism, and functional role of renal prostaglandins.

J. Frölich, L. Walker, 1980, Clinical and experimental hypertension.

Electrospray ionization mass spectrometry of low-molecular-mass S-nitroso compounds and their thiols.

M. Raida, D. Tsikas, W. Forssmann, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Gas chromatographic-mass spectrometric detection of S-nitroso-cysteine and S-nitroso-glutathione.

D. Tsikas, J. Frölich, F. Gutzki, 1999, Analytical biochemistry.

Effect of vasopressin blockade on blood pressure in conscious rats with malignant two-kidney Goldblatt hypertension.

G. Fejes-Tóth, J. Frölich, J. Filep, 1985, Clinical and experimental hypertension. Part A, Theory and practice.

Chronic arterial and venous catheterization of conscious, unrestrained rats.

A. Náray-Fejes-Tóth, G. Fejes-Tóth, J. Frölich, 1984, Hypertension.

Dexamethasone effect on prostanoid formation in healthy man.

A. Náray-Fejes-Tóth, G. Fejes-Tóth, J. Frölich, 1985, Clinical science.

Cimetidine increases steady state plasma levels of propranolol.

U. Klotz, J. Frölich, I. Reimann, 1981, British journal of clinical pharmacology.

Antidiuretic hormone increases renal prostaglandin synthesis in vivo.

J. Frölich, L. Walker, M. Smigel, 1978, The American journal of physiology.

Solid- and liquid-phase extraction for the gas chromatographic-tandem mass spectrometric quantification of 2,3-dinor-thromboxane B2 and 2,3-dinor-6-oxo-prostaglandin F1 alpha in human urine.

D. Tsikas, J. Frölich, F. Gutzki, 2000, Journal of chromatography. A.

Effects of chronic oral l-arginine administration on the l-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: l-Arginine prevents renal loss of nitrite, the major NO reservoir

D. Tsikas, J. Huneau, J. Frölich, 2015, Amino Acids.

Mechanism of antihypertensive action of ketanserin in man.

J. Frölich, I. Reimann, 1983 .

Dose-dependent stimulation of renal prostaglandin synthesis by deamino-8-D-arginine vasopressin in rats with hereditary diabetes insipidus.

J. Frölich, L. Walker, 1981, The Journal of pharmacology and experimental therapeutics.

Elevated plasma and urine levels of ADMA and 15(S)‐8‐iso‐PGF2α in end‐stage liver disease

D. Tsikas, J. Klempnauer, T. Becker, 2003, Hepatology.

Effect of aprotinin on the renal response to vasopressin in diabetes insipidus rats.

A. Náray-Fejes-Tóth, G. Fejes-Tóth, J. Frölich, 1983, The Journal of physiology.

Metabolism of digitoxin in man and its modification by spironolactone

J. Oates, J. Frölich, J. Hollifield, 1976, European Journal of Clinical Pharmacology.

Metabolism of peruvoside in man

J. Watson, J. Frölich, F. Scheler, 1972, European Journal of Clinical Pharmacology.

Effect of spironolactone on excretion of 3H-digoxin and its metabolites in rats.

J. Frölich, K. Wirth, 1974, European journal of pharmacology.

Quantification of nitrite and nitrate in human urine and plasma as pentafluorobenzyl derivatives by gas chromatography-mass spectrometry using their 15N-labelled analogs.

S. Bode-Böger, J. Frölich, R. Böger, 1994, Journal of chromatography. B, Biomedical applications.

Determination of nitrite as pentafluorobenzyl derivative by RP-HPLC and UV detection with and without ion-pair extraction

D. Tsikas, J. Frölich, 1992 .

Blood donors on medication

H. Deicher, J. Frölich, D. Stichtenoth, 2001, European Journal of Clinical Pharmacology.

Blood donors on medication. Are deferral periods necessary?

H. Deicher, J. Frölich, D. Stichtenoth, 2001, European journal of clinical pharmacology.

Gas Chromatography-Mass Spectrometry of Prostaglandins

J. Frölich, 1977 .

A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes.

J. Frölich, 1997, Trends in pharmacological sciences.

Analysis of cysteine and N-acetylcysteine in human plasma by high-performance liquid chromatography at the basal state and after oral administration of N-acetylcysteine.

J. Frölich, J. Fauler, D. Stichtenoth, 1998, Journal of chromatography. B, Biomedical sciences and applications.

The participation of prostaglandins in the control of renin release.

R. Branch, J. Oates, J. Frölich, 1979, Federation proceedings.

Investigations on Renal Prostaglandins by Gas Chromatography—Mass Spectrometry

J. Frölich, C. Fischer, I. Reimann, 1983 .

Tandem mass spectrometric quantification of 8-iso-prostaglandin F2α and its metabolite 2,3-dinor-5,6-dihydro-8-iso-prostaglandin F2α in human urine

D. Tsikas, T. Durand, E. Schwedhelm, 2000 .

Increased total body synthesis of prostacyclin in rats with adjuvant arthritis.

J. Frölich, D. Stichtenoth, F. Gutzki, 1995, Prostaglandins.

Effect of Lovastatin on Plaque Formation and Ldl Oxidation in Cholesterol-Fed Rabbits

S. Bode-Böger, J. Frölich, R. Böger, 1998 .

High performance liquid chromotography of prostaglandins: biological applications.

J. Frölich, B. Sweetman, K. Carr, 1976, Prostaglandins.

Development, validation and biomedical applications of stable-isotope dilution GC-MS and GC-MS/MS techniques for circulating malondialdehyde (MDA) after pentafluorobenzyl bromide derivatization: MDA as a biomarker of oxidative stress and its relation to 15(S)-8-iso-prostaglandin F2α and nitric oxide

D. Tsikas, N. Maassen, J. Frölich, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Effects of cimetidine and ranitidine on steady‐state propranolol kinetics and dynamics

U. Klotz, J. Frölich, I. Reimann, 1982, Clinical pharmacology and therapeutics.

Indomethacin increases plasma lithium.

J. Oates, J. Frölich, I. Reimann, 1979, British medical journal.

Unusual collision-induced dissociation of fluorated and non-fluorated alpha-nitrotoluene analogs in a gas chromatograph triple-stage quadrupole mass spectrometer under electron-capturing negative-ion chemical ionization conditions.

D. Tsikas, E. Schwedhelm, J. Frölich, 2005, Journal of chromatography. A.

Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings

D. Tsikas, D. Wedekind, J. Huneau, 2018, Amino Acids.

Trouble with the analysis of nitrite, nitrate, S-nitrosothiols and 3-nitrotyrosine: freezing-induced artifacts?

D. Tsikas, J. Frölich, 2004, Nitric oxide : biology and chemistry.

Effects of intravenous oxygen on prostacyclin and thromboxane formation in patients with peripheral occlusive arterial disease.

J. Frölich, D. Stichtenoth, F. Gutzki, 2001, Prostaglandins, leukotrienes, and essential fatty acids.

Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free l-arginine in humans

D. Tsikas, J. Huneau, E. Schwedhelm, 2015, Amino Acids.

Measurements of urinary kinins by HPLC-radioimmunoassay.

A. Náray-Fejes-Tóth, G. Fejes-Tóth, J. Frölich, 1984, Clinica chimica acta; international journal of clinical chemistry.

Increased prostacyclin production during exercise in untrained and trained men: effect of low-dose aspirin.

D. Tsikas, S. Bode-Böger, J. Frölich, 1995, Journal of applied physiology.

Enzyme-immunoassay of thromboxane B2 at the picogram level.

J. Frölich, T. Inagawa, M. Sawada, 1985, Prostaglandins.

Role of endogenous nitric oxide in circadian blood pressure regulation in healthy humans and in patients with hypertension or atherosclerosis.

S. Bode-Böger, J. Frölich, R. Böger, 2000, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

Problems of assessment of prostacyclin formation in vivo.

J. Frölich, B. Rosenkranz, 1984, Prostaglandins.

The Second Generation of COX-2 Inhibitors

J. Frölich, D. Stichtenoth, 2012, Drugs.

ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins.

D. Tsikas, B. Hornig, N. Arakawa, 2003, Cardiovascular research.

Urinary nitrate excretion is increased in patients with rheumatoid arthritis and reduced by prednisolone.

H. Zeidler, J. Frölich, J. Fauler, 1995, Annals of the rheumatic diseases.

Simplified HPLC method for urinary and circulating creatinine.

D. Tsikas, J. Frölich, Alexander Wolf, 2004, Clinical chemistry.

Urinary 8-iso-Prostaglandin F2&agr; as a Risk Marker in Patients With Coronary Heart Disease: A Matched Case-Control Study

D. Tsikas, E. Schwedhelm, R. Maas, 2004 .

A simplified assay of furosemide in plasma and urine by high-pressure liquid chromatography.

A. Rane, J. Frölich, K. Carr, 1978, Journal of chromatography.

Selective Attenuation of Endothelium‐Mediated Vasodilation in Atherosclerotic Human Coronary Arteries

U. Förstermann, A. Haverich, J. Frölich, 1988, Circulation research.

Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases

T. Welte, J. Frölich, K. Neumann, 2003, BMJ : British Medical Journal.

Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo.

D. Tsikas, S. Bode-Böger, J. Frölich, 1998, Cardiovascular research.

Variability in the pharmacokinetics of atenolol and metoprolol.

J. Frölich, H. Ledermann, H. Bippi, 1985, Arzneimittel-Forschung.

Pregraduate teaching clinical pharmacology in Germany

J. Frölich, D. Stichtenoth, 2004, European Journal of Clinical Pharmacology.

Analysis of nitrite and nitrate as 1-nitro-2,4,6-trimethoxybenzene derivatives by reversed-phase HPLC with UV-detection

D. Tsikas, J. Frölich, F. Gutzki, 1992 .

Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease

D. Tsikas, J. Frölich, A. Hahn, 2015, Amino Acids.

[Transcutaneous pO2 and laser Doppler flux in increasing doses of intraarterial and intravenously administered prostaglandin E1].

D. Kiessling, J. Frölich, A. Creutzig, 1987, VASA. Zeitschrift fur Gefasskrankheiten.

Determination of chloride in biological fluids as pentafluorobenzylchloride by reversed-phase high-performance liquid chromatography and UV detection

J. Frölich, J. Fauler, D. Tsikas, 1992 .

Relevance of urinary 6-keto-prostaglandin F1α determination

J. Frölich, B. Rosenkranz, W. Kitajima, 1981 .

Inhibition of platelet aggregation by S‐nitroso‐cysteine via cGMP‐independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets

M. Raida, D. Tsikas, J. Frölich, 1999, FEBS letters.

Enzymatic and chemical labelling of prostaglandin E1 and 13,14-dihydro-15-keto-prostaglandin E1

D. Tsikas, J. Frölich, D. Stichtenoth, 1993 .

The effects of metamizol on prostaglandin synthesis in man.

J. Frölich, M. Badian, W. Rupp, 1986, Agents and actions. Supplements.

Differential systemic and pulmonary hemodynamic effects of L-arginine in patients with coronary artery disease or primary pulmonary hypertension.

S. Bode-Böger, J. Frölich, R. Böger, 1996, International journal of clinical pharmacology and therapeutics.

Methodological considerations on the detection of 3-nitrotyrosine in the cardiovascular system.

D. Tsikas, E. Schwedhelm, J. Frölich, 2002, Circulation Research.

Thimerosal induces endothelium-dependent vascular smooth muscle relaxations by interacting with thiol groups

U. Förstermann, J. Frölich, K. Burgwitz, 1986, Naunyn-Schmiedeberg's Archives of Pharmacology.

The importance of renal prostaglandin synthesis in maintaining renal blood flow and glomerular filtration after renal artery stenosis in the conscious dog.

J. Oates, J. Frölich, A. Nies, 1978, Investigative urology.

Importance of NO/EDRF for glomerular and tubular function: studies in the isolated perfused rat kidney.

B. Klanke, J. Frölich, J. Radermacher, 1992, Kidney international.

Effects of Nonsteroidal Phospholipase Inhibitors and Glucocorticoids on Endothelium‐Dependent Relaxations of Rabbit Aorta Induced by Different Agents

U. Förstermann, J. Frölich, K. Burgwitz, 1987, Journal of cardiovascular pharmacology.

Effects of various nitric oxide donating agents on the contractility and cyclic nucleotide turnover of human seminal vesicles in vitro.

C. Stief, D. Tsikas, U. Jonas, 2002, Urology.

Prostaglandins in Human Hypertension: Relationships to Renin, Sodium, and Antihypertensive Drug Action

D. Robertson, J. Frölich, I. Reimann, 1981 .

Mechanisms of action of lipoxygenase and cytochrome P‐450‐mono‐oxygenase inhibitors in blocking endothelium‐dependent vasodilatation

U. Förstermann, J. Frölich, A. Mülsch, 1988, British journal of pharmacology.

IS KETANSERIN A D RECEPTOR ANTAGONIST?

P. Bradley, J. Frölich, I. Reimann, 1983, The Lancet.

The binding of prostaglandins to rat liver plasma membranes and its use in the assay of urinary prostaglandins.

J. Frölich, M. Smigel, 1974, Prostaglandins.

Are prostaglandins involved in the antihypertensive effect of dihydralazine?

J. Frölich, H. Wisser, D. Ratge, 1981, Clinical science.

Prostacyclin in hypertension.

J. Frölich, 1990, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Characterization of prostaglandin E receptor in membranes and its use in the assay of prostaglandin E.

S. Fleischer, J. Frölich, M. Smigel, 1974, Methods in enzymology.

[Vipoma. 9-year observations using currently available therapy methods].

J. Frölich, J. Bode, J. Binder, 2008, Deutsche Medizinische Wochenschrift.

Exercise Increases Systemic Nitric Oxide Production in Men

S. Bode-Böger, J. Frölich, R. Böger, 1994 .

Quantitative determination of prostaglandins.

J. Watson, J. Frölich, B. Sweetman, 1973, Prostaglandins.

Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease

D. Tsikas, J. Borlak, J. Klempnauer, 2010, Liver international : official journal of the International Association for the Study of the Liver.

Divergence in urinary 8-iso-PGF2α (iPF2α-III, 15-F2t-IsoP) levels from gas chromatography–tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF2α: Possible methodological, mechanistic and clinical implicati

J. Hohlfeld, D. Tsikas, E. Schwedhelm, 2003 .

ANALYSIS OF EICOSANOIDS BY GC-MS/MS

U. Förstermann, J. Frölich, J. Fauler, 1988 .

Analysis of prostacyclin

J. Frölich, B. Rosenkranz, 1984 .

DDAH activity is not associated with oxidative stress in elderly patients with peripheral arterial occlusive disease

D. Tsikas, J. Frölich, V. V. Pham, 2014, Experimental Gerontology.

Simultaneous GC-MS/MS measurement of malondialdehyde and 4-hydroxy-2-nonenal in human plasma: Effects of long-term L-arginine administration.

D. Tsikas, J. Frölich, Bibiana Beckmann, 2017, Analytical biochemistry.

Elevated Nitric Oxide Levels in Patients with Chronic Liver Disease and Cirrhosis Correlate with Disease Stage and Parameters of Hyperdynamic Circulation

M. Manns, H. Arkenau, K. Böker, 2002, Zeitschrift fur Gastroenterologie.

Effects of ketoprofen and ibuprofen on platelet aggregation and prostanoid formation in man

J. Frölich, D. Stichtenoth, F. Gutzki, 1996, European Journal of Clinical Pharmacology.

Thimerosal, an inhibitor of endothelial acyl-coenzyme A: lysolecithin acyltransferase, stimulates the production of a nonprostanoid endothelium-derived vascular relaxing factor.

R. Busse, U. Förstermann, J. Frölich, 1987, Advances in prostaglandin, thromboxane, and leukotriene research.

Plasma levels of sulfinpyrazone and of two of its metabolites after a single dose and during the steady state

J. Frölich, P. Jakobsen, C. Fischer, 2004, European Journal of Clinical Pharmacology.

Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings

D. Tsikas, D. Wedekind, J. Huneau, 2018, Amino Acids.

Synthesis of [14,15,17,17,18,18‐2H6]‐leukotriene B4

D. Tsikas, J. Frölich, J. Fauler, 1992 .

Impaired Degradation of Prostaglandins and Thromboxane in Zellweger Syndrome

D. Keppler, E. Mayatepek, J. Frölich, 1994, Pediatric Research.

Divergence in urinary 8-iso-PGF(2alpha) (iPF(2alpha)-III, 15-F(2t)-IsoP) levels from gas chromatography-tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF(2alpha). Possible methodological, mechanistic an

J. Hohlfeld, D. Tsikas, E. Schwedhelm, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Acute effects of antidiuretic hormone on urinary prostaglandin excretion.

A. Náray-Fejes-Tóth, G. Fejes-Tóth, J. Frölich, 1983, The Journal of pharmacology and experimental therapeutics.

Urinary nitrate excretion is increased in cardiac transplanted patients with acute graft rejection.

H. Schäfers, P. Lichtlen, S. Bode-Böger, 1996, Clinical transplantation.

Is S‐nitrosoglutathione formed in nitric oxide synthase incubates?

D. Tsikas, J. Frölich, J. Sandmann, 2000, FEBS letters.

Is S-nitroso-N-acetyl-L-cysteine a circulating or an excretory metabolite of nitric oxide (NO) in man? Assessment by gas chromatography-mass spectrometry.

M. Raida, J. Frölich, D. Stichtenoth, 1996, Biochemical and Biophysical Research Communications - BBRC.

Analysis of prostanoid metabolites by gas chromatography/mass spectrometry.

A. Náray-Fejes-Tóth, G. Fejes-Tóth, J. Frölich, 1985, Advances in prostaglandin, thromboxane, and leukotriene research.

Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency. A double-blind, placebo-controlled study.

G. Brabant, A. Mühlen, S. Bode-Böger, 1996, The Journal of clinical investigation.

Controlled trial of high-versus low-dose aspirin treatment after percutaneous transluminal angioplasty in patients with peripheral vascular disease

M. Galanski, S. Bode-Böger, J. Frölich, 1994, The clinical investigator.

Effect of arginine depletion on glomerular and tubular kidney function: studies in isolated perfused rat kidneys.

B. Klanke, S. Kastner, J. Frölich, 1991, The American journal of physiology.

Endothelial cyclic GMP and cyclic AMP do not regulate the release of endothelium-derived relaxing factor/nitric oxide from bovine aortic endothelial cells.

U. Förstermann, J. Frölich, M. Kuhn, 1991, The Journal of pharmacology and experimental therapeutics.

D. Tsikas, J. Huneau, J. Frölich, 2015, Amino Acids.

Helicobacter pylori produces histamine and spermidine.

D. Tsikas, J. Frölich, G. Brunner, 1996, Zeitschrift für Gastroenterologie - German Journal of Gastroenterology.

Measurement of icosanoids. Report of the Group for Standardization of Methods in Icosanoid Research.

J. Frölich, 1984, Prostaglandins.

Biosynthesis of homoarginine (hArg) and asymmetric dimethylarginine (ADMA) from acutely and chronically administered free l-arginine in humans

D. Tsikas, J. Huneau, E. Schwedhelm, 2015, Amino Acids.