M. Pascal

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Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands.

J. Maffrand, J. Wagnon, G. Le Fur, 2002, Progress in brain research.

Characterization of NPY receptors controlling lipolysis and leptin secretion in human adipocytes

P. Casellas, J. Maffrand, M. Lafontan, 2000, FEBS letters.

Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [H]-SR 121463.

G. Guillon, C. Serradeil-Le Gal, M. Pascal, 2000, Kidney international.

Defined glycosaminoglycan motifs have opposite effects on neuronal polarity in vitro.

A. Prochiantz, F. Lafont, A. Rousselet, 1994, Developmental biology.

Pancreatic vasopressin V1b receptors: characterization in In-R1-G9 cells and localization in human pancreas.

P. Rochard, C. Serradeil-Le Gal, M. Pascal, 2003, American journal of physiology. Endocrinology and metabolism.

Detection of atherosclerotic plaque with two monoclonal antibodies. 2P1A2 monoclonal antibody is specific for smooth muscle cells in atherosclerotic plaque.

A. Desmoulière, M. Pascal, J. Larrue, 1988, Atherosclerosis.

O-acylated heparin derivatives with low anticoagulant activity decrease proliferation and increase alpha-smooth muscle actin expression in cultured arterial smooth muscle cells.

A. Desmoulière, G. Gabbiani, J. Herbert, 1992, European journal of pharmacology.

Characterization of rat aortic smooth muscle cells resistant to the antiproliferative activity of heparin following long‐term heparin treatment

A. Desmoulière, J. Herbert, M. Pascal, 1994, Journal of cellular physiology.

Experimental studies on the antitussive properties of the new xanthine derivative 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]. 1st communication: in vivo demonstration of the effects on animal models of cough and of mucociliary clearance.

M. Pascal, V. Saano, P. Arányi, 1997, Arzneimittel-Forschung.

Glycosaminoglycans enhance megakaryocytopoiesis by modifying the activities of hematopoietic growth regulators

J. Maffrand, M. Pascal, M. Petitou, 1996, Journal of cellular physiology.

Long-term aquaretic efficacy of a selective nonpeptide V(2)-vasopressin receptor antagonist, SR121463, in cirrhotic rats.

C. S. Gal, W. Jiménez, M. Morales-Ruiz, 2000, The Journal of pharmacology and experimental therapeutics.

SSR240600 [(R)-2-(1-{2-[4-{2-[3,5-Bis(trifluoromethyl)phenyl]acetyl}-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl}- 4-piperidinyl)-2-methylpropanamide], a Centrally Active Nonpeptide Antagonist of the Tachykinin Neurokinin-1 Receptor: I. Biochemical and Pharmacological Characterization

P. Soubrié, R. Steinberg, F. Oury-Donat, 2002, Journal of Pharmacology and Experimental Therapeutics.

Proinflammatory role of vasopressin through V1b receptors in hapten-induced experimental colitis in rodents: implication in IBD.

F. De Ponti, C. Serradeil-Le Gal, M. Pascal, 2010, American journal of physiology. Gastrointestinal and liver physiology.

Fraxiparin, a low‐molecular‐weight heparin, stimulates megakaryocytopoiesis in vitro and in vivo in mice

J. Maffrand, M. Pascal, M. Petitou, 1994, British journal of haematology.

Biological characterization of rodent and human vasopressin V1b receptors using SSR-149415, a nonpeptide V1b receptor ligand.

J. Wagnon, C. Serradeil-Le Gal, M. Pascal, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

In Vitro and in Vivo Pharmacological Characterization of Ethyl-4-{trans-4-[((2S)-2-hydroxy-3-{4-hydroxy-3[(methylsulfonyl)amino]-phenoxy}propyl) Amino]cyclohexyl}benzoate Hydrochloride (SAR150640), a New Potent and Selective Human β3-Adrenoceptor Agonist for the Treatment of Preterm Labor

M. Leroy, G. Germain, M. Bardou, 2007, Journal of Pharmacology and Experimental Therapeutics.

Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist.

P. Soubrié, M. Poncelet, C. Gueudet, 2002, Canadian journal of physiology and pharmacology.

Effects of fenofibrate treatment on fatty acid oxidation in liver mitochondria of obese Zucker rats.

C. Henninger, M. Pascal, J. Bézard, 1987, Biochemical pharmacology.

High sensitivity of carnitine acyltransferase I to malonyl‐CoA inhibition in liver of obese Zucker rats

C. Henninger, M. Pascal, J. Bézard, 1985, FEBS letters.

SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. I. In vitro studies.

P. Soubrié, D. Gully, R. Boigegrain, 1999, The Journal of pharmacology and experimental therapeutics.

A new immunomodulator, LF 1695--II. Effects on allogenic and antigenic responses.

M. Pascal, J. Touraine, K. Sanhadji, 1991, International journal of immunopharmacology.

Stimulation of 12-HETE production in human platelets by an immunomodulator, LF 1695. Evidence for activation of arachidonate liberation coupled to cyclo-oxygenase inhibition.

L. Douste-Blazy, M. Pascal, H. Chap, 1989, Biochemical pharmacology.

Experimental studies on the antitussive properties of the new xanthine derivative 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]. 2nd communication: investigations on theophylline-like activities.

M. Pascal, F. Lacheretz, P. Arányi, 1997, Arzneimittel-Forschung.

A new immunomodulator, LF 1695--I. In vitro effects on the T lymphocyte lineage in man.

M. Pascal, J. Touraine, K. Sanhadji, 1985, International journal of immunopharmacology.

SSR126768A (4-Chloro-3-[(3R)-(+)-5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2- oxo-2,3-dihydro-1H-indol-3-yl]-N-ethyl-N-(3-pyridylmethyl)-benzamide, Hydrochloride): A New Selective and Orally Active Oxytocin Receptor Antagonist for the Prevention of Preterm Labor

B. Scatton, J. Maffrand, E. Naline, 2004, Journal of Pharmacology and Experimental Therapeutics.

SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. II. In vivo pharmacological characterization.

J. Simiand, P. Soubrié, R. Boigegrain, 1999, The Journal of pharmacology and experimental therapeutics.

Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist.

G. Griebel, J. Simiand, P. Soubrié, 2002, The Journal of pharmacology and experimental therapeutics.

The stereochemistry of calf spleen NAD‐glycohydrolase‐catalyzed NAD methanolysis

F. Schuber, M. Pascal, 1976, FEBS letters.

On the mechanism of action of calf spleen NAD+ glycohydrolase

F. Schuber, M. Pascal, P. Travo, 1979 .

Structure and stereochemistry of the active metabolite of clopidogrel.

M. Maftouh, J. Herbert, J. Maffrand, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Calf-spleen nicotinamide-adenine dinucleotide glycohydrolase. Properties of the active site.

F. Schuber, M. Pascal, P. Travo, 1978, European journal of biochemistry.

Calf-Spleen Nicotinamide-Adenine Dinucleotide Glycohydrolase Kinetic Mechanism

F. Schuber, M. Pascal, P. Travo, 1976 .

Entry and distribution of fluorescent antiproliferative heparin derivatives into rat vascular smooth muscle cells: Comparison between heparin‐sensitive and heparin‐resistant cultures

F. Lafont, A. Rousselet, M. Pascal, 1996, Journal of cellular physiology.

Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders

G. Griebel, J. Simiand, P. Soubrié, 2002, Proceedings of the National Academy of Sciences of the United States of America.

In vitro and in vivo immunomodulation by LF 1695 of human and rat macrophages and platelets in schistosomiasis.

A. Capron, M. Joseph, H. Vorng, 1988, International journal of immunopharmacology.

Differential Virtual Screening (DVS) with Active and Inactive Molecular Models for Finding and Profiling GPCR Modulators: Case of the CCK1 Receptor

Pascual Ferrara, Marc Pascal, Constantino Diaz, 2011, Molecular informatics.

High-performance liquid chromatographic procedure for measuring ATP and ADP levels in tissue microbiopsy: application to rat wound healing proliferative tissue.

M. Pascal, D. Pruneau, E. Wülfert, 1982, Analytical biochemistry.

Increased interleukin-1 and modulation of interleukin-2 production by murine macrophages and lymphocytes treated with LF 1695.

M. Pascal, P. Derrepas, 1986, International journal of immunopharmacology.

Thymectomy at weaning. An accelerated aging model for the mouse immune system

M. Pascal, P. Dutartre, 1991, Mechanisms of Ageing and Development.

Identification and Biological Activity of the Active Metabolite of Clopidogrel

J. Herbert, J. Maffrand, M. Pascal, 2000, Thrombosis and Haemostasis.

4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Biochemical and pharmacological characterization.

G. Griebel, J. Simiand, P. Soubrié, 2002, The Journal of pharmacology and experimental therapeutics.

Protein Kinase C α Expression Is Required for Heparin Inhibition of Rat Smooth Muscle Cell Proliferation in Vitro and in Vivo*

A. Clowes, J. Herbert, M. Pascal, 1996, The Journal of Biological Chemistry.

Evidence for the inhibition of platelet-derived growth factor induced rat smooth muscle cells DNA synthesis by fenofibric acid at the Go/G1 cell cycle level.

M. Pascal, C. Sepulchre, J. Chazan, 1983, Life sciences.

Pro-inflammatory role of vasopressin through V 1 b receptors in hapten-1 induced experimental colitis in rodents : implication in IBD 2 3 4 Running head : Vasopressin in experimental colitis 5 6 7

C. S. Gal, M. Pascal, A. Schulte, 2010 .

Mechanism of Action of Fenofibrate: New Data

M. Pascal, C. Legendre, H. Danh, 1987 .

[Action of an antioxygen food additive, di-tertio-butyl-hydroxy-toluene on the electron transport and on the coupling of oxidation and phosphorylation in the liver mitochondria of rats].

M. Pascal, T. Tennoine, 1975, Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles.

Implications of prostaglandin E2 synthesis and phospholipase C activation in potentiation of T-cell proliferation by LF 1695.

M. Pascal, P. Dutartre, J. Annat, 1991, International journal of immunopharmacology.

Experimental Studies on Guanosine 3’,5’-Cyclic Monophosphate Levels and Airway Responsiveness of the Novel Phosphodiesterase Type 5 Inhibitor

J. Herbert, M. Pascal, P. Schaeffer, 1999, Arzneimittelforschung.

Enhancement of T-cell differentiation and T-cell suppressor activity in vitro with LF 1695

M. Pascal, J. Touraine, K. Sanhadji, 1982 .

Evaluation of an immunodulator LF 1695 on murine immune function

M. Pascal, P. Desnoyers, B. Majoie, 1982 .

ADP‐ribonolactone: A potential activated intermediate analogue of NAD‐glycohydrolase

F. Schuber, M. Pascal, 1977, FEBS letters.