B. Muñoz

发表

An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules

Joshua C. Gilbert, Joshua A. Bittker, Andrew J. Wilson, 2013, Cell.

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase.

Chi‐Huey Wong, J. Haeggström, B. Samuelsson, 1993, Journal of medicinal chemistry.

Investigation of the inhibition of leukotriene A4 hydrolase.

I. Ollmann, J. Haeggström, B. Samuelsson, 1995, Bioorganic & medicinal chemistry.

Expedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology.

N. Cosford, B. Muñoz, Nicholas D Smith, 2004, Bioorganic & medicinal chemistry letters.

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.

N. Cosford, P. Prasit, B. Muñoz, 2004, Journal of medicinal chemistry.

Discovery of novel modulators of metabotropic glutamate receptor subtype-5.

B. Muñoz, M. F. Gardner, Janice Chung, 2004, Bioorganic & medicinal chemistry.

Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.

N. Cosford, B. Muñoz, Merryl D. Cramer, 2005, Bioorganic & medicinal chemistry letters.

5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.

Dehua Huang, N. Cosford, B. Muñoz, 2004, Bioorganic & medicinal chemistry letters.

Potent and selective inhibitors of leukotriene A4 hydrolase: effects on purified enzyme and human polymorphonuclear leukocytes.

J. Haeggström, B. Samuelsson, A. Wetterholm, 1995, The Journal of pharmacology and experimental therapeutics.

Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists.

B. Muñoz, M. F. Gardner, Bowei Wang, 2010, Bioorganic & medicinal chemistry letters.

Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).

S. Schreiber, J. Buolamwini, T. Lewis, 2014, Bioorganic & medicinal chemistry letters.

Anti-malarial Activity in the Mouse Model Dihydroorotate Dehydrogenase with Plasmodium falciparum Novel Inhibitors of Molecular Bases of Disease :

Margaret A. Phillips, Elizabeth J. Goldsmith, Dyann F. Wirth, 2010 .

Fungal hydroxylation of ethyl benzene and derivatives

B. Muñoz, S. Khan, H. Holland, 1985 .

Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys.

C. Kenific, C. Moxham, B. Pan, 2015, Bioorganic & medicinal chemistry letters.

The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.

P. Prasit, B. Muñoz, D. Beher, 2006, Bioorganic & medicinal chemistry letters.

N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the alpha2delta subunit of voltage gated calcium channels.

S. Venkatraman, B. Muñoz, H. Schaffhauser, 2004, Bioorganic & medicinal chemistry letters.

Antiplasmodial activity of piperazine sulfonamides.

J. Clardy, Ralph Mazitschek, B. Muñoz, 2010, Bioorganic & medicinal chemistry letters.

Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA.

R. Morimoto, D. Finley, J. Kelly, 2020, Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.

Use of a High-Throughput Phenotypic Screening Strategy to Identify Amplifiers, a Novel Pharmacological Class of Small Molecules That Exhibit Functional Synergy with Potentiators and Correctors

K. Giuliano, B. Tait, J. Miller, 2017, SLAS discovery : advancing life sciences R & D.

Potent benzoazepinone γ-secretase modulators with improved bioavailability.

C. Kenific, A. Szewczak, C. Moxham, 2015, Bioorganic & medicinal chemistry letters.

Triazoloamides as potent γ-secretase modulators with reduced hERG liability.

A. Szewczak, C. Moxham, Hua Zhou, 2012, Bioorganic & medicinal chemistry letters.

Evidence of calcium(2+)-dependent carbohydrate association through ion spray mass spectrometry

G. Siuzdak, Chi‐Huey Wong, K. Nicolaou, 1993 .

Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.

S. Venkatraman, B. Muñoz, Bowei Wang, 2009, Bioorganic & medicinal chemistry letters.

Influence of acid surrogates toward potency of VLA-4 antagonist.

S. Venkatraman, B. Muñoz, Merryl D. Cramer, 2005, Bioorganic & medicinal chemistry letters.

Triazoles as γ-secretase modulators.

C. Kenific, A. Szewczak, Hua Zhou, 2011, Bioorganic & medicinal chemistry letters.

Quinazolinones as γ-secretase modulators.

A. Szewczak, J. Crispino, B. Muñoz, 2011, Bioorganic & medicinal chemistry letters.

Side chain hydroxylation of aromatic compounds by fungi.: 1. Products and stereochemistry

B. Muñoz, S. Khan, H. Holland, 1987 .

Synthesis of dihydropyridone scaffolds on solid support: Resin activation/capture approach/REACAP technology

B. Muñoz, I. McDonald, Chixu Chen, 1998 .

Resin activation capture technology: libraries from stabilized acyl-pyridinium on solid support.

B. Muñoz, I. McDonald, C. Chen, 2000, Biotechnology and bioengineering.

Side chain hydroxylation of aromatic compounds by fungi: 3. Direct observation of fungal biotransformation by NMR

B. Muñoz, H. Holland, Timothy R. B. Jones, 1988 .

Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the α2δ-1 subunit of voltage gated calcium channel

S. Venkatraman, J. Gunzner, B. Muñoz, 2004 .

Alpha-ketoamide Phe-Pro isostere as a new core structure for the inhibition of HIV protease.

Chi‐Huey Wong, C. Wong, B. Muñoz, 1994, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives as high-affinity ligands of the α2δ subunit of voltage-gated calcium channels

Brian T. Campbell, S. Venkatraman, B. Muñoz, 2004 .

Purine derivatives as potent gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.

M. Tota, S. Krauss, I. Kariv, 2006, Bioorganic & medicinal chemistry letters.

Synthesis of chiral molecules from non-chiral crystals by controlled reaction at a single surface

B. Muñoz, H. Holland, M. F. Richardson, 1986 .

Papain-catalyzed synthesis of peptide isosteres

Chi‐Huey Wong, W. Yuan, B. Muñoz, 1993 .

Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.

B. Muñoz, N. Smith, Steve F. Poon, 2005, Bioorganic & medicinal chemistry letters.

Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum

Bradley I. Coleman, R. Barker, D. Wirth, 2011, Antimicrobial Agents and Chemotherapy.

γ‐Secretase Inhibition: An Overview of Development of Inhibitors for the Treatment of Alzheimer's Disease

B. Muñoz, Richard W. Heidebrecht, Christopher L. Hamblett, 2011 .

Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria.

R. Barker, B. Muñoz, J. Cortese, 2011, ACS medicinal chemistry letters.

Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.

N. Cosford, B. Muñoz, Merryl D. Cramer, 2005, Bioorganic & medicinal chemistry letters.

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model*

Bradley I. Coleman, E. Goldsmith, R. Barker, 2010, The Journal of Biological Chemistry.

Side chain hydroxylation of aromatic hydrocarbons by fungi. Part 2. Isotope effects and mechanism

F. M. Brown, B. Muñoz, H. Holland, 1988 .

Characterization of alpha(4)beta(1) (CD49d/CD29) on equine leukocytes: potential utility of a potent alpha(4)beta(1) (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction).

D. Thompson, P. Prasit, D. Nicholson, 2009, Veterinary immunology and immunopathology.

Fluorinated piperidine acetic acids as gamma-secretase modulators.

C. Kenific, A. Szewczak, J. Crispino, 2010, Bioorganic & medicinal chemistry letters.

Solid phase synthesis of 2-acyl-3,7,8-substituted-5-oxo-2-azabicyclo[2.2.2]octane and triaza analogs: Resin Activation/Capture Approach/REACAP Technology

B. Muñoz, Chixu Chen, 1999 .

Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators.

Alexey Rivkin, Chaomin Li, A. Szewczak, 2010, Bioorganic & Medicinal Chemistry Letters.

Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia.

D. Lorrain, P. Prasit, B. Muñoz, 2005, Bioorganic & medicinal chemistry letters.