Namandjé N. Bumpus

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Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.

James D. Campbell, J. Baeten, J. Tappero, 2012, The New England journal of medicine.

Biotransformation of the Antiretroviral Drug Etravirine: Metabolite Identification, Reaction Phenotyping, and Characterization of Autoinduction of Cytochrome P450-Dependent Metabolism

Namandjé N. Bumpus, Lindsay J Yanakakis, 2012, Drug Metabolism and Disposition.

Single Heteroatom Substitutions in the Efavirenz Oxazinone Ring Impact Metabolism by CYP2B6

Philip M. Cox, Namandjé N. Bumpus, Namandjé N. Bumpus, 2016, ChemMedChem.

DMD060194 1796..1802

E. Fuchs, C. Hendrix, Namandjé N. Bumpus, 2014 .

CYP3A5 Genotype Impacts Maraviroc Concentrations in Healthy Volunteers

E. Fuchs, C. Hendrix, Namandjé N. Bumpus, 2014, Drug Metabolism and Disposition.

Cytochrome P450 3A5 Plays a Prominent Role in the Oxidative Metabolism of the Anti-Human Immunodeficiency Virus Drug Maraviroc

C. Hendrix, Namandjé N. Bumpus, Yanhui Lu, 2012, Drug Metabolism and Disposition.

Identification of Novel UGT1A1 Variants Including UGT1A1 454C>A through the Genotyping of Healthy Participants of the HPTN 077 Study

Myron S. Cohen, C. Hendrix, M. Hosseinipour, 2021, ACS pharmacology & translational science.

Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1α-XBP1

Namandjé N. Bumpus, A. Hamlin, Carley J. S. Heck, 2018, Molecular Pharmacology.

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule–Related Therapeutic Modalities

Xingrong Liu, L. Di, K. Nagapudi, 2019, Drug Metabolism and Disposition.

Antiretroviral drug concentrations in brain tissue of adult decedents.

R. Ellis, C. Achim, S. Letendre, 2020, AIDS.

Spatial Distribution Profiles of Emtricitabine, Tenofovir, Efavirenz, and Rilpivirine in Murine Tissues Following In Vivo Dosing Correlate with Their Safety Profiles in Humans

Namandjé N. Bumpus, H. Seneviratne, A. Hamlin, 2020, ACS pharmacology & translational science.

MALDI Mass Spectrometry Imaging Reveals Heterogeneous Distribution of Tenofovir and Tenofovir Diphosphate in Colorectal Tissue of Subjects Receiving a Tenofovir-Containing Enema

E. Fuchs, C. Hendrix, Namandjé N. Bumpus, 2018, The Journal of Pharmacology and Experimental Therapeutics.

A Multi-Compartment Single and Multiple Dose Pharmacokinetic Comparison of Rectally Applied Tenofovir 1% Gel and Oral Tenofovir Disoproxil Fumarate

C. Hendrix, N. Richardson-Harman, C. Mauck, 2014, PloS one.

In silico approach toward the identification of unique peptides from viral protein infection: Application to COVID-19

Benjamin A. Neely, Namandjé N. Bumpus, Ben Orsburn, 2020 .

Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.

J. Stivers, Namandjé N. Bumpus, Kyle J. Seamon, 2016, Biochemistry.

A Mechanistic In Vivo/Ex Vivo Pharmacokinetic‐Pharmacodynamic Model of Tenofovir for HIV Prevention

C. Hendrix, P. Anton, Namandjé N. Bumpus, 2021, CPT: pharmacometrics & systems pharmacology.

Short-term Disulfiram to Reverse Latent HIV Infection: A Phase 2 Dose Escalation Study

S. Lewin, J. Lifson, M. Piatak, 2016 .

Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction.

Namandjé N. Bumpus, P. Hollenberg, 2010, Journal of inorganic biochemistry.

Investigation of the Mechanisms Underlying the Differential Effects of the K262R Mutation of P450 2B6 on Catalytic Activity

Namandjé N. Bumpus, P. Hollenberg, 2008, Molecular Pharmacology.

Biotransformation and bioactivation reactions – 2018 literature highlights

G. Miller, I. Rietjens, J. Driscoll, 2019, Drug metabolism reviews.

Transgender women on oral HIV pre‐exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men

T. Brown, E. Fuchs, C. Hendrix, 2019, Journal of the International AIDS Society.

Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066).

K. Mayer, E. Fuchs, C. Hendrix, 2016, AIDS research and human retroviruses.

Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir.

Namandjé N. Bumpus, A. Hamlin, J. Tillotson, 2019, Pharmacogenomics.

Genetic Variation of the Kinases That Phosphorylate Tenofovir and Emtricitabine in Peripheral Blood Mononuclear Cells.

K. Mayer, C. Hendrix, T. Wilkin, 2018, AIDS research and human retroviruses.

THE NATURALLY OCCURRING CYTOCHROME P450 (P450) 2B6 K262R MUTANT OF P450 2B6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION

Namandjé N. Bumpus, P. Hollenberg, U. Kent, 2005, Drug Metabolism and Disposition.

The Naturally Occurring P450 2B6 K262R Mutant of P450 2B6 Exhibits Alterations in Substrate Metabolism and Inactivation

Namandjé N. Bumpus, P. Hollenberg, U. Kent, 2005 .

Single Cell Proteomics Using a Trapped Ion Mobility Time-of-Flight Mass Spectrometer Provides Insight into the Post-translational Modification Landscape of Individual Human Cells

Namandjé N. Bumpus, Ben Orsburn, Yuting Yuan, 2022, bioRxiv.

Pharmacogenomics of Antiretroviral Drug Metabolism and Transport.

Namandjé N. Bumpus, Zaikuan J Yu, Eric P. Mosher, 2020, Annual review of pharmacology and toxicology.

C. Hendrix, Namandjé N. Bumpus, Elaine E. To, 2013, Biochemical pharmacology.

For better drugs, diversify clinical trials

Namandjé N. Bumpus, 2021, Science.

Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry

Namandjé N. Bumpus, Ben Orsburn, Yuting Yuan, 2022, Nature Communications.

HIV Protective Efficacy and Correlates of Tenofovir Blood Concentrations in a Clinical Trial of PrEP for HIV Prevention

J. Baeten, D. Bangsberg, C. Hendrix, 2014, Journal of acquired immune deficiency syndromes.

The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module

C. Wolberger, Namandjé N. Bumpus, Ben Orsburn, 2022, bioRxiv.

Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites

J. Berger, Namandjé N. Bumpus, Joyce H. Lee, 2021, bioRxiv.

Compartmentalization and Antiviral Effect of Efavirenz Metabolites in Blood Plasma, Seminal Plasma, and Cerebrospinal Fluid

C. Hendrix, Namandjé N. Bumpus, L. B. Avery, 2013, Drug Metabolism and Disposition.

Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole

Jun O. Liu, J. Shim, Namandjé N. Bumpus, 2016, Clinical Cancer Research.

Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV‐1 Transcription in a Phase IIb Trial

S. Lewin, J. Lifson, P. Bacchetti, 2018, Clinical pharmacology and therapeutics.

Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death

Namandjé N. Bumpus, H. Seneviratne, Carley J. S. Heck, 2020, Journal of medicinal chemistry.

MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments

J. Justman, A. Minnis, B. Richardson, 2013, PloS one.

RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate.

A. Carballo-Diéguez, W. Cumberland, C. Hendrix, 2012, AIDS research and human retroviruses.

Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner

C. Hendrix, Julie M. Lade, Namandjé N. Bumpus, 2015, EBioMedicine.

Dendritic Spine Injury Induced by the 8-Hydroxy Metabolite of Efavirenz

J. McArthur, N. Sacktor, Namandjé N. Bumpus, 2012, Journal of Pharmacology and Experimental Therapeutics.

The Effects of a Naturally Occurring Genetic Polymorphism on the Catalytic Properties of Human Cytochrome P450 2B6.

Namandjé N. Bumpus, 2008 .

Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites.

J. Berger, Namandjé N. Bumpus, Joyce H. Lee, 2021, Cell chemical biology.

Metabolism of N,N′,N″-Triethylenethiophosphoramide by CYP2B1 and CYP2B6 Results in the Inactivation of Both Isoforms by Two Distinct Mechanisms

J. Rae, Namandjé N. Bumpus, P. Hollenberg, 2004, Journal of Pharmacology and Experimental Therapeutics.

A pilot study assessing the safety and latency-reversing activity of disulfiram in HIV-1-infected adults on antiretroviral therapy.

R. Siliciano, J. Siliciano, A. Spivak, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison

Julie M. Lade, Namandjé N. Bumpus, L. B. Avery, 2013, Antimicrobial Agents and Chemotherapy.

Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications.

Namandjé N. Bumpus, P. Hollenberg, U. Kent, 2008, Chemical research in toxicology.

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.

Rebecca Hoh, Wendy Hartogensis, Peter Bacchetti, 2015, The lancet. HIV.

Undisclosed antiretroviral drug use in a multinational clinical trial (HIV Prevention Trials Network 052).

K. Mayer, C. Hendrix, I. Sanne, 2013, The Journal of infectious diseases.

Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism

P. Espenshade, Rita T. Brookheart, E. Selen, 2021, The Journal of biological chemistry.

Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes.

Namandjé N. Bumpus, 2011, Toxicology and applied pharmacology.

Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain

Jace W. Jones, R. Cole, T. Boronina, 2023, PLoS genetics.

EstG is a novel esterase required for cell envelope integrity in Caulobacter

F. Cava, S. Gabelli, Laura Alvarez, 2022, Current Biology.

Antiretroviral Therapy Does Not Restore Brain Lipids During SIV Infection: Regional Analysis of Metabolic Homeostasis and Depletion

Namandjé N. Bumpus, H. Seneviratne, Dionna W. Williams, 2022, bioRxiv.

Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer’s disease

K. Aoki, R. Schnaar, Tong Li, 2022, The Journal of biological chemistry.

A Targeted Proteomics Approach for Profiling Murine Cytochrome P450 Expression

Namandjé N. Bumpus, E. Hersman, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Small Molecule Inhibition of SAMHD1 dNTPase by Tetramer Destabilization

J. Stivers, Namandjé N. Bumpus, C. McKenna, 2014, Journal of the American Chemical Society.

Utility of Different Adherence Measures for PrEP: Patterns and Incremental Value

A. Kamali, C. Hendrix, J. Haberer, 2017, AIDS and Behavior.

Interaction of Depot Medroxyprogesterone Acetate and Tenofovir Disoproxil Fumarate/Emtricitabine on Peripheral Blood Mononuclear Cells and Cervical Tissue Susceptibility to HIV Infection and Pharmacokinetics

H. Farzadegan, E. Fuchs, C. Hendrix, 2022, Journal of acquired immune deficiency syndromes.

Correlation between Compartmental Tenofovir Concentrations and an Ex Vivo Rectal Biopsy Model of Tissue Infectibility in the RMP-02/MTN-006 Phase 1 Study

Ross D. Cranston, C. Hendrix, N. Richardson-Harman, 2014, PloS one.

Tenofovir Plasma Concentration from Preexposure Prophylaxis at the Time of Potential HIV Exposure: a Population Pharmacokinetic Modeling and Simulation Study Involving Serodiscordant Couples in East Africa

C. Hendrix, M. Marzinke, J. Haberer, 2019, Antimicrobial Agents and Chemotherapy.

Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067

James P Hughes, Timothy H Holtz, Robert M Grant, 2018, PloS one.

Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro

Namandjé N. Bumpus, Eric P. Mosher, Colten D. Eberhard, 2021, Molecular Pharmacology.

Achieving a Deeper Understanding of Drug Metabolism and Responses Using Single-Cell Technologies

Namandjé N. Bumpus, Ben Orsburn, H. Seneviratne, 2023, Drug Metabolism and Disposition.

In silico Approach Toward the Identification of Unique Peptides from Viral Protein Infection: Application to COVID-19

Benjamin A. Neely, Namandjé N. Bumpus, Ben Orsburn, 2020 .

Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems

Namandjé N. Bumpus, Ben Orsburn, Abigail M Wheeler, 2023, Drug Metabolism and Disposition.

5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-Stimulated Hepatic Expression of Cyp4a10, Cyp4a14, Cyp4a31, and Other Peroxisome Proliferator-Activated Receptor α-Responsive Mouse Genes Is AICAR 5′-Monophosphate-Dependent and AMP-Activated Protein Kinase-Independent

Eric F. Johnson, Namandjé N. Bumpus, 2011, Journal of Pharmacology and Experimental Therapeutics.

Probing Ligand Structure–Activity Relationships in Pregnane X Receptor (PXR): Efavirenz and 8‐Hydroxyefavirenz Exhibit Divergence in Activation

H. Wade, Julie M. Lade, Namandjé N. Bumpus, 2018, ChemMedChem.

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites

A. Wallqvist, S. Prigge, Shivendra G. Tewari, 2020, PLoS pathogens.

Metabolism of Efavirenz and 8-Hydroxyefavirenz by P450 2B6 Leads to Inactivation by Two Distinct Mechanisms

Namandjé N. Bumpus, P. Hollenberg, U. Kent, 2006, Journal of Pharmacology and Experimental Therapeutics.

Neurotoxicity with high-dose disulfiram and vorinostat used for HIV latency reversal

K. Blennow, S. Lewin, H. Zetterberg, 2021, AIDS.

Structure–Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz

Philip M. Cox, Namandjé N. Bumpus, 2014, ACS medicinal chemistry letters.

Too many senior white academics still resist recognizing racism

Namandjé N. Bumpus, 2020, Nature.

Impact of Adenylate Kinases and Naturally Occurring Adenylate Kinase 2 Variants on the Phosphorylation of the Anti‐HIV Drug Tenofovir

Namandjé N. Bumpus, J. Tillotson, 2018 .

Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice

Namandjé N. Bumpus, L. B. Avery, 2014, Molecular Pharmacology.

A Targeted Proteomics Approach for Profiling Murine Cytochrome P450 Expression

Namandjé N. Bumpus, E. Hersman, 2014, Journal of Pharmacology and Experimental Therapeutics.

Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.

J. Baeten, J. Tappero, D. Bangsberg, 2012, The New England journal of medicine.

Metabolism of Long-Acting Rilpivirine Following Intramuscular Injection: HIV Prevention Trials Network Study 076 (HPTN 076).

L. Bekker, N. Mgodi, C. Hendrix, 2020, AIDS research and human retroviruses.

Cytochrome P450 3A5 Genotype Impacts Maraviroc Concentrations in Healthy Volunteers

E. Fuchs, Namandjé N. Bumpus, Craig W Hendrix, 2014 .

Dendritic Spine Injury Induced by the 8-Hydroxy Metabolite of Efavirenz

J. McArthur, N. Sacktor, Namandjé N. Bumpus, 2012, Journal of Pharmacology and Experimental Therapeutics.

Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole

Jun O. Liu, J. Shim, Namandjé N. Bumpus, 2016, Clinical Cancer Research.

THE NATURALLY OCCURRING CYTOCHROME P 450 ( P 450 ) 2 B 6 K 262 R MUTANT OF P 450 2 B 6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION

Namandjé N. Bumpus, P. Hollenberg, U. Kent, 2005 .

RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate.

Ross D. Cranston, A. Carballo-Diéguez, W. Cumberland, 2012, AIDS research and human retroviruses.

C. Hendrix, Namandjé N. Bumpus, Elaine E. To, 2013, Biochemical pharmacology.

Compartmentalization and Antiviral Effect of Efavirenz Metabolites in Blood Plasma, Seminal Plasma, and Cerebrospinal Fluid

C. Hendrix, Namandjé N. Bumpus, L. B. Avery, 2013, Drug Metabolism and Disposition.

Compartmentalization and Antiviral Effect of Efavirenz Metabolites in Blood Plasma, Seminal Plasma, and Cerebrospinal Fluid

C. Hendrix, Namandjé N. Bumpus, L. B. Avery, 2013 .

Compartmentalization and Antiviral Effect of Efavirenz Metabolites in Blood Plasma, Seminal Plasma, and Cerebrospinal Fluid

C. Hendrix, Namandjé N. Bumpus, L. B. Avery, 2013 .