Q. Chao

发表

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

P. Zarrinkar, Mazen W. Karaman, G. Pallares, 2009, Blood.

Cloning and Identification o f M ouse Steroid Receptor C oactivator-1 (mSRC-1), as a Coactivator o f Peroxisom e Proliferator-Activated Receptor y

M. Rao, Q. Chao, Yi-jun Zhu, 2016 .

Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c.

Xiaodong Wang, X. Wang, H. Cottam, 1998, Proceedings of the National Academy of Sciences of the United States of America.

R-etodolac (SDX-101) and the related indole–pyran analogues SDX-308 and SDX-309 potentiate the antileukemic activity of standard cytotoxic agents in primary chronic lymphocytic leukaemia cells

R. Larsson, Q. Chao, L. Leoni, 2007, Cancer Chemotherapy and Pharmacology.

Incorrect targeting of plant vacuolar lectins in yeast.

M. Etzler, Q. Chao, 1994, The Journal of biological chemistry.

Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.

H. Cottam, D. Carson, Q. Chao, 1999, Journal of medicinal chemistry.

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.

M. Volgraf, A. Ebens, John G. Moffat, 2017, Journal of medicinal chemistry.

Approaches to novel bicarbocyclic nucleosides

Q. Chao, V. Nair, 1995 .

Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor.

P. Zarrinkar, H. Patel, T. Carter, 2009, Journal of medicinal chemistry.

Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria.

D. Rose, H. Cottam, D. Carson, 2000, Blood.

Recent Progress in Chemo-Enzymatic Methods for the Synthesis of N-Glycans

Q. Chao, Xiao-Dong Gao, Yi Ding, 2020, Frontiers in Chemistry.

Synthesis of bicarbocyclic dideoxynucleosides as potential antiviral agents

Q. Chao, V. Nair, 1997 .

Concise and stereospecific synthesis of novel bicyclic dideoxynucleosides as potential antiviral agents

L. Pickering, Jian Zhang, Q. Chao, 1998 .

Synthesis of Bicarbocyclic Dideoxynucleosides as Potential Antiviral Agents.

Q. Chao, V. Nair, 1997 .

Synthesis, enzymology, and anti-HIV studies of analogues of isodideoxyadenosine and its phosphorylated derivatives

T. Wenzel, Q. Chao, V. Nair, 1997 .

Concise and Stereospecific Synthesis of Novel Bicyclic Dideoxynucleosides as Potential Antiviral Agents.

L. Pickering, Q. Chao, V. Nair, 1998 .

Peroxisome-proliferator-activated receptor-binding protein ( PBP ) is essential for the growth of active Notch 4-immortalized mammary epithelial cells by activating SOX 10 expression

A. McCallion, Q. Chao, Yi-jun Zhu, 2009 .

Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series.

F. Diederich, G. Manning, I. Aliagas, 2015, ACS medicinal chemistry letters.

Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride

K. Caca, F. Baumann, C. Franklin, 2007, Cancer Chemotherapy and Pharmacology.

affecting the mitochondria lymphocytic leukemia cells by damaging the DNA and by directly Deoxyadenosine analogs induce programmed cell death in chronic

D. Rose, H. Cottam, D. Carson, 2013 .

treatment of acute myeloid leukemia (AML) AC220 is a uniquely potent and selective inhibitor of FLT3 for the

P. Zarrinkar, Mazen W. Karaman, G. Pallares, 2013 .

Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.

A. Ghose, Brian T. Campbell, Raffaella Faraoni, 2012, Journal of medicinal chemistry.

4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.

Brian T. Campbell, Raffaella Faraoni, Andiliy G. Lai, 2011, Bioorganic & Medicinal Chemistry Letters.

Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor

M. Sands, Ying Feng, Q. Chao, 2021, Scientific reports.

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.

I. Aliagas, K. Hoeflich, Weiru Wang, 2015, Journal of medicinal chemistry.

Structural organization of mouse peroxisome proliferator-activated receptor y ( mPPARy ) gene : Alternative promoter use and different splicing yield two mPPARy isoforms ( peroxisome proliferation / nuclear receptor superfamily / fatty acid P-oxidation )

M. Rao, Q. Chao, Yi-jun Zhu, 2005 .

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors.

A. Ebens, J. Lyssikatos, John G. Moffat, 2015, Bioorganic & medicinal chemistry letters.

A. Ghose, Brian T. Campbell, Raffaella Faraoni, 2012, Journal of medicinal chemistry.

P. Zarrinkar, H. Patel, T. Carter, 2009, Journal of medicinal chemistry.

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors.

I. Aliagas, K. Hoeflich, Weiru Wang, 2015, Journal of medicinal chemistry.

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

P. Zarrinkar, Mazen W. Karaman, H. Patel, 2009, Blood.

Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors.

D. Lockhart, P. Zarrinkar, D. K. Treiber, 2009, Bioorganic & medicinal chemistry letters.