C. Huston

发表

Galactose/N-acetylgalactosamine lectin: The coordinator of host cell killing

W. Petri,, D. Boettner, C. Huston, 2002, Journal of Biosciences.

Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin.

D. Griggs, J. E. Teixeira, C. Huston, 2021, Journal of medicinal chemistry.

Host-pathogen interaction in amebiasis and progress in vaccine development

W. Petri,, C. Huston, Christopher D. Huston, 1998, European Journal of Clinical Microbiology and Infectious Diseases.

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.

Mark A. Miller, X. Chen, G. Kang, 2015, The Lancet. Infectious diseases.

Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model

D. Griggs, C. Huston, M. J. Meyers, 2018, PLoS neglected tropical diseases.

Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step

A. Nalla, D. Leonard, S. Tighe, 2020, PLoS biology.

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

P. Schultz, A. Chatterjee, C. Huston, 2017, PLoS neglected tropical diseases.

A Proposed Target Product Profile and Developmental Cascade for New Cryptosporidiosis Treatments

W. V. Van Voorhis, C. Huston, J. Burrows, 2015, PLoS neglected tropical diseases.

Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Citation

Alessandro, Serge, Tyler B. Hughes, 2016 .

Entamoeba histolytica and Entamoeba dispar Utilize Externalized Phosphatidylserine for Recognition and Phagocytosis of Erythrocytes

D. Boettner, C. Huston, J. Sullivan, 2005, Infection and Immunity.

Impact and costs of a hepatitis C virus screening programme for adults hospitalised at an academic medical centre

K. Pierce, C. Huston, B. Kirkpatrick, 2021, BMJ open quality.

Coactosin Phosphorylation Controls Entamoeba histolytica Cell Membrane Protrusions and Cell Motility

C. Huston, Y. Lam, J. Teixeira, 2020, mBio.

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

J. Gut, C. Huston, J. Plattner, 2019, Nature Communications.

Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration

R. Choy, C. Huston, 2020, PLoS neglected tropical diseases.

Piperazine-Derivative MMV665917: An Effective Drug in the Diarrheic Piglet Model of Cryptosporidium hominis.

D. Griggs, S. Tzipori, G. Beamer, 2019, The Journal of infectious diseases.

Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have In Vitro Activity against Cryptosporidium

R. Guerrant, L. Bartelt, G. Kolling, 2018, Antimicrobial Agents and Chemotherapy.

Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children.

J. O’Neill, J. Pape, C. Sears, 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box

C. Huston, M. J. Meyers, J. Zambriski, 2018, Antimicrobial Agents and Chemotherapy.

A Sequential Model of Host Cell Killing and Phagocytosis by Entamoeba histolytica

C. Huston, Adam Sateriale, 2011, Journal of parasitology research.

Endoplasmic reticulum continuity in the protozoan parasite Entamoeba histolytica

C. Huston, J. Teixeira, A. Vaithilingam, 2008, Communicative & integrative biology.

Evidence of a Continuous Endoplasmic Reticulum in the Protozoan Parasite Entamoeba histolytica

C. Huston, J. Teixeira, 2008, Eukaryotic Cell.

Identification and characterization of EhABC A1, an Entamoeba histolytica Group A ABC transporter with similarity to Ced-7.

C. Huston, V. Miller-Sims, J. Teixeira, 2006, Molecular and biochemical parasitology.

Lyme Arthritis Synovial γδ T Cells Respond to Borrelia burgdorferi Lipoproteins and Lipidated Hexapeptides

J. Radolf, L. Sigal, R. Budd, 1998, The Journal of Immunology.

Immunization with the Entamoeba histolytica Surface Metalloprotease EhMSP-1 Protects Hamsters from Amebic Liver Abscess

C. Huston, J. E. Barbosa, E. C. Roncolato, 2014, Infection and Immunity.

Campylobacter jejuni strain CG8421: a refined model for the study of Campylobacteriosis and evaluation of Campylobacter vaccines in human subjects.

K. Pierce, C. Huston, D. Tribble, 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

parvum Growth Synthesis That Block Cryptosporidium HMG-CoA Reductase and Isoprenoid FDA-Approved Inhibitors of Human Drug Repurposing Screen Reveals

C. Huston, K. Bessoff, Adam Sateriale, 2014 .

Drug Repurposing Screen Reveals FDA-Approved Inhibitors of Human HMG-CoA Reductase and Isoprenoid Synthesis That Block Cryptosporidium parvum Growth

C. Huston, K. Bessoff, Adam Sateriale, 2013, Antimicrobial Agents and Chemotherapy.

Control of Entamoeba histolytica Adherence Involves Metallosurface Protease 1, an M8 Family Surface Metalloprotease with Homology to Leishmanolysin

C. Huston, K. Bessoff, Adam Sateriale, 2012, Infection and Immunity.

Apoptotic Killing and Phagocytosis of Host Cells by the Parasite Entamoeba histolytica

D. Boettner, C. Huston, V. Miller-Sims, 2003, Infection and Immunity.

C1q- and collectin-dependent phagocytosis of apoptotic host cells by the intestinal protozoan Entamoeba histolytica.

C. Huston, J. Teixeira, Bradley T Heron, 2008, The Journal of infectious diseases.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

Manuel Llinás, George Papadatos, Sundari Suresh, 2016, PLoS pathogens.

Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase

S. Schreiber, A. Wernimont, B. Melillo, 2020, Science Translational Medicine.

Current concepts: Amebiasis

Rashidul Haque, Eric R. Houpt, William A. Petri, 2003 .

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.

K. Harlos, F. Tacchini-Cottier, M. Matsumoto, 2017, Structure.

A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

C. Huston, M. Love, C. McNamara, 2019, Nature Communications.

Drug repurposing: mining protozoan proteomes for targets of known bioactive compounds

Indra Neil Sarkar, Adam Sateriale, Kovi Bessoff, 2014, J. Am. Medical Informatics Assoc..

A Veterinarian From Vermont Presenting With a Painful Right Index Finger Following a Needlestick Injury That Occurred While Caring for a Dog.

K. Pierce, C. Huston, T. Whitman, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Emerging and reemerging intestinal protozoa

C. Huston, Christopher D. Huston, W. Petri, 2001, Current opinion in gastroenterology.

Entamoeba histolytica Phagocytosis of Human Erythrocytes Involves PATMK, a Member of the Transmembrane Kinase Family

S. N. Buss, A. S. Linford, N. Sherman, 2008, PLoS pathogens.

Amebiasis: Clinical implications of the recognition of Entamoeba dispar

C. Huston, W. Petri, 1999, Current infectious disease reports.

Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection

D. Griggs, F. Buckner, C. Verlinde, 2021, Antimicrobial Agents and Chemotherapy.

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

J. Gut, C. Huston, J. Plattner, 2019, Nature Communications.

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

F. Buckner, C. Verlinde, W. Hol, 2019, Antimicrobial Agents and Chemotherapy.

A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors

C. Huston, M. Love, C. McNamara, 2019, Nature Communications.

Susceptibility Testing of Medically Important Parasites

D. Leroy, D. Pillai, W. V. Van Voorhis, 2017, Clinical Microbiology Reviews.

Evolution of Entamoeba Histolytica Virulence

U. Singh, C. Huston, 2013 .

Evidence for a novel Entamoeba histolytica lectin activity that recognises carbohydrates present on ovalbumin.

C. Huston, Adam Sateriale, J. Teixeira, 2011, International journal for parasitology.

Parasite and host contributions to the pathogenesis of amebic colitis.

C. Huston, 2004, Trends in parasitology.

Role of host caspases in cell killing by Entamoeba histolytica.

C. Hahn, C. Huston, B. Mann, 2000, Archives of medical research.

Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step

Scott Tighe, Keith R. Jerome, Alexander L. Greninger, 2020, PLoS biology.

SNAP-Tag Technology Optimized for Use in Entamoeba histolytica

Nathan H. Roy, C. Huston, Adam Sateriale, 2013, PloS one.

Molecular-based diagnosis of Entamoeba histolytica infection

C. Huston, W. Petri, R. Haque, 1999, Expert Reviews in Molecular Medicine.

Knockdown of Five Genes Encoding Uncharacterized Proteins Inhibits Entamoeba histolytica Phagocytosis of Dead Host Cells

C. Huston, P. Miller, Adam Sateriale, 2016, Infection and Immunity.

Participation of the Serine-Rich Entamoeba histolytica Protein in Amebic Phagocytosis of Apoptotic Host Cells

C. Huston, J. Teixeira, 2007, Infection and Immunity.

Kinetics and strain variation of phagosome proteins of Entamoeba histolytica by proteomic analysis.

W. Petri, T. Nozaki, C. Huston, 2006, Molecular and biochemical parasitology.

Proteomic Analysis of Phagocytosis in the Enteric Protozoan Parasite Entamoeba histolytica

T. Nozaki, C. Huston, K. Kita, 2005, Eukaryotic Cell.

HOST-PATHOGEN INTERACTION IN AMEBIASIS AND PROGRESS IN DEVELOPMENT

C. Huston, W. Petri, 1998 .

Feed-Forward Regulation of Phagocytosis by Entamoeba histolytica

C. Huston, P. Miller, Liam Donnelly, 2012, Infection and Immunity.

Entamoeba histolytica Cell Surface Calreticulin Binds Human C1q and Functions in Amebic Phagocytosis of Host Cells

C. Huston, P. Miller, J. Teixeira, 2012, Infection and Immunity.

Vaccines Against Entamoeba histolytica

C. Huston, W. Petri, 2009 .

Lyme arthritis synovial gamma delta T cells respond to Borrelia burgdorferi lipoproteins and lipidated hexapeptides.

J. Radolf, L. Sigal, R. Budd, 1998, Journal of immunology.

DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP

Scott Tighe, Christopher D. Huston, D. Leonard, 2020, bioRxiv.

Identification of Cryptosporidium parvum Active Chemical Series by Repurposing the Open Access Malaria Box

G. Ward, C. Huston, K. Bessoff, 2014, Antimicrobial Agents and Chemotherapy.

Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity

J. Derisi, C. Caffrey, U. Singh, 2020, PLoS neglected tropical diseases.

Structure-Activity relationships of replacements for the triazolopyridazine of Anti-Cryptosporidium lead SLU-2633.

C. Huston, Edmund Oboh, Tanner J Schubert, 2023, Bioorganic & medicinal chemistry.

Structure-Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against Cryptosporidium Reveals Remarkable Role of Fluorine.

D. Griggs, C. Huston, Edmund Oboh, 2023, Journal of medicinal chemistry.

The Clofazimine for Treatment of Cryptosporidiosis in HIV-Infected Adults (CRYPTOFAZ) and Lessons Learned for Anticryptosporidial Drug Development

C. Huston, 2020, Clinical Infectious Diseases.

Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria

Christopher J. Tonkin, A. Cowman, F. Gamo, 2018, Antimicrobial Agents and Chemotherapy.

Chapter 34 – Meningitis and Encephalitis in the Intensive Care Unit

C. Huston, Cindy D. Noyes, 2013 .

The complexity, relative value, and financial worth of curbside consultations in an academic infectious diseases unit.

C. Huston, B. Kirkpatrick, L. Polish, 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Vaccines Against Human Hookworm Disease

S. Hoffman, D. Vaughn, R. Brunham, 2004 .

Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.

W. Zuercher, Juntao Ye, M. Lautens, 2017, Bioorganic & medicinal chemistry.