K. Klugman

发表

Nomenclature of Major Antimicrobial-Resistant Clones of Streptococcus pneumoniae Defined by the Pneumococcal Molecular Epidemiology Network

A. Tomasz, J. Zhou, B. Spratt, 2001, Journal of Clinical Microbiology.

Immunogenicity and impact on nasopharyngeal carriage of a nonavalent pneumococcal conjugate vaccine.

R. Huebner, K. Klugman, N. Mbelle, 1999, The Journal of infectious diseases.

Increased Antimicrobial Resistance Among Nonvaccine Serotypes of Streptococcus pneumoniae in the Pediatric Population After the Introduction of 7-Valent Pneumococcal Vaccine in the United States

M. Pichichero, D. Farrell, K. Klugman, 2007, The Pediatric infectious disease journal.

Rapid Pneumococcal Evolution in Response to Clinical Interventions

J. Burton, M. Quail, A. Tomasz, 2011, Science.

Alterations in PBP 1A Essential for High-Level Penicillin Resistance in Streptococcus pneumoniae

Anthony M. Smith, K. Klugman, A. Smith, 1998, Antimicrobial Agents and Chemotherapy.

Community-Acquired Klebsiella pneumoniae Bacteremia: Global Differences in Clinical Patterns

Herman Goossens, Victor L. Yu, Keith P. Klugman, 2002, Emerging infectious diseases.

Emergence of endemic serogroup W135 meningococcal disease associated with a high mortality rate in South Africa.

S. Schrag, A. von Gottberg, K. Klugman, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

"Megaprimer" method of PCR-based mutagenesis: the concentration of megaprimer is a critical factor.

K. Klugman, A. Smith, A. Smith, 1997, BioTechniques.

Emergence, Spread, and Extinction of Pathogenic Bacterial Clones

F. Tenover, L. McGee, K. Klugman, 2008 .

Risk Factors for Multidrug-Resistant Invasive Pneumococcal Disease in South Africa, a Setting with High HIV Prevalence, in the Prevaccine Era from 2003 to 2008

A. von Gottberg, K. Klugman, C. Cohen, 2012, Antimicrobial Agents and Chemotherapy.

Emergence of Streptococcus pneumoniae with Very-High-Level Resistance to Penicillin

S. Schrag, C. Whitney, A. Craig, 2004, Antimicrobial Agents and Chemotherapy.

Serotype 19F Multiresistant Pneumococcal Clone Harboring Two Erythromycin Resistance Determinants [erm(B) and mef(A)] in South Africa

L. McGee, K. Klugman, A. Wasas, 2001, Antimicrobial Agents and Chemotherapy.

Pneumococcal resistance to antibiotics

K. Klugman, 1990, Clinical Microbiology Reviews.

International Meeting on Emerging Diseases and Surveillance

R. Dagan, K. Klugman, A. Kamarulzaman, 2011 .

Future Trends in Antimicrobial Chemotherapy: Expert Opinion on the 43rd ICAAC

A. P. Ball, J. Bartlett, L. Mandell, 2004, Journal of chemotherapy.

Hidden Epidemic of Macrolide-resistant Pneumococci

K. Klugman, J. Lonks, 2005, Emerging infectious diseases.

Clinical Epidemiology of Bocavirus, Rhinovirus, Two Polyomaviruses and Four Coronaviruses in HIV-Infected and HIV-Uninfected South African Children

S. Madhi, M. Nunes, J. Rossen, 2014, PloS one.

Surveillance of the impact of pneumococcal conjugate vaccines in developing countries

K. Klugman, G. Rodgers, 2015, Human vaccines & immunotherapeutics.

Path to impact: A report from the Bill and Melinda Gates Foundation convening on maternal immunization in resource-limited settings; Berlin - January 29-30, 2015.

H. Rees, K. Klugman, N. Schwalbe, 2015, Vaccine.

Contribution of vaccines to our understanding of pneumococcal disease

K. Klugman, 2011, Philosophical Transactions of the Royal Society B: Biological Sciences.

Population genetic structure, serotype distribution and antibiotic resistance of Streptococcus pneumoniae causing invasive disease in children in Argentina

S. Bentley, R. Breiman, A. Corso, 2021, Microbial genomics.

Invasive Disease Caused Simultaneously by Dual Serotypes of Streptococcus pneumoniae

Mushal Allam, A. von Gottberg, K. Klugman, 2017, Journal of Clinical Microbiology.

Population Snapshot of Streptococcus pneumoniae Causing Invasive Disease in South Africa Prior to Introduction of Pneumococcal Conjugate Vaccines

A. von Gottberg, K. Klugman, M. du Plessis, 2014, PloS one.

Population Snapshot of Invasive Serogroup B Meningococci in South Africa from 2005 to 2008

A. von Gottberg, K. Klugman, M. du Plessis, 2012, Journal of Clinical Microbiology.

Genotypic Comparison of Invasive Neisseria meningitidis Serogroup Y Isolates from the United States, South Africa, and Israel, Isolated from 1999 through 2002

L. Mayer, A. von Gottberg, K. Klugman, 2009, Journal of Clinical Microbiology.

Antimicrobial susceptibility and molecular epidemiology of Streptococcus pneumoniae isolated from Shanghai, China.

L. McGee, K. Klugman, Fan Yang, 2008, International journal of antimicrobial agents.

Antibiotic non-susceptibility among Streptococcus pneumoniae and Haemophilus influenzae isolates identified in African cohorts: a meta-analysis of three decades of published studies.

C. Gill, K. Klugman, A. Ginsburg, 2013, International journal of antimicrobial agents.

Pneumococcal vaccination in developing countries

T. Cherian, S. Madhi, K. O'Brien, 2006, The Lancet.

Molecular basis and clonal nature of increasing pneumococcal macrolide resistance in South Africa, 2000-2005.

A. von Gottberg, K. Klugman, M. du Plessis, 2008, International journal of antimicrobial agents.

The relationship between pneumococcal serotypes and antibiotic resistance.

R. Dagan, K. Klugman, Jae-Hoon Song, 2012, Vaccine.

Failure of chloramphenicol therapy in penicillin-resistant pneumococcal meningitis

K. Klugman, I. Friedland, 1992, The Lancet.

Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis

J. Bradley, K. Klugman, J. Bradley, 1995, Antimicrobial agents and chemotherapy.

Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae--and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization--in HIV-Infected and HIV-uninfected children.

S. Madhi, K. Klugman, W. Albrich, 2007, The Journal of infectious diseases.

Increased resistance to amikacin in a neonatal unit following intensive amikacin usage

K. Klugman, I. Friedland, E. Funk, 1992, Antimicrobial Agents and Chemotherapy.

Control of methicillin-resistantStaphylococcus aureus bacteraemia in high-risk areas

L. Blumberg, K. Klugman, 2005, European Journal of Clinical Microbiology and Infectious Diseases.

The Role of Influenza and Parainfluenza Infections in Nasopharyngeal Pneumococcal Acquisition Among Young Children

K. Edwards, John V. Williams, C. Lanata, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Acquisition of Streptococcus pneumoniae in Pneumococcal Conjugate Vaccine-naïve South African Children and Their Mothers

S. Madhi, M. Nunes, A. von Gottberg, 2013, The Pediatric infectious disease journal.

Temporal Changes in Pneumococcal Colonization in a Rural African Community With High HIV Prevalence Following Routine Infant Pneumococcal Immunization

S. Madhi, M. Nunes, K. Kahn, 2013, The Pediatric infectious disease journal.

Epidemiological differences among pneumococcal serotypes.

D. Feikin, K. Klugman, William P. Hausdorff, 2005, The Lancet. Infectious diseases.

Efficacy of pneumococcal conjugate vaccines and their effect on carriage and antimicrobial resistance.

K. Klugman, 2001, The Lancet. Infectious diseases.

Evernimicin (SCH27899) Inhibits a Novel Ribosome Target Site: Analysis of 23S Ribosomal DNA Mutants

D. Loebenberg, K. Klugman, K. Shaw, 2000, Antimicrobial Agents and Chemotherapy.

Antimicrobials: access and sustainable eff ectiveness 1 Access to eff ective antimicrobials: a worldwide challenge

R. Laxminarayan, J. Røttingen, Suraj Pant, 2015 .

Innovations in pneumonia diagnosis and treatment: a call to action on World Pneumonia Day, 2013.

K. Klugman, A. Ginsburg, S. Sadruddin, 2013, The Lancet. Global health.

Competing Interests: The phase 3

S. Madhi, K. Klugman, J. Heera, 2022 .

Human Metapneumovirus–Associated Lower Respiratory Tract Infections among Hospitalized Human Immunodeficiency Virus Type 1 (HIV-1)–Infected and HIV-1–Uninfected African Infants

S. Madhi, G. Boivin, Yacine Abed, 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Comparative Genomics of Disease and Carriage Serotype 1 Pneumococci

S. Bentley, N. Croucher, A. Roca, 2022, Genome biology and evolution.

Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism

S. Bentley, N. French, R. Heyderman, 2020, Communications Biology.

Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation

S. Bentley, R. Adegbola, M. Barer, 2020, Nature Communications.

Neisseria meningitidis Intermediately Resistant to Penicillin and Causing Invasive Disease in South Africa in 2001 to 2005

A. von Gottberg, K. Klugman, M. du Plessis, 2008, Journal of Clinical Microbiology.

Resistance in Streptococcus pneumoniae

L. McGee, K. Klugman, 2007 .

Emergence of the M phenotype of erythromycin-resistant pneumococci in South Africa.

K. Klugman, C. Widdowson, Carol A. Widdowson, 1998, Emerging infectious diseases.

Differences in clinical severity of respiratory viral infections in hospitalized children

Minh Nhat Le, M. Hashizume, B. Althouse, 2021, Scientific Reports.

The role of influenza in the severity and transmission of respiratory bacterial disease.

K. Klugman, Keith P Klugman, Michael J Mina, 2014, The Lancet. Respiratory medicine.

Efficacy of Maternal Influenza Vaccination Against All-Cause Lower Respiratory Tract Infection Hospitalizations in Young Infants: Results From a Randomized Controlled Trial

Stephanie A. Jones, S. Madhi, M. Nunes, 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Bacterial pathogens and death during the 1918 influenza pandemic.

D. Morens, K. Klugman, Yu-Wen Chien, 2009, The New England journal of medicine.

Invasive Pneumococcal Pneumonia and Respiratory Virus Co-infections

M. Haber, S. Ray, M. Farley, 2012, Emerging infectious diseases.

Live attenuated influenza vaccine, but not pneumococcal conjugate vaccine, protects against increased density and duration of pneumococcal carriage after influenza infection in pneumococcal colonized mice.

J. McCullers, M. Mina, K. Klugman, 2013, The Journal of infectious diseases.

Pathogen Replication, Host Inflammation, and Disease in the Upper Respiratory Tract

M. Mina, K. Klugman, 2013, Infection and Immunity.

Estimating the prevalence of coinfection with influenza virus and the atypical bacteria Bordetella pertussis, Chlamydophila pneumoniae, and Mycoplasma pneumoniae

M. Mina, K. Klugman, R. Burke, 2014, European Journal of Clinical Microbiology & Infectious Diseases.

Immunogenicity and safety of different dosing schedules of trivalent inactivated influenza vaccine in pregnant women with HIV: a randomised controlled trial

Stephanie A. Jones, S. Madhi, M. Nunes, 2020, The lancet. HIV.

Efficacy of whole-cell killed bacterial vaccines in preventing pneumonia and death during the 1918 influenza pandemic.

D. Morens, K. Klugman, Yu-Wen Chien, 2010, The Journal of infectious diseases.

Influence of bacterial interactions on pneumococcal colonization of the nasopharynx.

K. Klugman, J. Vidal, Joshua R. Shak, 2013, Trends in microbiology.

Carriage of penicillin resistant pneumococci.

H. Koornhof, K. Klugman, A. Wasas, 1986, Archives of disease in childhood.

Two cases of serotypeable and non-serotypeable variants of Streptococcus pneumoniae detected simultaneously during invasive disease

Mushal Allam, A. von Gottberg, K. Klugman, 2016, BMC Microbiology.

Pneumococcal Capsular Switching: A Historical Perspective

J. Parkhill, S. Bentley, N. Croucher, 2012, The Journal of infectious diseases.

Global Funders Consortium for Universal Influenza Vaccine Development.

J. Bresee, N. Wairagkar, K. Klugman, 2019, Vaccine.

Direct and indirect effect of 10 valent pneumococcal vaccine on nasopharyngeal carriage in children under 2 years of age in Matiari, Pakistan.

B. Althouse, C. Whitney, Hao Hu, 2021, Vaccine.

Increased activity of 16-membered lactone ring macrolides against erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae: characterization of South African isolates.

H. Koornhof, K. Klugman, T. Capper, 1998, The Journal of antimicrobial chemotherapy.

Clonal Analysis of Neisseria meningitidis Serogroup B Strains in South Africa, 2002 to 2006: Emergence of New Clone ST-4240/6688

A. von Gottberg, K. Klugman, M. du Plessis, 2012, Journal of Clinical Microbiology.

An Unusual Pneumococcal Sequence Type Is the Predominant Cause of Serotype 3 Invasive Disease in South Africa

S. Madhi, A. von Gottberg, K. Klugman, 2009, Journal of Clinical Microbiology.

Molecular Characterization of Emerging Non-Levofloxacin-Susceptible Pneumococci Isolated from Children in South Africa

A. von Gottberg, K. Klugman, M. du Plessis, 2009, Journal of Clinical Microbiology.

Meningococcal Disease in South Africa, 1999–2002

Anthony M. Smith, A. von Gottberg, K. Klugman, 2007, Emerging infectious diseases.

Altered PBP 2A and Its Role in the Development of Penicillin, Cefotaxime, and Ceftriaxone Resistance in a Clinical Isolate of Streptococcus pneumoniae

Anthony M. Smith, C. Feldman, O. Massidda, 2005, Antimicrobial Agents and Chemotherapy.

Prevalence of serotypes and molecular epidemiology of Streptococcus pneumoniae strains isolated from children in Beijing, China: identification of two novel multiply-resistant clones.

R. Huebner, L. McGee, K. Klugman, 2001, Microbial drug resistance.

Streptococcus pneumoniae blood culture isolates from patients with and without human immunodeficiency virus infection: alterations in penicillin susceptibilities and in serogroups or serotypes.

K. Klugman, A. Wasas, A. Karstaedt, 1997, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

A mosaic tetracycline resistance gene tet(S/M) detected in an MDR pneumococcal CC230 lineage that underwent capsular switching in South Africa

Andries J. van Tonder, S. Madhi, S. Sekaran, 2019, The Journal of antimicrobial chemotherapy.

A novel mosaic tetracycline resistance gene tet(S/M) detected in a multidrug-resistant pneumococcal CC230 lineage that underwent capsular switching in South Africa

Andries J. van Tonder, S. Madhi, S. Bentley, 2019, bioRxiv.

Competitive Dominance within Biofilm Consortia Regulates the Relative Distribution of Pneumococcal Nasopharyngeal Density

B. Levin, N. Jacobs, K. Klugman, 2017, Applied and Environmental Microbiology.

Emergence and Spread of Streptococcus pneumoniae with erm(B) and mef(A) Resistance

Steven D. Brown, D. Farrell, S. Jenkins, 2005, Emerging infectious diseases.

The impact of HIV on Streptococcus pneumoniae bacteraemia in a South African population

R. Huebner, K. Klugman, N. Jones, 1998, AIDS.

Re-examination of immune response and estimation of anti-Vi IgG protective threshold against typhoid fever-based on the efficacy trial of Vi conjugate in young children.

S. Szu, K. Klugman, Steven Hunt, 2014, Vaccine.

Increased incidence of meningococcal disease in HIV-infected individuals associated with higher case-fatality ratios in South Africa

N. Govender, Henry M. Wu, A. von Gottberg, 2010, AIDS.

46 – Pneumococcal Conjugate Vaccine and Pneumococcal Common Protein Vaccines

C. Whitney, R. Malley, R. Dagan, 2018 .

Influenza guideline for South Africa--update 2008.

S. Madhi, H. Zar, N. Cameron, 2008, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Increased Risk of Death in Human Immunodeficiency Virus-infected Children With Pneumococcal Meningitis in South Africa, 2003–2005

P. Nyasulu, C. Feldman, A. von Gottberg, 2011, The Pediatric infectious disease journal.

Epidemiology, Control and Treatment of Multiresistant Pneumococci

K. Klugman, 2012, Drugs.

Fluoroquinolone resistance among clinical isolates of Streptococcus pneumoniae belonging to international multiresistant clones.

L. McGee, K. Klugman, C. Goldsmith, 2002, The Journal of antimicrobial chemotherapy.

The role of fourth-generation cephalosporins in the treatment of infections caused by penicillin-resistant streptococci

F. Baquero, S. Kohno, K. Klugman, 1997 .

Molecular Basis of Rifampin Resistance inStreptococcus pneumoniae

K. Klugman, T. Padayachee, Thanugarani Padayachee, 1999, Antimicrobial Agents and Chemotherapy.

Clinical and nasopharyngeal isolates of unusual multiply resistant pneumococci.

H. Koornhof, K. Klugman, V. Kuhnle, 1986, American journal of diseases of children.

Antibiotic-resistant pneumococcal disease in South African children.

K. Klugman, I. Friedland, 1992, American journal of diseases of children.

Antimicrobial resistance in Streptococcus pneumoniae: a South African perspective.

H. Koornhof, K. Klugman, A. Wasas, 1992, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Rapid Detection of Penicillin-Resistant Streptococcus pneumoniae in Cerebrospinal Fluid by a Seminested-PCR Strategy

K. Klugman, M. du Plessis, A. Smith, 1998, Journal of Clinical Microbiology.

Drug resistance patterns and serogroups or serotypes of pneumococcal isolates from cerebrospinal fluid or blood, 1979-1986.

H. Koornhof, K. Klugman, 1988, The Journal of infectious diseases.

The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic success

J. Parkhill, S. Bentley, N. Croucher, 2012, Genome Biology.

PROTECTIVE ACTIVITY OF VI CAPSULAR POLYSACCHARIDE VACCINE AGAINST TYPHOID FEVER

R. Schneerson, H. Koornhof, K. Klugman, 1987, The Lancet.

61 – Typhoid Fever Vaccines

M. Levine, J. Clemens, K. Klugman, 1999 .

Human Metapneumovirus Genetic Variability, South Africa

S. Madhi, G. Boivin, Yacine Abed, 2005, Emerging infectious diseases.

Immunogenicity, efficacy and serological correlate of protection of Salmonella typhi Vi capsular polysaccharide vaccine three years after immunization.

J. Robbins, H. Koornhof, K. Klugman, 1996, Vaccine.

Preparing to introduce new maternal immunizations in low- and lower-middle-income countries: A report from the Bill & Melinda Gates Foundation convening "Allies in Maternal and Newborn Care"; May 3-4, 2018.

B. A. Williams, J. Lawn, S. Omer, 2020, Vaccine.

International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact

Jukka Corander, Andrew J. Page, Pekka Marttinen, 2019, EBioMedicine.

Widespread sharing of pneumococcal strains in a rural African setting: proximate villages are more likely to share similar strains that are carried at multiple timepoints

W. Hanage, S. Bentley, R. Adegbola, 2022, Microbial genomics.

A Streptococcus pneumoniae lineage usually associated with pneumococcal conjugate vaccine (PCV) serotypes is the most common cause of serotype 35B invasive disease in South Africa, following routine use of PCV

S. Bentley, B. Sigaúque, R. Breiman, 2022, Microbial genomics.

Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study

Andries J. van Tonder, S. Madhi, M. Hasanuzzaman, 2019, The Lancet. Infectious diseases.

Impact of Laboratory Methods, Colonization Density and Age on Detection of Streptococcus Pneumoniae in the Nasopharynx.

K. O'Brien, L. Hammitt, C. Sutcliffe, 2019, American journal of epidemiology.

Effectiveness of the 13-valent pneumococcal conjugate vaccine against invasive pneumococcal disease in South African children: a case-control study.

S. Madhi, K. O'Brien, C. Whitney, 2017, The Lancet. Global health.

Effectiveness of the 13-valent pneumococcal conjugate vaccine against invasive pneumococcal disease in South African children: a case-control study.

S. Madhi, K. O'Brien, C. Whitney, 2017, The Lancet. Global health.

Effects of vaccination on invasive pneumococcal disease in South Africa.

S. Madhi, K. O'Brien, C. Whitney, 2014, The New England journal of medicine.

Strain Level Streptococcus Colonization Patterns during the First Year of Life

G. Sutton, M. Lucero, S. Madhi, 2017, Front. Microbiol..

No impact of penicillin resistance on mortality. Authors' reply

V. Yu, V. Montori, L. Baddour, 2006 .

Effects of Clarithromycin at Sub-Minimum Inhibitory Concentrations on Early ermB Gene Expression, Metabolic Activity and Growth of an erm(B)-Expressing Macrolide-Resistant Strain of Streptococcus pneumoniae

Ronald Anderson, T. Mitchell, K. Klugman, 2012 .

Increased risk of invasive bacterial infections in African people with sickle-cell disease: a systematic review and meta-analysis.

O. Levine, K. Klugman, L. Grant, 2010, The Lancet. Infectious diseases.

Factors Associated with Ceftriaxone Nonsusceptibility of Streptococcus pneumoniae: Analysis of South African National Surveillance Data, 2003 to 2010

C. Feldman, A. von Gottberg, K. Klugman, 2014, Antimicrobial Agents and Chemotherapy.

Outpatient antibiotic prescribing and nonsusceptible Streptococcus pneumoniae in the United States, 1996-2003.

M. Haber, K. Klugman, T. Taylor, 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Resurgence of the multiresistant pneumococcus in the United States: a commentary.

L. McGee, K. Klugman, 2007, The Pediatric infectious disease journal.

Prevalence of First-Step Mutants among Levofloxacin-Susceptible Invasive Isolates of Streptococcus pneumoniae in the United States

C. Whitney, L. McGee, K. Klugman, 2006, Antimicrobial Agents and Chemotherapy.

Increased prevalence of pediatric pneumococcal serotypes in elderly adults.

A. Schuchat, C. Whitney, E. Zell, 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Capsule Homology Does Not Increase the Frequency of Transformation of Linked Penicillin Binding Proteins PBP 1a and PBP 2x in Streptococcus pneumoniae

M. Lipsitch, A. MacNeil, K. Klugman, 2005, Antimicrobial Agents and Chemotherapy.

Levofloxacin-Resistant Invasive Streptococcus pneumoniae in the United States: Evidence for Clonal Spread and the Impact of Conjugate Pneumococcal Vaccine

C. Whitney, J. Jorgensen, R. Facklam, 2004, Antimicrobial Agents and Chemotherapy.

Antibiotic selection of multiply resistant pneumococci.

K. Klugman, 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

CHAPTER 29 – Pneumococcal Infections

C. Feldman, K. Klugman, Charles Feldman, 2011 .

The remaining challenge of pneumonia: the leading killer of children.

Z. Bhutta, R. Dagan, O. Levine, 2011, The Pediatric infectious disease journal.

The impact of a 9-valent pneumococcal conjugate vaccine on the public health burden of pneumonia in HIV-infected and -uninfected children.

S. Madhi, K. Klugman, C. Cutland, 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Impact of human immunodeficiency virus type 1 on the disease spectrum of Streptococcus pneumoniae in South African children

S. Madhi, K. Klugman, A. Wasas, 2000, The Pediatric infectious disease journal.

Effect of 13-valent pneumococcal conjugate vaccine on admissions to hospital 2 years after its introduction in the USA: a time series analysis.

Robert J. Taylor, L. Simonsen, M. Haber, 2014, The Lancet. Respiratory medicine.

A Mechanism of Unidirectional Transformation, Leading to Antibiotic Resistance, Occurs within Nasopharyngeal Pneumococcal Biofilm Consortia

K. Klugman, Jennifer A. N. Brophy, J. Vidal, 2018, mBio.

Development and characterization of a synthetic DNA, NUversa, to be used as a standard in quantitative polymerase chain reactions for molecular pneumococcal serotyping

K. Klugman, J. Vidal, Fuminori Sakai, 2017, FEMS microbiology letters.

Single-Plex Quantitative Assays for the Detection and Quantification of Most Pneumococcal Serotypes

K. Mulholland, K. Klugman, J. Vidal, 2015, PloS one.

Impact of Experimental Human Pneumococcal Carriage on Nasopharyngeal Bacterial Densities in Healthy Adults

K. Klugman, M. D. de Jonge, P. Hermans, 2014, PloS one.

Correction: Expression of Streptococcus pneumoniae Virulence-Related Genes in the Nasopharynx of Healthy Children

C. Lanata, Carlos G. Grijalva, K. Klugman, 2014, PLoS ONE.

Expression of Streptococcus pneumoniae Virulence-Related Genes in the Nasopharynx of Healthy Children

K. Klugman, J. Vidal, Fuminori Sakai, 2013, PloS one.

Density Interactions Among Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in the Nasopharynx of Young Peruvian Children

K. Edwards, C. Lanata, A. Gil, 2013, The Pediatric infectious disease journal.

The LuxS-Dependent Quorum-Sensing System Regulates Early Biofilm Formation by Streptococcus pneumoniae Strain D39

K. Klugman, D. Zähner, J. Vidal, 2011, Infection and Immunity.

Pathogenesis and host ResPonse

K. Edwards, C. Lanata, A. Gil, 2022 .

The significance of serotype replacement for pneumococcal disease and antibiotic resistance.

K. Klugman, 2009, Advances in experimental medicine and biology.

Distribution of factor H binding protein beyond serogroup B: variation among five serogroups of invasive Neisseria meningitidis in South Africa.

S. Hoiseth, E. Murphy, A. von Gottberg, 2011, Vaccine.

The future of pneumococcal disease prevention.

K. Klugman, G. Rodgers, 2011, Vaccine.

Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines

K. Klugman, M. Préziosi, F. Laforce, 2019, The Journal of infectious diseases.

Influenza vaccination of pregnant women and protection of their infants.

Stephanie A. Jones, S. Madhi, M. Nunes, 2014, The New England journal of medicine.

Antibiotic resistance and serotype distribution of Streptococcus pneumoniae colonizing rural Malawian children

S. Dowell, P. Bloland, B. Schwartz, 2003, The Pediatric infectious disease journal.

Dynamics of pneumococcal transmission in vaccine-naive children and their HIV-infected or HIV-uninfected mothers during the first 2 years of life.

S. Madhi, K. Auranen, M. Nunes, 2013, American journal of epidemiology.

Antibiotic Resistance of Pneumococci

L. McGee, K. Klugman, M. Pletz, 2015 .

Novel Role for the Streptococcus pneumoniae Toxin Pneumolysin in the Assembly of Biofilms

H. Yi, K. Klugman, J. Paton, 2013, mBio.

Pneumolysin in the Assembly of Biofilms Toxin Streptococcus pneumoniae Novel Role for the 2013

H. Yi, K. Klugman, J. Paton, 2022 .

Emergence of a Pneumococcal Clone with Cephalosporin Resistance and Penicillin Susceptibility

H. Koornhof, K. Klugman, A. Smith, 2001, Antimicrobial Agents and Chemotherapy.

Alterations in MurM, a Cell Wall Muropeptide Branching Enzyme, Increase High-Level Penicillin and Cephalosporin Resistance in Streptococcus pneumoniae

K. Klugman, A. Smith, A. Smith, 2001, Antimicrobial Agents and Chemotherapy.

Non-Penicillin-Binding protein mediated high-level penicillin and cephalosporin resistance in a Hungarian clone of Streptococcus pneumoniae.

K. Klugman, A. Smith, A. Smith, 2000, Microbial drug resistance.

Vaccination to reduce antimicrobial resistance.

K. Klugman, A. Ginsburg, 2017, The Lancet. Global health.

Increased carriage of trimethoprim/sulfamethoxazole-resistant Streptococcus pneumoniae in Malawian children after treatment for malaria with sulfadoxine/pyrimethamine.

S. Dowell, P. Bloland, B. Schwartz, 2000, The Journal of infectious diseases.

Association of serotype with risk of death due to pneumococcal pneumonia: a meta-analysis.

K. O'Brien, M. Lipsitch, R. Adegbola, 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Invasive disease due to Haemophilus influenzae serotype b ten years after routine vaccination, South Africa, 2003-2009.

S. Madhi, M. Chhagan, B. Flannery, 2012, Vaccine.

Nasopharyngeal carriage of community-acquired, antibiotic-resistant Streptococcus pneumoniae in a Zambian paediatric population.

R. Huebner, P. Godfrey-Faussett, K. Klugman, 1997, Bulletin of the World Health Organization.

3-monthly azithromycin administration for trachoma

H. Goossens, S. Coenen, K. Klugman, 2009, The Lancet.

Nasopharyngeal carriage and antimicrobial resistance in isolates of Streptococcus pneumoniae and Haemophilus influenzae type b in children under 5 years of age in Botswana.

R. Huebner, K. Klugman, L. Mazhani, 1998, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Molecular mechanisms of resistance to commonly used non-betalactam drugs in Streptococcus pneumoniae.

K. Klugman, C. Widdowson, 1999, Seminars in respiratory infections.

Region-speciﬁc diversiﬁcation of the highly virulent serotype 1 Streptococcus pneumoniae the

S. Bentley, S. Harris, N. French, 2018 .

Nasopharyngeal Pneumococcal Serotypes Before and After Mass Azithromycin Distributions for Trachoma.

T. Gebre, P. Emerson, J. Keenan, 2016, Journal of the Pediatric Infectious Diseases Society.

Longitudinal study on Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonization in HIV-infected and -uninfected infants vaccinated with pneumococcal conjugate vaccine.

S. Madhi, M. Nunes, M. Cotton, 2015, Vaccine.

Risk Factors for Invasive Pneumococcal Disease Among Children Less Than 5 Years of Age in a High HIV Prevalence Setting, South Africa, 2010 to 2012

S. Madhi, C. Whitney, E. Zell, 2015, The Pediatric infectious disease journal.

Global Distribution of Invasive Serotype 35D Streptococcus pneumoniae Isolates following Introduction of 13-Valent Pneumococcal Conjugate Vaccine

Andries J. van Tonder, S. Madhi, S. Bentley, 2018, Journal of Clinical Microbiology.

The Emergence of Bacterial “Hopeful Monsters”

N. Croucher, K. Klugman, 2014, mBio.

The relationship between pneumococcal serotypes and antibiotic resistance

R. Dagan, K. Klugman, Jae-Hoon Song, 2013 .

Rationale for revised penicillin susceptibility breakpoints versus Streptococcus pneumoniae: coping with antimicrobial susceptibility in an era of resistance.

Ronald N. Jones, M. Weinstein, K. Klugman, 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Streptococcus pneumoniae: Review of Factors Relevant to Development and Management of Fluoroquinolone Resistance in a Nursing Home Setting

K. Klugman, G. Tillotson, D. Vaughan, 2007 .

Public health and economic impact of the 13-valent pneumococcal conjugate vaccine (PCV13) in the United States.

M. Weinstein, S. Pelton, K. Klugman, 2010, Vaccine.

Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study

S. Madhi, S. Bentley, D. Aanensen, 2022, The Lancet. Microbe.

Identification of the tetracycline resistance gene, tet(O), in Streptococcus pneumoniae

K. Klugman, C. Widdowson, D. Hanslo, 1996, Antimicrobial agents and chemotherapy.

Serotype 6C is associated with penicillin-susceptible meningeal infections in human immunodeficiency virus (HIV)-infected adults among invasive pneumococcal isolates previously identified as serotype 6A in South Africa.

S. Madhi, A. von Gottberg, K. Klugman, 2008, International journal of antimicrobial agents.

Novel Expansions of the Gene Encoding Dihydropteroate Synthase in Trimethoprim-Sulfamethoxazole-ResistantStreptococcus pneumoniae

K. Klugman, T. Padayachee, 1999, Antimicrobial Agents and Chemotherapy.

Spread of the Spanish multi-resistant serotype 23F clone of Streptococcus pneumoniae to Seoul, Korea.

L. McGee, K. Klugman, H. Lee, 1997, Microbial drug resistance.

Three predominant clones identified within penicillin-resistant South African isolates of Streptococcus pneumoniae.

K. Klugman, A. Smith, A. Smith, 1997, Microbial drug resistance.

Application of pbp1A PCR in Identification of Penicillin-Resistant Streptococcus pneumoniae

K. Klugman, M. du Plessis, A. Smith, 1999, Journal of Clinical Microbiology.

Application of pbp 1 A PCR in Identification of Penicillin-Resistant Streptococcus pneumoniae

K. Klugman, A. Smith, 1999 .

In Vitro Evaluation of the Antimicrobial Activity of Ceftaroline against Cephalosporin-Resistant Isolates of Streptococcus pneumoniae

C. Whitney, L. McGee, K. Klugman, 2008, Antimicrobial Agents and Chemotherapy.

Amino Acid Mutations Essential to Production of an Altered PBP 2X Conferring High-Level β-Lactam Resistance in a Clinical Isolate of Streptococcus pneumoniae

K. Klugman, A. Smith, A. Smith, 2005, Antimicrobial Agents and Chemotherapy.

Site-Specific Mutagenesis Analysis of PBP 1A from a Penicillin-Cephalosporin-Resistant Pneumococcal Isolate

K. Klugman, A. Smith, A. Smith, 2003, Antimicrobial Agents and Chemotherapy.

The successful clone: the vector of dissemination of resistance in Streptococcus pneumoniae.

K. Klugman, 2002, The Journal of antimicrobial chemotherapy.

Analysis of Penicillin-Binding Protein Genes of Clinical Isolates of Streptococcus pneumoniae with Reduced Susceptibility to Amoxicillin

E. Bingen, K. Klugman, M. du Plessis, 2002, Antimicrobial Agents and Chemotherapy.

High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia.

S. Madhi, K. Kahn, A. von Gottberg, 2014, The Journal of infectious diseases.

Determinants of invasiveness beneath the capsule of the pneumococcus.

S. Bentley, L. McGee, K. Klugman, 2014, The Journal of infectious diseases.

Timing of serotype 1 pneumococcal disease suggests the need for evaluation of a booster dose.

S. Madhi, R. Adegbola, B. Greenwood, 2011, Vaccine.

Association of serotypes of Streptococcus pneumoniae with disease severity and outcome in adults: an international study.

J. Rello, V. Yu, L. Baddour, 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Emergence of drug resistance. Impact on bacterial meningitis.

S. Madhi, K. Klugman, 1999, Infectious disease clinics of North America.

Randomized comparison of meropenem with cefotaxime for treatment of bacterial meningitis. Meropenem Meningitis Study Group

R. Dagan, K. Klugman, Keith P. Klugman, 1995, Antimicrobial agents and chemotherapy.

Pneumococcal resistance to the third-generation cephalosporins: clinical, laboratory and molecular aspects.

K. Klugman, 1994, International journal of antimicrobial agents.

Analysis of penicillin-binding protein lb and 2a genes from Streptococcus pneumoniae.

K. Klugman, M. du Plessis, A. Smith, 2000, Microbial drug resistance.

Alterations in penicillin-binding protein 2B from penicillin-resistant wild-type strains of Streptococcus pneumoniae

K. Klugman, A. Smith, A. Smith, 1995, Antimicrobial agents and chemotherapy.

LACK OF UTILITY OF SEROTYPING MULTIPLE COLONIES FOR DETECTION OF SIMULTANEOUS NASOPHARYNGEAL CARRIAGE OF DIFFERENT PNEUMOCOCCAL SEROTYPES

R. Dagan, R. Huebner, K. Klugman, 2000, The Pediatric infectious disease journal.

International Pneumococcal Clones Match or Exceed the Fitness of Other Strains despite the Accumulation of Antibiotic Resistance

T. Welte, Mathias W Pletz, M. P. van der Linden, 2011, Antimicrobial Agents and Chemotherapy.

The potential impact of the 13-valent conjugate pneumococcal vaccine on antibiotic resistance in pneumococci

S. Madhi, K. Klugman, S. Nzenze, 2011 .

Low prevalence of fluoroquinolone resistant strains and resistance precursor strains in Streptococcus pneumoniae from patients with community-acquired pneumonia despite high fluoroquinolone usage.

T. Welte, Mathias W Pletz, M. P. van der Linden, 2011, International journal of medical microbiology : IJMM.

Telithromycin Resistance in Streptococcus pneumoniae Is Conferred by a Deletion in the Leader Sequence of erm(B) That Increases rRNA Methylation

S. Douthwaite, D. Farrell, K. Klugman, 2007, Antimicrobial Agents and Chemotherapy.

Risk factors for antibiotic resistance in Streptococcus pneumoniae.

K. Klugman, Keith P. Klugman, 2007, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

High-Level Telithromycin Resistance in a Clinical Isolate of Streptococcus pneumoniae

D. Low, K. Klugman, N. Wolter, 2007, Antimicrobial Agents and Chemotherapy.

Vaccination: a novel approach to reduce antibiotic resistance.

K. Klugman, 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Increasing prevalence of penicillin-resistant pneumococcal infections in children in southern Israel: implications for future immunization policies.

R. Dagan, P. Yagupsky, K. Klugman, 1994, The Pediatric infectious disease journal.

Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape.

O. Ramilo, A. Mejias, P. Lemey, 2022, The Lancet. Infectious diseases.

Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro.

T. Mitchell, R. Anderson, A. von Gottberg, 2007, The Journal of antimicrobial chemotherapy.

Triumph of Pneumococcal Conjugate Vaccines: Overcoming a Common Foe

C. Whitney, K. Klugman, G. Rodgers, 2021, The Journal of infectious diseases.

Bacterial Density, Serotype Distribution and Antibiotic Resistance of Pneumococcal Strains from the Nasopharynx of Peruvian Children Before and After Pneumococcal Conjugate Vaccine 7

Mathias W Pletz, K. Edwards, C. Hornberg, 2016, The Pediatric infectious disease journal.

Impact of existing vaccines in reducing antibiotic resistance: Primary and secondary effects

S. Black, K. Klugman, 2018, Proceedings of the National Academy of Sciences.

Dose response of CRM197 and tetanus toxoid-conjugated Haemophilus influenzae type b vaccines.

M. Nicol, R. Huebner, H. Käyhty, 2004, Vaccine.

Haemophilus influenzae type b conjugate vaccine diluted tenfold in diphtheria-tetanus-whole cell pertussis vaccine: a randomized trial.

M. Nicol, R. Huebner, H. Käyhty, 2002, The Pediatric infectious disease journal.

Impact of cotrimoxazole on non-susceptibility to antibiotics in Streptococcus pneumoniae carriage isolates among HIV-infected mineworkers in South Africa.

R. Chaisson, S. Charalambous, A. Grant, 2008, The Journal of infection.

Long-Term Survival of Streptococcus pneumoniae at Room Temperature on Dorset Egg Medium

K. Klugman, A. Wasas, R. Huebner, 1998, Journal of Clinical Microbiology.

Cerebrospinal fluid bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in children with meningitis treated with high-dosage cefotaxime

K. Klugman, I. Friedland, 1997, Antimicrobial agents and chemotherapy.

Interspecies Recombination in Type II Topoisomerase Genes Is Not a Major Cause of Fluoroquinolone Resistance in Invasive Streptococcus pneumoniae Isolates in the United States

C. Whitney, L. McGee, K. Klugman, 2005, Antimicrobial Agents and Chemotherapy.

Ciprofloxacin treatment failure in a patient with resistant Streptococcus pneumoniae infection following prior ciprofloxacin therapy

H. Lode, L. McGee, K. Klugman, 2004, European Journal of Clinical Microbiology and Infectious Diseases.

Trimethoprim-Sulfamethoxazole Prophylaxis and Antibiotic Nonsusceptibility in Invasive Pneumococcal Disease

A. von Gottberg, K. Klugman, C. Cohen, 2012, Antimicrobial Agents and Chemotherapy.

Mortality in penicillin-resistant pneumococcal meningitis.

A. Walsh, K. Klugman, E. Molyneux, 2008, The Pediatric infectious disease journal.

Gender as a risk factor for both antibiotic resistance and infection with pediatric serogroups/serotypes, in HIV-infected and -uninfected adults with pneumococcal bacteremia.

S. Madhi, C. Feldman, A. von Gottberg, 2004, The Journal of infectious diseases.

Antibiotic resistance of nasopharyngeal isolates of Streptococcus pneumoniae from children in Lesotho.

R. Huebner, H. Koornhof, K. Klugman, 1998, Bulletin of the World Health Organization.

Clinical Relevance of Antibiotic Resistance in Pneumococcal Infections

K. Klugman, 2004 .

Bacteriological evidence of antibiotic failure in pneumococcal lower respiratory tract infections

K. Klugman, K. Klugman, 2002, European Respiratory Journal.

Cost-effectiveness of pneumococcal conjugate vaccine: an update after 7 years of use in the United States.

S. Pelton, K. Klugman, G. Ray, 2009, Vaccine.

Penicillin- and Cephalosporin-Resistant Streptococcus Pneumoniae

C. Feldman, K. Klugman, 1999, Drugs.

'Atypical' bacteria are a common cause of community-acquired pneumonia in hospitalised adults.

G. Maartens, K. Klugman, C. Bartie, 1994, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Guidelines for empiric antimicrobial prescribing in community-acquired pneumonia.

J. Ramirez, L. Mandell, T. File, 2004, Chest.

Factors associated with ceftriaxone non-susceptibility of Streptococcus pneumoniae: 2

C. Feldman, K. Klugman, A. V. Gottberg, 2014 .

Epidemiology of invasive pneumococcal disease among high-risk adults since the introduction of pneumococcal conjugate vaccine for children.

W. Schaffner, K. Narayan, R. Link-Gelles, 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The paradox in pneumococcal serotypes: highly invasive does not mean highly lethal

T. Welte, Mathias W Pletz, K. Klugman, 2010, European Respiratory Journal.

Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study

S. Schrag, N. Govender, A. Whitelaw, 2008, The Lancet.

Antibiotic prophylaxis—Preventing severe infections and saving lives in poor countries with very high mortality risk

K. Klugman, Rasa Izadnegahdar, 2018, PLoS medicine.

The future of paediatric pneumococcal conjugate vaccines.

K. Klugman, G. Rodgers, 2017, The Lancet. Respiratory medicine.

Assessing the Evidence for Maternal Pertussis Immunization: A Report From the Bill & Melinda Gates Foundation Symposium on Pertussis Infant Disease Burden in Low- and Lower-Middle-Income Countries

K. O'Brien, P. van Damme, K. Klugman, 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pneumococcal conjugate vaccines: proceedings from an interactive symposium at the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy.

K. O'Brien, S. Pelton, R. Dagan, 2003, Vaccine.

Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae.

T. Mitchell, R. Anderson, A. von Gottberg, 2006, The Journal of antimicrobial chemotherapy.

Systemic shigellosis in South Africa.

K. Keddy, A. Sooka, P. Naicker, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

pneumoniae Bacteremia: Global Differences in Clinical Patterns

H. Goossens, V. Yu, D. Paterson, 2002 .

Bacteremic pneumococcal pneumonia in HIV-seropositive and HIV-seronegative adults.

C. Feldman, K. Klugman, A. G. Mahomed, 1999, Chest.

Economic burden of acute lower respiratory tract infection in South African children

S. Madhi, U. Griffiths, K. Klugman, 2012, Paediatrics and international child health.

Implications for antimicrobial prescribing of strategies based on bacterial eradication.

K. Klugman, 2003, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Spring Scrub Typhus , People ’ s Republic of China

T. Welte, Mathias W Pletz, L. McGee, 2019 .

Impact of the Hajj on pneumococcal transmission.

K. O'Brien, Z. Memish, B. Gessner, 2015, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

A disease model descriptive of progression between chronic obstructive pulmonary disease exacerbations and community-acquired pneumonia: roles for underlying lung disease and the pharmacokinetics/pharmacodynamics of the antibiotic.

Jerome J. Schentag, T. File, V. Yu, 2009, International journal of antimicrobial agents.

Reduced effectiveness of Haemophilus influenzae type b conjugate vaccine in children with a high prevalence of human immunodeficiency virus type 1 infection

S. Madhi, R. Huebner, K. Klugman, 2002, The Pediatric infectious disease journal.

Trends in antimicrobial resistance and serotype distribution of blood and cerebrospinal fluid isolates of Streptococcus pneumoniae in South Africa, 1991-1998.

K. Klugman, A. Wasas, Huebner RE, 2000, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Global practices of meningococcal vaccine use and impact on invasive disease

Z. Bhutta, D. Durrheim, J. Eskola, 2014, Pathogens and global health.

Heterogeneous Macrolide Resistance and Gene Conversion in the Pneumococcus

D. Farrell, K. Klugman, N. Wolter, 2006, Antimicrobial Agents and Chemotherapy.

William of the Pneumococcus Chloramphenicol in Ribosomal Protein L 4 Oxazolidinones , Macrolides , and Novel Mechanism of Resistance to

W. Schaffner, C. Whitney, D. Farrell, 2005 .

Antibiotic-resistant pneumococci in pediatric disease.

K. Klugman, I. Friedland, Keith P. Klugman, 1995, Microbial drug resistance.

Maternal interventions vigilance harmonization in low- and middle-income countries: Stakeholder meeting report; Amsterdam, May 1–2, 2018

S. Omer, D. Kaslow, A. Stergachis, 2019, Vaccine.

A century of pneumococcal vaccination research in humans.

K. Klugman, J. Grabenstein, 2012, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Evidence that prevention of carriage by pneumococcal capsular vaccines may be the mechanism of protection from pneumococcal pneumonia

H. Koornhof, K. Klugman, S. W. Smith, 2011 .

Streptococcus pneumoniae bacteraemia: pharmacodynamic correlations with outcome and macrolide resistance--a controlled study.

Jerome J. Schentag, V. Yu, J. Paladino, 2007, International journal of antimicrobial agents.

Failures of beta-lactam therapy for invasive pneumococcal disease.

K. Klugman, 2004, The Pediatric infectious disease journal.

Penicillin- and cephalosporin-resistant Streptococcus pneumoniae. Emerging treatment for an emerging problem.

C. Feldman, K. Klugman, 1999, Drugs.

Virulence Characteristics of Klebsiella and Clinical Manifestations of K. pneumoniae Bloodstream Infections

H. Goossens, V. Yu, W. Ko, 2007, Emerging infectious diseases.

Evidence to support the rationale that bacterial eradication in respiratory tract infection is an important aim of antimicrobial therapy.

F. Baquero, W. Craig, R. Dagan, 2001, The Journal of antimicrobial chemotherapy.

Herd protection induced by pneumococcal conjugate vaccine.

K. Klugman, 2014, The Lancet. Global health.

Modeling the impact of the 13-valent pneumococcal conjugate vaccine serotype catch-up program using United States claims data

M. Weinstein, S. Pelton, K. Klugman, 2012, BMC Infectious Diseases.

Quantitative and qualitative anamnestic immune responses to pneumococcal conjugate vaccine in HIV-infected and HIV-uninfected children 5 years after vaccination.

S. Madhi, H. Käyhty, K. Klugman, 2009, The Journal of infectious diseases.

Long-term immunogenicity and efficacy of a 9-valent conjugate pneumococcal vaccine in human immunodeficient virus infected and non-infected children in the absence of a booster dose of vaccine.

Stephanie A. Jones, S. Madhi, K. Klugman, 2007, Vaccine.

Imputing the Direct and Indirect Effectiveness of Childhood Pneumococcal Conjugate Vaccine Against Invasive Pneumococcal Disease by Surveying Temporal Changes in Nasopharyngeal Pneumococcal Colonization

S. Madhi, M. Nunes, A. von Gottberg, 2017, American journal of epidemiology.

Epidemiology of invasive pneumococcal disease in the pre-conjugate vaccine era: South Africa, 2003-2008.

S. Madhi, C. Whitney, A. von Gottberg, 2013, Vaccine.

COVID-19 pneumonia and the appropriate use of antibiotics

K. Klugman, A. Ginsburg, 2020, The Lancet Global Health.

Serotype-specific Cardiac Involvement in Pneumococcal Pneumonia

C. Feldman, K. Klugman, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Clinical impact of antibiotic resistance in respiratory tract infections.

K. Klugman, 2007, International journal of antimicrobial agents.

Interspecies Recombination Occurs Frequently in Quinolone Resistance-Determining Regions of Clinical Isolates of Streptococcus pyogenes

H. Goossens, T. Welte, L. McGee, 2008, Antimicrobial Agents and Chemotherapy.

WORLDWIDE INCREASE IN PNEUMOCOCCAL ANTIBIOTIC RESISTANCE

K. Klugman, H. Koornhof, 1989, The Lancet.

Adult influenza vaccination guideline

C. Feldman, K. Klugman, 1999 .

Susceptibility of Yersinia pestis to novel and conventional antimicrobial agents.

J. Frean, K. Klugman, S. Bukofzer, 2003, The Journal of antimicrobial chemotherapy.

In vitro activities of 14 antibiotics against 100 human isolates of Yersinia pestis from a southern African plague focus

J. Frean, K. Klugman, A. Bryskier, 1996, Antimicrobial agents and chemotherapy.

HIV and influenza virus infections are associated with increased blood pneumococcal load: a prospective, hospital-based observational study in South Africa, 2009-2011.

S. Madhi, K. Kahn, A. von Gottberg, 2014, The Journal of infectious diseases.

HIV and Influenza Infection Are Associated with Increased Blood Pneumococcal Load : a Prospective , Hospital-Based Observational Study in South Africa , 2009-2011 Running Title : HIV / influenza increase pneumococcal load

S. Madhi, K. Kahn, E. Variava, 2013 .

Pneumococcal vaccines: the impact of conjugate vaccine.

G. Siber, K. Klugman, Mäkelä Ph, 2008 .

Serotypes and antibacterial susceptibility of pneumococci isolated from children with infections in Ankara in relation to proposed pneumococcal vaccine coverage

G. Kanra, K. Klugman, M. Ceyhan, 1998, Acta paediatrica Japonica : Overseas edition.

Fatal infection caused by a multiply resistant type 3 pneumococcus

S. Miller, K. Klugman, J. Lawrenson, 1988, Journal of clinical microbiology.

Prevention of Typhoid Fever by Single-Dose Capsular Polysaccharide Vaccination — 2-Year Results

K. Klugman, L. Arntzen, H. Koornhof, 1989 .

Immunogenicity and effectiveness of Haemophilus influenzae type b conjugate vaccine in HIV infected and uninfected African children.

S. Madhi, H. Käyhty, K. Klugman, 2005, Vaccine.

Consensus: management of infections in children caused by Streptococcus pneumoniae with decreased susceptibility to penicillin

S. Kaplan, J. Bradley, K. Klugman, 1995, The Pediatric infectious disease journal.

Mutations within the rplD Gene of Linezolid-Nonsusceptible Streptococcus pneumoniae Strains Isolated in the United States

L. McGee, K. Klugman, J. Vidal, 2014, Antimicrobial Agents and Chemotherapy.

New Gene Cassettes for Trimethoprim Resistance,dfr13, and Streptomycin-Spectinomycin Resistance,aadA4, Inserted on a Class 1 Integron

C. J. Thomson, S. Amyes, K. Klugman, 2000, Antimicrobial Agents and Chemotherapy.

New Trimethoprim-Resistant Dihydrofolate Reductase Cassette, dfrXV, Inserted in a Class 1 Integron

S. Amyes, K. Klugman, M. du Plessis, 1998, Antimicrobial Agents and Chemotherapy.

Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants.

David Goldblatt, Ron Dagan, T. Cherian, 2003, Vaccine.

Inferior quantitative and qualitative immune responses to pneumococcal conjugate vaccine in infants with nasopharyngeal colonization by Streptococcus pneumoniae during the primary series of immunization.

S. Madhi, M. Cotton, J. McIntyre, 2011, Vaccine.

Estimating the protective concentration of anti-pneumococcal capsular polysaccharide antibodies.

S. Madhi, K. O'Brien, G. Siber, 2007, Vaccine.

Incidence of high-level gentamicin resistance in enterococci at Johannesburg Hospital.

K. Klugman, L. Liebowitz, K. Keddy, 1996, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Immunogenicity after one, two or three doses and impact on the antibody response to coadministered antigens of a nonavalent pneumococcal conjugate vaccine in infants of Soweto, South Africa

R. Huebner, K. Klugman, N. Mbelle, 2002, The Pediatric infectious disease journal.

Detection of Penicillin Resistance in Streptococcus pneumoniae by a Seminested PCR Strategy.

K. Klugman, A. Smith, M. Plessis, 2001, Methods in molecular medicine.

Pneumococcal pneumonia and influenza: a deadly combination.

S. Madhi, K. Klugman, Yu-Wen Chien, 2009, Vaccine.

Antihypertensives suppress the emergence of fluoroquinolone-resistant mutants in pneumococci: an in vitro study.

T. Welte, Mathias W Pletz, M. P. van der Linden, 2013, International journal of medical microbiology : IJMM.

Key features of pneumococcal isolates recovered in Central and Northwestern Russia in 2011–2018 determined through whole-genome sequencing

S. Bentley, L. McGee, K. Klugman, 2022, Microbial genomics.

1732 COLONY MORPHOLOGY OF PILIATED NEISSERIA MENINGITIDIS

K. Klugman, M. Blake, C. MAcDONALD, 2003 .

COLONY MORPHOLOGY OF PILIATED

K. Klugman, M. Blake, C. MAcDONALD, 2003 .

Colony morphology of piliated Neisseria meningitidis

K. Klugman, M. Blake, C. MAcDONALD, 1989, The Journal of experimental medicine.

Interrelationship of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus colonization within and between pneumococcal-vaccine naïve mother-child dyads

S. Madhi, M. Nunes, K. Klugman, 2013, BMC Infectious Diseases.

Epidemiology of Group B Streptococcus in developing countries.

S. Black, M. Bottomley, A. Johri, 2013, Vaccine.

Nasopharyngeal Pneumococcal Density and Evolution of Acute Respiratory Illnesses in Young Children, Peru, 2009–2011

K. Edwards, Yuwei Zhu, R. Fan, 2016, Emerging infectious diseases.

Cohort profile: The study of respiratory pathogens in Andean children.

K. Edwards, C. Lanata, A. Gil, 2014, International journal of epidemiology.

Effects of haemorrhage on colloid osmotic pressure in the pigeon.

J. Hattingh, K. Klugman, S. T. Cornelius, 1982, Comparative biochemistry and physiology. A, Comparative physiology.

Susceptibility of Bacillus anthracis to eleven antimicrobial agents including novel fluoroquinolones and a ketolide.

J. Frean, K. Klugman, S. Bukofzer, 2003, The Journal of antimicrobial chemotherapy.

Time for a third-generation pneumococcal conjugate vaccine.

K. Klugman, G. Rodgers, 2020, The Lancet. Infectious diseases.

A new paradigm in pneumococcal conjugate vaccination: moving from individual to herd protection.

K. Klugman, G. Rodgers, 2017, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Pneumococcal polysaccharide vaccine efficacy and routine use of conjugate vaccines in infants: there is no need for a vaccine program in older adults at present.

I. Jónsdóttir, J. Trück, A. Pollard, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Introduction: historical perspective and development of amoxicillin/clavulanate.

G. Rolinson, K. Klugman, A. Geddes, 2007, International journal of antimicrobial agents.

Acquisition of Chloramphenicol Resistance by the Linearization and Integration of the Entire Staphylococcal Plasmid pC194 into the Chromosome of Streptococcus pneumoniae

K. Klugman, P. Adrian, Carol A. Widdowson, 2000, Antimicrobial Agents and Chemotherapy.

An Official Publication of the International Society for Infectious Diseases

K. Klugman, C. Nord, R. Isturiz, 2008 .

Clinical and microbiological features of invasive nontyphoidal Salmonella associated with HIV-infected patients, Gauteng Province, South Africa

K. Keddy, A. Sooka, K. Klugman, 2017, Medicine.

Ineffectiveness of trimethoprim-sulfamethoxazole prophylaxis and the importance of bacterial and viral coinfections in African children with Pneumocystis carinii pneumonia.

S. Madhi, K. Klugman, Clare L. Cutland, 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Variable recombination dynamics during the emergence, transmission and ‘disarming’ of a multidrug-resistant pneumococcal clone

A. Tomasz, W. Hanage, J. Parkhill, 2014, BMC Biology.

Penetration of meropenem into the cerebrospinal fluid of patients with inflamed meninges.

R. Dagan, K. Klugman, L. Velghe, 1994, The Journal of antimicrobial chemotherapy.

Fluoroquinolone-resistant Streptococcus pneumoniae

T. Welte, L. McGee, K. Klugman, 2006, Emerging infectious diseases.

Cluster of an erythromycin-resistant variant of the Spanish multiply resistant 23F clone ofStreptococcus pneumoniae in South Africa

B. Spratt, K. Klugman, A. Wasas, 1994, European Journal of Clinical Microbiology and Infectious Diseases.

Dynamics of Colonization of Streptococcus pneumoniae Strains in Healthy Peruvian Children

K. Edwards, C. Lanata, A. Gil, 2018, Open forum infectious diseases.

Pneumococcal conjugate vaccines in Asia and the Pacific, Singapore, 9–11 October 2000. Report of an Asia Pacific Advisory Board Meeting1For the Asia Pacific Advisory Board (see Appendix for faculty listing).1

J. Tam, K. Klugman, 2001 .

Meta-Analysis of the Efficacy of Conjugate Vaccines against Invasive Pneumococcal Disease

S. Madhi, K. O'Brien, J. Sterne, 2008 .

Quantitative and Qualitative Antibody Response to Pneumococcal Conjugate Vaccine Among African Human Immunodeficiency Virus-Infected and Uninfected Children

S. Madhi, H. Käyhty, K. Klugman, 2005, The Pediatric infectious disease journal.

Long-term antibody levels and booster responses in South African children immunized with nonavalent pneumococcal conjugate vaccine.

R. Huebner, K. Klugman, N. Mbelle, 2004, Vaccine.

Bacterial aetiology of non-resolving otitis media in South African children

R. Huebner, K. Klugman, A. Wasas, 2003, The Journal of Laryngology & Otology.

Antibiotics for paediatric community-acquired pneumonia in resource-constrained settings

K. Klugman, A. Ginsburg, 2020, European Respiratory Journal.

Association of Laboratory Methods, Colonization Density, and Age With Detection of Streptococcus pneumoniae in the Nasopharynx

K. O'Brien, L. Hammitt, C. Sutcliffe, 2020 .

UNIQUE TRIAL DESIGN SHOWS SDD TO DECREASE & ALTER COLONISATION OF UPPER RESP. TRACT IN A MULTIDISCIPLINARY ICU

K. Klugman, J. Lipman, D. Luyt, 1994 .

Increased risk for and mortality from invasive pneumococcal disease in HIV-exposed but uninfected infants aged <1 year in South Africa, 2009-2013.

K. O'Brien, C. Whitney, B. Eley, 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Epidemiology of invasive bacterial infections in pneumococcal conjugate vaccine-vaccinated and -unvaccinated children under 5 years of age in Soweto, South Africa: a cohort study from a high-HIV burden setting

S. Madhi, K. Klugman, D. Moore, 2020, Paediatrics and International Child Health.

Assessing the Full Burden of Respiratory Syncytial Virus in Young Infants in Low- and Middle-Income Countries: The Importance of Community Mortality Studies

K. Klugman, P. Srikantiah, Prachi Vora, 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Effect of HIV infection status and anti-retroviral treatment on quantitative and qualitative antibody responses to pneumococcal conjugate vaccine in infants.

S. Madhi, M. Cotton, J. McIntyre, 2010, The Journal of infectious diseases.

Herd immunity after pneumococcal conjugate vaccination

S. Madhi, K. Klugman, W. Albrich, 2007, The Lancet.

Clinical and Microbiological Features of Salmonella Meningitis in a South African Population, 2003-2013.

H. Ismail, K. Keddy, N. Tau, 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

HIV and pneumococcal disease

S. Madhi, C. Feldman, K. Klugman, 2007, Current opinion in infectious diseases.

Estimating the prevalence of coinfection with influenza virus and the atypical bacteria Bordetella pertussis, Chlamydophila pneumoniae, and Mycoplasma pneumoniae

M. Mina, K. Klugman, R. Burke, 2014, European Journal of Clinical Microbiology & Infectious Diseases.

Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlled trials

Stephanie A. Jones, S. Madhi, J. Katz, 2020, The Lancet. Respiratory medicine.

Dynamics of Increasing IFN-γ Exposure on Murine MH-S Cell-Line Alveolar Macrophage Phagocytosis of Streptococcus pneumoniae.

M. Mina, K. Klugman, L. Brown, 2015, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

The role of bacterial vaccines in the prevention of influenza mortality.

S. Madhi, K. Klugman, A. Ginsburg, 2018, The Lancet. Global health.

A preventable killer: Pneumonia.

K. Klugman, J. Garau, 2009, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Antimicrobial resistance in developing countries. Part I: recent trends and current status.

Ramanan Laxminarayan, Iruka N Okeke, Thomas F O'Brien, 2005, The Lancet. Infectious diseases.

Mutations in the dihydrofolate reductase gene of trimethoprim-resistant isolates of Streptococcus pneumoniae

K. Klugman, P. Adrian, 1997, Antimicrobial agents and chemotherapy.

In vitro activity of faropenem against respiratory pathogens.

K. Klugman, M. du Plessis, T. Capper, 2002, The Journal of antimicrobial chemotherapy.

Penetration of cefpodoxime into middle ear fluid in pediatric patients with acute otitis media.

K. Klugman, C. Meyer, J. van Dyk, 1997, The Pediatric infectious disease journal.

In-vitro activity of the fluoroquinolone trovafloxacin against penicillin-susceptible and -resistant Streptococcus pneumoniae.

K. Klugman, A. Wasas, 1995, The Journal of antimicrobial chemotherapy.

Communicating trends in resistance using a drug resistance index

R. Laxminarayan, K. Klugman, 2011, BMJ Open.

Outcome of Cephalosporin Treatment for Serious Infections Due to Apparently Susceptible Organisms Producing Extended-Spectrum β-Lactamases: Implications for the Clinical Microbiology Laboratory

Victor L. Yu, Keith P. Klugman, Robert A. Bonomo, 2001, Journal of Clinical Microbiology.

Corynebacterium group D2 urinary tract infection.

K. Klugman, R. Stewart, V. Nowbath, 1993, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Urinary tract infection withCorynebacterium urealyticum in South Africa

K. Klugman, S. Vally, P. Naidoo, 2005, European Journal of Clinical Microbiology and Infectious Diseases.

Antimicrobial resistance in developing countries. Part II: strategies for containment.

I. Okeke, Z. Bhutta, A. Pablos-Mendez, 2005, The Lancet. Infectious diseases.

Infection of the human orbit by Aspergillus stromatoides

K. Klugman, H. Sacho, K. J. Stead, 1987, Mycopathologia.

Disk susceptibility testing of penicillin-resistant pneumococci

H. Koornhof, K. Klugman, 1988, Journal of clinical microbiology.

Septic arthritis due to Cryptococcus neoformans.

H. Koornhof, K. Klugman, K. J. Stead, 1988, The Journal of infection.

Neonatal typhoid fever.

K. Klugman, R. Reed, 1994, The Pediatric infectious disease journal.

Background Paper on Vaccination against Typhoid Fever using New-Generation Vaccines - to be presented to WHO SAGE in November 2007 Typhoid Immunization Working Group: Chair:

M. Levine, M. Favorov, K. Klugman, 2007 .

An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome.

D. Snydman, J. Rello, V. Yu, 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases.

H. Goossens, L. Rice, V. Yu, 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Correlation between erythromycin and azithromycin resistance in Streptococcus pneumoniae.

R. Huebner, K. Klugman, A. Wasas, 2003, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis

Harish Nair, Igor Rudan, Philippe Buchy, 2011, The Lancet.

Pneumococcal Capsules and Their Types: Past, Present, and Future

M. Nahm, G. Gilbert, K. Klugman, 2015, Clinical Microbiology Reviews.

Evidence for clonal expansion after antibiotic selection pressure: pneumococcal multilocus sequence types before and after mass azithromycin treatments.

T. Gebre, P. Emerson, J. Keenan, 2015, The Journal of infectious diseases.

Pneumococcal Conjugate Vaccine Protection against Coronavirus-Associated Pneumonia Hospitalization in Children Living with and without HIV

S. Madhi, M. Nunes, K. Klugman, 2021, mBio.

Epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum beta-lactamase production in Klebsiella pneumoniae isolates causing bacteremia.

H. Goossens, V. Yu, D. Paterson, 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Severity of illness scoring systems in patients with bacteraemic pneumococcal pneumonia: implications for the intensive care unit care.

J. Rello, V. Yu, C. Feldman, 2009, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

International Prospective Study of Klebsiella pneumoniae Bacteremia: Implications of Extended-Spectrum -Lactamase Production in Nosocomial Infections

H. Goossens, L. Rice, V. Yu, 2004, Annals of Internal Medicine.

Concentration-dependent killing of antibiotic-resistant pneumococci by the methoxyquinolone moxifloxacin.

K. Klugman, T. Capper, 1997, The Journal of antimicrobial chemotherapy.

The battle against emerging antibiotic resistance: should fluoroquinolones be used to treat children?

L. Mandell, L. Peterson, D. Hooper, 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

In-vitro and in-vivo activity of trovafloxacin against Streptococcus pneumoniae.

T. Gootz, K. Klugman, 1997, The Journal of antimicrobial chemotherapy.

Part IV. Human infections and antibiotic resistance.

K. Keddy, N. Govender, A. von Gottberg, 2011, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

HIV Infection and the Epidemiology of Invasive Pneumococcal Disease (IPD) in South African Adults and Older Children Prior to the Introduction of a Pneumococcal Conjugate Vaccine (PCV)

S. Madhi, C. Feldman, A. von Gottberg, 2016, PloS one.

A century of South African battles against the pneumococcus — ‘the Captain of Death’

S. Madhi, H. Koornhof, K. Klugman, 2009 .

Historical changes in pneumococcal serogroup distribution: implications for the era of pneumococcal conjugate vaccines.

D. Feikin, K. Klugman, 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Carbapenem treatment of meningitis.

R. Dagan, K. Klugman, 1995, Scandinavian journal of infectious diseases. Supplementum.

Defining the Estimated Core Genome of Bacterial Populations Using a Bayesian Decision Model

Martin C. J. Maiden, Keith A. Jolley, James E. Bray, 2014, PLoS Comput. Biol..

Haematological changes associated with haemorrhage in the pigeon

J. Hattingh, K. Klugman, J. Palmer, 1979 .

Emergence and Resurgence of Bacterial Infectious Diseases

R. Berkelman, K. Klugman, 2010 .

Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data

Cécile Viboud, Keith P. Klugman, Lone Simonsen, 2015, PLoS medicine.

Typhoid Fever in South Africa in an Endemic HIV Setting

K. Keddy, N. Tau, A. Sooka, 2016, PloS one.

16th International Congress on Infectious Diseases

S. Arabia, Z. Memish, R. Dagan, 2013 .

Quinolone treatment for pediatric bacterial meningitis: a comparative study of trovafloxacin and ceftriaxone with or without vancomycin.

R. Frenck, G. Hussey, G. Mccracken, 2002, The Pediatric infectious disease journal.

Polyomaviruses-associated respiratory infections in HIV-infected and HIV-uninfected children

S. Madhi, M. Nunes, K. Klugman, 2014, Journal of Clinical Virology.

Global epidemiology of invasive meningococcal disease

Z. Bhutta, D. Durrheim, J. Eskola, 2013, Population Health Metrics.

Undernutrition and pneumonia mortality.

N. Rollins, J. Berkley, J. Walson, 2015, The Lancet. Global health.

Antimicrobial resistance of nasopharyngeal isolates of Streptococcus pneumoniae and Haemophilus influenzae from children in the Central African Republic

M. Deming, B. Schwartz, A. Rowe, 2000, The Pediatric infectious disease journal.

The Anticipated Severity of a “1918-Like” Influenza Pandemic in Contemporary Populations: The Contribution of Antibacterial Interventions

B. Levin, K. Klugman, Yu-Wen Chien, 2012, PloS one.

Impact of Haemophilus influenzae Type b Conjugate Vaccine in South Africa and Argentina

S. Madhi, Michael Martin, D. Feikin, 2004, The Pediatric infectious disease journal.

Future challenges in the elimination of bacterial meningitis.

M. Bottomley, D. Serruto, K. Klugman, 2012, Vaccine.

Putative novel cps loci in a large global collection of pneumococci

Andries J. van Tonder, S. Madhi, S. Bentley, 2019, Microbial genomics.

Defining the potential impact of conjugate bacterial polysaccharide-protein vaccines in reducing the burden of pneumonia in human immunodeficiency virus type 1-infected and -uninfected children

S. Madhi, K. Klugman, E. Cumin, 2002, The Pediatric infectious disease journal.

Global perspectives on maternal immunisation.

K. Klugman, Sharon Bergquist, A. T. Meulen, 2017, The Lancet. Infectious diseases.

The impact of antiretroviral treatment on the burden of invasive pneumococcal disease in South African children: a time series analysis

Cheryl Cohen, Shabir A Madhi, S. Madhi, 2011, AIDS.

Seasonality of respiratory viruses causing hospitalizations for acute respiratory infections in children in Nha Trang, Vietnam

M. Hashizume, B. Althouse, Hao Hu, 2018, International Journal of Infectious Diseases.

Impact of 13-valent pneumococcal conjugate vaccine (PCV13) in a pandemic similar to the 2009 H1N1 in the United States

M. Weinstein, K. Klugman, D. Strutton, 2013, BMC Infectious Diseases.

Public health and economic impact of vaccination with 7-valent pneumococcal vaccine (PCV7) in the context of the annual influenza epidemic and a severe influenza pandemic

M. Weinstein, K. Klugman, D. Strutton, 2010, BMC infectious diseases.

A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection.

S. Madhi, R. Huebner, K. Klugman, 2003, The New England journal of medicine.

Role of Streptococcus pneumoniae in Hospitalization for Acute Community-acquired Pneumonia Associated With Culture-confirmed Mycobacterium tuberculosis in Children: A Pneumococcal Conjugate Vaccine Probe Study

S. Madhi, K. Klugman, D. Moore, 2010, The Pediatric infectious disease journal.

Interaction between influenza virus and Streptococcus pneumoniae in severe pneumonia

S. Madhi, K. Klugman, B. Schoub, 2008, Expert review of respiratory medicine.

25 – Pneumococcal conjugate vaccine and pneumococcal common protein vaccines

C. Whitney, S. Black, R. Malley, 2013 .

Lower respiratory tract infections associated with influenza A and B viruses in an area with a high prevalence of pediatric human immunodeficiency type 1 infection

S. Madhi, K. Klugman, H. Saloojee, 2002, The Pediatric infectious disease journal.

Seasonality, Incidence, and Repeat Human Metapneumovirus Lower Respiratory Tract Infections in an Area With a High Prevalence of Human Immunodeficiency Virus Type-1 Infection

S. Madhi, K. Klugman, L. Kuwanda, 2007, The Pediatric infectious disease journal.

Mutations in Ribosomal Protein L16 Conferring Reduced Susceptibility to Evernimicin (SCH27899): Implications for Mechanism of Action

K. Klugman, K. Shaw, R. Hare, 2000, Antimicrobial Agents and Chemotherapy.

Fluoroquinolone Resistance in Invasive Streptococcus pyogenes Isolates Due to Spontaneous Mutation and Horizontal Gene Transfer

L. McGee, K. Klugman, M. Barlow, 2006, Antimicrobial Agents and Chemotherapy.

Fitness Costs of Fluoroquinolone Resistance in Streptococcus pneumoniae

B. Levin, D. Rozen, L. McGee, 2006, Antimicrobial Agents and Chemotherapy.

Five-year cohort study of hospitalization for respiratory syncytial virus associated lower respiratory tract infection in African children.

S. Madhi, K. Klugman, L. Kuwanda, 2006, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Evidence for Soft Selective Sweeps in the Evolution of Pneumococcal Multidrug Resistance and Vaccine Escape

W. Hanage, J. Parkhill, K. Ko, 2014, Genome biology and evolution.

Community-acquired pneumonia: new management strategies for evolving pathogens and antimicrobial susceptibilities.

J. Metlay, D. Low, K. Klugman, 2004, International journal of antimicrobial agents.

Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia.

D. Snydman, J. Rello, D. Hui, 2004, American journal of respiratory and critical care medicine.

The Clinical Relevance of Antibiotic Resistance in the Management of Pneumococcal Pneumonia

C. Feldman, K. Klugman, M. Path, 1997 .

Management of community-acquired pneumonia in the era of pneumococcal resistance: a report from the Drug-Resistant Streptococcus pneumoniae Therapeutic Working Group.

A. Schuchat, S. Dowell, D. Musher, 2000, Archives of internal medicine.

Quorum-Sensing Systems LuxS/Autoinducer 2 and Com Regulate Streptococcus pneumoniae Biofilms in a Bioreactor with Living Cultures of Human Respiratory Cells

K. Klugman, P. Nava, J. Vidal, 2013, Infection and Immunity.

The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1

S. Bentley, N. French, R. Heyderman, 2017, Vaccine.

Innovative vaccine approaches—a Keystone Symposia report

G. Kang, S. Madhi, G. Dougan, 2022, Annals of the New York Academy of Sciences.

Surveillance for Antimicrobial Drug Resistance in Under-Resourced Countries

O. Doumbo, Z. Bhutta, G. Vernet, 2014, Emerging infectious diseases.

Impact of Pneumococcal Conjugate Vaccination of Infants on Pneumonia and Influenza Hospitalization and Mortality in All Age Groups in the United States

Robert J. Taylor, Keith P. Klugman, Michael Haber, 2011, mBio.

Genes and spectrum : The theoretical limits. Discussion

J. Quinn, I. Phillips, F. Baquero, 1998 .

Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: updated recommendations from the World Health Organization Pneumococcal Carriage Working Group.

K. O'Brien, J. Scott, A. Leach, 2013, Vaccine.

Streptococcus pneumoniae . of trimethoprim-resistant isolates of Mutations in the dihydrofolate reductase gene

K. Klugman, P. Adrian, 1997 .

Prevalence and genetic location of non-transferable trimethoprim resistant dihydrofolate reductase genes in South African commensal faecal isolates

S. Amyes, K. Klugman, C. Thomson, 1995, Epidemiology and Infection.

Prevalence of maternal colonisation with group B streptococcus: a systematic review and meta-analysis.

S. Madhi, K. Klugman, M. Cunnington, 2016, The Lancet. Infectious diseases.

Marking November 12, 2010 – World Pneumonia Day: Where are we, where are vaccines?

R. Dagan, O. Levine, K. Klugman, 2010, Human vaccines.

Integrated pneumonia surveillance: pandemics and beyond

S. Dowell, K. Klugman, A. Ginsburg, 2022, The Lancet Global Health.

Impact of conjugate pneumococcal vaccines on antibiotic resistance.

R. Dagan, K. Klugman, 2008, The Lancet. Infectious diseases.

Persistence of antibodies to the Salmonella typhi Vi capsular polysaccharide vaccine in South African school children ten years after immunization.

K. Klugman, C. Blondeau, K. Keddy, 1999, Vaccine.

Conserved Mutations in the Pneumococcal Bacteriocin Transporter Gene, blpA, Result in a Complex Population Consisting of Producers and Cheaters

S. Madhi, J. Weiser, A. von Gottberg, 2011, mBio.

Usefulness of the Serial Measurement of Vi Antibodies

K. Klugman, 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Laboratory-based diagnosis of pneumococcal pneumonia: state of the art and unmet needs.

D. H. Burgess, M. Steinhoff, G. Vernet, 2011, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Novel approaches to the identification of Streptococcus pneumoniae as the cause of community-acquired pneumonia.

S. Madhi, K. Klugman, W. Albrich, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Phylogenetic Analysis of Invasive Serotype 1 Pneumococcus in South Africa, 1989 to 2013

S. Bentley, K. Jolley, R. Breiman, 2016, Journal of Clinical Microbiology.

Novel Expansions of the Gene Encoding Dihydropteroate Synthase in Trimethoprim-Sulfamethoxazole-Resistant Streptococcus pneumoniae

K. Klugman, T. Padayachee, 2000, Antimicrobial Agents and Chemotherapy.

Streptococcus pneumoniae genomic datasets from an Indian population describing pre-vaccine evolutionary epidemiology using a whole genome sequencing approach

S. Bentley, R. Breiman, L. McGee, 2021, Microbial genomics.

The Study of Respiratory Pathogens in

K. Edwards, C. Lanata, A. Gil, 2013 .

Childhood pneumonia in developing countries.

A. Cohen, K. Klugman, Rasa Izadnegahdar, 2013, The Lancet. Respiratory medicine.

Nasopharyngeal Pneumococcal Density during Asymptomatic Respiratory Virus Infection and Risk for Subsequent Acute Respiratory Illness

K. Edwards, Yuwei Zhu, C. Lanata, 2019, Emerging infectious diseases.

Multiplex Urinary Antigen Detection for 13 Streptococcus pneumoniae Serotypes Improves Diagnosis of Pneumococcal Pneumonia in South African HIV-Infected Adults

S. Madhi, K. Jansen, K. Klugman, 2016, Journal of Clinical Microbiology.

A tale of 2 pneumococcal vaccines.

K. Klugman, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Recommendations for treatment of childhood non-severe pneumonia

E. Mulholland, M. Steinhoff, S. Dowell, 2009, The Lancet Infectious Diseases.

Efficacy and Safety of Conjugate Pneumococcal Vaccine in the Prevention of Pneumonia

S. Madhi, K. Klugman, 2008 .

World Health Organisation definition of "radiologically-confirmed pneumonia" may under-estimate the true public health value of conjugate pneumococcal vaccines.

S. Madhi, K. Klugman, 2007, Vaccine.

Conjugate Vaccines as Probes To Define the Burden of Pneumococcal and Haemophilus influenzae Type b Pneumonia as Well as the Role of Viruses in the Pathogenesis of Pneumonia

S. Madhi, K. Klugman, 2007 .

Usefulness of C-Reactive Protein to Define Pneumococcal Conjugate Vaccine Efficacy in the Prevention of Pneumonia

S. Madhi, K. Klugman, C. Cutland, 2006, The Pediatric infectious disease journal.

Estimated severe pneumococcal disease cases and deaths before and after pneumococcal conjugate vaccine introduction in children younger than 5 years of age in South Africa

S. Madhi, K. O'Brien, C. Whitney, 2017, PloS one.

World Pneumonia Day 2016: pulse oximetry and oxygen.

K. Klugman, A. Ginsburg, Rasa Izadnegahdar, 2016, The Lancet. Global health.

Increased Nasopharyngeal Density and Concurrent Carriage of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Are Associated with Pneumonia in Febrile Children

B. Genton, L. Kaiser, K. Klugman, 2016, PloS one.

The adult nasopharyngeal microbiome as a determinant of pneumococcal acquisition

Aldert L. Zomer, S. V. van Hijum, A. Zomer, 2014, Microbiome.

A role for Streptococcus pneumoniae in virus-associated pneumonia

Shabir A Madhi, S. Madhi, K. Klugman, 2004, Nature Medicine.

The "Achilles heel" of global efforts to combat infectious diseases.

M. Hamburg, R. Berkelman, S. Specter, 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pneumococcal coinfection with human metapneumovirus.

S. Madhi, K. Klugman, C. Cutland, 2006, The Journal of infectious diseases.

Impact of Pneumococcal Conjugate Vaccine on Vaccine Serotype–Specific Pneumonia

K. Klugman, G. Rodgers, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Understanding pneumococcal serotype 1 biology through population genomic analysis

Cheryl P. Andam, J. Corander, W. Hanage, 2016, BMC Infectious Diseases.

The Relevance of a Novel Quantitative Assay to Detect up to 40 Major Streptococcus pneumoniae Serotypes Directly in Clinical Nasopharyngeal and Blood Specimens

H. Endtz, M. P. van der Linden, K. Klugman, 2016, PloS one.

The PneuCarriage Project: A Multi-Centre Comparative Study to Identify the Best Serotyping Methods for Examining Pneumococcal Carriage in Vaccine Evaluation Studies

Keith P. Klugman, E. Mulholland, K. Klugman, 2015, PLoS medicine.

Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae

S. Bentley, S. Harris, N. French, 2015, Microbial genomics.

220D-F2 from Rubus ulmifolius Kills Streptococcus pneumoniae Planktonic Cells and Pneumococcal Biofilms

C. Quave, K. Klugman, J. Vidal, 2014, PloS one.

Epidemiology of Serotype 1 Invasive Pneumococcal Disease, South Africa, 2003–2013

S. Madhi, A. von Gottberg, K. Klugman, 2016, Emerging infectious diseases.

Effectiveness of 7-Valent Pneumococcal Conjugate Vaccine Against Invasive Pneumococcal Disease in HIV-Infected and -Uninfected Children in South Africa: A Matched Case-Control Study

S. Madhi, K. O'Brien, C. Whitney, 2014, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Live Attenuated Influenza Vaccine Enhances Colonization of Streptococcus pneumoniae and Staphylococcus aureus in Mice

J. McCullers, M. Mina, K. Klugman, 2014, mBio.

Development of the Respiratory Index of Severity in Children (RISC) Score among Young Children with Respiratory Infections in South Africa

S. Madhi, C. Reed, L. Finelli, 2012, PloS one.

Use of 2 pneumococcal common protein real-time polymerase chain reaction assays in healthy children colonized with Streptococcus pneumoniae.

S. Madhi, N. Rouphael, K. Klugman, 2011, Diagnostic microbiology and infectious disease.

Apnea and its possible relationship to immunization in ex-premature infants.

I. Kleinschmidt, S. Madhi, S. Karim, 2008, Vaccine.

Bacteraemic pneumococcal pneumonia: impact of HIV on clinical presentation and outcome.

J. Rello, V. Yu, C. Feldman, 2007, The Journal of infection.

Vaccines as tools against resistance: the example of pneumococcal conjugate vaccine.

C. Whitney, K. Klugman, 2004, Seminars in pediatric infectious diseases.

The molecular mechanisms of tetracycline resistance in the pneumococcus.

K. Klugman, C. Widdowson, 1998, Microbial drug resistance.

Time from Illness Onset to Death, 1918 Influenza and Pneumococcal Pneumonia

M. Lipsitch, C. Astley, K. Klugman, 2009, Emerging infectious diseases.

Pneumococcal colonisation density: a new marker for disease severity in HIV-infected adults with pneumonia

S. Madhi, G. Vernet, B. Mueller, 2014, BMJ Open.

Streptococcus pneumoniae respiratory tract infections

C. Feldman, K. Klugman, 2001 .

Streptococcus pneumoniae respiratory tract infections.

C. Feldman, K. Klugman, 2001, Current opinion in infectious diseases.

The role of clonality in the global spread of fluoroquinolone-resistant bacteria.

K. Klugman, 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Nasopharyngeal carriage of pneumococcal pediatric serotypes: a risk for acute and recurrent otitis media in children and for invasive disease in susceptible adults.

K. Klugman, Kerry J. Welsh, 2005, The Journal of infectious diseases.

Phylogeography and resistome of pneumococcal meningitis in West Africa before and after vaccine introduction

S. Bentley, D. Ansong, R. Breiman, 2021, Microbial genomics.

Persistent High Burden of Invasive Pneumococcal Disease in South African HIV-Infected Adults in the Era of an Antiretroviral Treatment Program

S. Madhi, M. Nunes, A. von Gottberg, 2011, PloS one.

Novel Mechanism of Resistance to Oxazolidinones, Macrolides, and Chloramphenicol in Ribosomal Protein L4 of the Pneumococcus

W. Schaffner, C. Whitney, D. Farrell, 2005, Antimicrobial Agents and Chemotherapy.

Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life

S. Bentley, R. Adegbola, M. Barer, 2021, Frontiers in Pediatrics.

Pneumococci resistant to extended-spectrum cephalosporins in South Africa

K. Klugman, J. Saunders, 1993, The Lancet.

A framework for global surveillance of antibiotic resistance.

Ramanan Laxminarayan, Hajo Grundmann, John Stelling, 2011, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease

Andries J. van Tonder, J. Corander, S. Madhi, 2022, Vaccine.

PERCH in Perspective: What Can It Teach Us About Pneumonia Etiology in Children?

K. Klugman, G. Rodgers, 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Live attenuated influenza virus increases pneumococcal translocation and persistence within the middle ear.

J. McCullers, J. Rosch, M. Mina, 2015, The Journal of infectious diseases.

Sequence of the structural gene (rmpM) for the class 4 outer membrane protein of Neisseria meningitidis, homology of the protein to gonococcal protein III and Escherichia coli OmpA, and construction of meningococcal strains that lack class 4 protein

K. Klugman, E. Gotschlich, M. Blake, 1989, Infection and immunity.

Sequence oftheStructural Gene(rmpM)fortheClass 4Outer MembraneProtein ofNeisseria meningitidis, Homologyofthe Protein toGonococcal Protein IIIandEscherichia coli OmpA,and Construction ofMeningococcal Strains ThatLackClass 4Protein

K. Klugman, E. Gotschlich, M. Blake, 1989 .

Single report of β-lactam resistance in an invasive Haemophilus influenzae isolate from South Africa mediated by mutations in penicillin-binding protein 3, 2003-2008.

A. von Gottberg, K. Klugman, M. du Plessis, 2010, International journal of antimicrobial agents.

Laboratory surveillance for Haemophilus influenzae type B meningococcal, and pneumococcal disease. Haemophilus Surveillance Working Group.

G. Hussey, R. Huebner, K. Klugman, 1999, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Streptococcus pneumoniae Serotypes and Mortality in Adults and Adolescents in South Africa: Analysis of National Surveillance Data, 2003 - 2008

S. Madhi, C. Feldman, P. Naicker, 2015, PloS one.

Detection of Pneumococcal Pneumonia in a Phase 3 Trial Comparing Oral Solithromycin Versus Oral Moxifloxacin for Treatment of Community-Acquired Bacterial Pneumonia in Adults

K. Keedy, Anita F. Das, K. Klugman, 2015 .

In vitro susceptibility of penicillin-resistant Streptococcus pneumoniae to levofloxacin, selection of resistant mutants, and time-kill synergy studies of levofloxacin combined with vancomycin, teicoplanin, fusidic acid, and rifampin

K. Klugman, A. Bryskier, T. Capper, 1996, Antimicrobial agents and chemotherapy.

Community-acquired pneumonia in an adult due to a multiply-resistant pneumococcus.

H. Koornhof, K. Klugman, H. Sacho, 1987, The Journal of infection.

Genomic surveillance of invasive Streptococcus pneumoniae isolates in the period pre-PCV10 and post-PCV10 introduction in Brazil

S. Bentley, M. Brandileone, R. Breiman, 2021, Microbial genomics.

Benefits to mother and child of influenza vaccination during pregnancy

S. Madhi, S. Omer, R. Bednarczyk, 2012, Human vaccines & immunotherapeutics.

The clinical relevance of in-vitro resistance to penicillin, ampicillin, amoxycillin and alternative agents, for the treatment of community-acquired pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis.

K. Klugman, 1996, The Journal of antimicrobial chemotherapy.

Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidis.

Ellen Murphy, K. Jansen, C. Sacchi, 2009, The Journal of infectious diseases.

Population versus individual protection by pneumococcal conjugate vaccination

K. Klugman, G. Rodgers, 2019, The Lancet.

Visualizing variation within Global Pneumococcal Sequence Clusters (GPSCs) and country population snapshots to contextualize pneumococcal isolates

Richard J. Goater, Andries J. van Tonder, S. Madhi, 2020, Microbial genomics.

Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa

B. Spratt, K. Klugman, A. Smith, 1993, Antimicrobial Agents and Chemotherapy.

Wound colonization by Ewingella americana

K. Klugman, H. Koornhof, N. Bear, 1986, Journal of clinical microbiology.

One enzyme inactivates two antibiotics

B. Levin, K. Klugman, 2006, Nature Medicine.

Maternal Influenza Immunization and Reduced Likelihood of Prematurity and Small for Gestational Age Births: A Retrospective Cohort Study

B. Stoll, R. Rochat, S. Omer, 2011, PLoS medicine.

Invasive Neisseria meningitidis with decreased susceptibility to fluoroquinolones in South Africa, 2009.

Juno Thomas, L. Blumberg, A. von Gottberg, 2010, The Journal of antimicrobial chemotherapy.

Use of near-real-time medical claims data to generate timely vaccine coverage estimates in the US: the dynamics of PCV13 vaccine uptake.

L. Simonsen, C. Schuck-Paim, Robert Taylor, 2013, Vaccine.

Prevention of neonatal pneumonia and sepsis via maternal immunisation.

K. Klugman, A. Ginsburg, A. T. Meulen, 2014, The Lancet. Global health.

AIDS--the Baragwanath experience. Part I. Epidemiology of HIV infection at Baragwanath Hospital, 1988-1990.

J. McIntyre, K. Klugman, I. Friedland, 1992, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Nasopharyngeal Pneumococcal Density Is Associated With Viral Activity but Not With Use of Improved Stoves Among Young Andean Children

Y. Zhu, K. Edwards, Yuwei Zhu, 2017, Open forum infectious diseases.

Contribution of Serologic Assays in the Evaluation of Influenza Virus Infection Rates and Vaccine Efficacy in Pregnant Women: Report From Randomized Controlled Trials

Stephanie A. Jones, S. Madhi, M. Nunes, 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Lack of Efficacy of Trivalent Influenza Vaccination of HIV-Negative Pregnant Women Against Adverse Fetal Outcomes: A Randomized Clinical Trial

Stephanie A. Jones, S. Madhi, M. Nunes, 2015 .

Reply to “No Clinical Association of Live Attenuated Influenza Vaccine with Nasal Carriage of Bacteria or Acute Otitis Media”: Specific Recommendations for Future Studies

M. Mina, K. Klugman, 2014, mBio.

New respiratory syncytial virus immunization products in low- and middle-income countries: potential for cost-effective impact on a high burden of disease in young infants

K. Klugman, P. Srikantiah, 2023, BMC Medicine.

Trivalent influenza vaccination randomized control trial of pregnant women and adverse fetal outcomes

S. Madhi, M. Nunes, K. Neuzil, 2019, Vaccine.

The case for launch of an international DNA-based birth cohort study

S. Madhi, B. Horta, Z. Bhutta, 2011, Journal of global health.

Bacteremic pneumonia caused by penicillin-resistant pneumococci.

H. Koornhof, K. Klugman, 1988, The New England journal of medicine.

Antibiotic resistance in pneumococcal meningitis

K. Klugman, N. Simmons, I. Friedland, 1992, The Lancet.

Antimicrobial susceptibility of pneumococcal isolates causing bacteraemic pneumococcal pneumonia: analysis using current breakpoints and fluoroquinolone pharmacodynamics.

A. von Gottberg, O. Perovic, K. Klugman, 2010, International journal of antimicrobial agents.

Emergence of fluoroquinolone-resistant Streptococcus pneumoniae in a South African child in a tuberculosis treatment facility.

A. von Gottberg, K. Klugman, A. Sturm, 2003, The Pediatric infectious disease journal.

Fluoroquinolone-resistant Streptococcus pneumoniae, an emerging but unrecognized public health concern: is it time to resight the goalposts?

D. Low, G. Doern, R. Jones, 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Leveraging the COVID-19 response to end preventable child deaths from pneumonia

Q. Bassat, K. Watkins, K. Klugman, 2020, The Lancet.

Identifying transmission routes of Streptococcus pneumoniae and sources of acquisitions in high transmission communities

K. O'Brien, B. Althouse, B. Wagner, 2017, Epidemiology and Infection.

Prevalence of nasopharyngeal antibiotic-resistant pneumococcal carriage in children attending private paediatric practices in Johannesburg.

R. Huebner, K. Klugman, A. Wasas, 2000, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Recurrent penicillin-resistant pneumococcal meningitis after chloramphenicol therapy.

K. Klugman, I. Friedland, 1991, The Pediatric Infectious Disease Journal.

Management of antibiotic-resistant pneumococcal infections.

K. Klugman, 1994, The Journal of antimicrobial chemotherapy.

Explorer The case for launch of an international DNA-based birth cohort study

S. Madhi, B. Horta, Z. Bhutta, 2017 .

an international DNA- based birth cohort study

B. Horta, Z. Bhutta, I. Rudan, 2015 .

Acquisition, carriage, and transmission of pneumococci with decreased antibiotic susceptibility in young children attending a day care facility in southern Israel.

D Fraser, R. Dagan, P. Yagupsky, 1998, The Journal of infectious diseases.

Prevalence of trimethoprim resistant dihydrofolate reductase genes identified with oligonucleotide probes in plasmids from isolates of commensal faecal flora.

S. Amyes, K. Klugman, P. Adrian, 1995, The Journal of antimicrobial chemotherapy.

Antibiotic resistance in pneumococcal meningitis. Authors' replies

K. Klugman, N. Simmons, I. Friedland, 1992 .

Evaluation of the Etest as a means of determining the antibiotic susceptibilities of isolates of Streptococcus pneumoniae and Haemophilus influenzae from children in the Central African Republic.

B. Schwartz, K. Klugman, A. Wasas, 2000, The Journal of antimicrobial chemotherapy.

Efficacy and immunogenicity of inactivated influenza vaccine in pregnant women: A randomized, double-blind, placebo controlled trial

Stephanie A. Jones, S. Madhi, M. Nunes, 2014 .

Randomized, placebo-controlled trial on safety and efficacy of inactivated influenza vaccination of pregnant women in preventing illness in their infants

Stephanie A. Jones, S. Madhi, M. Nunes, 2014 .

An evaluation of two indirect fluorescent antibody tests for the diagnosis of Legionnaire's disease in South Africa.

H. Koornhof, K. Klugman, M. E. Ratshikhopha, 1990, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Editorial: Breathing New Life Into Pneumonia Epidemiology

O. Levine, K. Klugman, 2009, American journal of epidemiology.

Oral antibiotics for the treatment of severe pneumonia in children

S. Madhi, K. Klugman, 2004, The Lancet.

In-vitro activity of cefepime against bacterial pathogens from hospitalized patients.

K. Klugman, M. Khoosal, J. Saunders, 1993, The Journal of antimicrobial chemotherapy.

Pneumococcal Vaccines and Flu Preparedness

S. Madhi, K. Klugman, 2007, Science.

An association between decreasing incidence of invasive non-typhoidal salmonellosis and increased use of antiretroviral therapy, Gauteng Province, South Africa, 2003–2013

A. Puren, K. Keddy, A. Sooka, 2017, PloS one.

Differing manifestations of respiratory syncytial virus-associated severe lower respiratory tract infections in human immunodeficiency virus type 1-infected and uninfected children.

S. Madhi, K. Klugman, M. Venter, 2001, The Pediatric infectious disease journal.

Influenza vaccination of pregnant women and protection of their infants.

Stephanie A. Jones, S. Madhi, M. Nunes, 2014, The New England journal of medicine.

Increased burden of respiratory viral associated severe lower respiratory tract infections in children infected with human immunodeficiency virus type-1.

S. Madhi, B. Schoub, K. Klugman, 2000, The Journal of pediatrics.

Use of a rapid test of pneumococcal colonization density to diagnose pneumococcal pneumonia.

S. Madhi, K. Jansen, M. Wong, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Lethal Synergism of 2009 Pandemic H1N1 Influenza Virus and Streptococcus pneumoniae Coinfection Is Associated with Loss of Murine Lung Repair Responses

K. Walters, J. Taubenberger, A. Davis, 2011, mBio.

Seasonality of respiratory viruses causing hospitalizations for acute respiratory infections in children in Nha Trang, Vietnam

M. Hashizume, B. Althouse, Hao Hu, 2018, International Journal of Infectious Diseases.

Actinobacillus (Pasteurella) ureae meningitis in a HIV-positive patient.

K. Klugman, S. Kaka, R. Lunz, 1994, Diagnostic microbiology and infectious disease.

Trends in disease and complications of hepatitis A virus infection in the United States, 1999-2011: a new concern for adults.

A. Zaas, E. Tsalik, J. McCullers, 2015, The Journal of infectious diseases.

The relationship between pneumococcal serotypes and antibiotic resistance.

R. Dagan, K. Klugman, Jae-Hoon Song, 2012, Vaccine.

Antimicrobial Resistance—Fluoroquinolones and the Tiger's Tail

K. Klugman, G. Tillotson, J. Carroll, 2006, Journal of chemotherapy.

Public health and economic impact of vaccination with 7-valent pneumococcal vaccine (PCV7) in the context of the annual influenza epidemic and a severe influenza pandemic

M. Weinstein, K. Klugman, D. Strutton, 2010, BMC infectious diseases.

Susceptibility of Bacillus anthracis to eleven antimicrobial agents including novel fluoroquinolones and a ketolide.

J. Frean, K. Klugman, S. Bukofzer, 2003, The Journal of antimicrobial chemotherapy.

Emergence of levofloxacin-non-susceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study

S. Schrag, N. Govender, A. Whitelaw, 2008, The Lancet.

Pathogen Replication, Host Inflammation, and Disease in the Upper Respiratory Tract

M. Mina, K. Klugman, 2013, Infection and Immunity.

Increased disease burden and antibiotic resistance of bacteria causing severe community-acquired lower respiratory tract infections in human immunodeficiency virus type 1-infected children.

S. Madhi, K. Klugman, M. Khoosal, 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Potential interventions for the prevention of childhood pneumonia: geographic and temporal differences in serotype and serogroup distribution of sterile site pneumococcal isolates from children--implications for vaccine strategies.

S. Gove, D. Lehmann, B. Schwartz, 1995, The Pediatric infectious disease journal.

Global practices of meningococcal vaccine use and impact on invasive disease

Z. Bhutta, D. Durrheim, J. Eskola, 2014, Pathogens and global health.

Meningitis and pneumonia due to novel multiply resistant pneumococci.

S. Miller, H. Koornhof, K. Klugman, 1986, British medical journal.

No impact of penicillin resistance on mortality.

V. Yu, K. Klugman, 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Invasive Neisseria meningitidis with decreased susceptibility to fluoroquinolones in South Africa, 2009.

Juno Thomas, L. Blumberg, A. von Gottberg, 2010, The Journal of antimicrobial chemotherapy.

HIV and influenza virus infections are associated with increased blood pneumococcal load: a prospective, hospital-based observational study in South Africa, 2009-2011.

S. Madhi, K. Kahn, A. von Gottberg, 2014, The Journal of infectious diseases.

S. Madhi, M. Cotton, J. McIntyre, 2011, Vaccine.

Pneumococcal vaccines: the impact of conjugate vaccine.

G. Siber, K. Klugman, Mäkelä Ph, 2008 .

Temporal Changes in Pneumococcal Colonization in a Rural African Community With High HIV Prevalence Following Routine Infant Pneumococcal Immunization

S. Madhi, M. Nunes, K. Kahn, 2013, The Pediatric infectious disease journal.

Bacterial Density, Serotype Distribution and Antibiotic Resistance of Pneumococcal Strains from the Nasopharynx of Peruvian Children Before and After Pneumococcal Conjugate Vaccine 7

Mathias W Pletz, K. Edwards, C. Hornberg, 2016, The Pediatric infectious disease journal.

Impact of conjugate Haemophilus influenzae type b (Hib) vaccine introduction in South Africa.

S. Madhi, A. Schuchat, B. Flannery, 2006, Bulletin of the World Health Organization.

Nasopharyngeal carriage of pneumococcal pediatric serotypes: a risk for acute and recurrent otitis media in children and for invasive disease in susceptible adults.

K. Klugman, Kerry J. Welsh, 2005, Journal of Infectious Diseases.

Impact of the Hajj on pneumococcal transmission.

K. O'Brien, B. Gessner, A. Rabeeah, 2015, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.