L. McLellan

发表

Oxidative DNA damage in CD34+ myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor‐α concentration

C. Wolf, A. Collins, D. Bowen, 1997 .

Hepatocellular response to chemical stress in CD‐1 mice: Induction of early genes and γ‐glutamylcysteine synthetase

M. Pirmohamed, D. Smith, N. Kitteringham, 2000 .

Regulation of human gamma-glutamylcysteine synthetase: co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells.

D. Blake, L. McLellan, A. Shepherd, 1997, The Biochemical journal.

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.

M. McMahon, J. Hayes, L. McLellan, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.

Paul J Thornalley, K. Itoh, Masayuki Yamamoto, 2004, The Journal of nutrition.

Contribution of the glutathione S-transferases to the mechanisms of resistance to aflatoxin B1.

J. Hayes, D. Judah, G. Neal, 1991, Pharmacology & therapeutics.

Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver.

J. Hayes, L. McLellan, A. Cronshaw, 1991, The Biochemical journal.

Modulation of glutathione S-transferases and glutathione peroxidase by the anticarcinogen butylated hydroxyanisole in murine extrahepatic organs.

D. Harrison, J. Hayes, L. McLellan, 1992, Carcinogenesis.

Human microsomal glutathione S-transferase. Its involvement in the conjugation of hexachlorobuta-1,3-diene with glutathione.

C. Wolf, J. Hayes, L. McLellan, 1989, Biochemical Journal.

Hepatic glutathione S-transferases in mice fed on a diet containing the anticarcinogenic antioxidant butylated hydroxyanisole. Isolation of mouse glutathione S-transferase heterodimers by gradient elution of the glutathione-Sepharose affinity matrix.

J. Hayes, L. McLellan, A. Cronshaw, 1991, The Biochemical journal.

Sex-specific constitutive expression of the pre-neoplastic marker glutathione S-transferase, YfYf, in mouse liver.

J. Hayes, L. McLellan, 1987, The Biochemical journal.

Characterization of the basic glutathione S-transferase B1 and B2 subunits from human liver.

J. Hayes, L. McLellan, P. Stockman, 1987, The Biochemical journal.

Cytosolic and microsomal glutathione S-transferase isoenzymes in normal human liver and intestinal epithelium.

P. Hayes, D. Harrison, J. Hayes, 1989, Gut.

Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors.

J. Hayes, D. Judah, G. Neal, 1994, The Biochemical journal.

Differential induction of class alpha glutathione S-transferases in mouse liver by the anticarcinogenic antioxidant butylated hydroxyanisole. Purification and characterization of glutathione S-transferase Ya1Ya1.

J. Hayes, L. McLellan, 1989, The Biochemical journal.

Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide.

J. Hayes, D. Judah, G. Neal, 1991, The Biochemical journal.

Indole-3-carbinol induces a rat liver glutathione transferase subunit (Yc2) with high activity toward aflatoxin B1 exo-epoxide. Association with reduced levels of hepatic aflatoxin-DNA adducts in vivo.

D. Williams, G. Bailey, T. Harris, 1994, Drug metabolism and disposition: the biological fate of chemicals.

Glutathione S-transferases in man: the relationship between rat and human enzymes.

J. Hayes, G. Beckett, L. McLellan, 1987, Biochemical Society transactions.

Amino acid sequences of bacterial cytochromes c' and c-556.

J. V. Van Beeumen, L. McLellan, T. Meyer, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning of Drosophila γ‐glutamylcysteine synthetase by functional complementation of a yeast mutant

R. Saunders, L. McLellan, 2000, FEBS letters.

Regulation of gamma-glutamylcysteine synthetase regulatory subunit (GLCLR) gene expression: identification of the major transcriptional start site in HT29 cells.

D. Blake, L. McLellan, D. Galloway, 1999, Biochimica et biophysica acta.

Oxidative DNA damage in CD34+ myelodysplastic cells is associated with intracellular redox changes and elevated plasma tumour necrosis factor-alpha concentration.

C. Wolf, A. Collins, D. Bowen, 1997, British journal of haematology.

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

J. Hayes, L. McLellan, J D Hayes, 1999, Free radical research.

Glutathione and glutathione-dependent enzymes in cancer drug resistance.

C. Wolf, L. McLellan, Lesley I. McLellan, 1999, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

C. Wolf, K. Itoh, M. McMahon, 2001, Cancer research.

Reduction of Gstm1 Expression in the Stroke-Prone Spontaneously Hypertension Rat Contributes to Increased Oxidative Stress

A. Dominiczak, M. Brosnan, M. McBride, 2005, Hypertension.

Drosophila melanogaster Glutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form*

R. Saunders, J. Fraser, L. McLellan, 2002, The Journal of Biological Chemistry.

Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury.

D. Harrison, J. Hayes, L. McLellan, 1989, Journal of clinical pathology.

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

C. Wolf, K. Itoh, Masayuki Yamamoto, 2002, The Biochemical journal.

Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia.

M. Manson, L. McLellan, A. Shepherd, 2000, Carcinogenesis.

Antioxidant and cytoprotective responses to redox stress.

R. Saunders, J. Fraser, M. McMahon, 2004, Biochemical Society symposium.

Uptake and distribution of N-acetylcysteine in mice: tissue-specific effects on glutathione concentrations.

C. Wolf, L. McLellan, A. Lewis, 1995, Carcinogenesis.

Overexpression of the regulatory subunit of gamma-glutamylcysteine synthetase in HeLa cells increases gamma-glutamylcysteine synthetase activity and confers drug resistance.

D. Blake, L. McLellan, S. Tipnis, 1999, The Biochemical journal.

The Modifier Subunit of Drosophila Glutamate-Cysteine Ligase Regulates Catalytic Activity by Covalent and Noncovalent Interactions and Influences Glutathione Homeostasis in Vivo*

R. Saunders, J. Fraser, L. McLellan, 2003, Journal of Biological Chemistry.

Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes.

Dominic P. Williams, W. Hillen, C. Berens, 2006, American journal of physiology. Cell physiology.

Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents.

J. Hayes, P. Sherratt, L. McLellan, 2003, Biochemical pharmacology.

Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to aflatoxin B1.

J. Hayes, E. Ellis, D. Judah, 1996, IARC scientific publications.

Inducible expression of the gamma-glutamylcysteine synthetase light subunit by t-butylhydroquinone in HepG2 cells is not dependent on an antioxidant-responsive element.

L. McLellan, D. Galloway, 1998, The Biochemical journal.

Reduced glutathione levels and expression of the enzymes of glutathione synthesis in cryopreserved hepatocyte monolayer cultures.

L. McLellan, M. Helen Grant, D. J. Stevenson, 2007, Toxicology in vitro : an international journal published in association with BIBRA.