A. Villalobos

发表

Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties.

P. Verhoest, Travis T Wager, Xinjun Hou, 2010, ACS Chemical Neuroscience.

Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs

Y. Zou, B. L. Kormos, G. de Fabritiis, 2018, Scientific Reports.

Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes.

P. Verhoest, Y. Will, Travis T Wager, 2010, ACS chemical neuroscience.

Strategies to optimize the brain availability of central nervous system drug candidates

P. Verhoest, Travis T Wager, Xinjun Hou, 2011, Expert opinion on drug discovery.

The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).

L. Chen, B. Cravatt, K. Zasadny, 2012, Nuclear medicine and biology.

Imaging Techniques for Central Nervous System (CNS) Drug Discovery

A. Villalobos, Lei Zhang, 2015 .

Recent Advances in the Development of PET and SPECT Tracers for Brain Imaging

A. Villalobos, Lei Zhang, 2012 .

PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [18F]PF-06684511

C. Halldin, A. Varrone, L. Chen, 2020, European Journal of Nuclear Medicine and Molecular Imaging.

Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.

L. Chen, K. Zasadny, P. Verhoest, 2013, Journal of medicinal chemistry.

Synthesis of two useful, enantiomerically pure derivatives of (S)-4-hydroxy-2-cyclohexenone

S. Danishefsky, J. Audia, A. Villalobos, 1989 .

Identification and development of an irreversible monoacylglycerol lipase (MAGL) positron emission tomography (PET) radioligand with high specificity.

C. Halldin, A. Takano, Patrick E. Trapa, 2019, Journal of medicinal chemistry.

Design, synthesis and evaluation of [(3)H]PF-7191, a highly specific nociceptin opioid peptide (NOP) receptor radiotracer for in vivo receptor occupancy (RO) studies.

J. Cianfrogna, A. Villalobos, S. Grimwood, 2014, Bioorganic & medicinal chemistry letters.

Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.

J. Blake, C. K. Biggers, A. Villalobos, 1994, Journal of medicinal chemistry.

Dihedral Angle-Based Sampling of Natural Product Polyketide Conformations: Application to Permeability Prediction

Qin Wang, Matthew P. Jacobson, Gabriela Barreiro, 2016, J. Chem. Inf. Model..

Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery.

Anabella Villalobos, P. Verhoest, Travis T Wager, 2016, ACS chemical neuroscience.

Stereoselective syntheses of FK-506 subunits by the Rhodium(I)-catalyzed hydrogenation of dienes. The synthesis and coupling of a C10-C19 fragment

S. Danishefsky, A. Villalobos, 1989 .

Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.

R. Volkmann, J. Lowe, P. Seymour, 2004, Journal of medicinal chemistry.

Stereoselective routes to the C10−C19 fragment of FK-506

S. Danishefsky, A. Villalobos, 1990 .

Total synthesis of a novel benz[A]anthracycline analog of the antitumor agent 4-demethoxydaunorubicin

L. Mitscher, A. Villalobos, S. M. Borcherding, 1994 .

Borrelidin B: isolation, biological activity, and implications for nitrile biosynthesis.

Roger G. Linington, F. Loganzo, Walter M. Bray, 2014, Journal of natural products.

ON THE REMARKABLE PROPENSITY FOR CARBON-CARBON BOND CLEAVAGE REACTIONS IN THE C2-C10 REGION OF FK-506

S. Danishefsky, A. Villalobos, K. Chow, 1991 .

Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease.

Anabella Villalobos, Andres D. Ramirez, W. White, 2004, European journal of pharmacology.

Preclinical Evaluation of 18F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme

Yiyun Huang, R. Carson, J. Ropchan, 2016, The Journal of Nuclear Medicine.

Preclinical Evaluation of 18 FPF-05270430 , a Novel PET Radioligand for the Phosphodiesterase 2 A Enzyme

Yiyun Huang, R. Carson, J. Ropchan, 2016 .

5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.

A. Villalobos, A. Nagel, D. Liston, 1995, Journal of medicinal chemistry.

PET imaging of brain acetylcholinesterase using [11C]CP‐126,998, a brain selective enzyme inhibitor

R. Dannals, C. Endres, J. Hilton, 2002, Synapse.

5,7‐Dihydro‐3‐(2‐(1‐(phenylmethyl)‐4‐piperidinyl)ethyl)‐6H‐pyrrolo(3,2‐ f)‐1,2‐benzisoxazol‐6‐one: A Potent and Centrally‐Selective Inhibitor of Acetylcholinesterase with an Improved Margin of Safety.

Andres D. Ramirez, W. White, A. Villalobos, 1995 .

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.

Claude Ambroise, D. Karanian, K. Bales, 2018, Journal of medicinal chemistry.

Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs

Y. Zou, B. L. Kormos, G. de Fabritiis, 2018, Scientific Reports.

Strategies to facilitate the discovery of novel CNS PET ligands

A. Villalobos, Lei Zhang, 2016, EJNMMI Radiopharmacy and Chemistry.

Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates

Jenna M. Sullivan, J. Seibyl, G. Tamagnan, 2021, The Journal of Nuclear Medicine.

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.

R. J. Mather, L. Chen, K. Zasadny, 2017, Journal of medicinal chemistry.

Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides

K. Guckian, J. Iglesias-Fernández, A. Villalobos, 2023, Nucleic acids research.

Quantitative Analysis of 18F-PF-06684511, a Novel PET Radioligand for Selective β-Secretase 1 Imaging, in Nonhuman Primate Brain

C. Halldin, L. Chen, A. Takano, 2018, The Journal of Nuclear Medicine.

Quantitative Analysis of 18 F-PF-06684511, a Novel PET Radioligand for Selective β-secretase 1 Imaging, in Non-human Primate Brain

C. Halldin, L. Chen, A. Takano, 2018 .

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.

R. J. Mather, L. Chen, K. Zasadny, 2017, Journal of medicinal chemistry.