A. Offenbacher

发表

Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.

E. M. Thompson, J. Klinman, C. Gee, 2019, Journal of the American Chemical Society.

Thermodynamic and biophysical study of fatty acid effector binding to soybean lipoxygenase: implications for allostery driven by helix α2 dynamics

A. Offenbacher, Daniel Roberts, Amy M Benton, 2022, FEBS letters.

Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases

T. Holman, A. Offenbacher, 2020, Molecules.

Perturbations of aromatic amino acids are associated with iron cluster assembly in ribonucleotide reductase.

A. Offenbacher, B. Barry, Jun Chen, 2011, Journal of the American Chemical Society.

Protein function | Kinetic Isotope Effects

J. Klinman, A. Offenbacher, J. Roth, 2021, Encyclopedia of Biological Chemistry III.

The Soybean Lipoxygenase-Substrate Complex: Correlation between the Properties of Tunneling-Ready States and ENDOR-Detected Structures of Ground States.

J. Klinman, Ajay Sharma, B. Hoffman, 2020, Biochemistry.

Kinetic characterization of the C-H activation step for the lipoxygenase from the pathogenic fungus, M. oryzae: Impact of N-linked glycosylation.

A. T. Iavarone, A. Offenbacher, A. Kostenko, 2019, Biochemistry.

Understanding Biological Hydrogen Transfer Through the Lens of Temperature Dependent Kinetic Isotope Effects.

J. Klinman, A. Offenbacher, 2018, Accounts of chemical research.

Synthesis of Site-Specifically 13C Labeled Linoleic Acids.

J. Klinman, A. Offenbacher, Hui Zhu, 2016, Tetrahedron letters.

Detection of Catalytically Linked Conformational Changes in Wild-Type Class Ia Ribonucleotide Reductase Using Reaction-Induced FTIR Spectroscopy.

A. Offenbacher, B. Barry, Ryan Atlee Watson, 2021, The journal of physical chemistry. B.

Proton Coupled Electron Transfer and Redox Active Tyrosines: Structure and Function of the Tyrosyl Radicals in Ribonucleotide Reductase and Photosystem II.

C. Pagba, A. Offenbacher, B. Barry, 2012, The journal of physical chemistry letters.

Temporal and Spatial Resolution of a Protein Quake that Activates Hydrogen Tunneling in Soybean Lipoxygenase

J. Klinman, C. Gee, A. Offenbacher, 2022, bioRxiv.

First site-specific incorporation of a noncanonical amino acid into the photosynthetic oxygen-evolving complex.

C. Pagba, A. Offenbacher, Brandon C. Polander, 2014, ACS chemical biology.

Chorography and conformational dynamism of the Soluble Human Fibrinogen in solution

A. Offenbacher, N. Hudson, M. Sen, 2022, bioRxiv.

E. coli Ribonucleotide Reductase β2 Subunit Inactivation by Triapine Occurs through Binding of a Triapine-Fe(II) Adduct.

A. Offenbacher, B. Barry, R. Lieberman, 2021, The journal of physical chemistry letters.

pH-Dependent cis --> trans isomerization rates for azobenzene dyes in aqueous solution.

Nicholas J H Dunn, William H. Humphries, T. L. King, 2009, The journal of physical chemistry. A.

Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder

T. Holman, M. Tran, A. Offenbacher, 2022, Archives of biochemistry and biophysics.

13C ENDOR Spectroscopy-Guided MD Computations Reveals the Structure of the Enzyme-Substrate Complex of an Active, N-linked Glycosylated Lipoxygenase

Ajay Sharma, B. Hoffman, Pengfei Li, 2022, bioRxiv.

Redox-linked conformational control of proton-coupled electron transfer: Y122 in the ribonucleotide reductase β2 subunit.

C. Sherrill, L. Burns, A. Offenbacher, 2013, The journal of physical chemistry. B.

Redox-dependent structural coupling between the α2 and β2 subunits in E. coli ribonucleotide reductase.

C. Pagba, A. Offenbacher, B. Barry, 2014, The journal of physical chemistry. B.

Redox-linked structural changes in ribonucleotide reductase.

J. Stubbe, A. Offenbacher, M. Seyedsayamdost, 2009, Journal of the American Chemical Society.

Electrochemical and Structural Study of the Buried Tryptophan in Azurin: Effects of Hydration and Polarity on the Redox Potential of W48.

A. Offenbacher, M. Zeug, J. Choe, 2022, The journal of physical chemistry. B.

Synthesis of redox-active fluorinated 5-hydroxytryptophans as molecular reporters for biological electron transfer.

A. Offenbacher, A. L. Sargent, Eli G. Hvastkovs, 2021, Chemical communications.

A Proton Wire Mediates Proton Coupled Electron Transfer from Hydroxyurea and Other Hydroxamic Acids to Tyrosyl Radical in Class Ia Ribonucleotide Reductase.

A. Offenbacher, B. Barry, 2020, The journal of physical chemistry. B.

Hydrogen–deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase

J. Klinman, A. Offenbacher, A. Iavarone, 2017, The Journal of Biological Chemistry.

A spectroscopic investigation of a tridentate Cu-complex mimicking the tyrosine-histidine cross-link of cytochrome C oxidase.

A. Oliver, A. Offenbacher, I. Sen, 2009, The journal of physical chemistry. B.

Membrane-Mimicking Reverse Micelles for High-Resolution Interfacial Study of Proteins and Membranes.

Brian Fuglestad, A. Offenbacher, Courtney L. Labrecque, 2022, Langmuir : the ACS journal of surfaces and colloids.

Development of Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen

M. Guthold, A. Offenbacher, N. Hudson, 2022, International journal of molecular sciences.

Impact of Local Electrostatics on the Redox Properties of Tryptophan Radicals in Azurin: Implications for Redox-Active Tryptophans in Proton-Coupled Electron Transfer.

L. Bartolotti, A. Offenbacher, Eli G. Hvastkovs, 2020, The journal of physical chemistry letters.

Detecting and Characterizing the Kinetic Activation of Thermal Networks in Proteins: Thermal Transfer from a Distal, Solvent-Exposed Loop to the Active Site in Soybean Lipoxygenase.

J. Klinman, A. Offenbacher, J. P. T. Zaragoza, 2019, The journal of physical chemistry. B.

Origins of Enzyme Catalysis: Experimental Findings for C-H Activation, New Models, and Their Relevance to Prevailing Theoretical Constructs.

J. Klinman, Shenshen Hu, A. Offenbacher, 2017, Journal of the American Chemical Society.

Hydrogen–Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling

J. Klinman, Alexander D. Scouras, E. Poss, 2017, ACS central science.

13C ENDOR Spectroscopy of Lipoxygenase–Substrate Complexes Reveals the Structural Basis for C–H Activation by Tunneling

J. Klinman, B. Hoffman, Tao Yu, 2017, Journal of the American Chemical Society.

An Intrinsically Disordered Photosystem II Subunit, PsbO, Provides a Structural Template and a Sensor of the Hydrogen-bonding Network in Photosynthetic Water Oxidation*

A. Offenbacher, Brandon C. Polander, B. Barry, 2013, The Journal of Biological Chemistry.

Redox-linked changes to the hydrogen-bonding network of ribonucleotide reductase β2.

J. Stubbe, A. Offenbacher, B. Barry, 2013, Journal of the American Chemical Society.

Comparative kinetic isotope effects on first- and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network

J. Klinman, Shenshen Hu, A. Offenbacher, 2019, The Journal of Biological Chemistry.

Redox-active tyrosine residues in pentapeptides.

A. Offenbacher, B. Barry, I. R. Vassiliev, 2005, The journal of physical chemistry. B.

Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.

Adam Yasgar, A. Jadhav, A. Simeonov, 2021, Bioorganic & medicinal chemistry.

Effect of solvent viscosity on the activation barrier of hydrogen tunneling in the lipoxygenase reaction.

A. Offenbacher, A. Ohler, Luis Guevara, 2023, Archives of biochemistry and biophysics.

Investigating membrane-binding properties of lipoxygenases using surface plasmon resonance.

B. Garcia, A. Offenbacher, N. Gilbert, 2023, Biochemical and Biophysical Research Communications - BBRC.

13C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme-Substrate Complex of an Active, N-Linked Glycosylated Lipoxygenase.

Ajay Sharma, B. Hoffman, A. Offenbacher, 2023, Biochemistry.

Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase

J. Klinman, C. Gee, A. Offenbacher, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase.

T. Holman, M. Jacobson, C. Kalyanaraman, 2021, Biochemistry.

Impact of N-Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C-H Activation in the M. oryzae Lipoxygenase.

Ajay Sharma, A. Offenbacher, A. Iavarone, 2024, Biochemistry.