C. Manera

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Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist

M. Marcoli, B. Polini, C. Cervetto, 2020, Life.

The isoprenoid derivative N6‐benzyladenosine CM223 exerts antitumor effects in glioma patient‐derived primary cells through the mevalonate pathway

M. Scrima, M. Grimaldi, A. D'Ursi, 2017, British journal of pharmacology.

The Extra Virgin Olive Oil Polyphenol Oleocanthal Exerts Antifibrotic Effects in the Liver

M. Carrara, B. Polini, S. Carpi, 2021, Frontiers in Nutrition.

Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB2R modulators in neurodegenerative diseases.

F. Gado, Rebecca Ferrisi, S. Bertini, 2021, Pharmacological research.

Carbazole-containing arylcarboxamides as BACE1 inhibitors.

S. Moro, J. Mason, A. Bortolato, 2011, Bioorganic & medicinal chemistry letters.

Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells

M. Breschi, S. Fogli, A. Saba, 2016, Nutrition and cancer.

Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity.

M. Frosini, M. Cascio, V. Di Marzo, 2020, Bioorganic & medicinal chemistry.

Cannabinoid-Based Medicines and Multiple Sclerosis.

S. Bertini, C. Manera, 2020, Advances in experimental medicine and biology.

Preliminary Investigation of a Novel 18F Radiopharmaceutical for Imaging CB2 Receptors in a SOD Mouse Model

P. Iozzo, S. Burchielli, Mariarosaria De Simone, 2021, Australian Journal of Chemistry.

Development of potent dual PDK1/AurA kinase inhibitors for cancer therapy: Lead-optimization, structural insights, and ADME-Tox profile.

S. Gul, S. Sestito, S. Rapposelli, 2021, European journal of medicinal chemistry.

Anti-Proliferative Properties and Proapoptotic Function of New CB2 Selective Cannabinoid Receptor Agonist in Jurkat Leukemia Cells

V. Manganelli, C. Manera, M. Sorice, 2018, International journal of molecular sciences.

Synthesis and beta-blocking activity of (R,S)-(E)-oximeethers of 2, 3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2, 3-b]pyridine:potential antihypertensive agents - part IX.

A. Martinelli, V. Calderone, P. Nieri, 2000, European journal of medicinal chemistry.

A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress

A. Urbani, F. Ciregia, A. Lucacchini, 2018, International journal of molecular sciences.

Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief.

C. Ghelardini, T. Tuccinardi, E. Lucarini, 2018, Journal of medicinal chemistry.

Allosteric modulators targeting cannabinoid cb1 and cb2 receptors: implications for drug discovery.

F. Gado, S. Bertini, C. Manera, 2019, Future medicinal chemistry.

PSNCBAM-1 analogs: Structural evolutions and allosteric properties at cannabinoid CB1 receptor.

A. Saba, R. Pertwee, L. Stevenson, 2020, European journal of medicinal chemistry.

The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis.

M. Marcoli, C. Ghelardini, J. Gertsch, 2020, European journal of medicinal chemistry.

Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system.

J. Gertsch, T. Tuccinardi, F. Gado, 2019, Bioorganic chemistry.

Application of An Improved HPLC-FL Method to Screen Serine Palmitoyl Transferase Inhibitors

S. Bertini, C. Manera, R. Ghidoni, 2017, Molecules.

Chiral 2-(3′-(5′-p-chlorophenyl)isoxazolidinyl)ethanolamines as conformationally restrained analogs of methyloxyiminomethyl (MOIM) β-adrenergic antagonists: synthesis, configuration and β-adrenergic properties*

P. Cozzini, M. Breschi, G. Chiellini, 1996 .

Microfluidic approach for fast labeling optimization and dose-on-demand implementation.

C. Manera, G. Pascali, P. Salvadori, 2010, Nuclear medicine and biology.

Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands

S. Rapposelli, C. Ghelardini, G. Chiellini, 2022, Journal of medicinal chemistry.

Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor.

R. Pertwee, L. Stevenson, F. Gado, 2020, European journal of medicinal chemistry.

New quinolone- and 1,8-naphthyridine-3-carboxamides as selective CB2 receptor agonists with anticancer and immuno-modulatory activity.

S. Fogli, A. Malfitano, V. Di Marzo, 2015, European journal of medicinal chemistry.

Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors.

G. Gessa, V. Calderone, C. Manera, 2004, Bioorganic & medicinal chemistry.

4-[6-(Dansylamino)hexylamino]-7-methyl-2-phenyl-1,8-naphthyridine as a new potential fluorescent probe for studying A1-adenosine receptor.

D. Tuscano, C. Martini, S. Bertini, 2002, Farmaco.

A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives.

G. Giannaccini, A. Lucacchini, A. Martinelli, 2000, Journal of medicinal chemistry.

Stereoselective synthesis and β-blocking activity of substituted (E)- and (Z)-4(1H)-[1-(3-alkylamino-2-hydroxypropyl)oximino]-2,3-dihydro-1,8-naphthyridine. Potential antihypertensive agents. Part VI.

V. Calderone, C. Manera, C. Mori, 1998 .

Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.

J. Gertsch, F. Gado, S. Bertini, 2017, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R)

S. Rapposelli, G. Chiellini, R. Pertwee, 2022, Frontiers in Chemistry.

Anti-Inflammatory Activity of a CB2 Selective Cannabinoid Receptor Agonist: Signaling and Cytokines Release in Blood Mononuclear Cells

V. Manganelli, F. Gado, C. Manera, 2021, Molecules.

1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15 exerts immune-modulatory effects with good intestinal and blood brain barrier permeability

T. Tuccinardi, D. Marasco, A. Malfitano, 2019 .

Immunomodulatory properties of 1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15.

T. Tuccinardi, D. Marasco, A. Malfitano, 2017, Biochimie.

Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands.

J. Gertsch, S. Bertini, C. Manera, 2016, European journal of medicinal chemistry.

Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives

M. Vitale, T. Tuccinardi, A. Martinelli, 2013, Journal of Neuroimmune Pharmacology.

Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis

C. Procaccini, G. Matarese, T. Tuccinardi, 2013, PloS one.

1,2,3-Triazolo[1,5-a][1,4]- and 1,2,3-triazolo[1,5-a]-[1,5]benzodiazepine derivatives: synthesis and benzodiazepine receptor binding.

C. Martini, G. Giannaccini, C. Manera, 1998, Farmaco.

Modified RP-LC of Phenylthiocarbamyl Amino Acid Adducts in Plasma Acetonitrile Extracts Using Multiple Internal Standards and Photo-Diode UV Detection

A. Rossi, G. Giannaccini, A. Lucacchini, 2010 .

Design, synthesis and preliminary evaluation of (18)F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging of CB2 cannabinoid receptor.

S. Burchielli, Mariarosaria De Simone, D. Panetta, 2015, Bioorganic & medicinal chemistry letters.

Use of non-azeotropically dried complex in microfluidic radiofluorinations

C. Manera, G. Pascali, P. Salvadori, 2012 .

Determination of tramadol and metabolites by HPLC-FL and HPLC-MS/MS in urine of dogs.

A. Saba, M. Giorgi, C. Manera, 2010, Journal of pharmaceutical and biomedical analysis.

Immuno-Modulatory Properties of a Quinolin-2-(1H)-on-3-Carboxamide Derivative: Relevance in Multiple Sclerosis.

A. Malfitano, C. Manera, C. Laezza, 2016, Recent patents on CNS drug discovery.

Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists.

A. Vannacci, T. Tuccinardi, A. Martinelli, 2006, Journal of medicinal chemistry.

Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase.

J. Gertsch, S. Bertini, C. Manera, 2015, Journal of pharmaceutical and biomedical analysis.

Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma

S. Fogli, D. Monti, B. Polini, 2019, Molecules.

A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis.

P. Matarrese, W. Malorni, C. Manera, 2012, Anti-cancer agents in medicinal chemistry.

Unusual nitration of substituted 7-amino-1,8-naphthyridine in the synthesis of compounds with antiplatelet activity

A. Martinelli, C. Manera, C. Mori, 1997 .

Condensation of substituted 2-aminopyridine with β-ketocarboxylic esters: 4H-pyrido[1,2-a]pyrimidin-4-ones and pyridin-2-ones

V. Calderone, C. Manera, E. Martinotti, 1999 .

Composition of health-promoting phenolic compounds in two extra virgin olive oils and diversity of associated yeasts

M. Agnolucci, C. Cristani, M. Giovannetti, 2018, Journal of Food Composition and Analysis.

CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES

A. Lapucci, M. Breschi, A. Martinelli, 1994 .

Synthesis and antiplatelet activity of some 2,7-di(N-cycloamino)-3-phenyl-1,8-naphthyridine derivatives.

F. Franconi, C. Manera, C. Mori, 2001, Farmaco.

Substituted 1,2,3-triazolo[1,5-a]quinazolines: synthesis and binding to benzodiazepine and adenosine receptors.

G. Giannaccini, A. Lucacchini, C. Manera, 2000, European journal of medicinal chemistry.

Synthesis and antimicrobial activity of benzo[a]dihydrocarbazole and benzotetrahydrocyclohept[1,2-b]indole derivatives.

S. Nencetti, A. Rossello, C. Manera, 1996, Farmaco.

Unusual Nitration of Substituted 7-Amino-1,8-naphthyridine in the Synthesis of Compounds with Antiplatelet Activity.

A. Martinelli, C. Manera, C. Mori, 1998 .

Synthesis and β-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]pyridine: identification of β3-antagonists

V. Calderone, C. Manera, L. Testai, 2003 .

Synthesis and Antiplatelet Activity of Some 2,7‐Di(N‐cycloamino)‐3‐phenyl‐1,8‐naphthyridine Derivatives.

F. Franconi, C. Manera, C. Mori, 2001 .

Synthesis and antiplatelet activity of some 3-phenyl-1,8-naphthyridine derivatives.

F. Franconi, C. Manera, C. Mori, 2000, Farmaco.

Traditional Uses of Cannabinoids and New Perspectives in the Treatment of Multiple Sclerosis

F. Gado, S. Bertini, C. Manera, 2018, Medicines.

Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.

G. Giannaccini, A. Lucacchini, T. Tuccinardi, 2004, Journal of medicinal chemistry.

Conformationally restrained analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2',5'-morpholines].

A. Lapucci, G. Giannaccini, A. Martinelli, 2002, European journal of medicinal chemistry.

Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol

C. Martini, M. Breschi, G. Giannaccini, 1993 .

Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting α-adrenergic activity. Synthesis and α1- and α2-adrenergic activity of 3-phenyl-3-piperidinols and their desoxy analogs*

S. Nencetti, E. Orlandini, A. Rossello, 1995 .

Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.

C. Martini, A. Lapucci, M. Breschi, 1993, Journal of medicinal chemistry.

Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.

C. Martini, A. Lapucci, M. Breschi, 1992, Journal of medicinal chemistry.

X-ray analysis, theoretical studies and α-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue

P. Cozzini, G. Giannaccini, A. Martinelli, 1992 .

Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: an investigation of the 1,8-naphthyridin-2(1H)-one scaffold.

A. Giordano, T. Tuccinardi, A. Martinelli, 2012, European journal of medicinal chemistry.

Determination of water-soluble vitamins in multivitamin dietary supplements and in artichokes by micellar electrokinetic chromatography

C. Manera, M. Macchia, G. Saccomanni, 2013, Natural product research.

Synthesis and evaluation of antimycobacterial activity of 4-phenyl-1,8-naphthyridine derivatives.

C. Manera, C. Mori, M. Badawneh, 1998, Farmaco.

Spirotetrahydronaphthalene analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6‐ and 6,7‐dihydroxy‐3,4‐dihydrospiro[naphthalen‐1(2H)‐3′ ‐piperidines]

C. Martini, M. Breschi, A. Martinelli, 2002, The Journal of pharmacy and pharmacology.

Conformationally restrained β-blocking oxime ethers: synthesis and β-adrenergic properties of diastereoisomeric anti and syn 2-(5′-isoxazolidinyl)-ethanolamines

C. Martini, M. Breschi, G. Giannaccini, 1992 .

Conformationally restrained β-blocking oxime ethers. 3. Synthesis and β-adrenergic antagonistic activity of diastereomeric anti and syn 2-(5′-(3′-methyl)isoxazolidinyl)-N-alkylethanolamines*

M. Breschi, S. Nencetti, A. Rossello, 1996 .

High performance liquid chromatographic determination of thalidomide in patients affected by hepatocellular carcinoma.

C. Jemos, M. Giorgi, C. Manera, 2008, Journal of pharmaceutical and biomedical analysis.

Oleocanthal and oleacein contribute to the in vitro therapeutic potential of extra virgin oil-derived extracts in non-melanoma skin cancer.

S. Fogli, B. Polini, S. Carpi, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation

R. de Caterina, M. Wabitsch, F. Santorelli, 2019, Nutrients.

Oleocanthalic acid from extra-virgin olive oil: analysis, preparative isolation and radical scavenging activity

A. Saba, C. Manera, M. Macchia, 2021, Journal of Food Composition and Analysis.

miRNA Modulation and Antitumor Activity by the Extra-Virgin Olive Oil Polyphenol Oleacein in Human Melanoma Cells

E. Scoditti, B. Polini, S. Carpi, 2020, Frontiers in Pharmacology.

Beyond the Direct Activation of Cannabinoid Receptors: New Strategies to Modulate the Endocannabinoid System in CNS-Related Diseases.

C. Manera, A. Chicca, C. Arena, 2016, Recent patents on CNS drug discovery.

Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice

F. Gado, C. Manera, A. Escayg, 2021, Neuropharmacology.

Synthetic Cannabinoid Receptor Agonists and Antagonists: Implication in CNS Disorders.

C. Manera, A. Chicca, C. Arena, 2016, Recent patents on CNS drug discovery.

Evaluation of tramadol and its main metabolites in horse plasma by high-performance liquid chromatography/fluorescence and liquid chromatography/electrospray ionization tandem mass spectrometry techniques.

M. De Leo, M. Giorgi, C. Manera, 2009, Rapid communications in mass spectrometry : RCM.

Pharmacokinetics of Tramadol and its Metabolites M1, M2 and M5 in Horses Following Intravenous, Immediate Release (Fasted/Fed) and Sustained Release Single Dose Administration

M. Giorgi, C. Manera, G. Soldani, 2007 .

D13 In vitro metabolism of tramadol in horses: preliminary data

M. Giorgi, C. Manera, G. Soldani, 2006 .

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

F. J. Luque, R. Capasso, C. Hulme, 2019, Molecules.

Cannabinoid Receptor Activation Induces Apoptosis through Tumor Necrosis Factor α–Mediated Ceramide De novo Synthesis in Colon Cancer Cells

F. Cianchi, L. Magnelli, L. Papucci, 2008, Clinical Cancer Research.

Synthesis of variously substituted 1,8-naphthyridine derivatives and evaluation of their antimycobacterial activity.

C. Manera, C. Mori, M. Badawneh, 2002, Il Farmaco.

Synthesis of 3- or 4-phenyl-1,8-naphthyridine derivatives and evaluation of antimycobacterial and antimicrobial activity.

C. Manera, M. Badawneh, G. Saccomanni, 2003, Farmaco.

Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands.

Ettore Novellino, Luciana Marinelli, Marco Macchia, 2015, European journal of medicinal chemistry.

Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts

S. Rocchiccioli, G. Signore, C. Manera, 2014, Journal of Radioanalytical and Nuclear Chemistry.

Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors.

M. Sturlese, S. Moro, S. Rapposelli, 2017, Bioorganic & medicinal chemistry letters.

CB1 receptor binding sites for NAM and PAM: a first approach for studying, new n-butyl-diphenylcarboxamides as allosteric modulators.

R. Pertwee, L. Stevenson, F. Gado, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

T. Tuccinardi, A. Martinelli, F. Rizzolio, 2016, Journal of medicinal chemistry.

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

C. Ghelardini, J. Gertsch, L. De Stefano, 2018, Journal of medicinal chemistry.

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

A. Giordano, T. Tuccinardi, A. Martinelli, 2016, Journal of enzyme inhibition and medicinal chemistry.

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.

J. Gertsch, T. Tuccinardi, F. Gado, 2018, European journal of medicinal chemistry.

CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

Brandie M. Ehrmann, V. Di Marzo, A. Ligresti, 2014, Journal of medicinal chemistry.

Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives

M. Vitale, T. Tuccinardi, A. Martinelli, 2013, Journal of Neuroimmune Pharmacology.

Design, Synthesis, and In Vitro Evaluation of Novel 8-Amino-Quinoline Combined with Natural Antioxidant Acids

S. Sestito, S. Rapposelli, C. Manera, 2022, Pharmaceuticals.

New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.

M. Cascio, C. Ghelardini, T. Tuccinardi, 2007, Bioorganic & medicinal chemistry letters.

The Efficacy of Camelina sativa Defatted Seed Meal against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief

E. Pagnotta, C. Ghelardini, A. Troccoli, 2022, Nutrients.

Synthesis, in vitro and in vivo evaluation of 1,3,5-triazines as cannabinoid CB2 receptor agonists.

A. Poso, M. Sarparanta, A. Airaksinen, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Potential use of TG68 - A novel thyromimetic - for the treatment of non-alcoholic fatty liver (NAFLD)-associated hepatocarcinogenesis

S. Rapposelli, A. Perra, A. Columbano, 2023, Frontiers in Oncology.

1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.

A. Malfitano, V. Di Marzo, A. Ligresti, 2014, European journal of medicinal chemistry.

Cannabinoid CB2/CB1 selectivity. Receptor modeling and automated docking analysis.

Tiziano Tuccinardi, Adriano Martinelli, Gabriella Ortore, 2006, Journal of medicinal chemistry.

Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists.

E. Masini, M. Cascio, T. Tuccinardi, 2009, Journal of medicinal chemistry.

1,2,3-Triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines

C. Manera, O. Livi, I. Giorgi, 1999 .

1,2,3-Triazolo[4,5-e]-1,2,4-triazolo[3,4-c]pyrimidines.

C. Manera, O. Livi, I. Giorgi, 2000 .