W. Nicklas

发表

Excitotoxicity and Oxidative Stress during Inhibition of Energy Metabolism

G. Zeevalk, L. P. Bernard, C. Sinha, 1998, Developmental Neuroscience.

Control of citric acid cycle activity in rat heart mitochondria.

J. Williamson, K. Lanoue, W. Nicklas, 1970, The Journal of biological chemistry.

AMINO ACID METABOLISM IN GLIAL CELLS: HOMEOSTATIC REGULATION OF INTRA‐ and EXTRACELLULAR MILIEU BY C‐6 GLIOMA CELLS

W. Nicklas, E. T. Browning, E. Browning, 1978, Journal of neurochemistry.

Lactate Prevents the Alterations in Tissue Amino Acids, Decline in ATP, and Cell Damage Due to Aglycemia in Retina

G. Zeevalk, W. Nicklas, 2000, Journal of neurochemistry.

MK‐801 Fails to Protect Against the Dopaminergic Neuropathology Produced by Systemic 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine in Mice or Intranigral 1‐Methyl‐4‐Phenylpyridinium in Rats

G. Zeevalk, W. Nicklas, P. Sonsalla, 1992, Journal of neurochemistry.

Excitatory amino acid neurotoxins: selectivity, specificity, and mechanisms of action. Based on an NRP one-day conference held June 30, 1980.

R. H. Evans, J. Coyle, J. Nadler, 1981, Neurosciences Research Program bulletin.

Mitochondria and the neurotoxicity of MPTP

W. Nicklas, P. Sonsalla, M. Kindt, 1986 .

Mitochondrial Mechanisms of Neurotoxicity

H. M. Geller, W. Nicklas, R. Heikkila, 1992, Annals of the New York Academy of Sciences.

1‐Methyl‐4‐(2′‐Ethylphenyl)‐1,2,3,6‐Tetrahydropyridine‐ Induced Toxicity in PC12 Cells Is Enhanced by Preventing Glycolysis

H. M. Geller, W. Nicklas, R. Heikkila, 1992, Journal of neurochemistry.

Potentiation by the Tetraphenylboron Anion of the Effects of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine and Its Pyridinium Metabolite

H. M. Geller, W. Nicklas, R. Heikkila, 1990, Journal of neurochemistry.

1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐ and 1‐Methyl‐4‐(2′‐Ethylphenyl)‐1,2,3,6‐Tetrahydropyridine‐Induced Toxicity in PC 12 Cells: Role of Monoamine Oxidase A

H. M. Geller, W. Nicklas, R. Heikkila, 1990, Journal of neurochemistry.

Mesencephalic Dopamine Neurons Become Less Sensitive to 1 ‐Methyl‐4‐Phenyl‐l,2,3,6‐Tetrahydropyridine Toxicity During Development In Vitro

P. Danias, W. Nicklas, C. Mytilineou, 1989, Journal of neurochemistry.

Activity at the GABA transporter contributes to acute cellular swelling produced by metabolic impairment in retina

G. Zeevalk, W. Nicklas, 1997, Vision Research.

Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition.

G. Zeevalk, W. Nicklas, 1991, The Journal of pharmacology and experimental therapeutics.

NMDA Receptor Involvement in Toxicity to Dopamine Neurons In Vitro Caused by the Succinate Dehydrogenase Inhibitor 3‐Nitropropionic Acid

G. Zeevalk, W. Nicklas, E. Derr-Yellin, 1995, Journal of neurochemistry.

Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockade.

G. Zeevalk, W. Nicklas, E. Derr-Yellin, 1995, The Journal of pharmacology and experimental therapeutics.

Glutamate Metabolism in Rat Cortical Astrocyte Cultures

W. Nicklas, S. Farinelli, 1992, Journal of neurochemistry.

Effects of Cytochalasin B on Uptake and Release of Putative Transmitters by Synaptosomes and on Brain Actomyosin-like Protein

W. Nicklas, S. Berl, 1974, Nature.

Oxidative stress during energy impairment in mesencephalic cultures is not a downstream consequence of a secondary excitotoxicity

G. Zeevalk, L. P. Bernard, W. Nicklas, 2000, Neuroscience.

Chemically induced hypoglycemia and anoxia: relationship to glutamate receptor-mediated toxicity in retina.

G. Zeevalk, W. Nicklas, 1990, The Journal of pharmacology and experimental therapeutics.

DECARBOXYLATION STUDIES OF GLUTAMATE, GLUTAMINE, AND ASPARTATE FROM BRAIN LABELLED WITH [1‐14C] ACETATE, l‐[U‐14C]‐ASPARTATE, AND l‐[U‐14C]GLUTAMATE

W. Nicklas, S. Berl, D. Clarke, 1969, Journal of neurochemistry.

Interactions between neurons and glia in glutamate/glutamine compartmentation.

G. Zeevalk, W. Nicklas, A. Hyndman, 1987, Biochemical Society transactions.

COMPARTMENTATION OF CITRIC ACID CYCLE METABOLISM IN BRAIN: LABELLING OF GLUTAMATE, GLUTAMINE, ASPARTATE AND GABA BY SEVERAL RADIOACTIVE TRACER METABOLITES 1

W. Nicklas, S. Berl, D. Clarke, 1970, Journal of neurochemistry.

Contents

Humphries, Williams, Davison, 2007 .

Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: Effects of MK-801 and kynurenate

G. Zeevalk, W. Nicklas, 1989, Neuroscience Letters.

NMDA receptor involvement in two animal models of Parkinson's disease

G. Zeevalk, W. Nicklas, P. Sonsalla, 1994, Neurobiology of Aging.

Studies on the Neurotoxicity of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine: Inhibition of NAD‐Linked Substrate Oxidation by Its Metabolite, 1‐Methyl‐4‐Phenylpyridinium

W. Nicklas, R. Heikkila, I. Vyas, 1986, Journal of neurochemistry.

Excitotoxicity at Both NMDA and Non‐NMDA Glutamate Receptors Is Antagonized by Aurintricarboxylic Acid: Evidence for Differing Mechanisms of Action

D. Schoepp, G. Zeevalk, W. Nicklas, 1995, Journal of neurochemistry.

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

R. Duvoisin, W. Nicklas, R. Heikkila, 1985, Neuroscience Letters.

Dopaminergic toxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to rats

R. Duvoisin, W. Nicklas, R. Heikkila, 1985, Neuroscience Letters.

4'-alkylated analogs of 1-methyl-4-phenylpyridinium ion are potent inhibitors of mitochondrial respiration.

W. Nicklas, R. Heikkila, S. Youngster, 1990, Biochemical and biophysical research communications.

l‐DOPA Cytotoxicity to PC12 Cells in Culture Is via Its Autoxidation

H. M. Geller, W. Nicklas, Alie N. Basma, 1995, Journal of neurochemistry.

IV. MPTP, MPP+ and mitochondrial function

W. Nicklas, M. Kindt, R. Heikkila, 1987 .

MPTP, MPP+ and mitochondrial function.

W. Nicklas, M. Kindt, R. Heikkila, 1987, Life sciences.

Role of Oxidative Stress and the Glutathione System in Loss of Dopamine Neurons Due to Impairment of Energy Metabolism

G. Zeevalk, L. P. Bernard, W. Nicklas, 1998, Journal of neurochemistry.

The metabolism of rat brain mitochondria. Preparation and characterization.

W. Nicklas, J. Clark, 1970, The Journal of biological chemistry.

Interrelationships of Energy Metabolism to Oxidative Damage and Neurodegeneration

G. Zeevalk, L. P. Bernard, C. Sinha, 1998 .

Aurintricarboxylic Acid Prevents NMDA‐Mediated Excitotoxicity: Evidence for Its Action as an NMDA Receptor Antagonist

D. Schoepp, G. Zeevalk, W. Nicklas, 1993, Journal of neurochemistry.

Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity.

W. Nicklas, P. Sonsalla, R. Heikkila, 1989, Science.

Oxidative Metabolism of 4‐Aminobutyrate by Rat Brain Mitochondria: Inhibition by Branched‐chain Fatty Acid

W. Nicklas, D. Clarke, J. Cunningham, 1980, Journal of neurochemistry.

Neurophysiologic study of olivopontocerebellar atrophy with or without glutamate dehydrogenase deficiency

S. Chokroverty, R. Duvoisin, R. Sachdeo, 1985, Neurology.

Thiamine deficiency

W. Nicklas, S. Berl, A. Plaitakis, 1978, Neurology.

EFFECT OF VINBLASTINE AND COLCHICINE ON UPTAKE AND RELEASE OF PUTATIVE TRANSMITTERS BY SYNAPTOSOMES AND ON BRAIN ACTOMYOSIN‐LIKE PROTEIN

W. Nicklas, S. Berl, S. Puszkin, 1973, Journal of neurochemistry.

Actomyosin-like protein in brain.

W. Nicklas, S. Berl, S. Puszkin, 1973, Science.

Hypothermia, Metabolic Stress, and NMDA‐Mediated Excitotoxicity

G. Zeevalk, W. Nicklas, 1993, Journal of neurochemistry.

Tricarboxylic acid-cycle metabolism in brain. Effect of fluoroacetate and fluorocitrate on the labelling of glutamate aspartate, glutamine and γ-amino butyrate

W. Nicklas, S. Berl, D. Clarke, 1970 .

Action of the anti-ischemic agent ifenprodil onN-methyl-d-aspartate and kainate-mediated excitotoxicity

G. Zeevalk, W. Nicklas, 1990, Brain Research.

Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration.

H. M. Geller, W. Nicklas, R. Heikkila, 1992, The Journal of pharmacology and experimental therapeutics.

Characterization of the inhibitory mechanism of 1-methyl-4-phenylpyridinium and 4-phenylpyridine analogs in inner membrane preparations.

R. Ramsay, W. Nicklas, T. Singer, 1994, The Journal of biological chemistry.

Structural dependence of the inhibition of mitochondrial respiration and of NADH oxidase by 1-methyl-4-phenylpyridinium (MPP+) analogs and their energized accumulation by mitochondria.

R. Ramsay, W. Nicklas, R. Heikkila, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Origins of the Extracellular Glutamate Released During Total Metabolic Blockade in the Immature Retina

G. Zeevalk, W. Nicklas, A. Hyndman, 1998, Journal of neurochemistry.

Hypothermia and metabolic stress: narrowing the cellular site of early neuroprotection.

G. Zeevalk, W. Nicklas, 1996, The Journal of pharmacology and experimental therapeutics.

In vivo studies on the effect of 6-hydroxydopamine on amino acid metabolism in brain.

W. Nicklas, S. Berl, 1973, Brain research.

Effect of halogenated hydrocarbons on synaptosomal uptake and release of neurotransmitters.

W. Nicklas, S. Berl, C. Mahendran, 1979, Progress in clinical and biological research.

Actomyosin-Like Protein in Brain Actomyosin-like protein may function in the release of transmitter material at synaptic endings

W. Nicklas, S. Berl, S. Puszkin, 1973 .

Contractile Proteins in Relation to Transmitter Release

W. Nicklas, S. Berl, 1975 .

Excitatory Amino Acid‐Induced Toxicity in Chick Retina: Amino Acid Release, Histology, and Effects of Chloride Channel Blockers

G. Zeevalk, W. Nicklas, A. Hyndman, 1989, Journal of neurochemistry.

Fluorofumarate--a substrate for fumarate hydratase.

W. Nicklas, D. Clarke, J. Palumbo, 1968, Archives of biochemistry and biophysics.

Glutamate dehydrogenase deficiency in three patients with spinocerebellar syndrome

R. Desnick, W. Nicklas, A. Plaitakis, 1980, Annals of neurology.

NEURONAL‐GLIAL CONTRIBUTIONS TO TRANSMITTER AMINO ACID METABOLISM: STUDIES WITH KAINIC ACID‐INDUCED LESIONS OF RAT STRIATUM

R. Duvoisin, W. Nicklas, S. Berl, 1979, Journal of neurochemistry.

Alteration in Neuronal‐Glial Metabolism of Glutamate by the Neurotoxin Kainic Acid

W. Nicklas, S. Berl, B. Krespan, 1982, Journal of neurochemistry.

Alterations in uptake and metabolism of aspartate and glutamate in brain of thiamine deficient animals

W. Nicklas, S. Berl, A. Plaitakis, 1979, Brain Research.

Glia–Neuronal Interrelationships in the Metabolism of Excitatory Amino Acids

W. Nicklas, 1986 .

Glutamate Uptake and Metabolism in C‐6 Glioma Cells: Alterations by Potassium Ion and Dibutyryl cAMP

W. Nicklas, E. Browning, William J. Nicklas, 1983, Journal of neurochemistry.

Alteration by Kainate of Energy Stores and Neuronal-Glial Metabolism of Glutamate In Vitro

W. Nicklas, 1983 .

Induction of Glutamine Synthetase by Dibutyryl Cyclic AMP in C‐6 Glioma Cells

W. Nicklas, E. Browning, William J. Nicklas, 1982, Journal of neurochemistry.

Studies on Neuronal-Glial Metabolism of Glutamate in Cerebellar Slices

W. Nicklas, B. Krespan, 1982 .

Effect of kainate on ATP levels and glutamate metabolism in cerebellar slices.

W. Nicklas, S. Berl, B. Krespan, 1980, European journal of pharmacology.

Amino acids in rat neostriatum: Alteration by kainic acid lesion

R. Duvoisin, W. Nicklas, S. Berl, 1979, Brain Research.

COMPARTMENTATION OF CITRIC ACID CYCLE METABOLISM IN BRAIN: EFFECT OF AMINOOXYACETIC ACID, OUABAIN AND Ca2+ ON THE LABELLING OF GLUTAMATE, GLUTAMINE, ASPARTATE AND GABA BY [1‐14C]ACETATE, [U‐14C]GLUTAMATE AND [U‐14C] ASPARTATE 1

W. Nicklas, S. Berl, D. Clarke, 1970, Journal of neurochemistry.

Computer simulation of the metabolism of guinea pig brain slices, and how they differ from the intact brain

D. Garfinkel, J. London, L. Dzubow, 1975, Brain Research.

Glial cells and metabolic compartmentation /

S., A. U.S, W. Nicklas, 2017 .

Tricarboxylic acid-cycle metabolism in brain. Effect of fluoroacetate and fluorocitrate on the labelling of glutamate, aspartate, glutamine and gamma-aminobutyrate.

W. Nicklas, S. Berl, D. Clarke, 1970, The Biochemical journal.

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

W. Nicklas, R. Heikkila, I. Vyas, 1985, Life sciences.

Mechanism of action of anticonvulsants

J. Weinberger, W. Nicklas, S. Berl, 1976, Neurology.

ACTOMYOSIN‐LIKE PROTEIN IN BRAIN: SUBCELLULAR DISTRIBUTION

W. Nicklas, S. Berl, S. Puszkin, 1972, Journal of neurochemistry.

Relationship between Amino Acid and Catecholamine Metabolism in Brain

W. Nicklas, S. Berl, D. Clarke, 1975 .

EVIDENCE FOR CALCIUM‐SENSITIVE COMPONENT IN BRAIN ACTOMYOSIN‐LIKE PROTEIN (NEUROSTENIN)

W. Nicklas, S. Berl, C. Mahendran, 1974, Journal of neurochemistry.

Structure-activity study of the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity. II. Evaluation of the biological activity of the pyridinium metabolites formed from the monoamine oxidase-catalyzed oxidation of MPTP analogs.

W. Nicklas, R. Heikkila, S. Youngster, 1989, The Journal of pharmacology and experimental therapeutics.

Biochemical mechanisms underlying MPTP-induced and idiopathic parkinsonism. New vistas.

R. Ramsay, W. Nicklas, P. Sonsalla, 1993, Advances in neurology.

Multiple system degeneration with glutamate dehydrogenase deficiency: pathology and biochemistry.

S. Chokroverty, D. Miller, R. Duvoisin, 1990, Journal of neurology, neurosurgery, and psychiatry.

Contribution of glial metabolism to neuronal damage caused by partial inhibition of energy metabolism in retina.

G. Zeevalk, W. Nicklas, 1997, Experimental eye research.

Mitochondrial and metabolic toxicity of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine.

W. Nicklas, M. Kindt, R. Heikkila, 1987, Journal of Pharmacology and Experimental Therapeutics.

Metabolism of rat brain mitochondria. Studies on the potassium ion-stimulated oxidation of pyruvate.

J. Williamson, W. Nicklas, J. Clark, 1971, The Biochemical journal.

Low leukocyte glutamate dehydrogenase activity does not correlate with a particular type of multiple system atrophy.

S. Chokroverty, R. Duvoisin, W. Nicklas, 1988, Journal of neurology, neurosurgery, and psychiatry.

Glutamate dehydrogenase deficiency in patients with olivopontocerebellar atrophy

S. Chokroverty, R. Duvoisin, W. Nicklas, 1983, Neurology.

Pathology of olivopontocerebellar atrophy with glutamate dehydrogenase deficiency

S. Chokroverty, C. Yook, R. Duvoisin, 1984, Neurology.

multiple system atrophy . correlate with a particular type of dehydrogenase activity does not Low leukocyte glutamate

R. Duvoisin, W. Nicklas, V. Ritchie, 2022 .

Developmental differences in antagonism of NMDA toxicity by the polyamine site antagonist ifenprodil.

G. Zeevalk, W. Nicklas, 1992, Brain research. Developmental brain research.

Amino acid metabolism in the central nervous system: role of glutamate dehydrogenase.

W. Nicklas, 1984, Advances in neurology.

Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO‐711

G. Zeevalk, L. P. Bernard, W. Nicklas, 2001, Journal of neuroscience research.

Attenuation of excitotoxic cell swelling and GABA release by the GABA transport inhibitor SKF 89976A.

G. Zeevalk, W. Nicklas, 1996, Molecular and chemical neuropathology.

Focal epileptogenic activity induced by topical application of antisera to brain actomyosin-like protein

W. Nicklas, S. Berl, F. P. Bowen, 1976, Brain Research.

Autoradiographic demonstration of loss of labeled indoleamine axons of the cerebellum in chronic diet-induced thiamine deficiency

V. Chan‐Palay, W. Nicklas, S. Berl, 1977, Brain Research.

Uptake and metabolism of serotonin and amino acids in thiamine deficiency.

W. Nicklas, S. Berl, A. Plaitakis, 1981, Advances in experimental medicine and biology.

The apparent Km for oxygen of rat brain mitochondrial respiration

H. Degn, W. Nicklas, J. Clark, 1976, Journal of neurochemistry.

Studies on the Characterization of the Inhibitory Mechanism of 4′‐Alkylated 1‐Methyl‐4‐Phenylpyridinium and Phenylpyridine Analogues in Mitochondria and Electron Transport Particles

R. Ramsay, W. Nicklas, T. Singer, 1994, Journal of neurochemistry.

Evidence that the Loss of the Voltage‐Dependent Mg2+ Block at the N‐Methyl‐D‐Aspartate Receptor Underlies Receptor Activation During Inhibition of Neuronal Metabolism

G. Zeevalk, W. Nicklas, Gail D. Zeevalk, 1992, Journal of neurochemistry.

INTERACTION OF CATECHOLAMINE AND AMINO ACID METABOLISM IN BRAIN: EFFECT OF PARGYLINE AND l‐DOPA

W. Nicklas, S. Berl, D. Clarke, 1974, Journal of neurochemistry.

Glutamate dehydrogenase deficiency in three patients with spinocerebellar ataxia: a new enzymatic defect?

W. Nicklas, R. Desnick, A. Plaitakis, 1979, Transactions of the American Neurological Association.

Energy Stress‐Induced Dopamine Loss in Glutathione Peroxidase‐Overexpressing Transgenic Mice and in Glutathione‐Depleted Mesencephalic Cultures

D. S. Albers, G. Zeevalk, L. P. Bernard, 1997, Journal of neurochemistry.

THE COMPLEX BINDING OF γ‐AMINOBUTYRIC ACID TO A RAT BRAIN SYNAPTIC MEMBRANE PREPARATION

W. Nicklas, S. Berl, M. Winkler, 1979 .

γ‐Aminobutyric Acid Formation from Glucose: Metabolic Pathway

R. Shank, W. Nicklas, 1990 .

Tricarboxylic Acid-Cycle Metabolism in Brain EFFECT OF FLUOROACETATE AND FLUOROCITRATE ON THE LABELLING OF GLUTAMATE , ASPARTATE , GLUTAMINE AND y-AMINOBUTYRATE

W. Nicklas, D. Clarke, 2022 .