A. Fernandes

发表

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

D. Brites, A. Fernandes, 2015, Front. Cell. Neurosci..

Linking Cognitive Impairment to Neuroinflammation in Multiple Sclerosis using neuroimaging tools.

A. Fernandes, C. Barros, 2020, Multiple sclerosis and related disorders.

ER Stress, Mitochondrial Dysfunction and Calpain/JNK Activation are Involved in Oligodendrocyte Precursor Cell Death by Unconjugated Bilirubin

D. Brites, A. Fernandes, S. L. Silva, 2012, NeuroMolecular Medicine.

MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes

Rui F. M. Silva, D. Brites, A. Fernandes, 2007, The European journal of neuroscience.

S100B inhibition protects from chronic experimental autoimmune encephalomyelitis

L. Graça, D. Brites, A. Fernandes, 2022, Brain communications.

Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation

Rui F. M. Silva, D. Brites, A. Fernandes, 2010, Neurobiology of Disease.

Protective Signature of IFNγ-Stimulated Microglia Relies on miR-124-3p Regulation From the Secretome Released by Mutant APP Swedish Neuronal Cells

F. Stein, D. Brites, A. Fernandes, 2022, Frontiers in Pharmacology.

Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities.

D. Brites, A. Fernandes, 2015, Seminars in fetal & neonatal medicine.

Frailty—A promising concept to evaluate disease vulnerability

S. Howlett, A. Fernandes, Ana Rita Ribeiro, 2020, Mechanisms of Ageing and Development.

Elevated levels of bilirubin and long-term exposure impair human brain microvascular endothelial cell integrity.

Rui F. M. Silva, K. Kim, D. Brites, 2011, Current neurovascular research.

Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis

E. Fernandes, B. Sepodes, A. Serra, 2020, Journal of dietary supplements.

Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat.

E. Fernandes, B. Sepodes, A. Serra, 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice.

B. Sepodes, M. P. Duarte, J. Mota, 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis.

B. Sepodes, M. Bronze, D. Brites, 2015, The Journal of nutritional biochemistry.

Inflammatory signalling pathways involved in astroglial activation by unconjugated bilirubin

Rui F. M. Silva, D. Brites, A. Fernandes, 2006, Journal of neurochemistry.

Tricellulin expression in brain endothelial and neural cells

K. Kim, D. Brites, A. Fernandes, 2012, Cell and Tissue Research.

Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment

R. Satchi‐Fainaro, L. Graça, R. Guedes, 2022, Journal for ImmunoTherapy of Cancer.

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

Jasmin Herz, B. Sepodes, D. McGavern, 2015, Journal of Neuroinflammation.

Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin

D. Brites, A. Fernandes, M. Brito, 2011, Experimental Neurology.

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

A. M. Correia, D. Brites, A. Fernandes, 2017, Molecular Neurobiology.

Unconjugated bilirubin activates and damages microglia

Rui F. M. Silva, D. Brites, A. Fernandes, 2006, Journal of neuroscience research.

Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS

Rui F. M. Silva, D. Brites, A. Fernandes, 2004, Journal of Neuroimmunology.

Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juices

B. Sepodes, M. Ribeiro, A. Fernandes, 2019 .

Astrocyte reactivity to unconjugated bilirubin requires TNF‐α and IL‐1β receptor signaling pathways

D. Brites, A. Fernandes, M. Brito, 2011, Glia.

Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease

A. Mendonça, J. Koistinaho, T. Malm, 2022, Cells.

Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment

D. Brites, A. Fernandes, A. Lopes, 2020, Neurotoxicity Research.

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

P. Peterson, M. D. de Angelis, G. Pani, 2018, Ageing Research Reviews.

BASHY Dye Platform Enables the Fluorescence Bioimaging of Myelin Debris Phagocytosis by Microglia during Demyelination

Pedro M. P. Gois, U. Pischel, A. Fernandes, 2021, Cells.

Extracellular Vesicles in Blood: Sources, Effects, and Applications

A. Fernandes, D. Otaegui, Leire Iparraguirre, 2021, International journal of molecular sciences.

Women in the field of multiple sclerosis: How they contributed to paradigm shifts

A. Fernandes, Ana Rita Ribeiro, C. Barros, 2023, Frontiers in Molecular Neuroscience.

Influence of hypoxia and ischemia preconditioning on bilirubin damage to astrocytes

Rui F. M. Silva, D. Brites, A. Fernandes, 2007, Brain Research.

N-Methyl-d-Aspartate Receptor and Neuronal Nitric Oxide Synthase Activation Mediate Bilirubin-Induced Neurotoxicity

Rui F. M. Silva, D. Brites, A. Fernandes, 2010 .

Topical gels of etofenamate: in vitro and in vivo evaluation

H. Ribeiro, J. Marto, A. Duarte, 2015, Pharmaceutical development and technology.

Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice

B. Sepodes, M. P. Duarte, A. Fernandes, 2019, Medicines.

Attenuation of Colonic Injury and Inflammation by Administration of a Phenolic Extract of Summer Savory (Satureja hortensis L.) in Experimental Inflammatory Bowel Disease in Mice

B. Sepodes, M. P. Duarte, A. Fernandes, 2020, Applied Sciences.

Anti‐inflammatory Effect of Rosmarinic Acid and an Extract of Rosmarinus officinalis in Rat Models of Local and Systemic Inflammation

E. Fernandes, B. Sepodes, H. Mota-Filipe, 2015, Basic & clinical pharmacology & toxicology.

Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment

D. Brites, A. Fernandes, Pedro R. Florindo, 2020, Neurotoxicity Research.

Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities.

B. Sepodes, R. Ferreira, J. Mota, 2017, The Journal of nutritional biochemistry.

Interventions for age-related diseases: Shifting the paradigm

E. Gonos, I. Bellantuono, E. Ferreiro, 2016, Mechanisms of Ageing and Development.

Erythropoietin Reduces Acute Lung Injury and Multiple Organ Failure/Dysfunction Associated to a Scald-Burn Inflammatory Injury in the Rat

E. Fernandes, B. Sepodes, H. Mota-Filipe, 2015, Inflammation.

Rat Cerebellar Slice Cultures Exposed to Bilirubin Evidence Reactive Gliosis, Excitotoxicity and Impaired Myelinogenesis that Is Prevented by AMPA and TNF-α Inhibitors

J. Relvas, D. Brites, A. Fernandes, 2014, Molecular Neurobiology.

Unconjugated Bilirubin Restricts Oligodendrocyte Differentiation and Axonal Myelination

C. ffrench-Constant, J. Relvas, D. Brites, 2013, Molecular Neurobiology.

Unconjugated bilirubin differentially affects the redox status of neuronal and astroglial cells

Rui F. M. Silva, D. Butterfield, D. Brites, 2008, Neurobiology of Disease.

Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells

Rui F. M. Silva, D. Brites, A. Fernandes, 2005, Neurobiology of Disease.

Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion.

B. Sepodes, H. Mota-Filipe, D. Brites, 2014, Journal of neurosurgery.

Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor

J. Koistinaho, D. Brites, A. Fernandes, 2021, Cells.

TDZD-8 pre-treatment in transient middle cerebral artery occlusion

B. Sepodes, H. Mota-Filipe, D. Brites, 2014 .

Microglial Phagocytosis—Rational but Challenging Therapeutic Target in Multiple Sclerosis

A. Fernandes, M. V. Pinto, 2020, International journal of molecular sciences.

Enhanced cognitive performance in experimental autoimmune encephalomyelitis mice treated with dimethyl fumarate after the appearance of disease symptoms

F. Marques, J. Cerqueira, A. Fernandes, 2020, Journal of Neuroimmunology.

S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis

J. Cerqueira, D. Brites, A. Fernandes, 2015, Molecular Neurobiology.

Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis

D. Henrique, L. Lanier, D. Brites, 2009, Developmental neurobiology.

Apoptosis and impairment of neurite network by short exposure of immature rat cortical neurons to unconjugated bilirubin increase with cell differentiation and are additionally enhanced by an inflammatory stimulus

Rui F. M. Silva, D. Brites, A. Fernandes, 2007, Journal of neuroscience research.

Bilirubin-induced immunostimulant effects and toxicity vary with neural cell type and maturation state

Rui F. M. Silva, D. Brites, A. Fernandes, 2006, Acta Neuropathologica.

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease.

Adelaide Fernandes, Dora Brites, D. Brites, 2016, Current pharmaceutical design.

ER Stress, Mitochondrial Dysfunction and Calpain/JNK Activation are Involved in Oligodendrocyte Precursor Cell Death by Unconjugated Bilirubin

D. Brites, A. Fernandes, S. L. Silva, 2012, NeuroMolecular Medicine.

Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia

R. Tukey, O. Barbier, J. Relvas, 2016, Molecular Pharmacology.

Microglia and inflammation: conspiracy, controversy or control?

L. Miller-Fleming, T. F. Pais, A. Fernandes, 2014, Cellular and Molecular Life Sciences.

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation

D. Brites, A. Fernandes, E. Seixas, 2017, Front. Aging Neurosci..

Temporal oligodendrocyte lineage progression: in vitro models of proliferation, differentiation and myelination.

A. Fernandes, A. Barateiro, 2014, Biochimica et biophysica acta.

Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment

C. Gomes, D. Brites, A. Fernandes, 2018, Neuropharmacology.

Microglia and inflammation: conspiracy, controversy or control?

L. Miller-Fleming, T. F. Pais, A. Fernandes, 2014, Cellular and Molecular Life Sciences.

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10

Rui F. M. Silva, N. Rooijen, D. Brites, 2012, Neuropharmacology.

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid.

Rui F. M. Silva, D. Butterfield, D. Brites, 2008, Neurotoxicology.

Inhibition of Glycogen Synthase Kinase-3&bgr; Attenuates Organ Injury and Dysfunction Associated With Liver Ischemia-Reperfusion and Thermal Injury in the Rat

E. Fernandes, B. Sepodes, H. Mota-Filipe, 2015, Shock.

Microglia change from a reactive to an age-like phenotype with the time in culture

Adelaide Fernandes, Dora Brites, D. Brites, 2014, Front. Cell. Neurosci..

Glycoursodeoxycholic Acid and Interleukin-10 Modulate the Reactivity of Rat Cortical Astrocytes to Unconjugated Bilirubin

Rui F. M. Silva, D. Brites, A. Fernandes, 2007, Journal of neuropathology and experimental neurology.

Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Adverse Secondary Impacts

Rui F. M. Silva, C. Tiribelli, D. Brites, 2014, Neurotoxicity Research.

Selective vulnerability of rat brain regions to unconjugated bilirubin

D. Brites, A. Fernandes, M. Brito, 2011, Molecular and Cellular Neuroscience.

Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Early Beneficial Effects

Rui F. M. Silva, D. Brites, A. Fernandes, 2013, Neurochemical Research.

Contribution of inflammatory processes to nerve cell toxicity by bilirubin and efficacy of potential therapeutic agents.

D. Brites, A. Fernandes, 2009, Current pharmaceutical design.

Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice

E. Ferreiro, D. Brites, A. Fernandes, 2022, Cells.

Secretome from SH-SY5Y APPSwe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling.

Adelaide Fernandes, Dora Brites, Ana Rita Vaz, 2018, Biochimie.

Neural precursor cell proliferation and differentiation: Looking at the redox environment and cell defense mechanisms

C. Tiribelli, C. Bellarosa, A. Fernandes, 2010, International Journal of Developmental Neuroscience.

S100B Impairs Oligodendrogenesis and Myelin Repair Following Demyelination Through RAGE Engagement

D. Brites, A. Fernandes, A. Barateiro, 2020, Frontiers in Cellular Neuroscience.

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

Jasmin Herz, B. Sepodes, D. McGavern, 2015, Journal of Neuroinflammation.

Modelling physical resilience in ageing mice

A. Matheu, I. Varela-Nieto, I. Bellantuono, 2018, Mechanisms of Ageing and Development.

Tricellulin expression in brain endothelial and neural cells

K. Kim, D. Brites, A. Fernandes, 2012, Cell and Tissue Research.

Automated analysis of NeuronJ tracing data

Jonathan Popko, Adelaide Fernandes, Dora Brites, 2009, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides.

Pedro M. P. Gois, G. Gasser, A. Fernandes, 2021, Angewandte Chemie.

Efficient Amino‐Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS‐Activated Acrylamides

Pedro M. P. Gois, G. Gasser, A. Fernandes, 2021, Angewandte Chemie.

Peptidomimetic β-Secretase Inhibitors Comprising a Sequence of Amyloid-β Peptide for Alzheimer's Disease.

C. Maycock, A. Fernandes, O. Iranzo, 2015, Journal of medicinal chemistry.

Evidence of tricellulin expression by immune cells, particularly microglia.

Adelaide Fernandes, Dora Brites, D. Brites, 2011, Biochemical and biophysical research communications.

Directing mouse embryonic neurosphere differentiation toward an enriched neuronal population

D. Brites, A. Fernandes, A. Falcão, 2014, International Journal of Developmental Neuroscience.

Neuronal and glial CSF biomarkers in multiple sclerosis: a systematic review and meta-analysis

P. Klivényi, C. Teunissen, N. Rezaei, 2021, Reviews in the neurosciences.

Cyanine-like Boronic Acid Derived Salicylidenehydrazone Complexes (Cy-BASHY) for Bioimaging Applications.

Pedro M. P. Gois, J. F. Arteaga, U. Pischel, 2020, Chemistry.

Dissociated primary nerve cell cultures as models for assessment of neurotoxicity.

Rui F. M. Silva, D. Brites, A. Fernandes, 2006, Toxicology letters.

Title : Modelling physical resilience in ageing mice

A. Matheu, I. Varela-Nieto, M. Schosserer, 2018 .

Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

P. Peterson, M. D. de Angelis, G. Pani, 2018, Ageing Research Reviews.

Rat Cerebellar Slice Cultures Exposed to Bilirubin Evidence Reactive Gliosis, Excitotoxicity and Impaired Myelinogenesis that Is Prevented by AMPA and TNF-α Inhibitors

J. Relvas, D. Brites, A. Fernandes, 2013, Molecular Neurobiology.

Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Early Beneficial Effects

Rui F. M. Silva, D. Brites, A. Fernandes, 2013, Neurochemical Research.

Temporal oligodendrocyte lineage progression: in vitro models of proliferation, differentiation and myelination.

A. Fernandes, A. Barateiro, 2014, Biochimica et biophysica acta.

Erythropoietin Reduces Acute Lung Injury and Multiple Organ Failure/Dysfunction Associated to a Scald-Burn Inflammatory Injury in the Rat

E. Fernandes, B. Sepodes, H. Mota-Filipe, 2014, Inflammation.

Cross-Talk Between Neurons and Astrocytes in Response to Bilirubin: Adverse Secondary Impacts

Rui F. M. Silva, C. Tiribelli, D. Brites, 2013, Neurotoxicity Research.

Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin

Rui F. M. Silva, C. Tiribelli, A. Fernandes, 2007, Neuroscience.

Improved assessment of overall health in variably aged murine models of Multiple Sclerosis with a novel frailty index tool.

S. Howlett, A. Fernandes, Ana Rita Ribeiro, 2021, The journals of gerontology. Series A, Biological sciences and medical sciences.

Unconjugated Bilirubin Restricts Oligodendrocyte Differentiation and Axonal Myelination

C. ffrench-Constant, J. Relvas, D. Brites, 2012, Molecular Neurobiology.

Selective vulnerability of rat brain regions to unconjugated bilirubin

D. Brites, A. Fernandes, M. Brito, 2011, Molecular and Cellular Neuroscience.

N-methyl-D-aspartate receptor and neuronal nitric oxide synthase activation mediate bilirubin-induced neurotoxicity Short title : Mediators of bilirubin-induced neurotoxicity

Rui F. M. Silva, D. Brites, A. Fernandes, 2010 .