N. Morioka

发表

The regulation of glycine transporter GLYT1 is mainly mediated by protein kinase Cα in C6 glioma cells

N. Morioka, Joynal Abdin, K. Morita, 2008, Neurochemistry International.

Neuropathic Pain in Rats with a Partial Sciatic Nerve Ligation Is Alleviated by Intravenous Injection of Monoclonal Antibody to High Mobility Group Box-1

M. Nishibori, Keyue Liu, N. Morioka, 2013, PloS one.

Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).

N. Morioka, Y. Nakata, T. Dohi, 2010, Journal of pharmacological sciences.

Pentobarbital may protect against neurogenic inflammation after surgery via inhibition of substance P release from peripheral nerves of rats

T. Kanematsu, N. Morioka, Y. Nakata, 2022, Neuroscience Letters.

Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate–NO–cyclic GMP signalling in spinal cord in mice

N. Morioka, K. Morita, T. Kitayama, 2008, PAIN.

Spinal Antiallodynia Action of Glycine Transporter Inhibitors in Neuropathic Pain Models in Mice

N. Morioka, K. Morita, T. Kitayama, 2008, Journal of Pharmacology and Experimental Therapeutics.

Activation of transient receptor potential ankyrin 1 evokes nociception through substance P release from primary sensory neurons

N. Morioka, Y. Nakata, Yoki Nakamura, 2012, Journal of neurochemistry.

Nonsteroidal Anti-Inflammatory Drugs Potentiate 1-Methyl-4-phenylpyridinium ( MPP )-Induced Cell Death by Promoting the Intracellular Accumulation of MPP in PC 12 Cells

N. Morioka, K. Morita, T. Dohi, 2004 .

Nonsteroidal Anti-Inflammatory Drugs Potentiate 1-Methyl-4-phenylpyridinium (MPP+)-Induced Cell Death by Promoting the Intracellular Accumulation of MPP+ in PC12 Cells

N. Morioka, K. Morita, T. Dohi, 2004, Journal of Pharmacology and Experimental Therapeutics.

Downregulation of connexin43 potentiates noradrenaline‐induced expression of brain‐derived neurotrophic factor in primary cultured cortical astrocytes

N. Morioka, Y. Nakata, Yoki Nakamura, 2021, Journal of cellular physiology.

Analgesic action of nicotine on tibial nerve transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord.

N. Morioka, K. Morita, T. Kitayama, 2006, Life sciences.

High-mobility group box 1-mediated hippocampal microglial activation induces cognitive impairment in mice with neuropathic pain

M. Nishibori, Keyue Liu, N. Morioka, 2022, Experimental Neurology.

[Roles of ATP receptors in the regulation of various functions in spinal microglia].

N. Morioka, 2011, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation

Y. Kotake, K. Tsuga, N. Morioka, 2022, Neurochemistry International.

Proinflammatory cytokines downregulate connexin 43-gap junctions via the ubiquitin-proteasome system in rat spinal astrocytes.

N. Morioka, Y. Nakata, F. Zhang, 2015, Biochemical and biophysical research communications.

Involvement of voltage-gated sodium channel Na(v)1.8 in the regulation of the release and synthesis of substance P in adult mouse dorsal root ganglion neurons.

N. Morioka, Y. Nakata, Taixing Zheng, 2008, Journal of pharmacological sciences.

Treatment with Histone Deacetylase Inhibitor Attenuates Peripheral Inflammation-Induced Cognitive Dysfunction and Microglial Activation: The Effect of SAHA as a Peripheral HDAC Inhibitor

Y. Kotake, N. Morioka, Y. Nakata, 2021, Neurochemical Research.

Pretreatment with High Mobility Group Box-1 Monoclonal Antibody Prevents the Onset of Trigeminal Neuropathy in Mice with a Distal Infraorbital Nerve Chronic Constriction Injury

M. Nishibori, Keyue Liu, N. Morioka, 2021, Molecules.

The expression of glial cell line-derived neurotrophic factor mRNA by antidepressants involves matrix metalloproteinase-9 activation in rat astroglial cells.

N. Morioka, Y. Nakata, Hiromi Abe, 2016, Biochemical and biophysical research communications.

Nitric oxide synergistically potentiates interleukin-1β-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms

N. Morioka, Y. Nakata, T. Dohi, 2002, Neuropharmacology.

Interleukin‐1β‐induced substance P release from rat cultured primary afferent neurons driven by two phospholipase A2 enzymes: secretory type IIA and cytosolic type IV

N. Morioka, Y. Nakata, A. Inoue, 2002, Journal of neurochemistry.

Identification of Lysophosphatidic Acid Receptor 1 in Astroglial Cells as a Target for Glial Cell Line-derived Neurotrophic Factor Expression Induced by Antidepressants*

Y. Uezono, N. Morioka, Hiromi Abe, 2016, The Journal of Biological Chemistry.

Lycopene ameliorates neuropathic pain by upregulating spinal astrocytic connexin 43 expression.

N. Morioka, Y. Nakata, Yoki Nakamura, 2016, Life sciences.

History of the G protein-coupled receptor (GPCR) assays from traditional to a state-of-the-art biosensor assay.

Y. Higami, Y. Uezono, N. Morioka, 2014, Journal of pharmacological sciences.

Cyclic ADP-ribose mediates formyl methionyl leucyl phenylalanine (fMLP)-induced intracellular Ca(2+) rise and migration of human neutrophils.

Y. Akagawa, N. Morioka, K. Morita, 2008, Journal of pharmacological sciences.

Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice

N. Morioka, Joynal Abdin, K. Morita, 2004, Pain.

p-Nitroterphenyl units for near-infrared two-photon uncaging of calcium ions

Tzu-Chau Lin, N. Morioka, Yoki Nakamura, 2021 .

Regulation by Nicotinic Acetylcholine Receptors of Microglial Glutamate Transporters: Role of Microglia in Neuroprotection

N. Morioka, Y. Nakata, K. Hisaoka-Nakashima, 2018 .

Selective blockade of N-methyl-d-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility

T. Kanematsu, N. Morioka, K. Morita, 2014, Psychopharmacology.

Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice

N. Morioka, Y. Nakata, Yoki Nakamura, 2015, Brain, Behavior, and Immunity.

Glycine transporter inhibitors as a novel drug discovery strategy for neuropathic pain.

N. Morioka, K. Morita, T. Kitayama, 2009, Pharmacology & therapeutics.

Antidepressant Acts on Astrocytes Leading to an Increase in the Expression of Neurotrophic/Growth Factors: Differential Regulation of FGF-2 by Noradrenaline

N. Morioka, Y. Nakata, K. Hisaoka-Nakashima, 2012, PloS one.

Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive Gαi/o Activation in Astroglial Cells*

Y. Uezono, N. Morioka, Y. Nakata, 2015, The Journal of Biological Chemistry.

Tricyclic Antidepressant Amitriptyline Activates Fibroblast Growth Factor Receptor Signaling in Glial Cells

N. Morioka, Y. Nakata, M. Takebayashi, 2011, The Journal of Biological Chemistry.

Interleukin‐1β Induces Substance P Release from Primary Afferent Neurons Through the Cyclooxygenase‐2 System

N. Morioka, Y. Nakata, A. Inoue, 1999, Journal of neurochemistry.

Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors

N. Morioka, Y. Nakata, Yoki Nakamura, 2020, Behavioural Brain Research.

Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin‐6 and cyclooxygenase‐2 and mechanical hypersensitivity in mice

N. Morioka, Y. Nakata, Yoki Nakamura, 2018, Glia.

Perineural expression of high‐mobility group box‐1 contributes to long‐lasting mechanical hypersensitivity via matrix metalloprotease‐9 up‐regulation in mice with painful peripheral neuropathy

M. Nishibori, Keyue Liu, N. Morioka, 2016, Journal of neurochemistry.

Perineural high-mobility group box 1 induces mechanical hypersensitivity through activation of spinal microglia: involvement of glutamate-NMDA receptor dependent mechanism in spinal dorsal horn.

M. Nishibori, Keyue Liu, N. Morioka, 2021, Biochemical pharmacology.

Neuropathic pain is a chronic pain state that can arise from the result of injury or disease within the peripheral or central nervous system. Activation of glial and immune cells, and the subsequent production of proinflammatory molecules

M. Nishibori, Keyue Liu, N. Morioka, 2016 .

Pharmacological Activation Gi/o Protein Increases Glial Cell Line-Derived Neurotrophic Factor Production through Fibroblast Growth Factor Receptor and Extracellular Signal-Regulated Kinase Pathway in Primary Cultured Rat Cortical Astrocytes.

N. Morioka, Y. Nakata, K. Hisaoka-Nakashima, 2017, Biological & pharmaceutical bulletin.

Paclitaxel and vinorelbine, evoked the release of substance P from cultured rat dorsal root ganglion cells through different PKC isoform-sensitive ion channels

N. Morioka, Y. Nakata, Yoki Nakamura, 2009, Neuropharmacology.

Stimulation of toll-like receptor 4 downregulates the expression of α7 nicotinic acetylcholine receptors via histone deacetylase in rodent microglia

N. Morioka, Y. Nakata, Yoki Nakamura, 2020, Neurochemistry International.

Amitriptyline up‐regulates connexin43‐gap junction in rat cultured cortical astrocytes via activation of the p38 and c‐Fos/AP‐1 signalling pathway

N. Morioka, Y. Nakata, K. Hisaoka-Nakashima, 2014, British journal of pharmacology.

Mirtazapine increases glial cell line-derived neurotrophic factor production through lysophosphatidic acid 1 receptor-mediated extracellular signal-regulated kinase signaling in astrocytes.

N. Morioka, Y. Nakata, Yoki Nakamura, 2019, European journal of pharmacology.

Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells.

N. Morioka, Y. Nakata, F. Zhang, 2016, Biochemical and biophysical research communications.

Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-κB activation in spinal astrocytes

N. Morioka, Y. Nakata, Hiromi Abe, 2014, Molecular and Cellular Neuroscience.

Volume transmission of substance P in striatum induced by intraplantar formalin injection attenuates nociceptive responses via activation of the neurokinin 1 receptor.

N. Morioka, Y. Nakata, Yoki Nakamura, 2013, Journal of pharmacological sciences.

Role of Connexins in Chronic Pain and Their Potential as Therapeutic Targets for Next-Generation Analgesics.

N. Morioka, Y. Nakata, Yoki Nakamura, 2019, Biological & pharmaceutical bulletin.

Blockade of receptor for advanced glycation end-products with azeliragon ameliorates streptozotocin-induced diabetic neuropathy

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2022, Neurochemistry International.

Downregulation of the spinal dorsal horn clock gene Per1 expression leads to mechanical hypersensitivity via c-jun N-terminal kinase and CCL2 production in mice

N. Morioka, Y. Nakata, Yoki Nakamura, 2016, Molecular and Cellular Neuroscience.

The induction of Per1 expression by the combined treatment with glutamate, 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes

N. Morioka, Y. Nakata, K. Hisaoka-Nakashima, 2015, Neurochemistry International.

The regulation of exon-specific brain-derived neurotrophic factor mRNA expression by protein kinase C in rat cultured dorsal root ganglion neurons

N. Morioka, Y. Nakata, Yoki Nakamura, 2013, Brain Research.

Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via β-adrenergic receptors–cAMP–protein kinase A-dependent mechanism in cultured rat spinal microglia

N. Morioka, Y. Nakata, T. Dohi, 2009, Neurochemistry International.

Spinal astrocytes stimulated by tumor necrosis factor‐α and/or interferon‐γ attenuate connexin 43‐gap junction via c‐jun terminal kinase activity

N. Morioka, Y. Nakata, F. Zhang, 2013, Journal of neuroscience research.

Spinal astrocytes contribute to the circadian oscillation of glutamine synthase, cyclooxygenase-1 and clock genes in the lumbar spinal cord of mice

N. Morioka, Y. Nakata, T. Dohi, 2012, Neurochemistry International.

Antinociceptive effects of glycine transporter inhibitors in neuropathic pain models in mice.

N. Morioka, K. Morita, T. Kitayama, 2007, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Transport of dopamine and levodopa and their interaction in COS-7 cells heterologously expressing monoamine neurotransmitter transporters and in monoaminergic cell lines PC12 and SK-N-SH.

N. Morioka, K. Morita, T. Dohi, 2005, Life sciences.

High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain

M. Nishibori, Keyue Liu, N. Morioka, 2019, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Stimulation of nuclear receptor REV-ERBs suppresses inflammatory responses in spinal microglia

N. Morioka, Yoki Nakamura, F. Zhang, 2021, Neurochemistry International.

Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice

N. Morioka, Y. Nakata, Yoki Nakamura, 2019, Brain, Behavior, and Immunity.

Continuous infusion of substance P into rat striatum alleviates nociceptive behavior via phosphorylation of extracellular signal‐regulated kinase 1/2

A. Hama, N. Morioka, Y. Nakata, 2014, Journal of neurochemistry.

Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal‐regulated kinase‐dependent early growth response 1 production in rat primary cultured astrocytes

N. Morioka, Y. Nakata, K. Hisaoka-Nakashima, 2015, Journal of neurochemistry.

TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia.

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2020, Journal of pharmacological sciences.

The indirect γ-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway

T. Kanematsu, N. Morioka, Y. Nakata, 2020, Pharmacology Biochemistry and Behavior.

Downregulation of connexin36 in mouse spinal dorsal horn neurons leads to mechanical allodynia

N. Morioka, Y. Nakata, Yoki Nakamura, 2015, Journal of neuroscience research.

Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms

M. Nishibori, Keyue Liu, N. Morioka, 2020, Cells.

Spinal high‐mobility group box‐1 induces long‐lasting mechanical hypersensitivity through the toll‐like receptor 4 and upregulation of interleukin‐1β in activated astrocytes

M. Nishibori, Keyue Liu, N. Morioka, 2019, Journal of neurochemistry.

Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson's disease.

M. Nishibori, Keyue Liu, N. Morioka, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase

N. Morioka, Y. Nakata, Yoki Nakamura, 2016, Neurochemistry International.

The activation of P2Y6 receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-κB pathway

N. Morioka, Y. Nakata, Yoki Nakamura, 2013, Neuropharmacology.

Lysophosphatidic acid induces thrombospondin‐1 production in primary cultured rat cortical astrocytes

N. Morioka, Y. Nakata, Yoki Nakamura, 2020, Journal of neurochemistry.

Downregulation of connexin 43 potentiates amitriptyline-induced brain-derived neurotrophic factor expression in primary astrocytes through lysophosphatidic acid receptor1/3, Src, and extracellular signal-regulated kinase.

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2022, European journal of pharmacology.

Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia

N. Morioka, Y. Nakata, K. Hisaoka-Nakashima, 2016, Brain Research.

Anti-interleukin-6 receptor antibody improves allodynia and cognitive impairment in mice with neuropathic pain following partial sciatic nerve ligation.

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2022, International immunopharmacology.

Mirogabalin alleviates nociceptive hypersensitivity without causing sedation in a mouse model of post-traumatic trigeminal neuropathy

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2022, Behavioural Brain Research.

Decreased connexin43 expression in the hippocampus is related to the antidepressant effect of amitriptyline in neuropathic pain mice.

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2021, Biochemical and biophysical research communications.

Activation of the neurokinin-1 receptor in rat spinal astrocytes induces Ca2+ release from IP3-sensitive Ca2+ stores and extracellular Ca2+ influx through TRPC3

Y. Uezono, N. Morioka, Y. Nakata, 2010, Neurochemistry International.

Mitochondrial dysfunction and type I interferon signaling induce anxiodepressive-like behaviors in mice with neuropathic pain

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2023, Experimental Neurology.

Inhibition of Nuclear Receptor Related Orphan Receptor γ Ameliorates Mechanical Hypersensitivity Through the Suppression of Spinal Microglial Activation

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2023, Neuroscience.

A β1/2 Adrenergic Receptor‐Sensitive Intracellular Signaling Pathway Modulates CCL2 Production in Cultured Spinal Astrocytes

N. Morioka, Y. Nakata, Yoki Nakamura, 2014, Journal of cellular physiology.

Noradrenergic regulation of period1 expression in spinal astrocytes is involved in protein kinase A, c-Jun N-terminal kinase and extracellular signal-regulated kinase activation mediated by α1- and β2-adrenoceptors

N. Morioka, Y. Nakata, K. Sato, 2011, Neuroscience.

Selective blockade of N-methyl-d-aspartate channels in combination with dopamine receptor antagonism induces loss of the righting reflex in mice, but not immobility

T. Kanematsu, N. Morioka, K. Morita, 2014, Psychopharmacology.

P2X7 receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport

N. Morioka, K. Morita, T. Kitayama, 2008, Glia.

Primary cultures of rat cortical microglia treated with nicotine increases in the expression of excitatory amino acid transporter 1 (GLAST) via the activation of the α7 nicotinic acetylcholine receptor

N. Morioka, Y. Nakata, Yoki Nakamura, 2014, Neuroscience.

Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics

N. Morioka, K. Morita, T. Kitayama, 2006, Brain Research.

Stimulation of α7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia

N. Morioka, Y. Nakata, K. Hisaoka-Nakashima, 2015, Brain Research.

Down-regulation of norepinephrine transporter expression on membrane surface induced by chronic administration of desipramine and the antagonism by co-administration of local anesthetics in mice

N. Morioka, K. Morita, T. Kitayama, 2008, Neurochemistry International.

N-methyl-d-aspartate receptors and glycinergic transmission, respectively, mediate muscle relaxation and immobility of pentobarbital in mice

N. Morioka, Y. Nakata, Y. Ago, 2023, Neuroscience Letters.

Assessing an eating disorder induced by 6-OHDA and the possibility of nerve regeneration therapy by transplantation of neural progenitor cells in rats.

N. Morioka, K. Morita, T. Kitayama, 2007, Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.

Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice

N. Morioka, Y. Nakata, Yoki Nakamura, 2015, Brain, Behavior, and Immunity.

Spinal astrocytes stimulated by tumor necrosis factor‐α and/or interferon‐γ attenuate connexin 43‐gap junction via c‐jun terminal kinase activity

N. Morioka, Y. Nakata, Kazue Nakashima-Hisaoka, 2013, Journal of neuroscience research.

Stimulation of nuclear receptor REV-ERBs regulates tumor necrosis factor-induced expression of proinflammatory molecules in C6 astroglial cells.

N. Morioka, Y. Nakata, K. Hisaoka-Nakashima, 2016, Biochemical and biophysical research communications.

Clock gene Per1 regulates the production of CCL2 and interleukin-6 through p38, JNK1 and NF-κB activation in spinal astrocytes

N. Morioka, Y. Nakata, Hiromi Abe, 2014, Molecular and Cellular Neuroscience.

Enhanced anxiety-like behavior induced by chronic neuropathic pain and related parvalbumin-positive neurons in male rats

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2023, Behavioural Brain Research.

High mobility group box-1: A therapeutic target for analgesia and associated symptoms in chronic pain.

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2024, Biochemical pharmacology.

N. Morioka, Y. Nakata, K. Hisaoka-Nakashima, 2017, Biological & pharmaceutical bulletin.

Stimulation of nuclear receptor REV-ERBs alleviates monosodium iodoacetate-induced osteoarthritis pathology of mice and the induction of inflammatory molecules expression in primary cultured chondrocytes.

N. Morioka, Yoki Nakamura, K. Hisaoka-Nakashima, 2023, International immunopharmacology.