J. Orellana

发表

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons

M. Nedergaard, M. Bennett, C. Giaume, 2012, Brain Research.

Amyloid β-Induced Death in Neurons Involves Glial and Neuronal Hemichannels

C. Naus, Jean X. Jiang, C. Giaume, 2011, The Journal of Neuroscience.

Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels

M. Bennett, C. Giaume, V. Velarde, 2009, Glia.

Cell membrane permeabilization via connexin hemichannels in living and dying cells.

K. Schalper, M. Bennett, J. Sáez, 2010, Experimental cell research.

10 Role of Connexin Hemichannels in Neurodegeneration

C. Giaume, J. Sáez, J. Orellana, 2017 .

Role of Connexin Hemichannels in Neurodegeneration

C. Giaume, J. Sáez, J. Orellana, 2011 .

Modulation of interferon‐γ‐induced glial cell activation by transforming growth factor β1: A role for STAT1 and MAPK pathways

J. Orellana, R. von Bernhardi, R. Herrera-Molina, 2012, Journal of neurochemistry.

Chlorpromazine reduces the intercellular communication via gap junctions in mammalian cells.

J. Sáez, J. Orellana, N. Palacios-Prado, 2006, Toxicology and applied pharmacology.

Plasma Membrane Channels Formed by Connexins or Pannexins in Microglia: Possible Role in the Inflamed Brain

J. Orellana, 2013 .

HIV increases the release of dickkopf‐1 protein from human astrocytes by a Cx43 hemichannel‐dependent mechanism

M. Bennett, J. Berman, S. Morgello, 2014, Journal of neurochemistry.

Neurodegeneration in Multiple Sclerosis: The Role of Nrf2-Dependent Pathways

Paloma P. Maldonado, J. Orellana, R. Quintanilla, 2022, Antioxidants.

TNF-α Plus IL-1β Induces Opposite Regulation of Cx43 Hemichannels and Gap Junctions in Mesangial Cells through a RhoA/ROCK-Dependent Pathway

V. Velarde, J. Sáez, J. Orellana, 2021, International journal of molecular sciences.

Editorial: Single membrane channels formed by connexins or pannexins: focus on the nervous system

J. Orellana, 2015, Front. Cell. Neurosci..

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases.

K. Schalper, J. Sáez, J. Orellana, 2009, Current vascular pharmacology.

Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function

V. Velarde, J. Sáez, J. Orellana, 2018, Front. Immunol..

Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes

J. Berman, J. Sáez, J. Orellana, 2013, Journal of leukocyte biology.

Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro‐inflammatory treatments

M. Cohen-Salmon, C. Giaume, P. Ezan, 2009, Journal of neurochemistry.

Currently Used Methods for Identification and Characterization of Hemichannels

K. Schalper, J. Sáez, J. Orellana, 2008, Cell communication & adhesion.

Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species.

K. Schalper, M. Bennett, J. Sáez, 2011, Biochemical and biophysical research communications.

Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells.

J. Sáez, V. Verselis, J. Orellana, 2009, American journal of physiology. Cell physiology.

Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage.

V. Velarde, J. Sáez, J. Orellana, 2020, Biochimica et biophysica acta. Molecular cell research.

Role of connexins and pannexins in ischemic stroke.

J. Orellana, T. Montero, B. C. Avendaño, 2014, Current medicinal chemistry.

Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats

F. Aboitiz, M. Concha, J. Montiel, 2006, Journal of neurochemistry.

Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival

J. Orellana, R. von Bernhardi, T. Montero, 2015, Glia.

Astrocytes inhibit nitric oxide‐dependent Ca2+ dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels

J. Orellana, R. Bernhardi, T. Montero, 2013, Glia.

The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System

M. Bennett, J. Berman, E. Eugenin, 2012, Journal of Neuroimmune Pharmacology.

Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease

J. Orellana, M. Retamal, J. E. Oyarzún, 2019, Front. Cell. Neurosci..

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

M. Bennett, C. Naus, Jean X. Jiang, 2011, Journal of neurochemistry.

Astroglial Hemichannels and Pannexons: The Hidden Link between Maternal Inflammation and Neurological Disorders

J. Orellana, G. Ramírez, G. Gómez, 2021, International journal of molecular sciences.

Excess cholesterol induces mouse egg activation and may cause female infertility

D. Page, A. Rigotti, M. Krieger, 2014, Proceedings of the National Academy of Sciences.

Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR‐dependent transmission and short‐term fear memory in the basolateral amygdala

Nur Jury, J. Stehberg, L. Varela-Nallar, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Activation of Melanocortin-4 Receptor by a Synthetic Agonist Inhibits Ethanol-induced Neuroinflammation in Rats.

E. Karahanian, J. Orellana, G. Gómez, 2019, Current pharmaceutical design.

New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis

E. Karahanian, J. Orellana, R. Quintanilla, 2017, Front. Cell. Neurosci..

Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions

J. Orellana, Valeria C. Labra, Rosario Gajardo-Gómez, 2016, Front. Mol. Neurosci..

Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration.

K. Schalper, M. Bennett, C. Giaume, 2009, Antioxidants & redox signaling.

Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species

C. Giaume, J. Sáez, J. Orellana, 2020, International journal of molecular sciences.

Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules

J. Orellana, Agustín D. Martínez, Mauricio A. Retamal, 2013, Neuropharmacology.

Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels

Jean X. Jiang, V. Velarde, J. Sáez, 2012, Glia.

Glial hemichannels and their involvement in aging and neurodegenerative diseases

C. Giaume, J. Sáez, J. Orellana, 2012, Reviews in the neurosciences.

Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment

J. Orellana, R. Quintanilla, W. Cerpa, 2017, Molecular Neurobiology.

Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

J. Stehberg, J. Sáez, J. Orellana, 2015, Front. Cell. Neurosci..

Chronic stress impairs acoustic conditioning more than visual conditioning in rats: Morphological and behavioural evidence

F. Aboitiz, A. Dagnino-Subiabre, G. Terreros, 2005, Neuroscience.

The Neuroglial Dialog Between Cannabinoids and Hemichannels

J. Orellana, G. Gómez, Valeria C. Labra, 2018, Front. Mol. Neurosci..

Connexin-based channels in astrocytes: how to study their properties.

C. Giaume, V. Abudara, J. Sáez, 2012, Methods in molecular biology.

Disruption in Connexin-Based Communication Is Associated with Intracellular Ca2+ Signal Alterations in Astrocytes from Niemann-Pick Type C Mice

Jean X. Jiang, J. Sáez, J. Orellana, 2013, PloS one.

Possible Involvement of Different Connexin43 Domains in Plasma Membrane Permeabilization Induced by Ischemia-Reperfusion

M. Bennett, K. Schalper, J. Sáez, 2007, Journal of Membrane Biology.

Connexin 43 hemichannels and pannexin‐1 channels contribute to the α‐synuclein‐induced dysfunction and death of astrocytes

J. Orellana, R. Quintanilla, Nicole Salgado, 2019, Glia.

Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization

J. Orellana, R. Quintanilla, W. Cerpa, 2018, Front. Cell. Neurosci..

Glial connexin expression and function in the context of Alzheimer's disease.

C. Giaume, A. Koulakoff, J. Sáez, 2012, Biochimica et biophysica acta.

Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions.

V. Velarde, J. Sáez, J. Orellana, 2011, CNS & neurological disorders drug targets.

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective

C. Naus, C. Giaume, J. Sáez, 2010, Molecular and Cellular Neuroscience.

Physiological Functions of Glial Cell Hemichannels.

J. Orellana, 2016, Advances in experimental medicine and biology.

Neuron-Glia Crosstalk in the Autonomic Nervous System and Its Possible Role in the Progression of Metabolic Syndrome: A New Hypothesis

R. Del Río, J. Orellana, R. Quintanilla, 2015, Front. Physiol..

Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet

A. Rigotti, J. Orellana, D. Busso, 2014, Front. Cell. Neurosci..

Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword

V. Abudara, R. Del Río, J. Orellana, 2018, Front. Mol. Neurosci..

HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function

E. Eugenin, J. Orellana, G. Gómez, 2020, International journal of molecular sciences.

The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring

J. Orellana, J. E. Oyarzún, Luis A Mellado, 2019, Front. Cell. Neurosci..

Hemichannels: new roles in astroglial function

J. Stehberg, J. Orellana, 2014, Front. Physiol..

Understanding risk factors for Alzheimer's disease: interplay of neuroinflammation, connexin-based communication and oxidative stress.

J. Orellana, R. Quintanilla, R. von Bernhardi, 2012, Archives of medical research.

Hypertensive Nephropathy: Unveiling the Possible Involvement of Hemichannels and Pannexons

J. Orellana, M. Retamal, G. Gómez, 2022, International journal of molecular sciences.

Cannabinoids prevent the amyloid β‐induced activation of astroglial hemichannels: A neuroprotective mechanism

C. Giaume, J. Sáez, J. Orellana, 2017, Glia.

Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases

J. Stehberg, J. Orellana, M. Retamal, 2016, Front. Integr. Neurosci..

Hemichannels: New pathways for gliotransmitter release

J. Orellana, T. Montero, 2015, Neuroscience.

Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels.

K. Schalper, J. Sáez, J. Orellana, 2012, Advances in experimental medicine and biology.

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

L. Leybaert, G. Bultynck, J. Stehberg, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

NEUROSCIENCE FOREFRONT REVIEW HEMICHANNELS: NEW PATHWAYS FOR GLIOTRANSMITTER RELEASE

J. Orellana, T. Montero, 2015 .

The Role of Gap Junction Channels During Physiologic and Pathologic Conditions of the Human Central Nervous System

M. Bennett, J. Berman, E. Eugenin, 2012, Journal of Neuroimmune Pharmacology.

Synaptic Functions of Astroglial Hemichannels

J. Orellana, 2019, Glia in Health and Disease.

GABAergic Regulation of Astroglial Gliotransmission through Cx43 Hemichannels

J. Stehberg, J. Orellana, M. Retamal, 2022, International journal of molecular sciences.

Astrocytes inhibit nitric oxide‐dependent Ca2+ dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels

J. Orellana, R. Bernhardi, T. Montero, 2013, Glia.

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective

C. Naus, C. Giaume, J. Sáez, 2010, Molecular and Cellular Neuroscience.

Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment

J. Orellana, R. Quintanilla, W. Cerpa, 2017, Molecular Neurobiology.

Correction to: Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment

J. Orellana, R. Quintanilla, W. Cerpa, 2018, Molecular Neurobiology.

Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels

V. Velarde, J. Sáez, J. Orellana, 2012, Glia.

Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells.

J. Sáez, V. Verselis, J. Orellana, 2009, American journal of physiology. Cell physiology.

Metabolic Inhibition Increases Activity of Connexin-32 Hemichannels Permeable to Ca 2ϩ in Transfected Hela Cells

V. Verselis, J. Orellana, Helmuth A Sánchez, 2022 .

Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage

J. Orellana, Juan Prieto-Villalobos, Tanhia F. Alvear, 2024, Biological research.

Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression

J. Orellana, W. Cerpa, M. Rovegno, 2024, Biological research.

Activation of Pannexin-1 channels causes cell dysfunction and damage in mesangial cells derived from angiotensin II-exposed mice

J. Orellana, Gonzalo I. Gómez, Claudia M. Lucero, 2024, Frontiers in cell and developmental biology.