P. Trackman

S. Kakar, D. Toben, T. Einhorn, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Apoptosis in Gingival Overgrowth Tissues

D. Graves, P. Trackman, A. Kantarcı, 2007, Journal of dental research.

Tissue-specific Mechanisms for CCN2/CTGF Persistence in Fibrotic Gingiva

P. Trackman, S. A. Black, A. H. Palamakumbura, 2007, Journal of Biological Chemistry.

Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis

J. A. Badwey, T. Ohira, P. Trackman, 2005, Journal of leukocyte biology.

A role for advanced glycation end products in diminished bone healing in type 1 diabetes.

D. Graves, S. Amar, P. Trackman, 2003, Diabetes.

Lysyl oxidase is associated with increased thrombosis and platelet reactivity.

M. Koupenova, P. Toselli, K. Ravid, 2016, Blood.

Diabetes-induced fibrotic matrix inhibits intramembranous bone healing

P. Trackman, R. Khosravi, 2014, Journal of Cell Communication and Signaling.

Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways.

D. Graves, L. Gerstenfeld, M. Alikhani, 2007, Bone.

Collagen advanced glycation inhibits its Discoidin Domain Receptor 2 (DDR2)-mediated induction of lysyl oxidase in osteoblasts.

P. Trackman, K. Sodek, R. Khosravi, 2014, Bone.

Epithelial to mesenchymal transition in gingival overgrowth.

P. Trackman, A. Kantarcı, H. Hasturk, 2010, The American journal of pathology.

Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis

P. Trackman, G. Emingil, A. Kantarcı, 2006, The Journal of pathology.

Mechanism for oral tumor cell lysyl oxidase like-2 in cancer development: synergy with PDGF-AB

N. Shrestha, P. Trackman, A. Kantarcı, 2019, Oncogenesis.

Lysyl Oxidase-like-2 (LOXL2) Is a Major Isoform in Chondrocytes and Is Critically Required for Differentiation*

L. Gerstenfeld, P. Trackman, M. Bais, 2010, The Journal of Biological Chemistry.

Functions and Mechanisms of Pro-Lysyl Oxidase Processing in Cancers and Eye Pathologies with a Focus on Diabetic Retinopathy

P. Trackman, Sayon Roy, Yaser Peymanfar, 2022, International journal of molecular sciences.

A procollagen C‐proteinase inhibitor diminishes collagen and lysyl oxidase processing but not collagen cross‐linking in osteoblastic cultures

E. Kessler, P. Trackman, M. Brenner, 2005, Journal of cellular physiology.

The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene).

R. Eddy, T. Shows, T. Mariani, 1992, Matrix.

Hypoxia-inducible factor (HIF)-1 regulated lysyl oxidase (LOX)

B. Brüne, M. Bonin, M. Hansmann, 2013 .

Hypoxia-Inducible Factor 1-Regulated Lysyl Oxidase Is Involved in Staphylococcus aureus Abscess Formation

B. Brüne, M. Bonin, M. Hansmann, 2013, Infection and Immunity.

Connective tissue metabolism and gingival overgrowth.

P. Trackman, A. Kantarcı, 2004, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

Fibrosis and Cancer

P. Trackman, 2014 .

Activation of RAGE induces elevated O2− generation by mononuclear phagocytes in diabetes

P. Trackman, A. Kantarcı, H. Hasturk, 2007, Journal of leukocyte biology.

Regulation of Collagen Deposition and Lysyl Oxidase by Tumor Necrosis Factor-α in Osteoblasts*

E. Kessler, P. Trackman, N. Pischon, 2004, Journal of Biological Chemistry.

Lysyl Oxidase (Lox) Gene Deficiency Affects Osteoblastic Phenotype

R. Radlanski, H. Renz, J. Myllyharju, 2009, Calcified Tissue International.

Hereditary gingival fibromatosis associated with generalized aggressive periodontitis: a case report.

T. Hart, P. Trackman, A. Kantarcı, 2004, Journal of periodontology.

β-Catenin mediates glucose-dependent insulinotropic polypeptide increases in lysyl oxidase expression in osteoblasts

P. Trackman, Eileen J. Daley, 2021, Bone reports.

Molecular Events that Contribute to Lysyl Oxidase Enzyme Activity and Insoluble Collagen Accumulation in Osteosarcoma Cell Clones

L. Gerstenfeld, E. Kessler, P. Trackman, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Lysyl Oxidase Pro-peptide Attenuates Fibronectin-mediated Activation of Focal Adhesion Kinase and p130Cas in Breast Cancer Cells*

G. Sonenshein, K. Kirsch, S. Vora, 2009, Journal of Biological Chemistry.

Megakaryocyte polyploidy is inhibited by lysyl oxidase propeptide

K. Ravid, S. Matsuura, P. Trackman, 2013, Cell cycle.

Development of a peroxidase-coupled fluorometric assay for lysyl oxidase.

P. Trackman, H. Kagan, C. G. Zoski, 1981, Analytical biochemistry.

Repeat polypeptide models of elastin as substrates for lysyl oxidase.

R. Rapaka, D. Urry, P. Trackman, 1980, The Journal of biological chemistry.

Control of Megakaryocyte Expansion and Bone Marrow Fibrosis by Lysyl Oxidase*

K. Ravid, A. Migliaccio, P. Trackman, 2011, The Journal of Biological Chemistry.

Oxidation, cross-linking, and insolubilization of recombinant tropoelastin by purified lysyl oxidase.

P. Trackman, D. Bedell-Hogan, H. Kagan, 1993, The Journal of biological chemistry.

Vicinal diamines as pyrroloquinoline quinone-directed irreversible inhibitors of lysyl oxidase.

P. Trackman, H. Kagan, S. Gacheru, 1989, The Journal of biological chemistry.

Evidence for a functional role for histidine in lysyl oxidase catalysis.

P. Trackman, H. Kagan, S. Gacheru, 1988, The Journal of biological chemistry.

Lysyl oxidase propeptide stimulates osteoblast and osteoclast differentiation and enhances PC3 and DU145 prostate cancer cell effects on bone in vivo

P. Trackman, M. Bais, Mona Alsulaiman, 2015, Journal of Cell Communication and Signaling.

A role for lysyl oxidase regulation in the control of normal collagen deposition in differentiating osteoblast cultures

D. Gantz, Ying Guo, P. Trackman, 2004, Journal of cellular physiology.

Lysyl oxidase gene expression and enzyme activity in the rat ovary: regulation by follicle-stimulating hormone, androgen, and transforming growth factor-beta superfamily members in vitro.

S. Hillier, P. Trackman, M. Rae, 2003, Endocrinology.

TGF-ß1 Regulation of Gingival Lysyl Oxidase and Connective Tissue Growth Factor

P. Trackman, M. Sheff, M. I. Uzel, 2000 .

Characterization and developmental expression of chick aortic lysyl oxidase.

Y. Wu, P. Trackman, H. Kagan, 1992, The Journal of biological chemistry.

Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence.

P. Trackman, H. Kagan, S. Tang, 1991, Biochemistry.

Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence.

P. Trackman, H. Kagan, S. Tang, 1990, Biochemistry.

Inflammation-associated lysyl oxidase protein expression in vivo, and modulation by FGF-2 plus IGF-1

D. Graves, D. Carnes, P. Trackman, 1998, Histochemistry and Cell Biology.

Pre- and Post-translational Regulation of Lysyl Oxidase by Transforming Growth Factor-β1 in Osteoblastic MC3T3-E1 Cells (*)

T. Takala, P. Trackman, E. Feres-Filho, 1995, The Journal of Biological Chemistry.

The 3'-untranslated region of rat lysyl oxidase cDNA.

P. Trackman, Y. Choi, E. Feres-Filho, 1995, Biochimica et biophysica acta.

Cytokine regulation of gingival fibroblast lysyl oxidase, collagen, and elastin.

P. Trackman, H. Hong, Hsiang-Hsi Hong, 2002, Journal of periodontology.

Requirement for active glycogen synthase kinase-3β in TGF-β1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts.

P. Trackman, S. S. Sume, M. Bahammam, 2013, American journal of physiology. Cell physiology.

CALL FOR PAPERS Cellular Mechanisms of Tissue Fibrosis Requirement for active glycogen synthase kinase-3 (cid:1) in TGF- (cid:1) 1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival ﬁbroblasts

P. Trackman, S. S. Sume, M. Bahammam, 2013 .

Cellular Mechanisms of Tissue Fibrosis Requirement for active glycogen synthase kinase-3 in TGF-1 upregulation of connective tissue growth factor ( CCN 2 / CTGF ) levels in human gingival fibroblasts

P. Trackman, S. S. Sume, M. Bahammam, 2013 .

Orthotopic non-metastatic and metastatic oral cancer mouse models.

P. Trackman, M. Bais, M. Kukuruzinska, 2015, Oral oncology.

CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and α6‐ and β1 integrins

P. Trackman, Yuan Huang, S. Black, 2006 .

Connective tissue growth factor in drug-induced gingival overgrowth.

P. Trackman, A. Kantarcı, E. Fıratlı, 2001, Journal of periodontology.

Methionine synthesis from 5'-S-Methylthioadenosine. Resolution of enzyme activities and identification of 1-phospho-5-S methylthioribulose.

P. Trackman, R. Abeles, 1983, The Journal of biological chemistry.

Reaction of lysyl oxidase with trans-2-phenylcyclopropylamine.

P. Gallop, P. Trackman, H. Kagan, 1993, The Journal of biological chemistry.

Measurement of lysyl oxidase activity from small tissue samples and cell cultures.

P. Trackman, M. Bais, 2018, Methods in cell biology.

Loss of Basement Membrane Integrity in Human Gingival Overgrowth

P. Trackman, A. Kantarcı, S. S. Sume, 2011, Journal of dental research.

CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins.

P. Trackman, Yuan Huang, S. Black, 2006, Journal of cellular biochemistry.

Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone.

P. Trackman, 2016, Matrix biology : journal of the International Society for Matrix Biology.

Stimulation of osteoblasts with Emdogain increases the expression of specific mineralization markers.

J. Bernimoulin, P. Trackman, P. Weishaupt, 2008, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

Identification of FAM20C binding proteins

P. Trackman, Y. Mochida, H. Goldman, 2016 .

Lysyl Oxidase Propeptide Inhibits FGF-2-induced Signaling and Proliferation of Osteoblasts*

M. Nugent, Ying Guo, S. Vora, 2010, The Journal of Biological Chemistry.

Properties and function of lysyl oxidase.

P. Trackman, H. Kagan, 1991, American journal of respiratory cell and molecular biology.

Reaction of aortic lysyl oxidase with beta-aminopropionitrile.

P. Trackman, H. Kagan, S. Tang, 1983, The Journal of biological chemistry.

The metabolism of 1-phospho-5-methylthioribose.

P. Trackman, R. Abeles, 1981, Biochemical and biophysical research communications.

Diabetes-enhanced Inflammation and Apoptosis—Impact on Periodontal Pathology

D. Graves, M. Alikhani, P. Trackman, 2006, Journal of dental research.

A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples.

P. Trackman, A. H. Palamakumbura, 2002, Analytical biochemistry.

Molecular and Clinical Aspects of Drug-induced Gingival Overgrowth

P. Trackman, A. Kantarcı, 2015, Journal of dental research.

Controlled release of fibroblast growth factor 2 stimulates bone healing in an animal model of diabetes mellitus.

P. Trackman, Ronaldo B. Santana, R. Santana, 2006, The International journal of oral & maxillofacial implants.

Intracellular distribution of the lysyl oxidase propeptide in osteoblastic cells.

Ying Guo, P. Trackman, N. Pischon, 2007, American journal of physiology. Cell physiology.

The Ras Signaling Inhibitor LOX-PP Interacts with Hsp70 and c-Raf To Reduce Erk Activation and Transformed Phenotype of Breast Cancer Cells

G. Sonenshein, K. Kirsch, J. Myllyharju, 2011, Molecular and Cellular Biology.

Blimp1 Activation by AP-1 in Human Lung Cancer Cells Promotes a Migratory Phenotype and Is Inhibited by the Lysyl Oxidase Propeptide

G. Sonenshein, K. Kirsch, P. Trackman, 2012, PloS one.

Driven Breast Cancer − Propeptide Reverses the Invasive Phenotype of Her-2 / neu The Tumor Suppressor Activity of the Lysyl Oxidase

G. Sonenshein, K. Kirsch, S. Jeay, 2007 .

The Propeptide Domain of Lysyl Oxidase Induces Phenotypic Reversion of Ras-transformed Cells*

P. Sommer, G. Sonenshein, S. Jeay, 2004, Journal of Biological Chemistry.

Functional importance of lysyl oxidase family propeptide regions

P. Trackman, 2018, Journal of Cell Communication and Signaling.

A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.

J. Palmer, G. Sonenshein, K. Kirsch, 2009, Cancer research.

The Lysyl Oxidase Propeptide Interacts with the Receptor-Type Protein Tyrosine Phosphatase Kappa and Inhibits β-Catenin Transcriptional Activity in Lung Cancer Cells

G. Sonenshein, K. Kirsch, P. Trackman, 2011, Molecular and Cellular Biology.

High Glucose Increases Lysyl Oxidase Expression and Activity in Retinal Endothelial Cells: Mechanism for Compromised Extracellular Matrix Barrier Function

P. Trackman, Sayon Roy, Amanda Tang, 2010, Diabetes.

A Novel Function for Lysyl Oxidase in Pluripotent Mesenchymal Cell Proliferation and Relevance to Inflammation-Associated Osteopenia

P. Trackman, M. Bais, K. Sodek, 2014, PloS one.

Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer

P. Trackman, 2016, Expert opinion on therapeutic targets.

Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells.

M. Wu, G. Sonenshein, K. Kirsch, 2007, Cancer research.

Repression of BCL 2 by the Tumor Suppressor Activity of the Lysyl Oxidase Propeptide Inhibits Transformed Phenotype of Lung and Pancreatic Cancer Cells

M. Wu, G. Sonenshein, K. Kirsch, 2007 .

A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer

Shi Yang, G. Sonenshein, K. Kirsch, 2018, Carcinogenesis.

Transforming Growth Factor-β1 (TGFβ1) Stimulates Connective Tissue Growth Factor (CCN2/CTGF) Expression in Human Gingival Fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent Mechanism

P. Trackman, S. Black, 2008, Journal of Biological Chemistry.

Diverse biological functions of extracellular collagen processing enzymes

P. Trackman, 2005, Journal of cellular biochemistry.

Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus

P. Trackman, Sayon Roy, P. Pajevic, 2019, JBMR plus.

Pre- and post-translational regulation of lysyl oxidase by transforming growth factor-beta 1 in osteoblastic MC3T3-E1 cells.

T. Takala, P. Trackman, Y. Choi, 1995, The Journal of biological chemistry.

Studies on the Properties and Role of the Organic Cofactor in Lysyl Oxidase

P. Gallop, P. Trackman, H. Kagan, 1991 .

Induction of lung lysyl oxidase activity and lysyl oxidase protein by exposure of rats to cadmium chloride: properties of the induced enzyme.

D. Calvaresi, P. Trackman, H. Kagan, 1991, Connective tissue research.

Enzymology of Lysyl Oxidase

P. Trackman, H. Kagan, S. Gacheru, 1989 .

Transient expression of lysyl oxidase by liver myofibroblasts in murine schistosomiasis.

P. Sommer, M. Raccurt, P. Trackman, 1993, Laboratory investigation; a journal of technical methods and pathology.

Oral Sciences PhD Program Enrollment, Graduates, and Placement: 1994 to 2016

R. Quivey, K. Hargreaves, F. Scannapieco, 2018, Journal of dental research.

The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer.

G. Sonenshein, K. Kirsch, S. Jeay, 2007, Cancer research.

Lysyl Oxidase Pro-peptide Inhibits Prostate Cancer Cell Growth by Mechanisms that Target FGF-2-Cell Binding and Signaling

M. Nugent, G. Sonenshein, K. Kirsch, 2009, Oncogene.

Characterization of a defect in the pathway for converting 5'-deoxy-5'-methylthioadenosine to methionine in a subline of a cultured heterogeneous human colon carcinoma.

L. Ghoda, D. Dexter, P. Trackman, 1984, The Journal of biological chemistry.

Lysyl oxidase and rrg messenger RNA.

R. Friedman, P. Trackman, J. Tang, 1991, Science.

Advanced Glycation End Products Enhance Expression of Pro-apoptotic Genes and Stimulate Fibroblast Apoptosis through Cytoplasmic and Mitochondrial Pathways*

D. Graves, M. Alikhani, Z. Alikhani, 2005, Journal of Biological Chemistry.

UXT Is a LOX‐PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells

G. Sonenshein, K. Kirsch, P. Trackman, 2017, Journal of cellular biochemistry.

Functional analysis of the promoter and first intron of the human lysyl oxidase gene

D. Samid, K. Csiszȧr, P. Trackman, 2004, Molecular Biology Reports.

Lysyl oxidase propeptide stimulates osteoblast and osteoclast differentiation and enhances PC3 and DU145 prostate cancer cell effects on bone in vivo

P. Trackman, M. Bais, Mona Alsulaiman, 2016, Journal of Cell Communication and Signaling.

Characterization of recombinant lysyl oxidase propeptide.

G. Sonenshein, K. Kirsch, Ying Guo, 2010, Biochemistry.

Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-α signaling.

M. Koupenova, Dan Yang, K. Ravid, 2011, Experimental hematology.

Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation.

Dan Yang, C. St. Hilaire, B. Schreiber, 2008, Biochemical and biophysical research communications.

Effects of High Glucose-Induced Lysyl Oxidase Propeptide on Retinal Endothelial Cell Survival: Implications for Diabetic Retinopathy.

P. Trackman, Dongjoon Kim, Sayon Roy, 2019, The American journal of pathology.

Multiple Bone Morphogenetic Protein 1-related Mammalian Metalloproteinases Process Pro-lysyl Oxidase at the Correct Physiological Site and Control Lysyl Oxidase Activation in Mouse Embryo Fibroblast Cultures

W. N. Pappano, D. Greenspan, I. Scott, 2001, The Journal of Biological Chemistry.

Autocrine Growth Factor Regulation of Lysyl Oxidase Expression in Transformed Fibroblasts*

P. Sommer, P. Trackman, A. H. Palamakumbura, 2003, Journal of Biological Chemistry.

TGF-β1- and CCN2-Stimulated Sirius Red Assay for Collagen Accumulation in Cultured Cells.

P. Trackman, M. Bais, D. Saxena, 2017, Methods in molecular biology.

Nonpeptidyl amine inhibitors are substrates of lysyl oxidase.

P. Trackman, H. Kagan, 1979, The Journal of biological chemistry.

Studies on lysyl oxidase of bovine ligamentum nuchae and bovine aorta.

P. Milbury, P. Trackman, H. Kagan, 1977, Advances in experimental medicine and biology.

Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva.

P. Trackman, H H Hong, M I Uzel, 1999, Laboratory investigation; a journal of technical methods and pathology.

Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor.

D. Graves, M. Alikhani, P. Trackman, 2007, American journal of physiology. Cell physiology.

Regulation of collagen deposition and lysyl oxidase by tumor necrosis factor-alpha in osteoblasts.

E. Kessler, P. Trackman, N. Pischon, 2004, The Journal of biological chemistry.

Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin‐induced apoptosis

G. Sonenshein, K. Kirsch, P. Trackman, 2010, Journal of cellular biochemistry.

The Complete Derived Amino Acid Sequence of Human Lysyl Oxidase and Assignment of the Gene to Chromosomes 5

R. Eddy, T. Shows, T. Mariani, 1992 .

Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice.

P. Trackman, A. Kantarcı, S. S. Sume, 2015, The American journal of pathology.

Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice

L. Gerstenfeld, E. Morgan, P. Trackman, 2016, Calcified Tissue International.

Multiple Functions of Lysyl Oxidase Like-2 in Oral Fibroproliferative Processes

P. Trackman, A. Kantarcı, A. Findlay, 2018, Journal of dental research.

Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose–Induced Apoptosis

R. Mecham, P. Trackman, Dongjoon Kim, 2017, Investigative ophthalmology & visual science.

Inhibition of CIN85-Mediated Invasion by a Novel SH3 Domain Binding Motif in the Lysyl Oxidase Propeptide

P. Simister, S. Feller, G. Sonenshein, 2013, PloS one.

Increased mRNAs for procollagens and key regulating enzymes in rat skeletal muscle following downhill running

T. Takala, V. Kovanen, S. Koskinen, 1999, Pflügers Archiv.

The Lysyl Oxidase G473A Polymorphism Exacerbates Oral Cancer Development in Humans and Mice

Ying Chen, K. Kirsch, N. Shrestha, 2023, International journal of molecular sciences.