S. Apte

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Time-resolved Analysis of the Matrix Metalloproteinase 10 Substrate Degradome*

P. Nanni, Pascal Schlage, Fabian E Egli, 2013, Molecular & Cellular Proteomics.

Time-resolved Analysis of the Matrix Metalloproteinase 10 Substrate Degradome.

P. Nanni, Pascal Schlage, Fabian E Egli, 2014, Molecular & cellular proteomics : MCP.

ADAMTSL3/punctin‐2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancer

G. Casey, T. Hurskainen, S. Apte, 2007, International journal of cancer.

Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.

D. Menick, Laura J. Dixon, S. Apte, 2010, Matrix biology : journal of the International Society for Matrix Biology.

The Gene Structure of Tissue Inhibitor of Metalloproteinases (TIMP)-3 and Its Inhibitory Activities Define the Distinct TIMP Gene Family (*)

S. Apte, Bjorn R. Olsen, G. Murphy, 1995, The Journal of Biological Chemistry.

Human Tissue Inhibitor of Metalloproteinases 3 Interacts with Both the N- and C-terminal Domains of Gelatinases A and B

G. Butler, S. Apte, Georgina S. Butler, 1999, The Journal of Biological Chemistry.

Identification and functional analysis of an ADAMTSL1 variant associated with a complex phenotype including congenital glaucoma, craniofacial, and other systemic features in a three‐generation human pedigree

Lauren W. Wang, S. Apte, L. Reis, 2017, Human mutation.

Limb- and tendon-specific Adamtsl2 deletion identifies a role for ADAMTSL2 in tendon growth in a mouse model for geleophysic dysplasia.

R. Schweitzer, S. Apte, D. Birk, 2019, Matrix biology : journal of the International Society for Matrix Biology.

Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP‐3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10

M. Seldin, M. Mattei, S. Apte, 1994, Developmental dynamics : an official publication of the American Association of Anatomists.

ADAMTS10 Protein Interacts with Fibrillin-1 and Promotes Its Deposition in Extracellular Matrix of Cultured Fibroblasts*

D. Keene, L. Sakai, E. Traboulsi, 2011, The Journal of Biological Chemistry.

Characterization of proADAMTS5 processing by proprotein convertases.

R. Leduc, D. McCulloch, S. Apte, 2009, The international journal of biochemistry & cell biology.

Regulation of ADAMTS9 Secretion and Enzymatic Activity by Its Propeptide*

R. Leduc, S. Apte, R. Somerville, 2007, Journal of Biological Chemistry.

Cell-surface Processing of Pro-ADAMTS9 by Furin*

R. Leduc, S. Apte, R. Somerville, 2006, Journal of Biological Chemistry.

MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling.

J. Risteli, R. Chiarle, Marta C Guadamillas, 2010, Developmental cell.

[1] Nonfibrillar collagens

B. Olsen, N. Fukai, S. Apte, 1994 .

A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family.

S. Apte, 2004, The international journal of biochemistry & cell biology.

Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion.

H. Takeuchi, S. Apte, R. Somerville, 2016, Developmental biology.

A Disintegrin-like and Metalloprotease (Reprolysin-type) with Thrombospondin Type 1 Motif (ADAMTS) Superfamily: Functions and Mechanisms*

S. Apte, 2009, The Journal of Biological Chemistry.

ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis.

Jason C. Ho, J. Hollyfield, E. Traboulsi, 2012, Investigative ophthalmology & visual science.

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Nathan A. Bihlmeyer, Henry J. Lin, Blair H. Smith, 2018, Genome Biology.

ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations

T. Hansen, O. Pedersen, N. Grarup, 2019, Diabetes.

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.

S. Apte, J. Dubail, 2015, Matrix biology : journal of the International Society for Matrix Biology.

ADAMTS-like proteins from mammalian genetics il and

S. Apte, 2015 .

A new Adamts9 conditional mouse allele identifies its non‐redundant role in interdigital web regression

B. Olsen, S. Apte, Courtney M. Nelson, 2014, Genesis.

Chapter 265 – ADAMTS9

S. Apte, 2013 .

Proteomics identifies a convergent innate response to infective endocarditis and extensive proteolysis in vegetation components.

Daniel R. Martin, E. Blackstone, S. Apte, 2020, JCI insight.

Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome

Michael W. Jenkins, M. Jenkins, Deepika Vasudevan, 2016, Scientific Reports.

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia – a novel mouse model providing insights into geleophysic dysplasia

R. Mecham, D. Reinhardt, Lauren W. Wang, 2015, Disease Models & Mechanisms.

Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function

S. Apte, D. Hubmacher, 2011, Cellular and Molecular Life Sciences.

ADAMTS proteins as modulators of microfibril formation and function.

S. Apte, D. Hubmacher, 2015, Matrix biology : journal of the International Society for Matrix Biology.

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

R. Mecham, D. Keene, D. Mosher, 2013, Investigative ophthalmology & visual science.

Membrane Type 1-Matrix Metalloproteinase Is Regulated by Chemokines Monocyte-Chemoattractant Protein-1/CCL2 and Interleukin-8/CXCL8 in Endothelial Cells during Angiogenesis*

K. Tryggvason, S. Apte, B. Gálvez, 2005, Journal of Biological Chemistry.

O-Fucosylation of ADAMTSL2 is required for secretion and is impacted by geleophysic dysplasia-causing mutations

Deepika Vasudevan, S. Apte, R. Haltiwanger, 2020, The Journal of Biological Chemistry.

ADAMTS9 and ADAMTS20 are differentially affected by loss of B3GLCT in a mouse model of Peters Plus Syndrome.

David E. Komatsu, R. Honkanen, H. Narimatsu, 2019, Human molecular genetics.

O-Fucosylation of Thrombospondin Type 1 Repeats in ADAMTS-like-1/Punctin-1 Regulates Secretion

Lauren W. Wang, S. Apte, R. Somerville, 2007, Journal of Biological Chemistry.

Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1.

G. Muschler, S. Apte, B. Willard, 2022, Osteoarthritis and cartilage.

ADAMTS Proteins: Concepts, Challenges, and Prospects.

S. Apte, 2020, Methods in molecular biology.

ADAMTS Proteases: Mediators of Physiological and Pathogenic Extracellular Proteolysis

S. Apte, 2016 .

Overview of the ADAMTS Superfamily

S. Apte, 2015 .

Post-translational Modification of Thrombospondin Type-1 Repeats in ADAMTS-like 1/Punctin-1 by C-Mannosylation of Tryptophan*

Lauren W. Wang, S. Apte, R. Haltiwanger, 2009, The Journal of Biological Chemistry.

Punctin, a Novel ADAMTS-like Molecule, ADAMTSL-1, in Extracellular Matrix*

M. Seldin, M. Miyagi, D. Keene, 2002, The Journal of Biological Chemistry.

A Selective Extracellular Matrix Proteomics Approach Identifies Fibronectin Proteolysis by A Disintegrin-like and Metalloprotease Domain with Thrombospondin Type 1 Motifs (ADAMTS16) and Its Impact on Spheroid Morphogenesis *

R. Sack, D. Hess, D. Mosher, 2018, Molecular & Cellular Proteomics.

A selective extracellular matrix proteomics approach identifies fibronectin proteolysis by ADAMTS16 and its impact on spheroid morphogenesis

R. Sack, D. Hess, D. Mosher, 2018 .

A type X collagen mutation causes Schmid metaphyseal chondrodysplasia

B. Olsen, M. Warman, T. Hefferon, 1993, Nature Genetics.

92‐kDa type IV collagenase and TIMP‐3, but not 72‐kDa type IV collagenase or TIMP‐1 or TIMP‐2, are highly expressed during mouse embryo implantation

B. Olsen, I. Thesleff, K. Tryggvason, 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11–q12 and mouse chromosome 14 and has plant and nematode homologs

M. Seldin, B. Olsen, M. Mattei, 1995, FEBS letters.

Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development

C. Kostic, Y. Arsenijévic, C. Brisken, 2016, Biology Open.

Mutations in the TGFβ binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias.

D. Sillence, A. Munnich, J. Casanova, 2011, American journal of human genetics.

ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis.

C. M. Weyman, A. Vasanji, S. Apte, 2007, Matrix biology : journal of the International Society for Matrix Biology.

Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry.

W. J. Perry, Daniel R. Martin, Eric P. Skaar, 2022, Cell chemical biology.

Ki-67 monoclonal antibody (MAb) reacts with a proliferation associated nuclear antigen in the rabbitOryctolagus cuniculus

S. Apte, 2006, Histochemistry.

Validation of bromodeoxyuridine immunohistochemistry for localization of S-phase cells in decalcified tissues. A comparative study with tritiated thymidine autoradiography

S. Apte, 1990, The Histochemical Journal.

PHYSEAL DISTRACTION AND CELL PROLIFERATION IN

J. Kenwright, S. Apte, 1994 .

Expression of the cell proliferation-associated nuclear antigen reactive with the Ki-67 monoclonal antibody by cells of the skeletal system in humans and other species.

S. Apte, 1990, Bone and mineral.

Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families.

J. Myllyharju, S. Apte, D. Hubmacher, 2019, Matrix biology : journal of the International Society for Matrix Biology.

Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta.

B. Olsen, M. Mattei, S. Apte, 1995, Genomics.

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

T. Cox, F. Hildebrandt, Lauren W. Wang, 2019, Nature Communications.

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis

A. Colige, B. Peers, A. Noel, 2015, Angiogenesis.

Murine tissue inhibitor of metalloproteinases—4 (Timp—4): cDNA isolation and expression in adult mouse tissues 1

R. Khokha, G. Schultz, D. Edwards, 1997, FEBS letters.

A review of tissue inhibitor of metalloproteinases-3 (TIMP-3) and experimental analysis of its effect on primary tumor growth.

B. Olsen, B. Zetter, K. Iwata, 1996, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Versican Processing by a Disintegrin-like and Metalloproteinase Domain with Thrombospondin-1 Repeats Proteinases-5 and -15 Facilitates Myoblast Fusion*

D. McCulloch, A. Ward, N. Stupka, 2012, The Journal of Biological Chemistry.

The ADAMTS endopeptidases

S. Apte, 2004 .

Chromosomal mapping of Adam9, Adam15 and Adam21.

S. Apte, M. F. Seldin, S. Hirohata, 2000, Matrix biology : journal of the International Society for Matrix Biology.

ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-β bioavailability regulation

A. Munnich, Y. Crow, D. Krakow, 2008, Nature Genetics.

Adamts5 (aggrecanase‐2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines

Jason C. Ho, D. McCulloch, S. Apte, 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Characterization of Proteoglycanomes by Mass Spectrometry

S. Apte, Christopher D Koch, 2020 .

Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11.

S. Apte, M. F. Seldin, S. Hirohata, 1998, Genomics.

ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells.

D. Lindner, Laura J. Dixon, Lauren W. Wang, 2010, The American journal of pathology.

A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the Glu441-Ala442 peptide bond in the V1 isoform is essential for interdigital web regression

C. Burin des Roziers, S. Apte, S. Valleix, 2021, Matrix biology plus.

In situ hybridization for metalloproteinases and their inhibitors.

T. Hurskainen, S. Apte, 2010, Methods in molecular biology.

ADAMs and ADAMTSs☆

C. Blobel, S. Apte, 2020, Reference Module in Biomedical Sciences.

Chapter 259 – The ADAMTS Endopeptidases

S. Apte, 2013 .

Cell-surface Processing of the Metalloprotease Pro-ADAMTS9 Is Influenced by the Chaperone GRP94/gp96*

S. Apte, B. Koo, 2009, The Journal of Biological Chemistry.

Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues.

D. McCulloch, Laura J. Dixon, S. Apte, 2009, Gene expression patterns : GEP.

Expression of concern: Characterization of a novel epigenetically‐silenced, growth‐suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma

A. Cheung, H. Lung, E. Stanbridge, 2008, International journal of cancer.

The Secreted Metalloprotease ADAMTS20 Is Required for Melanoblast Survival

W. Pavan, S. Apte, R. Somerville, 2008, PLoS genetics.

ADAMs and ADAMTSs

C. Blobel, S. Apte, 2020, Reference Module in Biomedical Sciences.

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development

Daniel R. Martin, C. Baldock, C. Lo, 2021, bioRxiv.

Limb- and tendon-specific Adamtsl2 deletion identifies a soft tissue mechanism modulating bone length

R. Schweitzer, S. Apte, D. Birk, 2018, bioRxiv.

The biology of the extracellular matrix: novel insights

S. Apte, D. Hubmacher, 2013, Current opinion in rheumatology.

Isolation and Purification of Versican and Analysis of Versican Proteolysis.

S. Apte, A. Day, S. Foulcer, 2021, Methods in molecular biology.

The Pivotal Role of Versican Turnover by ADAMTS Proteases in Mammalian Reproduction and Development

S. Apte, 2021 .

ADAMTS Proteases: Methods and Protocols

S. Apte, 2020 .

Exosites in Hypervariable Loops of ADAMTS Spacer Domains control Substrate Recognition and Proteolysis

S. Apte, D. Lane, Salvatore Santamaria, 2019, Scientific Reports.

The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.

Jason C. Ho, D. McCulloch, S. Apte, 2018, JCI insight.

Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma

T. Falcone, S. Apte, C. Biscotti, 2017, The Journal of clinical endocrinology and metabolism.

Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.

S. Apte, 2016, The Biochemical journal.

ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.

S. Apte, Courtney M. Nelson, Sumeda Nandadasa, 2015, Cell reports.

Isolation and purification of versican and analysis of versican proteolysis.

S. Apte, A. Day, S. Foulcer, 2015, Methods in molecular biology.

ADAMTS 9-Mediated Extra cellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation Graphical

S. Apte, Courtney M. Nelson, Sumeda Nandadasa, 2015 .

The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis.

S. Apte, Sumeda Nandadasa, S. Foulcer, 2014, Matrix biology : journal of the International Society for Matrix Biology.

The Role of the ADAMTS Proteins in the Intervertebral Disc

Jason C. Ho, S. Apte, J. Wylie, 2014 .

Chapter 266 – ADAMTS10

S. Apte, 2013 .

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

Takako Sasaki, D. McCulloch, Laura J. Dixon, 2009, Developmental cell.

Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis

K. Powell, A. Colige, S. Apte, 2006, Development.

Adamts9 is widely expressed during mouse embryo development.

S. Apte, R. Somerville, C. Le Goff, 2005, Gene expression patterns : GEP.

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

M. Jenkins, D. Reinhardt, Lauren W. Wang, 2019, Matrix biology : journal of the International Society for Matrix Biology.

ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.

S. Apte, B. Anand-Apte, P. Klenotic, 2003, Matrix biology : journal of the International Society for Matrix Biology.

Human eye development is characterized by coordinated expression of fibrillin isoforms.

K. Schenke-Layland, D. Reinhardt, S. Apte, 2014, Investigative ophthalmology & visual science.

Proteolysis: a key post-translational modification regulating proteoglycans.

Daniel R. Martin, S. Apte, S. Bhutada, 2022, American journal of physiology. Cell physiology.

Oncostatin M differentially regulates tissue inhibitors of metalloproteinases TIMP-1 and TIMP-3 gene expression in human synovial lining cells.

P. Heinrich, S. Apte, H. Haubeck, 1996, European journal of biochemistry.

Expression Analysis by RNAscope™ In Situ Hybridization.

S. Apte, T. Mead, 2020, Methods in molecular biology.

TIMP-3 Accumulation in Bruch’s Membrane and Drusen in Eyes From Normal and Age-Related Macular Degeneration Donors

M. Kamei, J. Hollyfield, S. Apte, 1997 .

Structure of the human TIMP-3 gene and its cell cycle-regulated promoter.

B. Olsen, M. Budarf, R. Müller, 1995, The Biochemical journal.

Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate

Daniel R. Martin, M. Stack, Y. Itoh, 2022, bioRxiv.

Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5

Maritza V Quintero, S. Apte, Courtney M. Nelson, 2018 .

Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5*

Maritza V Quintero, S. Apte, Courtney M. Nelson, 2014, The Journal of Biological Chemistry.

ADAMTS3 and ADAMTS14

C. L. Goff, S. Apte, 2005 .

Determinants of Versican-V 1 Proteoglycan Processing by the Metalloproteinase ADAMTS 5 *

Maritza V Quintero, S. Apte, Courtney M. Nelson, 2022 .

ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11.

S. Apte, M. F. Seldin, S. Hirohata, 1999, Genomics.

Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

J. Humphrey, M. Veigl, D. Sedwick, 2020, bioRxiv.

Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth.

J. Martignetti, A. Difeo, S. Doty, 2007, Human molecular genetics.

Pericellular Versican Regulates the Fibroblast-Myofibroblast Transition

A. Vasanji, S. Apte, Mark E. Lauer, 2011, The Journal of Biological Chemistry.

Regulation of extracellular matrix composition by fibroblasts during perinatal cardiac maturation.

L. Mestroni, T. McKinsey, S. Apte, 2022, Journal of molecular and cellular cardiology.

Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively.

B. Olsen, M. Mattei, S. Apte, 1997, Genomics.

Erratum: The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family (Journal of Biological Chemistry (1995) 270 (14313-14318))

B. Olsen, S. Apte, G. Murphy, 1996 .

Matrix metalloproteinases: old dogs with new tricks

S. Apte, R. Somerville, Samantha A. Oblander, 2003, Genome Biology.

Visualization and Quantification of Pericellular Matrix.

S. Apte, T. Mead, 2020, Methods in molecular biology.

Immunoregulatory roles of versican proteolysis in the myeloma microenvironment.

N. Callander, S. Miyamoto, P. Hematti, 2016, Blood.

Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively.

J. Ye, S. Apte, M. F. Seldin, 1998, Genomics.

Production of Membrane-type Matrix Metalloproteinase-1 (MT-MMP-1) in Early Human Placenta: A Possible Role in Placental Implantation?

T. Hurskainen, M. Seiki, A. Oikarinen, 1998, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

An immunohistological study of cartilage and synovium in primary synovial chondromatosis

N. Athanasou, S. Apte, N. A. Athanasou, 1992, The Journal of pathology.

Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10.

B. Olsen, S. Apte, M. F. Seldin, 1992, European journal of biochemistry.

Miikka Vikkula, Laurence M. Boon, Andrea Superti-Furga, 2001, Cell.

Procollagen II Amino Propeptide Processing by ADAMTS-3

D. Eyre, A. Colige, D. Cohn, 2001, The Journal of Biological Chemistry.

The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ precursors in vasculogenesis and primitive hematopoiesis

R. Midura, Y. Yamaguchi, Lorin E. Olson, 2019, bioRxiv.

Tissue inhibitor of metalloproteinases-3 is a component of Bruch's membrane of the eye.

A. Milam, B. Olsen, K. Iwata, 1997, The American journal of pathology.

Functional analysis of an ADAMTS10 signal peptide mutation in Weill‐Marchesani syndrome demonstrates a long‐range effect on secretion of the full‐length enzyme

Elias I. Traboulsi, Suneel S. Apte, E. Traboulsi, 2008, Human mutation.

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis

A. Colige, B. Peers, A. Noel, 2015, Angiogenesis.

ADAM-TS5, ADAM-TS6, and ADAM-TS7, Novel Members of a New Family of Zinc Metalloproteases

M. Seldin, T. Hurskainen, S. Apte, 1999, The Journal of Biological Chemistry.

Positional identification of variants of Adamts16 linked to inherited hypertension

Bryan Frank, C. Bouchard, A. Chakravarti, 2009, Human molecular genetics.

ADAMTS proteins in human disorders.

S. Apte, T. Mead, 2018, Matrix biology : journal of the International Society for Matrix Biology.

Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation.

K. Tryggvason, Zhongjun Zhou, S. Apte, 2005, Developmental biology.

Characterization of the mouse type X collagen gene.

B. Olsen, S. Apte, 1993, Matrix.

Overcoming neurite‐inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix

R. Midha, V. Yong, S. Apte, 2013, Glia.

Cloning of human α1(X) collagen DNA and localization of the COL10A1 gene to the q21–q22 region of human chromosome 6

M. Mattei, S. Apte, B. Olsen, 1991, FEBS letters.

Bromodeoxyuridine (BrdUrd) immunohistochemistry in undecalcified plastic-embedded tissue. Elimination of the DNA denaturation step

S. Apte, B. Puddle, 2004, Histochemistry.

Functional interplay between endothelial nitric oxide synthase and membrane type 1 matrix metalloproteinase in migrating endothelial cells.

Antonio S. Tutor, K. Tryggvason, S. Apte, 2007, Blood.

Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis

T. Ohtsuki, D. Lindner, S. Apte, 2017, Scientific Reports.

Egr-1 Mediates Extracellular Matrix-driven Transcription of Membrane Type 1 Matrix Metalloproteinase in Endothelium*

S. Apte, T. Haas, J. Madri, 1999, The Journal of Biological Chemistry.

Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease

D. Reinhardt, H. Takeuchi, S. Apte, 2017, Scientific Reports.

Induction of the MMP-14 Gene in Macrophages of the Atherosclerotic Plaque: Role of SAF-1 in the Induction Process

A. Shakya, B. Ray, S. Apte, 2004, Circulation research.

The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts

G. Christensen, T. Tønnessen, S. Apte, 2021, Scientific Reports.

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

T. Cox, F. Hildebrandt, Lauren W. Wang, 2019, Nature Communications.

An ADAMTSL2 Founder Mutation Causes Musladin-Lueke Syndrome, a Heritable Disorder of Beagle Dogs, Featuring Stiff Skin and Joint Contractures

M. Neff, K. Broman, A. Ruhe, 2010, PloS one.

Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis.

E. Zabarovsky, S. Law, A. Cheung, 2010, Cancer research.

Alternative splicing of the metalloprotease ADAMTS17 spacer regulates secretion and modulates autoproteolytic activity

S. Misra, D. Reinhardt, S. Apte, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A novel pathogenic missense ADAMTS17 variant that impairs secretion causes Weill-Marchesani Syndrome with variably dysmorphic hand features

B. Fernandez, M. Brudno, M. Woods, 2020, Scientific Reports.

The characterisation of six ADAMTS proteases in the basal chordate Ciona intestinalis provides new insights into the vertebrate ADAMTS family.

J. Huxley-Jones, D. Robertson, R. Boot-Handford, 2005, The international journal of biochemistry & cell biology.

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

P. Bucher, C. Brisken, Csaba Laszlo, 2020, Nature Communications.

Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.

J. Naggert, M. Krebs, N. Peachey, 2015, Human molecular genetics.

Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.

D. McCulloch, S. Apte, A. Wessels, 2011, Developmental biology.

Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

B. Alman, J. Wunder, Lauren W. Wang, 2014, Molecular Cancer Therapeutics.

A Call to Action for Musculoskeletal Research Funding: The Growing Economic and Disease Burden of Musculoskeletal Conditions in the United States Is Not Reflected in Musculoskeletal Research Funding.

A. Erdemir, A. Klika, S. Apte, 2022, The Journal of bone and joint surgery. American volume.

Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8

Daniel R. Martin, S. Apte, Salvatore Santamaria, 2021, The Journal of biological chemistry.

Consequences of PDGFRα+ fibroblast reduction in adult murine hearts

S. Apte, Vikram K. Shettigar, M. Tallquist, 2021, bioRxiv.

The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family.

B. Olsen, S. Apte, G. Murphy, 1996, The Journal of biological chemistry.

Mapping of two mouse membrane-type matrix metalloproteinase (MT-MMP) genes, Mmp15 and Mmp16, to mouse chromosomes 8 and 4, respectively.

S. Apte, M. Gustavson, M. F. Seldin, 1998, Genomics.

A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation

J. McPherson, W. Pavan, D. Beier, 2003, Development.

ADAMTS-9 is synergistically induced by interleukin-1β and tumor necrosis factor α in OUMS-27 chondrosarcoma cells and in human chondrocytes

K. Nishida, T. Yonezawa, Y. Ninomiya, 2005 .

Modulated expression of type X collagen in Meckel's cartilage with different developmental fates.

H. Takita, S. Apte, I. Nishimura, 1995, Developmental biology.

Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling

Raoul F. V. Germano, R. Sandberg, V. Lauschke, 2019, Arteriosclerosis, thrombosis, and vascular biology.

Discovery and Characterization of a Novel, Widely Expressed Metalloprotease, ADAMTS10, and Its Proteolytic Activation*

S. Apte, R. Somerville, Katherine A Jungers, 2004, Journal of Biological Chemistry.

The Matrix Metalloproteinase-14 (MMP-14) Gene Is Structurally Distinct from Other MMP Genes and Is Co-expressed with the TIMP-2 Gene during Mouse Embryogenesis*

D. Beier, N. Fukai, S. Apte, 1997, The Journal of Biological Chemistry.

A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module.

Jason C. Ho, R. Atit, D. Reinhardt, 2012, Matrix biology : journal of the International Society for Matrix Biology.

Characterization of ADAMTS-9 and ADAMTS-20 as a Distinct ADAMTS Subfamily Related to Caenorhabditis elegans GON-1*

R. Leduc, S. Apte, T. Wight, 2003, The Journal of Biological Chemistry.

Metalloproteinases: A parade of functions in matrix biology and an outlook for the future.

W. Parks, S. Apte, 2015, Matrix biology : journal of the International Society for Matrix Biology.

Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22.

B. Olsen, M. Mattei, S. Apte, 1994, Genomics.

Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation

K. Powell, H. Enomoto, Laura J. Dixon, 2010, Development.

ADAMTS7B, the Full-length Product of the ADAMTS7 Gene, Is a Chondroitin Sulfate Proteoglycan Containing a Mucin Domain*

J. Sanes, R. Leduc, Lauren W. Wang, 2004, Journal of Biological Chemistry.

The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors.

R. Midura, Y. Yamaguchi, Lorin E. Olson, 2021, Matrix biology : journal of the International Society for Matrix Biology.

Application of monoclonal antibody to bromodeoxyuridine to detect chondrocyte proliferation in growth plate cartilage in vivo

S. Apte, 1988 .

Identification and Characterization of a Novel Human Matrix Metalloproteinase with Unique Structural Characteristics, Chromosomal Location, and Tissue Distribution*

X. Puente, C. López-Otín, M. Mattei, 1997, The Journal of Biological Chemistry.

Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3.

B. Olsen, B. Zetter, E. Voest, 1997, Investigative ophthalmology & visual science.

Aggrecan in Cardiovascular Development and Disease

S. Apte, C. Lee, Christopher D Koch, 2020, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection.

E. Blackstone, M. Eagleton, S. Apte, 2018, JCI insight.

Matrix Metalloproteinase-14 Deficiency in Bone Marrow–Derived Cells Promotes Collagen Accumulation in Mouse Atherosclerotic Plaques

P. Libby, M. Aikawa, G. Sukhova, 2008, Circulation.

Aggrecan accumulates at sites of increased pulmonary arterial pressure in idiopathic pulmonary arterial hypertension

M. Bech, H. Brunnström, K. Hoetzenecker, 2023, Pulmonary circulation.

The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1.

B. Olsen, M. Mattei, Y. Muragaki, 1991, The Journal of biological chemistry.

A disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif 9 (ADAMTS9) regulates fibronectin fibrillogenesis and turnover

D. Mosher, Lauren W. Wang, S. Apte, 2019, The Journal of Biological Chemistry.

ADAMTSL5 is an epigenetically activated gene underlying tumorigenesis and drug resistance in hepatocellular carcinoma.

Fabrice Daian, U. Hibner, S. Audebert, 2020, Journal of hepatology.

ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload

Daniel R. Martin, S. Heymans, I. Sjaastad, 2022, Communications biology.

Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach.

Daniel R. Martin, S. Apte, Salvatore Santamaria, 2021, Journal of proteomics.

Accumulation of tissue inhibitor of metalloproteinases-3 in human eyes with Sorsby’s fundus dystrophy or retinitis pigmentosa

A. Milam, P. Luthert, R. Fariss, 1998, The British journal of ophthalmology.

ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes.

K. Nishida, T. Yonezawa, Y. Ninomiya, 2005, Arthritis and rheumatism.

10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin.

R. Leduc, D. McCulloch, S. Apte, 2010, Osteoarthritis and cartilage.

LRG1 is a novel ligand of HER3 and promotes metastatic colorectal cancer growth

M. Miyagi, Derek J. Taylor, S. Apte, 2023 .

Beyond the Matrisome: New Frontiers in ECM Research.

A. Naba, S. Apte, 2022, Matrix biology : journal of the International Society for Matrix Biology.

An update on metalloproteases in the musculoskeletal system

S. Apte, R. Somerville, Samantha A. Oblander, 2003 .

ADAMTS9-Regulated Pericellular Matrix Dynamics Governs Focal Adhesion-Dependent Smooth Muscle Differentiation

J. Drazba, S. Apte, Courtney M. Nelson, 2018, Cell reports.

Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy.

R. Lifton, F. Hildebrandt, M. Schueler, 2019, American journal of human genetics.

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.

R. W. Rauser, G. Baaklini, Yihai Cao, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Physeal distraction and cell proliferation in the growth plate.

J. Kenwright, S. Apte, 1994, The Journal of bone and joint surgery. British volume.

Clinical Phenotype of Musladin‐Lueke Syndrome in 2 Beagles

G. Johnson, Ling T Guo, G. Shelton, 2017, Journal of veterinary internal medicine.

Immunohistochemical analysis of TIMP-3 expression in degenerative retinal disease

K. Iwata, S. Apte, C. Jomary, 1996 .

Faculty Opinions recommendation of Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

Jason C. Ho, S. Apte, 2010 .

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

P. Bucher, C. Brisken, Csaba Laszlo, 2020, Nature Communications.

Pericellular Versican Regulates the Fibroblast-Myofibroblast Transition

A. Vasanji, S. Apte, Mark E. Lauer, 2011, The Journal of Biological Chemistry.

The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.

Jason C. Ho, D. McCulloch, S. Apte, 2018, JCI insight.

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Henry J. Lin, Blair H. Smith, M. Waldenberger, 2018, Genome Biology.

Versican Processing by a Disintegrin-like and Metalloproteinase Domain with Thrombospondin-1 Repeats Proteinases-5 and -15 Facilitates Myoblast Fusion*

D. McCulloch, A. Ward, N. Stupka, 2012, The Journal of Biological Chemistry.

Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.

S. Apte, 2016, The Biochemical journal.

Mutations in the TGFβ binding-protein-like domain 5 of FBN1 are responsible for acromicric and geleophysic dysplasias.

D. Sillence, A. Munnich, J. Casanova, 2011, American journal of human genetics.

MT1-MMP is required for myeloid cell fusion via regulation of Rac1 signaling.

J. Risteli, R. Chiarle, Marta C Guadamillas, 2010, Developmental cell.

Consequences of PDGFRα+ fibroblast reduction in adult murine hearts

S. Apte, Vikram K. Shettigar, M. Tallquist, 2022, eLife.

Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

B. Alman, J. Wunder, Lauren W. Wang, 2014, Molecular Cancer Therapeutics.

R. Sack, D. Hess, D. Mosher, 2018, Molecular & Cellular Proteomics.

Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.

J. Naggert, M. Krebs, N. Peachey, 2015, Human molecular genetics.

Identification of protein biomarkers associated with congenital diaphragmatic hernia in human amniotic fluid

E. Blackstone, S. Apte, Benjamin Kramer, 2023, Scientific reports.

Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development.

S. Apte, Courtney M. Nelson, Simon J. Foulcer, 2024, Matrix biology : journal of the International Society for Matrix Biology.