D. González-Pacanowska

发表

Correction: Squalene Synthase As a Target for Chagas Disease Therapeutics

E. Oldfield, Zhen Zhu, A. H. Wang, 2014, PLoS Pathogens.

Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei

J. Balzarini, E. V. Van Damme, A. E. Vidal, 2013, Molecular microbiology.

DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools

A. E. Vidal, D. González-Pacanowska, G. Pérez-Moreno, 2019, Cellular and Molecular Life Sciences.

Kinetic Characterization of Squalene Synthase from Trypanosoma cruzi: Selective Inhibition by Quinuclidine Derivatives

I. Gilbert, J. Urbina, R. Brun, 2007, Antimicrobial Agents and Chemotherapy.

Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives.

D. González-Pacanowska, L. Ruiz-Pérez, Indalecio Quesada‐Soriano, 2007, Biochimica et biophysica acta.

Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.

I. Gilbert, D. González-Pacanowska, H. Cui, 2010, Bioorganic & medicinal chemistry.

Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae.

W. de Souza, D. González-Pacanowska, C. Gancedo, 2003, Molecular biology of the cell.

Collaborative actions in anti-trypanosomatid chemotherapy with partners from disease endemic areas.

S. Croft, J. Dujardin, O. Olesen, 2010, Trends in parasitology.

Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents

F. Gamarro, C. Caffrey, D. González-Pacanowska, 2019, PLoS neglected tropical diseases.

Farnesyl Diphosphate Synthase Is a Cytosolic Enzyme in Leishmania major Promastigotes and Its Overexpression Confers Resistance to Risedronate

D. González-Pacanowska, Juana Carrero-Lérida, L. Ruiz-Pérez, 2006, Eukaryotic Cell.

Saturation site-directed mutagenesis of thymidylate synthase.

R. Stroud, P. Prapunwattana, S. Climie, 1990, The Journal of biological chemistry.

Co-existence of circular and multiple linear amplicons in methotrexate-resistant Leishmania.

D. González-Pacanowska, L. Ruiz-Pérez, V. Bernier, 1995, Nucleic acids research.

Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.

I. Gilbert, R. Brun, D. González-Pacanowska, 2005, Bioorganic & medicinal chemistry.

Isolation and characterization of a mutant dihydrofolate reductase-thymidylate synthase from methotrexate-resistant Leishmania cells.

P. Reche, D. Santi, E. Garvey, 1994, The Journal of biological chemistry.

Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.

D. González-Pacanowska, L. Ruiz-Pérez, A. Estévez, 2005, Molecular and biochemical parasitology.

Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.

H. Krokan, Ragnhild Sneve, G. Slupphaug, 2004, Journal of molecular biology.

Trypanosoma brucei gambiense Adaptation to Different Mammalian Sera Is Associated with VSG Expression Site Plasticity

J. Cano, A. Benito, J. Bart, 2013, PloS one.

Effects of different nutritional conditions on chick liver mevalonate-activating enzymes.

D. González-Pacanowska, C. Marco, E. García-Peregrín, 1986, Biochimica et biophysica acta.

Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase☆

I. Gilbert, A. Schipani, D. González-Pacanowska, 2013, Bioorganic & medicinal chemistry.

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni

I. Gilbert, K. Wilson, A. E. Vidal, 2009, Journal of enzyme inhibition and medicinal chemistry.

Description of a novel eukaryotic deoxyuridine 5'-triphosphate nucleotidohydrolase in Leishmania major.

D. González-Pacanowska, L. Ruiz-Pérez, J. Peña-Diaz, 1997, The Biochemical journal.

The Crystal Structure of the Leishmania major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, dUMP, and Deoxyuridine*

K. Wilson, G. R. Hemsworth, M. Fogg, 2011, The Journal of Biological Chemistry.

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei.

F. Gamarro, D. González-Pacanowska, C. Butler, 2017, Bioorganic & medicinal chemistry letters.

Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.

L. Chiaradia, A. Giménez, A. Benito, 2011, European journal of medicinal chemistry.

Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.

M. Gelb, J. Urbina, D. González-Pacanowska, 2012, International journal for parasitology.

Relationship between changes in free cholesterol and pyrophosphomevalonate decarboxylase activity during myelination

D. González-Pacanowska, C. Marco, E. García-Peregrín, 1983, Neurochemical Research.

Distribution of 3‐hydroxy‐3‐methylglutaryl‐CoA reductase in isolated villus and crypt cells of chick duodenum, jejunum and ileum

J. Iglesias, D. González-Pacanowska, E. García-Peregrín, 1989, Cell biochemistry and function.

Amplification of the H locus in Leishmania infantum.

S. Castanys, F. Gamarro, D. González-Pacanowska, 1994, Biochimica et biophysica acta.

High-Throughput Screening Platform for Natural Product–Based Drug Discovery Against 3 Neglected Tropical Diseases

S. Castanys, F. Gamarro, N. de Pedro, 2015, Journal of biomolecular screening.

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

J. Balzarini, S. Liekens, Y. Igarashi, 2016, PLoS pathogens.

Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents.

A. E. Vidal, D. González-Pacanowska, Víctor M. Castillo-Acosta, 2012, DNA repair.

Quantitation of deoxynucleoside triphosphates by click reactions

D. González-Pacanowska, Z. Chang, Chang-Yu Huang, 2020, Scientific Reports.

Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity.

Travis J DeLano, F. Gamarro, D. González-Pacanowska, 2020, RSC medicinal chemistry.

Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei

A. E. Vidal, D. González-Pacanowska, G. Pérez-Moreno, 2017, Scientific Reports.

3-Hydroxy-3-methyl-glutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: subcellular localization and kinetic properties.

J. Concepción, J. Urbina, D. González-Pacanowska, 1998, Archives of biochemistry and biophysics.

Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.

A. E. Vidal, D. González-Pacanowska, Víctor M. Castillo-Acosta, 2008, The international journal of biochemistry & cell biology.

SQ109, a New Drug Lead for Chagas Disease

E. Oldfield, R. Guo, W. de Souza, 2015, Antimicrobial Agents and Chemotherapy.

Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target.

I. Gilbert, R. Brun, D. González-Pacanowska, 2005, Journal of medicinal chemistry.

MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353.

Jesús Martín, F. Vicente, O. Genilloud, 2018, Journal of natural products.

Modified 5′‐Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase

G. F. Ruda, I. Gilbert, R. Brun, 2011, ChemMedChem.

Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides

A. E. Vidal, D. González-Pacanowska, L. Ruiz-Pérez, 2022, Scientific reports.

Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase.

D. González-Pacanowska, L. Ruiz-Pérez, A. Vargas-Berenguel, 2008, Biochimica et biophysica acta.

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

E. Oldfield, D. González-Pacanowska, J. Sanders, 2003, Journal of medicinal chemistry.

Overview of the role of kinetoplastid surface carbohydrates in infection and host cell invasion: prospects for therapeutic intervention

A. E. Vidal, D. González-Pacanowska, Víctor M. Castillo-Acosta, 2019, Parasitology.

Evaluation of azasterols as anti-parasitics.

I. Gilbert, V. Yardley, S. Croft, 2006, Journal of medicinal chemistry.

Lasionectrin, a naphthopyrone from a Lasionectria sp.

Jesús Martín, F. Vicente, F. Reyes, 2012, Journal of natural products.

MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii.

Jesús Martín, F. Vicente, O. Genilloud, 2014, Journal of natural products.

Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae)

G. Bitchagno, Jesús Martín, B. Cautain, 2020, BMC complementary medicine and therapies.

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells.

A. E. Vidal, D. González-Pacanowska, G. Pérez-Moreno, 2014, The Biochemical journal.

Squalene Synthase As a Target for Chagas Disease Therapeutics

E. Oldfield, Zhen Zhu, A. H. Wang, 2014, PLoS pathogens.

Thermodynamic analysis of the binding of 5-fluoro-2'-deoxyuridine 5'-monophosphate to thymidylate synthase over a range of temperatures.

P. Reche, D. Santi, O. López-Mayorga, 1995, European journal of biochemistry.

Embryonic development of mevalonate metabolism by sterol and nonsterol pathways in chick brain and liver

D. González-Pacanowska, C. Marco, E. García-Peregrín, 1986, International Journal of Developmental Neuroscience.

Synthesis of sterols by chick brain and liver during embryonic development

D. González-Pacanowska, C. Marco, E. García-Peregrín, 1985, Neurochemistry International.

Evolution of 3-hydroxy-3-methylglutaryl-CoA reductase and microsomal membrane fluidity throughout chick embryo development.

D. González-Pacanowska, J. Segovia, C. Marco, 1985, The International journal of biochemistry.

Antiprotozoan sesterterpenes and triterpenes isolated from two Ghanaian mushrooms.

Jesús Martín, F. Vicente, O. Genilloud, 2018, Fitoterapia.

Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.

G. F. Ruda, I. Gilbert, A. Schipani, 2006, Journal of medicinal chemistry.

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

K. Read, I. Gilbert, K. Wilson, 2012, Journal of medicinal chemistry.

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

G. F. Ruda, I. Gilbert, D. González-Pacanowska, 2010, European journal of medicinal chemistry.

Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171

Jesús Martín, F. Vicente, O. Genilloud, 2023, Pharmaceutics.

Oleoyl-CoA incorporation into triglycerides and phospholipids by chick enterocytes. Effect of cholesterol and cholestyramine feeding

J. Iglesias, D. González-Pacanowska, C. Marco, 1992 .

Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides

A. E. Vidal, D. González-Pacanowska, Blanca Martínez-Arribas, 2022, Scientific Reports.

Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme

D. González-Pacanowska, Juana Carrero-Lérida, G. Pérez-Moreno, 2019, mSphere.

Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei

L. Bird, K. Wilson, J. Nettleship, 2016, Molecular microbiology.

Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major

K. Wilson, J. Nettleship, D. González-Pacanowska, 2015, PLoS neglected tropical diseases.

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

J. Balzarini, A. Gigante, M. Camarasa, 2014, European journal of medicinal chemistry.

Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

A. E. Vidal, J. Bart, D. González-Pacanowska, 2012, DNA repair.

A novel calcium‐dependent soluble inorganic pyrophosphatase from the trypanosomatid Leishmania major

A. Serrano, D. González-Pacanowska, M. Gómez-García, 2004, FEBS letters.

Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation in Trypanosoma brucei

K. Wilson, D. González-Pacanowska, M. Valente, 2017, mSphere.

A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments.

D. González-Pacanowska, A. Camacho, R. Arrebola, 1996, Molecular and biochemical parasitology.

β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.

Ian H. Gilbert, Keith S. Wilson, Marcel Kaiser, 2011, Bioorganic & medicinal chemistry.

Differential response of chick liver and brain membranes to short ethanol treatment

D. González-Pacanowska, J. Segovia, C. Marco, 1986, Neurochemical Research.

Alterations induced by chronic ethanol treatment on lipid composition of microsomes, mitochondria and myelin from neonatal chick liver and brain.

D. González-Pacanowska, J. Segovia, C. Marco, 1986, Biochemistry international.

Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase.

I. Gilbert, K. Wilson, A. Wilkinson, 2010, The Biochemical journal.

Kinetic properties and inhibition of the dimeric dUTPase‐dUDPase from Leishmania major

D. González-Pacanowska, V. Bernier-Villamor, A. Camacho, 2001, Protein science : a publication of the Protein Society.

Surface Glycans: A Therapeutic Opportunity for Kinetoplastid Diseases.

J. Balzarini, D. González-Pacanowska, Víctor M. Castillo-Acosta, 2017, Trends in parasitology.

Base excision repair plays an important role in the protection against nitric oxide‐ and in vivo‐induced DNA damage in Trypanosoma brucei

A. E. Vidal, D. González-Pacanowska, Víctor M. Castillo-Acosta, 2019, Free radical biology & medicine.

Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major.

K. Wilson, M. Harkiolaki, A. E. Vidal, 2007, Journal of molecular biology.

The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases.

Michael Y. Galperin, Keith S Wilson, Michael Y Galperin, 2004, Journal of molecular biology.

Design, Synthesis, and Evaluation of 5′‐Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase

I. Gilbert, K. Wilson, J. Brannigan, 2011, ChemMedChem.

Expression and characterization of the Trypanosoma cruzi dihydrofolate reductase domain.

P. Reche, D. Santi, D. González-Pacanowska, 1996, Molecular and biochemical parasitology.

Structures of adenosine kinase from Trypanosoma brucei brucei.

K. Wilson, D. González-Pacanowska, J. Timm, 2014, Acta crystallographica. Section F, Structural biology communications.

Cloning and expression of the dihydrofolate reductase-thymidylate synthase gene from Trypanosoma cruzi.

P. Reche, D. Santi, D. González-Pacanowska, 1994, Molecular and biochemical parasitology.

The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase.

Maria Paola Costi, R. Stroud, J. Finer-Moore, 2003, Protein engineering.

Thermodynamic characterization of the binding of dCMP to the Asn229Asp mutant of thymidylate synthase

D. González-Pacanowska, V. Bernier-Villamor, R. Téllez-Sanz, 1997, FEBS letters.

Exposure of Trypanosoma brucei to an N-acetylglucosamine-Binding Lectin Induces VSG Switching and Glycosylation Defects Resulting in Reduced Infectivity

J. Balzarini, E. V. Van Damme, D. González-Pacanowska, 2015, PLoS neglected tropical diseases.

Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates.

E. Oldfield, S. Gabelli, D. González-Pacanowska, 2014, Acta crystallographica. Section D, Biological crystallography.

Crystallization and preliminary X-ray diffraction of Trypanosoma cruzi dUTPase.

K. Wilson, A. Antson, D. González-Pacanowska, 1999, Acta crystallographica. Section D, Biological crystallography.

Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.

A. E. Vidal, D. González-Pacanowska, Víctor M. Castillo-Acosta, 2013, Molecular and biochemical parasitology.

Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.

A. E. Vidal, D. González-Pacanowska, M. Navarro, 2012, The international journal of biochemistry & cell biology.

The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding fold.

K. Wilson, E. Dodson, J. Turkenburg, 2004, Structure.

On the catalytic mechanism of dimeric dUTPases.

K. Wilson, G. R. Hemsworth, D. González-Pacanowska, 2013, The Biochemical journal.

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

Olga Genilloud, Fernando Reyes, Ignacio Pérez-Victoria, 2016, PloS one.

Characterization of uracil-DNA glycosylase activity from Trypanosoma cruzi and its stimulation by AP endonuclease.

D. González-Pacanowska, M. E. Fárez-Vidal, C. Gallego, 2001, Nucleic acids research.

Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli.

D. González-Pacanowska, V. Bernier-Villamor, A. Camacho, 1999, Nucleic acids research.

A soluble 3-hydroxy-3-methylglutaryl-CoA reductase in the protozoan Trypanosoma cruzi.

D. González-Pacanowska, J. Peña-Diaz, A. Camacho, 1997, Biochemical Journal.

Identification of a residue critical for the excision of 3′-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family

Wei Yang, A. E. Vidal, D. González-Pacanowska, 2009, Nucleic acids research.

Kinetic properties and inhibition of Trypanosoma cruzi 3‐hydroxy‐3‐methylglutaryl CoA reductase

D. González-Pacanowska, J. Peña-Diaz, A. Montalvetti, 2002, FEBS letters.

Characterization of deoxyuridine 5′‐triphosphate nucleotidohydrolase from Trypanosoma cruzi 1

D. González-Pacanowska, A. Camacho, V. Bernier-Villamor, 2002, FEBS letters.

The nucleotidohydrolases DCTPP 1 and dUTPase are involved in the cellular response to the DNA-demethylating drug decitabine

B. Vértessy, A. E. Vidal, D. González-Pacanowska, 2017 .

The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine.

B. Vértessy, A. E. Vidal, D. González-Pacanowska, 2016, The Biochemical journal.

Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity

I. Gilbert, S. Müller, D. González-Pacanowska, 2019, Malaria Journal.

Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase.

G. F. Ruda, I. Gilbert, A. E. Vidal, 2011, European journal of medicinal chemistry.

Kinetic properties and specificity of trimeric Plasmodium falciparum and human dUTPases.

D. González-Pacanowska, E. Recio, A. Vargas-Berenguel, 2010, Biochimie.

Quantitative role of different embryonic tissues in mevalonate metabolism by sterol and nonsterol pathways. Relationship with enzyme activities of cholesterogenesis.

D. González-Pacanowska, J. Segovia, C. Marco, 1986, Biochimica et biophysica acta.

Studies on the diurnal rhythm of mevalonate metabolism by sterol and nonsterol pathways and of mevalonate-activating enzymes.

D. González-Pacanowska, E. García-Peregrín, J. A. Aguilera, 1985, The International journal of biochemistry.

Further characterization of mevalonate metabolism in neonatal chick kidney

M. D. Suárez, D. González-Pacanowska, E. García-Peregrín, 1981 .

Cholesterol synthesis and esterification in isolated enterocytes: Regulation by cholesterol and cholestyramine feeding

J. Iglesias, D. González-Pacanowska, C. Marco, 1993, Lipids.

Mevalonate 5-pyrophosphate decarboxylase in isolated villus and crypt cells of chick intestine

J. Iglesias, D. González-Pacanowska, E. García-Peregrín, 1988, Lipids.

Role of mevalonate-5-pyrophosphate decarboxylase in the regulation of chick intestinal cholesterogenesis.

D. González-Pacanowska, C. Marco, E. García-Peregrín, 1985, Biochimica et biophysica acta.

Changes in chick liver and brain mevalonate kinase, mevalonate-5-phosphate kinase and mevalonate-5-pyrophosphate decarboxylase during development.

D. González-Pacanowska, C. Marco, E. García-Peregrín, 1984, The International journal of biochemistry.

Brain phosphorylation and decarboxylation of mevalonic acid in the neonatal chick.

D. González-Pacanowska, E. García-Peregrín, J. Garcia-Martinez, 1981, Enzyme.

Localization of acyl-coenzyme A: cholesterol acyltransferase in villus and crypt cells of chick intestine.

J. Iglesias, D. González-Pacanowska, M. Castillo, 1989, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Influence of cholestyramine feeding on mevalonate-activating enzymes.

J. Iglesias, D. González-Pacanowska, C. Marco, 1988, Enzyme.

3-Hydroxy-3-methyl-glutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: subcellular localization and kinetic properties.

J. Urbina, D. González-Pacanowska, J. Concepción, 1998, Archives of biochemistry and biophysics.

Calorimetric determination of thermodynamic parameters of 2'-dUMP binding to Leishmania major dUTPase.

D. González-Pacanowska, R. Téllez-Sanz, I. Leal, 2004, Biochimica et biophysica acta.

Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase.

D. González-Pacanowska, V. Bernier-Villamor, J. A. Musso-Buendia, 2007, Biochimie.

2-Alkylaminoethyl-1,1-Bisphosphonic Acids Are Potent Inhibitors of the Enzymatic Activity of Trypanosoma cruzi Squalene Synthase

D. González-Pacanowska, Juan B Rodriguez, S. Szajnman, 2012, Antimicrobial Agents and Chemotherapy.

Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.

E. Oldfield, Yongcheng Song, D. González-Pacanowska, 2005, Journal of medicinal chemistry.

Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei

A. E. Vidal, D. González-Pacanowska, G. Pérez-Moreno, 2017, Scientific Reports.

Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.

D. González-Pacanowska, J. Peña-Diaz, A. Montalvetti, 2000, Biochemical Journal.

Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei.

D. González-Pacanowska, Juana Carrero-Lérida, G. Pérez-Moreno, 2009, International journal for parasitology.

Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity

Jesús Martín, Francisco Castillo, F. Vicente, 2023, bioRxiv.

Strasseriolides A-D, A Family of Antiplasmodial Macrolides Isolated from the Fungus Strasseria geniculata CF-247251.

Jesús Martín, N. de Pedro, F. Vicente, 2020, Organic letters.

Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity

I. Gilbert, S. Müller, D. González-Pacanowska, 2019, Malaria Journal.

Isopentenoid synthesis in isolated embryonic Drosophila cells. Farnesol catabolism and omega-oxidation.

B. Arison, D. González-Pacanowska, J. Watson, 1988, The Journal of biological chemistry.

Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes

D. Kyle, F. Gamarro, D. González-Pacanowska, 2023, Frontiers in Microbiology.

A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in Trypanosoma brucei.

D. González-Pacanowska, C. Bosch-Navarrete, Miriam Yagüe-Capilla, 2021, ACS infectious diseases.

A nuclear orthologue of the dNTP triphosphohydrolase SAMHD1 controls dNTP homeostasis and genomic stability in Trypanosoma brucei

D. González-Pacanowska, C. Bosch-Navarrete, L. Ruiz‐Pérez, 2023, Frontiers in cellular and infection microbiology.

1,2-Diphenoxiethane salts as potent antiplasmodial agents.

L. C. López-Cara, D. González-Pacanowska, C. Marco, 2018, Bioorganic & medicinal chemistry letters.

New Compounds with Bioisosteric Replacement of Classic Choline Kinase Inhibitors Show Potent Antiplasmodial Activity

E. Parisini, L. C. López-Cara, D. González-Pacanowska, 2021, Pharmaceutics.

Preclinical evaluation of strasseriolides A–D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251

Ana Rodriguez, F. Vicente, Caridad Díaz, 2021, Malaria journal.